A Study on the Planarian Model Confirms the Antioxidant Properties of Tameron against X-ray- and Menadione-Induced Oxidative Stress

Ionizing radiation and radiation-related oxidative stress are two important factors responsible for the death of actively proliferating cells, thus drastically reducing the regeneration capacity of living organisms. Planarian flatworms are freshwater invertebrates that are rich in stem cells called neoblasts and, therefore, present a well-established model for studies on regeneration and the testing of novel antioxidant and radioprotective substances. In this work, we tested an antiviral and antioxidant drug Tameron (Monosodium alpha-Luminol or 5-amino-2,3-dihydro-1,4-phthalazinedione sodium salt) for its ability to reduce the harm of X-ray- and chemically induced oxidative stress on a planarian model. Our study has revealed the ability of Tameron to effectively protect planarians from oxidative stress while enhancing their regenerative capacity by modulating the expression of neoblast marker genes and NRF-2-controlled oxidative stress response genes.

Automated summary

Ionizing radiation and radiation-related oxidative stress significantly reduce the regeneration capacity of living organisms. Planarian flatworms, known for their abundant stem cells, serve as a valuable model for studying regeneration and testing novel antioxidants and radioprotective substances. Our study demonstrates that Tameron, an antiviral and antioxidant drug, effectively protects planarians from oxidative stress and enhances their regenerative capacity by modulating gene expression related to neoblasts and oxidative stress response.