4.7 Article

Mitochondria Need Their Sleep: Redox, Bioenergetics, and Temperature Regulation of Circadian Rhythms and the Role of Cysteine-Mediated Redox Signaling, Uncoupling Proteins, and Substrate Cycles

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance

Supriya Bevinakoppamath et al.

Summary: The article discusses the interplay between circadian rhythm and the Nrf2 pathway, their impact on breast cancer pathogenesis, and proposes the significance of treatment strategies regulating circadian rhythm for maximizing treatment efficacy with minimal side effects.

FRONTIERS IN PHARMACOLOGY (2022)

Review Biotechnology & Applied Microbiology

Mitochondrial Membrane Remodeling

Ziyun Yang et al.

Summary: Mitochondria play a crucial role in cellular processes and are linked to various human disorders. Their function is closely tied to their complex membrane architecture. The mechanisms behind membrane curvature generation and maintenance, as well as factors involved, are still largely unknown.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Article Biology

Peripheral circadian gene activity is altered during hibernation in the thirteen-lined ground squirrel

Alexander J. Watts et al.

Summary: The study indicates that peripheral circadian clock activity persists during hibernation, with tissue-specific responses in mRNA transcript levels. Core clock proteins show tissue- and time-dependent changes over the torpor/arousal cycle.

CRYOBIOLOGY (2022)

Review Pediatrics

Hyperthermia and Heat Stress as Risk Factors for Sudden Infant Death Syndrome: A Narrative Review

Veronique Bach et al.

Summary: Heat stress and hyperthermia may increase the risk of sudden infant death syndrome (SIDS) by directly causing lethal hyperthermia or indirectly altering autonomic functions. Impairments of vital physiological functions when exposed to thermal stress are the major risk factors for SIDS, except for excessive thermal insulation.

FRONTIERS IN PEDIATRICS (2022)

Article Medicine, General & Internal

Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome

Carmel Therese Harrington et al.

Summary: This study investigated the changes in butyrylcholinesterase (BChE) activity in infants and young children who died from Sudden Infant Death Syndrome (SIDS). The findings suggest a potential association between cholinergic deficit and SIDS. The measurement of BChE activity in dried blood spots taken 2-3 days after birth may serve as a potential method to identify vulnerability to SIDS.

EBIOMEDICINE (2022)

Review Biochemistry & Molecular Biology

S-Glutathionylation and S-Nitrosylation in Mitochondria: Focus on Homeostasis and Neurodegenerative Diseases

Sofia Vrettou et al.

Summary: Redox post-translational modifications, such as S-glutathionylation and S-nitrosylation, play crucial roles in regulating protein function, localization, activity, and structure. These modifications are controlled by fluctuations in reactive oxygen and nitrogen species and have significant impacts on mitochondrial processes, including bioenergetics, morphology, metabolism, and apoptosis. Dysregulation of S-glutathionylation and S-nitrosylation is associated with neurodegenerative disorders such as Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, and Friedreich's ataxia.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Ophthalmology

The role of oxygen and the Goldilocks range in the development of cataracts induced by space radiation in US astronauts

Richard B. Richardson

Summary: This article explores the role of oxygen levels in US spacecraft from 1961 to 1998 on the development of cataracts induced by space radiation in astronauts, and whether these oxygen levels are well accounted for in experimental studies examining cataractogenesis. The findings suggest that higher lens doses are associated with increased risk of certain types of cataracts, and that both high and low oxygen levels can impact cataract development. However, current studies often overlook the hypoxic state of the normal lens. Therefore, it is recommended to consider ocular physioxic levels when designing in vitro studies to better understand the progression of cataractogenesis during long-duration missions.

EXPERIMENTAL EYE RESEARCH (2022)

Article Physiology

The integrated stress response as a key pathway downstream of mitochondrial dysfunction

Maria Bilen et al.

