4.7 Review

Cannabidiol: Bridge between Antioxidant Effect, Cellular Protection, and Cognitive and Physical Performance

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets

Vincenzo Micale et al.

Summary: The etiopathogenesis of mental disorders involves multiple genetic factors and a tight association between genes and environmental risk factors mediated by epigenetic mechanisms. Epigenetic modifications such as DNA methylation, histone modification, and interference of microRNA or long non-coding RNA have been found to influence the severity of the disease and the outcome of therapy. Understanding these mechanisms can help identify vulnerable patients and serve as biomarkers for diagnosis and treatment of psychiatric disorders.

PHARMACOLOGY & THERAPEUTICS (2023)

Article Biochemistry & Molecular Biology

Cannabidiol Treatment Improves Glucose Metabolism and Memory in Streptozotocin-Induced Alzheimer's Disease Rat Model: A Proof-of-Concept Study

Daniele de Paula Faria et al.

Summary: This study evaluated the effect of cannabidiol on brain glucose metabolism in an AD model and found that cannabidiol could potentially serve as an early treatment for the neurodegenerative process observed in Alzheimer's disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Behavioral Sciences

Cannabidiol reverses memory impairments and activates components of the Akt/GSK3β pathway in an experimental model of estrogen depletion

Marcio da Silveira Corre et al.

Summary: CBD has the potential to completely reverse memory impairments induced by estrogen depletion, and it achieves functional recovery by activating the Akt/GSK30 survival pathway, suggesting its potential as a treatment for neural deterioration caused by estrogen decline.

BEHAVIOURAL BRAIN RESEARCH (2022)

Article Neurosciences

Antioxidant and anti-apoptotic effects of cannabidiol in model of ischemic stroke in rats

Sepideh Khaksar et al.

Summary: CBD pretreatment attenuated oxidative stress and cell death in the brain ischemia, reducing the infarct volume and MDA level, while enhancing the activity of antioxidant enzymes. CBD also modulated the expression of apoptotic proteins and improved histological outcomes in the brain.

BRAIN RESEARCH BULLETIN (2022)

Article Plant Sciences

A Nrf-2 Stimulatory Hydroxylated Cannabidiol Derivative from Hemp (Cannabis sativa)

Giuseppina Chianese et al.

Summary: A phytochemical analysis of mother liquors obtained from crystallization of CBD from hemp (Cannabis sativa) resulted in the identification of 13 phytocannabinoids. Among them, anhydrocannabimovone was isolated for the first time as a natural product, and three new hydroxylated CBD analogues were obtained. One of the hydroxylated phytocannabinoids, hexocannabitriol, showed potent modulation of the Nrf2 pathway and has potential as a new chemopreventive compound against cancer and other degenerative diseases.

JOURNAL OF NATURAL PRODUCTS (2022)

Article Geriatrics & Gerontology

Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity

Zhizhen Wang et al.

Summary: CBD treatment can extend lifespan and rescue age-associated physiological declines in C. elegans by promoting autophagy and improving neuronal health. These findings highlight the potential anti-aging benefits of CBD in both in vitro and in vivo models.

GEROSCIENCE (2022)

Article Biochemistry & Molecular Biology

Positive Aspects of Oxidative Stress at Different Levels of the Human Body: A Review

George Jitca et al.

Summary: This review examines the negative effects of oxidative stress at molecular and cellular levels and highlights the importance and adaptive mechanisms of basal oxidative stress. It also discusses the positive effects of oxidative stress and the risks of consuming excessive antioxidants.

ANTIOXIDANTS (2022)

Review Medicine, Research & Experimental

Pharmacological effects of cannabidiol by transient receptor potential channels

Leila Etemad et al.

Summary: CBD, as a promising natural compound, shows potential in the treatment of diseases by interacting with TRP channels.

LIFE SCIENCES (2022)

Article Pharmacology & Pharmacy

A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function

Carol J. Milligan et al.

Summary: CBD-dominant nutraceutical product (NP) can strongly inhibit Na-V channels, which may be attributed to the presence of other bioactive compounds such as phytocannabinoids and terpenes.

JOURNAL OF CANNABIS RESEARCH (2022)

Article Chemistry, Analytical

Therapeutic application of cannabidiol on UVA and UVB irradiated rat skin. A proteomic study

Sinemyiz Atalay et al.

Summary: The study evaluated the effect of CBD on the metabolism of skin keratinocytes in nude rats exposed to UVA/UVB radiation. The results show that CBD can protect keratinocytes from UV-induced metabolic changes by maintaining proteostasis and reducing inflammation and redox imbalance.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

Article Sport Sciences

The Effects of Cannabidiol Oil on Noninvasive Measures of Muscle Damage in Men

Kristen C. Cochrane-Snyman et al.

