Journal
ANTIOXIDANTS
Volume 12, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/antiox12030541
Keywords
prenatal alcohol exposure; renin-angiotensin system; kallikrein-kinin system; hippocampus; heart; oxidative stress
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This study analyzed the effects of prenatal alcohol exposure on the expression of peptidergic systems in the hippocampus and heart of mice. The results showed that alcohol exposure can modulate the renin-angiotensin system and kallikrein-kinin system in these tissues. Additionally, females exposed to prenatal alcohol showed reduced susceptibility to the effects of alcohol.
Prenatal alcohol exposure (PAE) impairs fetal development. Alcohol consumption was shown to modulate the renin-angiotensin system (RAS). This study aimed to analyze the effects of PAE on the expression of the renin-angiotensin system (RAS) and kallikrein-kinin system (KKS) peptide systems in the hippocampus and heart of mice of both sexes. C57Bl/6 mice were exposed to alcohol during pregnancy at a concentration of 10% (v/v). On postnatal day 45 (PN45), mouse hippocampi and left ventricles (LV) were collected and processed for messenger RNA (mRNA) expression of components of the RAS and KKS. In PAE animals, more pronounced expression of AT1 and ACE mRNAs in males and a restored AT2 mRNA expression in females were observed in both tissues. In LV, increased AT2, ACE2, and B2 mRNA expressions were also observed in PAE females. Furthermore, high levels of H2O2 were observed in males from the PAE group in both tissues. Taken together, our results suggest that modulation of the expression of these peptidergic systems in PAE females may make them less susceptible to the effects of alcohol.
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