Summary: Mitochondrial function is crucial for maintaining metabolic homeostasis and is associated with various metabolic and neurological diseases. The integrated stress response (ISR) serves as an important communication pathway between organelles, responding to mitochondrial stress. However, the mechanisms by which ISR coordinates cell death and survival under different insults remain unclear.

CURRENT OPINION IN PHYSIOLOGY (2022)

Article Biochemistry & Molecular Biology

Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production

David A. Patten et al.

Summary: The study explores the relationship between mitochondrial dynamics and the cellular antioxidant glutathione, showing that cells lacking the mitochondrial fusion machinery exhibit elevated levels of GSH which limits oxidative damage. Additionally, it was found that cells lacking the inner membrane fusion GTPase OPA1 undergo metabolic remodeling altering the balance of citric acid cycle intermediates and favoring GSH synthesis. The findings suggest a novel role for mitochondrial fusion in regulating GSH synthesis and imply that cysteine availability is not limiting for GSH synthesis in conditions of mitochondrial fragmentation.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Review Biochemistry & Molecular Biology

Reductive Stress of Sulfur-Containing Amino Acids within Proteins and Implication of Tandem Protein-Lipid Damage

Chryssostomos Chatgilialoglu et al.

Summary: This article examines the reactivity of hydrogen atoms and hydrated electrons associated with peptides/proteins, discussing the formation of sulfur-centered radicals and their utilization in biomimetic radical chemistry. It also highlights the potential applications of these findings in pharmaceutical and pharmacological contexts.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Parp1 promotes sleep, which enhances DNA repair in neurons

David Zada et al.

Summary: This study reveals that DNA damage is a homeostatic driver for sleep, with neuronal activity and mutagens triggering repair during sleep. DDR proteins show increased activity during sleep, while Parp1 promotes sleep and repair, sensing cellular pressure for sleep.

MOLECULAR CELL (2021)

Article Endocrinology & Metabolism

Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans

Bala S. C. Koritala et al.

Summary: Circadian disruption, particularly from night shift work, affects cancer hallmark pathway genes, potentially increasing cancer risk in shift workers.

JOURNAL OF PINEAL RESEARCH (2021)

Article Geriatrics & Gerontology

Body Temperature Is Associated With Cognitive Performance in Older Adults With and Without Mild Cognitive Impairment: A Cross-sectional Analysis

Patrick Eggenberger et al.

Summary: This study explored the association between body temperature and cognitive performance in older adults. The findings suggest that lower median body temperature and higher peak-to-peak body temperature amplitude are associated with better cognitive performance. Additionally, cognitively healthy older adults exhibited better body temperature measures compared to those with MCI.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Article Biology

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

Margaret E. Torrence et al.

Summary: The study found that the mTORC1-ATF4 pathway activates a subset of ATF4 target genes induced by the ISR, including genes related to amino acid uptake, synthesis, and tRNA charging. ATF4 is identified as a metabolic effector of mTORC1, playing a role in promoting protein synthesis and in a previously unappreciated function for mTORC1 in stimulating cellular cystine uptake and glutathione synthesis.

ELIFE (2021)

Review Biology

DNA damage-how and why we age?

Matt Yousefzadeh et al.

Summary: Aging is a complex process that involves DNA damage leading to cells entering apoptosis or senescence to avoid replicating a damaged genome. DNA damage is also linked to other cellular processes implicated as drivers of aging, supporting the idea that DNA damage could be the root cause of aging.

ELIFE (2021)

Article Cell Biology

Rapid and reversible control of human metabolism by individual sleep states

Nora Nowak et al.

Summary: Using exhaled breath analysis, this study found that different vigilance states during sleep rapidly and reversibly control major metabolic pathways, with wake reducing fatty acid oxidation, slow-wave sleep increasing it, and rapid eye movement sleep resulting in elevation of tricarboxylic acid cycle intermediates. This complex orchestration between sleep and wake likely plays an important role in optimizing metabolic circuits for human performance and health.