Summary: The study found that CBD oil had no effect on noninvasive markers of muscle damage, showing no condition-time interaction or main effect of condition. However, there were main effects for time on perceived soreness and hanging joint angle.

MEDICINE & SCIENCE IN SPORTS & EXERCISE (2021)

Article Neurosciences

Cannabidiol reduces lesion volume and restores vestibulomotor and cognitive function following moderately severe traumatic brain injury

L. K. Friedman et al.

Summary: Direct administration of CBD to the brain injury site reduces local neural excitation and inflammation to protect neural tissue and improve neurological outcomes. Combining systemic supplementation with CBD treatment may offer a more effective countermeasure against the deleterious effects of penetrating head wounds compared to systemic or implant treatment alone.

EXPERIMENTAL NEUROLOGY (2021)

Article Pharmacology & Pharmacy

Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Δ9-tetrahydrocannabinol-exposed rats

Martina Di Bartolomeo et al.

Summary: Perinatal exposure to THC affects brain development and increases the risk of psychopathology in adulthood, possibly due to dysregulation of endocannabinoid and dopaminergic systems. Cannabidiol treatment may normalize these abnormalities by modulating altered dopaminergic activity.

PHARMACOLOGICAL RESEARCH (2021)

Article Neurosciences

Differential contribution of CB1, CB2, 5-HT1A, and PPAR-γ receptors to cannabidiol effects on ischemia-induced emotional and cognitive impairments

Marco Aurelio Mori et al.

Summary: CBD has shown neuroprotective effects against impairments caused by cerebral ischemia through the involvement of CB1, CB2, 5-HT1A, and PPAR-gamma receptors. The anxiolytic-like effects of CBD in transient global cerebral ischemia were attenuated by receptor antagonists, indicating the complex neuropharmacological mechanisms of CBD action.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Profiling the Concentration of Reduced and Oxidized Glutathione in Rat Brain Using HPLC/DAD Chromatographic System

George Jitca et al.

Summary: This study successfully developed an HPLC/DAD method for detecting and quantifying GSH and GSSG levels in the rat brain, meeting validation criteria. The method has been applied in a chronic toxicology study of haloperidol under different treatment regimens.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Cannabidiol Attenuates MK-801-Induced Cognitive Symptoms of Schizophrenia in the Passive Avoidance Test in Mice

Marta Kruk-Slomka et al.

Summary: Schizophrenia is a chronic mental disorder that disturbs feelings and behavior. Research on the potential of cannabidiol (CBD) in treating memory impairment associated with cognitive symptoms of schizophrenia has shown positive effects in memory and learning processes in mice. CBD has been found to attenuate memory impairment caused by hypofunction of glutamate transmission in a murine model of schizophrenia.

MOLECULES (2021)

Article Nutrition & Dietetics

Cannabidiol Does Not Impair Anabolic Signaling Following Eccentric Contractions in Rats

Henning T. Langer et al.

Summary: CBD has shown to decrease pro-inflammatory signaling in the tibialis anterior muscle of rats without affecting the anabolic response to exercise. However, higher levels of p62 were observed in the CBD group and one animal experienced serious side effects. Further research is needed to determine if these effects extend to improved recovery without altering adaptation in humans.

INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM (2021)

Article Neurosciences

Cannabidiol Ameliorates Cognitive Function via Regulation of IL-33 and TREM2 Upregulation in a Murine Model of Alzheimer's Disease

Hesam Khodadadi et al.

Summary: Our study found that CBD treatment enhanced the expression of IL-33 and TREM2, ameliorated AD symptoms, and slowed down cognitive decline in a translational model of familial AD.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Review Pharmacology & Pharmacy

Phytocannabinoids and schizophrenia: Focus on adolescence as a critical window of enhanced vulnerability and opportunity for treatment

Tibor Stark et al.

Summary: The recent trend of liberalization in Cannabis use has raised concerns about its impact on vulnerable populations, such as adolescents. Increasing daily use of Cannabis among adolescents, along with a decline in perceived harms, may lead to compromised social and cognitive functioning in adulthood. Cannabis exerts its effects by altering signaling within the endocannabinoid system, potentially impacting neurodevelopment and leading to adult neurodevelopmental deficits.

PHARMACOLOGICAL RESEARCH (2021)

Article Multidisciplinary Sciences

Cannabidiol induces autophagy via ERK1/2 activation in neural cells

Talita A. M. Vrechi et al.

Summary: CBD activates autophagy through ERK1/2 activation and AKT suppression, dependent on ULK1 but independent of mTORC1, suggesting a potential non-canonical pathway and highlighting CBD as a potential therapeutic target for neurodegenerative disorders.

SCIENTIFIC REPORTS (2021)

Review Oncology

Molecular Mechanism of Autophagy and Its Regulation by Cannabinoids in Cancer

Xin Chien Lee et al.

Summary: Autophagy is a crucial cellular process for maintaining homeostasis and has a dual role in cancer, either promoting cell death or enabling cancer cell survival. Cannabinoids have been shown to regulate autophagy and could potentially be used as a novel anticancer therapy strategy.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Psychoactive Drugs-From Chemical Structure to Oxidative Stress Related to Dopaminergic Neurotransmission. A Review

George Jitca et al.

Summary: The increasing desire of young people to experiment with illegal, psychoactive substances without awareness of the risks poses a significant threat to their social life and health. Drug abuse can lead to neural cell damage and the development of neurodegenerative diseases, highlighting the importance of understanding the link between oxidative stress, neurotoxicity, and substance abuse for developing new therapeutic strategies.

ANTIOXIDANTS (2021)

Review Biochemistry & Molecular Biology

TRP Channels as Sensors of Aldehyde and Oxidative Stress

Katharina E. M. Hellenthal et al.

Summary: The transient receptor potential (TRP) cation channel superfamily consists of more than 50 channels playing crucial roles in physiological processes. Aldehydes can activate TRP channels, triggering a cellular cascade that may lead to disease pathophysiology. Studies have shown that aldehyde dehydrogenase 2 protects against aldehyde toxicity by clearing toxic aldehydes.

BIOMOLECULES (2021)

Article Neurosciences

Cannabidiol Induces Autophagy to Protects Neural Cells From Mitochondrial Dysfunction by Upregulating SIRT1 to Inhibits NF-κB and NOTCH Pathways

Shaolei Kang et al.

Summary: Recent study found that Cannabidiol has a protective effect on Parkinson's disease, by regulating SIRT1 and inhibiting NF-κB and NOTCH pathways to protect nerve cells from mitochondrial dysfunction.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Article Pharmacology & Pharmacy

Cannabidiol and Amisulpride Improve Cognition in Acute Schizophrenia in an Explorative, Double-Blind, Active-Controlled, Randomized Clinical Trial

F. Markus Leweke et al.

Summary: CBD and AMI show comparable efficacy in improving neurocognitive functioning in young and acutely ill schizophrenia patients, with CBD also enhancing sustained attention and visuomotor coordination.

FRONTIERS IN PHARMACOLOGY (2021)

Review Cell Biology

Regulatory Effects of Cannabidiol on Mitochondrial Functions: A Review

John Zewen Chan et al.

Summary: CBD, a phytocannabinoid derived from Cannabis sativa, has been found to have antipsychotic, anti-depressive, anxiolytic, and antiepileptic effects. Recent research indicates that CBD plays a role in regulating mitochondrial processes, but current data show contradictory findings on the magnitude and direction of its effects.

CELLS (2021)

Article Nutrition & Dietetics

Increased Oxidative Stress in the Prefrontal Cortex as a Shared Feature of Depressive- and PTSD-Like Syndromes: Effects of a Standardized Herbal Antioxidant

Johannes de Munter et al.

Summary: Major depression and posttraumatic stress disorder share common brain mechanisms and treatment strategies, and the rapidly developing COVID-19 situation has led to stress, psychological trauma, and high incidence of MD and PTSD, highlighting the potential of herbal medicine in treating these disorders.

FRONTIERS IN NUTRITION (2021)

Article Medicine, Research & Experimental

Cannabidiol attenuates cognitive deficits and neuroinflammation induced by early alcohol exposure in a mice model

Alba Garcia-Baos et al.

Summary: The study found that CBD administration during peri-adolescence period can ameliorate cognitive deficits induced by early alcohol exposure and restore the neuroinflammation caused by PLAE, providing new insights for CBD as a therapeutic agent to counteract FASD.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

A Simple HPLC/DAD Method Validation for the Quantification of Malondialdehyde in Rodent's Brain

George Jitca et al.

Summary: A HPLC/DAD method was developed for the determination and quantification of MDA in the brain of rodents, showing good linearity, precision, and accuracy. The method was successfully applied in a study of chronic toxicology following different treatment regimens, demonstrating its reliability and effectiveness.

MOLECULES (2021)

Article Nutrition & Dietetics

Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

Eduard Isenmann et al.

Summary: The study found that single CBD supplementation had small but significant effects on muscle damage and recovery of squat performance after 72 hours in athletes. However, more data is needed to make clearer statements about the potential pro-regenerative effects of CBD supplementation after resistance training.