CELL REPORTS (2021)

Article Cardiac & Cardiovascular Systems

Cell-Free Mitochondrial DNA as a Potential Biomarker for Astronauts' Health

Malik Bisserier et al.

Summary: This study found that levels of circulating cell-free mitochondrial DNA increased in astronauts after space missions, with significant variability between individuals. Additionally, gene expression analysis of peripheral blood mononuclear cells showed significant increases in markers of inflammation, oxidative stress, and DNA damage after returning to Earth.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Biochemistry & Molecular Biology

Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior

Yuki Yasumoto et al.

Summary: The study revealed a novel interaction between microglia and neurons in the ventral hippocampus, which plays a role in regulating synaptic number, reactive oxygen species production, and neuronal circuit functions, ultimately influencing anxiety-like behavior.

MOLECULAR PSYCHIATRY (2021)

Article Biochemistry & Molecular Biology

Redox and Antioxidant Modulation of Circadian Rhythms: Effects of Nitroxyl, N-Acetylcysteine and Glutathione

Santiago Andres Plano et al.

Summary: The study reveals that light signaling at the end of subjective night can advance the phase of locomotor rhythms in hamsters through the action of free radical nitric oxide. The phase-delays at CT14 seem to be influenced by a reductive SCN environment, while an oxidative environment favors photic advances. This suggests that circadian phase-locking mechanisms should take into account the redox SCN environment and the generation of relatives of NO center dot.

MOLECULES (2021)

Article Neurosciences

Longer and Deeper Desaturations Are Associated With the Worsening of Mild Sleep Apnea: The Sleep Heart Health Study

Tuomas Karhu et al.

Summary: In both men and women, longer and deeper desaturations are significantly associated with the worsening of sleep apnea, while the oxygen desaturation index (ODI) is not. In men, longer desaturation duration, average desaturation area, and desaturation severity are significantly associated with sleep apnea worsening.

FRONTIERS IN NEUROSCIENCE (2021)

Review Cell Biology

The Mitochondrial Response to DNA Damage

Ziye Rong et al.

Summary: Mitochondria are essential organelles in eukaryotic cells that provide energy through oxidative phosphorylation. Mitochondrial DNA is prone to damage by DNA damaging agents, which can lead to dysfunction and contribute to various human diseases. Understanding mtDNA repair mechanisms is crucial for developing therapeutic strategies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Circadian Rhythm of NER and ATR Pathways

Tae-Hong Kang

Summary: Studies have shown that DNA damage responses are evolved to limit genomic instability caused by UV radiation, and they are under the control of circadian clock systems, showing daily oscillations in their catalytic activities. The molecular basis for the circadian rhythm of UV-induced DNA damage responses in mammalian cells will be discussed.

BIOMOLECULES (2021)

Article Biochemistry & Molecular Biology

The glutathionylation agent disulfiram augments superoxide/hydrogen peroxide production when liver mitochondria are oxidizing ubiquinone pool-linked and branched chain amino acid substrates

Jonathan Hirschenson et al.

Summary: The study demonstrates that glutathionylation can enhance ROS production by mitochondria, with different effects depending on the oxidizing sources and inhibitors used.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Cell Biology

Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity

Bruno A. Aguilar-Lopez et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster

Filippo Scialo et al.

REDOX BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Caprylic (Octanoic) Acid as a Potential Fatty Acid Chemotherapeutic for Glioblastoma

Meric A. Altinoz et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2020)

Review Biochemistry & Molecular Biology

An Update on Mitochondrial Reactive Oxygen Species Production

Ryan J. Mailloux

ANTIOXIDANTS (2020)

Article Biochemistry & Molecular Biology

Mitochondrial calcium drives clock gene-dependent activation of pyruvate dehydrogenase and of oxidative phosphorylation

Rosella Scrima et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

Editorial Material Endocrinology & Metabolism

Is the Observed Decrease in Body Temperature During Industrialization Due to Thyroid Hormone-Dependent Thermoregulation Disruption?

Pieter Vancamp et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Multidisciplinary Sciences

Electron Transport Chain Complex II Regulates Steroid Metabolism

Himangshu S. Bose et al.

ISCIENCE (2020)

Review Geriatrics & Gerontology

Impairments to Thermoregulation in the Elderly During Heat Exposure Events

Alison Millyard et al.

GERONTOLOGY AND GERIATRIC MEDICINE (2020)

Article Biochemistry & Molecular Biology

Protein S-glutathionylation: The linchpin for the transmission of regulatory information on redox buffering capacity in mitochondria

Adrian Young et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2019)

Review Cardiac & Cardiovascular Systems

Circadian-Regulated Cell Death in Cardiovascular Diseases

Inna Rabinovich-Nikitin et al.

CIRCULATION (2019)

Review Clinical Neurology

Association between circadian rhythms and neurodegenerative diseases

Yue Leng et al.

LANCET NEUROLOGY (2019)

Article Multidisciplinary Sciences

A potassium channel β-subunit couples mitochondrial electron transport to sleep

Anissa Kempf et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Mitochondrial adaptation in human mesenchymal stem cells following ionizing radiation

David A. Patten et al.

FASEB JOURNAL (2019)

Review Medicine, General & Internal

The Circadian Syndrome: is the Metabolic Syndrome and much more!

P. Zimmet et al.

JOURNAL OF INTERNAL MEDICINE (2019)

Review Neurosciences

The Temperature Dependence of Sleep

Edward C. Harding et al.

FRONTIERS IN NEUROSCIENCE (2019)

Article Medicine, Research & Experimental

Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation

Koen D. W. Hendriks et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

Review Endocrinology & Metabolism

Interconnection between circadian clocks and thyroid function

Keisuke Ikegami et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Article Biochemistry & Molecular Biology

Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice

Matthew D. Campbell et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Cell Biology

Crosstalk between metabolism and circadian clocks

Hans Reinke et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemical Research Methods

UCP2 Overexpression Redirects Glucose into Anabolic Metabolic Pathways

Annapoorna Sreedhar et al.

PROTEOMICS (2019)

Article Cell Biology

Cellular Timekeeping: It's Redox o' Clock

Nikolay B. Milev et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Protein S-glutathionylation induced by hypoxia increases hypoxia-inducible factor-1α in human colon cancer cells

Daun Jeon et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Mitochondrial uncoupling, ROS generation and cardioprotection

Susana Cadenas

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2018)

Article Cell Biology

Metabolic Plasticity Enables Circadian Adaptation to Acute Hypoxia in Zebrafish Cells

Adolf M. Sandbichler et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Regulation of vascular function and blood pressure by circadian variation in redox signalling

Glenn C. Rodrigo et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Review Immunology

Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts

Brenda Raud et al.

IMMUNOLOGICAL REVIEWS (2018)

Review Endocrinology & Metabolism

Circadian rhythms in mitochondrial respiration

Paul de Goede et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2018)

Article Endocrinology & Metabolism

Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway

Mingge Ding et al.

JOURNAL OF PINEAL RESEARCH (2018)

Review Neurosciences

Regulation of Body Temperature by the Nervous System

Chan Lek Tan et al.

NEURON (2018)

Article Multidisciplinary Sciences

Diurnal transcriptome atlas of a primate across major neural and peripheral tissues

Ludovic S. Mure et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

A proteomics landscape of circadian clock in mouse liver

Yunzhi Wang et al.

NATURE COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Mitochondria are physiologically maintained at close to 50 degrees C

Dominique Chretien et al.

PLOS BIOLOGY (2018)

Review Biochemistry & Molecular Biology

PARP1 promoter links cell cycle progression with adaptation to oxidative environment

Julita Pietrzak et al.

REDOX BIOLOGY (2018)

Article Endocrinology & Metabolism

Time-of-Day effects on Metabolic and clock-related adjustments to cold

Frederico Sander Mansur Machado et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Biochemistry & Molecular Biology

Human Resting Energy Expenditure Varies with Circadian Phase

Kirsi-Marja Zitting et al.

CURRENT BIOLOGY (2018)

Editorial Material Clinical Neurology

PERSPECTIVE: The Long-Term Effects of Light Exposure on Establishment of Newborn Circadian Rhythm

Jacqueline Yates

JOURNAL OF CLINICAL SLEEP MEDICINE (2018)

Review Physiology

Recent Progress in Space Physiology and Aging

Felice Strollo et al.

FRONTIERS IN PHYSIOLOGY (2018)

Review Cell Biology

Heat shock proteins and DNA repair mechanisms: an updated overview

Mayra L. Sottile et al.

CELL STRESS & CHAPERONES (2018)

Article Biochemistry & Molecular Biology

Protein S-glutathionylation alters superoxide/hydrogen peroxide emission from pyruvate dehydrogenase complex

Marisa O'Brien et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Cell Biology

Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases

Sun Joo Cha et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Review Psychology, Biological

The mouse thermoregulatory system: Its impact on translating biomedical data to humans

Christopher J. Gordon

PHYSIOLOGY & BEHAVIOR (2017)

Article Multidisciplinary Sciences

Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism?

Michael J. Pecaut et al.

PLOS ONE (2017)

Article Multidisciplinary Sciences

High serum serotonin in sudden infant death syndrome

Robin L. Haynes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Geriatrics & Gerontology

Neurodegeneration and the Circadian Clock

Suzanne Hood et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Increased core body temperature in astronauts during long-duration space missions

Alexander C. Stahn et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart

Anna Stepanova et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2016)

Article Cell Biology

The Pentose Phosphate Pathway Regulates the Circadian Clock

Guillaume Rey et al.

CELL METABOLISM (2016)

Article Endocrinology & Metabolism

Deficiency in the Heat Stress Response Could Underlie Susceptibility to Metabolic Disease

Robert S. Rogers et al.

DIABETES (2016)

Review Endocrinology & Metabolism

Uncoupling Proteins and the Molecular Mechanisms of Thyroid Thermogenesis

A. Solmonson et al.

ENDOCRINOLOGY (2016)

Review Biochemistry & Molecular Biology

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

Dun-Xian Tan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Biochemistry & Molecular Biology

Reciprocal Control of the Circadian Clock and Cellular Redox State - a Critical Appraisal

Marrit Putker et al.

MOLECULES AND CELLS (2016)

Review Nutrition & Dietetics

Circadian regulation of lipid metabolism

Joshua J. Gooley

PROCEEDINGS OF THE NUTRITION SOCIETY (2016)

Article Cardiac & Cardiovascular Systems

Increased activity of mitochondrial uncoupling protein 2 improves stress resistance in cultured endothelial cells exposed in vitro to high glucose levels

Agnieszka Koziel et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)

Review Biochemistry & Molecular Biology

The Redox Code

Dean P. Jones et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

Article Biochemistry & Molecular Biology

Temperature controls oxidative phosphorylation and reactive oxygen species production through uncoupling in rat skeletal muscle mitochondria

Wieslawa Jarmuszkiewicz et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Biotechnology & Applied Microbiology

Futile cycling increases sensitivity toward oxidative stress in Escherichia coli

Kristin J. Adolfsen et al.

METABOLIC ENGINEERING (2015)

Article Biochemistry & Molecular Biology

Circadian Oscillation of Sulfiredoxin in the Mitochondria

In Sup Kil et al.

MOLECULAR CELL (2015)

Review Cell Biology

Sleep Deprivation and Oxidative Stress in Animal Models: A Systematic Review

Gabriel Villafuerte et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

Article Multidisciplinary Sciences

Circadian Modulation of 8-Oxoguanine DNA Damage Repair

Nicola Manzella et al.

SCIENTIFIC REPORTS (2015)

Article Respiratory System

Mitochondrial DNA alteration in obstructive sleep apnea

Donato Lacedonia et al.

RESPIRATORY RESEARCH (2015)

Article Biochemistry & Molecular Biology

Redox-Optimized ROS Balance and the relationship between mitochondrial respiration and ROS

Sonia Cortassa et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2014)

Editorial Material Immunology

Futility Sustains Memory T Cells

Samuel E. Weinberg et al.

IMMUNITY (2014)

Review Oncology

Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review

Imen Belhadj Slimen et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2014)

Article Biochemistry & Molecular Biology

The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

Casey L. Quinlan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Behavioral Sciences

The energy allocation function of sleep: A unifying theory of sleep, torpor, and continuous wakefulness

Markus H. Schmidt

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2014)

Review Cell Biology

Oxidative Stress-Mediated Aging during the Fetal and Perinatal Periods

Lucia Marseglia et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)

Review Cell Biology

Heat shock proteins in neurodegenerative disorders and aging

Rehana K. Leak

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2014)

Review Biochemistry & Molecular Biology

Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions

Ryan J. Mailloux et al.

REDOX BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Circadian Rhythm Connections to Oxidative Stress: Implications for Human Health

Melissa Wilking et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

Causes and Consequences of Cysteine S-Glutathionylation

Christina L. Grek et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

Alexander S. Hebert et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

Sleep Drives Metabolite Clearance from the Adult Brain

Lulu Xie et al.

SCIENCE (2013)

Article Biochemistry & Molecular Biology

Nitric Oxide Regulates Mitochondrial Fatty Acid Metabolism Through Reversible Protein S-Nitrosylation

Paschalis-Thomas Doulias et al.

SCIENCE SIGNALING (2013)

Article Biochemistry & Molecular Biology

The Circadian Clock Coordinates Ribosome Biogenesis

Celine Jouffe et al.

PLOS BIOLOGY (2013)

Review Immunology

Circadian control of the immune system

Christoph Scheiermann et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Physiology

Mitochondrial metabolic suppression and reactive oxygen species production in liver and skeletal muscle of hibernating thirteen-lined ground squirrels

Jason C. L. Brown et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2012)

Review Biochemistry & Molecular Biology

Mechanisms of Altered Redox Regulation in Neurodegenerative Diseases-Focus on S-Glutathionylation

Elizabeth A. Sabens Liedhegner et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Review Biochemistry & Molecular Biology

Mitochondrial-nuclear co-evolution and its effects on OXPHOS activity and regulation

Dan Bar-Yaacov et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2012)

Review Biochemistry & Molecular Biology

Regulation of mitochondrial processes by protein S-nitrosylation

Claude A. Piantadosi

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

Article Biochemistry & Molecular Biology

The intracellular redox state is a core determinant of mitochondrial fusion

Timothy Shutt et al.

EMBO REPORTS (2012)

Article Biochemistry & Molecular Biology

Glutathionylation State of Uncoupling Protein-2 and the Control of Glucose-stimulated Insulin Secretion

Ryan J. Mailloux et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

S-Glutathionylation of the Na,K-ATPase Catalytic α Subunit Is a Determinant of the Enzyme Redox Sensitivity

Irina Yu. Petrushanko et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Oxidative Stress Induced S-glutathionylation and Proteolytic Degradation of Mitochondrial Thymidine Kinase 2

Ren Sun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons

Tongfei A. Wang et al.

SCIENCE (2012)

Review Clinical Neurology

Nitric oxide in the regulation of the sleep-wake states

Raymond Cespuglio et al.

SLEEP MEDICINE REVIEWS (2012)

Review Biochemistry & Molecular Biology

S-Glutathionylation: From Molecular Mechanisms to Health Outcomes

Ying Xiong et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

Review Biochemistry & Molecular Biology

The Interplay Between Mitochondrial Dynamics and Mitophagy

Gilad Twig et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

Review Biochemistry & Molecular Biology

Uncoupling proteins and the control of mitochondrial reactive oxygen species production

Ryan J. Mailloux et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Review Biochemistry & Molecular Biology

Oxidative stress, insulin signaling, and diabetes

Justin L. Rains et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Biochemistry & Molecular Biology

Glutathionylation Acts as a Control Switch for Uncoupling Proteins UCP2 and UCP3

Ryan J. Mailloux et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Geriatrics & Gerontology

Is Older Colder or Colder Older? The Association of Age With Body Temperature in 18,630 Individuals

Jill Waalen et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2011)

Article Multidisciplinary Sciences

Circadian clocks in human red blood cells

John S. O'Neill et al.

NATURE (2011)

Review Pharmacology & Pharmacy

Diabetes and alpha lipoic acid

Saeid Golbidi et al.

FRONTIERS IN PHARMACOLOGY (2011)

Article Endocrinology & Metabolism

Effects of sleep and circadian rhythm on the human immune system

Tanja Lange et al.

NEUROENDOCRINE IMMUNOLOGY IN RHEUMATIC DISEASES: TRANSLATION FROM BASICS TO CLINICS (2010)

Article Biochemistry & Molecular Biology

Mitochondrial fatty acid synthesis and respiration

J. Kalervo Hiltunen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2010)

Review Biochemistry & Molecular Biology

Mitochondrial proton and electron leaks

Martin Jastroch et al.

ESSAYS IN BIOCHEMISTRY: MITOCHONDRIAL FUNCTION (2010)

Review Biochemistry & Molecular Biology

Circadian clock control of the cellular response to DNA damage

Aziz Sancar et al.

FEBS LETTERS (2010)

Article Biochemistry & Molecular Biology

Metabolic Depression and Increased Reactive Oxygen Species Production by Isolated Mitochondria at Moderately Lower Temperatures

Sameh S. Ali et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Glutathionylation of Adenine Nucleotide Translocase Induced by Carbon Monoxide Prevents Mitochondrial Membrane Permeabilization and Apoptosis

Claudia S. F. Queiroga et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Regulation of Mitochondrial Glutathione Redox Status and Protein Glutathionylation by Respiratory Substrates

Jerome Garcia et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Psychiatry

Impairment of the mitochondrial electron transport chain due to sleep deprivation in mice

Ana C. Andreazza et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2010)

Article Public, Environmental & Occupational Health

Incidence of metabolic syndrome among night-shift healthcare workers

A. Pietroiusti et al.

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2010)

Article Multidisciplinary Sciences

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

Tae-Hong Kang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Cell Biology

Ionizing radiation and aging: rejuvenating an old idea

Richard B. Richardson

AGING-US (2009)

Review Biochemistry & Molecular Biology

How mitochondria produce reactive oxygen species

Michael P. Murphy

BIOCHEMICAL JOURNAL (2009)

Article Biochemistry & Molecular Biology

Special relationship between sterols and oxygen: Were sterols an adaptation to aerobic life?

Anne M. Galea et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Review Biochemistry & Molecular Biology

UCP2, A Metabolic Sensor Coupling Glucose Oxidation to Mitochondrial Metabolism?

Claire Pecqueur et al.

IUBMB LIFE (2009)

Article Biochemistry & Molecular Biology

Novel Role for Glutathione S-Transferase π REGULATOR OF PROTEIN S-GLUTATHIONYLATION FOLLOWING OXIDATIVE AND NITROSATIVE STRESS

Danyelle M. Townsend et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Endocrinology & Metabolism

Glucocorticoids and the circadian clock

Thomas Dickmeis

JOURNAL OF ENDOCRINOLOGY (2009)

Review Biochemistry & Molecular Biology

Protein S-nitrosylation in health and disease: a current perspective

Matthew W. Foster et al.

TRENDS IN MOLECULAR MEDICINE (2009)

Article Endocrinology & Metabolism

Free triiodothyronine has a distinct circadian rhythm that is delayed but parallels thyrotropin levels

W. Russell et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)

Article Endocrinology & Metabolism

Thyroid hormone effects on mitochondrial energetics

Mary-Ellen Harper et al.

THYROID (2008)

Review Biochemistry & Molecular Biology

S-glutathionylation -: Indicator of cell stress and regulator of the unfolded protein response

Danyelle M. Townsend

MOLECULAR INTERVENTIONS (2007)

Article Biochemistry & Molecular Biology

Mitochondrial complex II in the post-ischemic heart - Oxidative injury and the role of protein S-glutathionylation

Yeong-Renn Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Nutrition & Dietetics

Diurnal variation in glutathione and cysteine redox states in human plasmas

Roberto A. Blanco et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2007)

Article Cell Biology

Identification of the circadian transcriptome in adult mouse skeletal muscle

John J. McCarthy et al.

PHYSIOLOGICAL GENOMICS (2007)

Article Biochemistry & Molecular Biology

Fatty acids decrease mitochondrial generation of reactive oxygen species at the reverse electron transport but increase it at the forward transport

Peter Schoenfeld et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2007)

Article Biochemistry & Molecular Biology

Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers

Valeri Beck et al.

FASEB JOURNAL (2007)

Article Multidisciplinary Sciences

A quantitative, theoretical framework for understanding mammalian sleep

Van M. Savage et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Physiology

Regulation of UCP1 and UCP3 in arctic ground squirrels and relation with mitochondrial proton leak

Jamie L. Barger et al.

JOURNAL OF APPLIED PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

The basal proton conductance of mitochondria depends on adenine nucleotide translocase content

MD Brand et al.

BIOCHEMICAL JOURNAL (2005)

Article Multidisciplinary Sciences

Characterization of human glutaredoxin 2 as iron-sulfur protein:: A possible role as redox sensor

CH Lillig et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Cell Biology

The effects of stress and aging on glutathione metabolism

P Maher

AGEING RESEARCH REVIEWS (2005)

Review Biochemistry & Molecular Biology

Mitochondria, oxidants, and aging

RS Balaban et al.

Article Endocrinology & Metabolism

The diurnal patterns of the adrenal steroids cortisol and dehydroepiandrosterone (DHEA) in relation to awakening

F Hucklebridge et al.

PSYCHONEUROENDOCRINOLOGY (2005)

Article Biochemistry & Molecular Biology

Signaling in the mammalian circadian clock: the NO/cGMP pathway

DA Golombek et al.

NEUROCHEMISTRY INTERNATIONAL (2004)

Review Biochemistry & Molecular Biology

The free radical theory of aging

D Harman

ANTIOXIDANTS & REDOX SIGNALING (2003)

Article Biochemistry & Molecular Biology

Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase

S Canals et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Physiology

Hibernation induces glutathione redox imbalance in ground squirrel intestine

HV Carey et al.

JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY (2003)

Article Biochemistry & Molecular Biology

Reversible glutathionylation of complex I increases mitochondrial superoxide formation

ER Taylor et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Nutrition & Dietetics

Living fast, dying when? The link between aging and energetics

JR Speakman et al.

JOURNAL OF NUTRITION (2002)

Article Multidisciplinary Sciences

Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes

M Fratelli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Superoxide activates mitochondrial uncoupling proteins

KS Echtay et al.

NATURE (2002)

Review Nutrition & Dietetics

Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered

AG Dulloo et al.

BRITISH JOURNAL OF NUTRITION (2001)

Review Biochemistry & Molecular Biology

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

FQ Schafer et al.

FREE RADICAL BIOLOGY AND MEDICINE (2001)

Review Multidisciplinary Sciences

Oxidants, oxidative stress and the biology of ageing

T Finkel et al.

NATURE (2000)

Article Geriatrics & Gerontology

Uncoupling to survive? The role of mitochondrial inefficiency in ageing

MD Brand

EXPERIMENTAL GERONTOLOGY (2000)