NUTRIENTS (2021)

Article Biochemistry & Molecular Biology

Changes in Hepatic Phospholipid Metabolism in Rats under UV Irradiation and Topically Treated with Cannabidiol

Michal Biernacki et al.

Summary: The study shows that topical application of CBD can regulate liver antioxidants and phospholipid metabolism to counteract oxidative stress and inflammation caused by UV radiation.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity ... and Return

Anna Brancato et al.

Summary: Binge alcohol consumption among adolescents can have long-lasting effects on the neural networks in NAc and stress processing, leading to decreased sensitivity to positive stimuli and dysfunctional stress-axis functionality. Cannabidiol shows promise in counteracting the harmful effects of alcohol, reducing negative behaviors and adjusting neuroplasticity.

BIOMEDICINES (2021)

Article Pharmacology & Pharmacy

Effect of Cannabidiol on the Long-Term Toxicity and Lifespan in the Preclinical Model Caenorhabditis elegans

M. Hunter Land et al.

Summary: The study found that cannabidiol (CBD) showed no significant acute or long-term toxicity in Caenorhabditis elegans at physiologically relevant concentrations. Notably, 40 micromolar CBD significantly increased heat stress resistance and led to the highest life extension and late-stage activity increase.

CANNABIS AND CANNABINOID RESEARCH (2021)

Review Pharmacology & Pharmacy

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

Elizabeth M. Williamson et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

Current Prospects of Nutraceuticals: A Review

Vedant Sachdeva et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2020)

Review Biochemistry & Molecular Biology

Antioxidative and Anti-Inflammatory Properties of Cannabidiol

Sinemyiz Atalay et al.

ANTIOXIDANTS (2020)

Article Biochemistry & Molecular Biology

Antioxidant and Neuroprotective Effects Induced by Cannabidiol and Cannabigerol in Rat CTX-TNA2 Astrocytes and Isolated Cortexes

Viviana di Giacomo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

Laura Casares et al.

REDOX BIOLOGY (2020)

Review Behavioral Sciences

The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights

Willian Lazarini-Lopes et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2020)

Article Pharmacology & Pharmacy

Cannabidiol in sport: Ergogenic or else?

Francois-Xavier Gamelin et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Biochemistry & Molecular Biology

Cannabidiol Reverses Deficits in Hippocampal LTP in a Model of Alzheimer's Disease

Blathnaid Hughes et al.

NEUROCHEMICAL RESEARCH (2019)

Review Chemistry, Multidisciplinary

Brain activity of anandamide: a rewarding bliss?

Maria Scherma et al.

ACTA PHARMACOLOGICA SINICA (2019)

Article Pharmacology & Pharmacy

Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice

Fabio Arturo Iannotti et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Interaction of metal ions with tau protein. The case for a metal-mediated tau aggregation

Soha Ahmadi et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2019)

Review Oncology

Inflammation, Cancer and Immunity-Implication of TRPV1 Channel

Joanna Katarzyna Bujak et al.

FRONTIERS IN ONCOLOGY (2019)

Review Biochemistry & Molecular Biology

A Bibliometric Review of the Keap1/Nrf2 Pathway and its Related Antioxidant Compounds

Ana Paunkov et al.

ANTIOXIDANTS (2019)

Article Behavioral Sciences

Enhancing effects of acute exposure to cannabis smoke on working memory performance

Shelby L. Blaes et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2019)

Article Psychiatry

Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test

Ila M. Linares et al.

BRAZILIAN JOURNAL OF PSYCHIATRY (2019)

Review Neurosciences

Cannabinoid Ligands Targeting TRP Channels

Chante Muller et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Chemistry, Multidisciplinary

Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu2+

Soha Ahmadi et al.

ACS OMEGA (2019)

Article Physiology

Recovery following a marathon: a comparison of cold water immersion, whole body cryotherapy and a placebo control

Laura J. Wilson et al.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2018)

Review Pharmacology & Pharmacy

Endocannabinoid system, stress and HPA axis

Vincenzo Micale et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Article Clinical Neurology

Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD

Sharon Fidelman et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2018)

Article Medicine, General & Internal

Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome

Orrin Devinsky et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Endocrinology & Metabolism

Pharmacological augmentation of endocannabinoid signaling reduces the neuroendocrine response to stress

Pablo Nicolas Surkin et al.

PSYCHONEUROENDOCRINOLOGY (2018)

Review Orthopedics

Cannabis and the Health and Performance of the Elite Athlete

Mark A. Ware et al.

CLINICAL JOURNAL OF SPORT MEDICINE (2018)

Article Biochemistry & Molecular Biology

New Methods for the Comprehensive Analysis of Bioactive Compounds in Cannabis sativa L. (hemp)

Federica Pellati et al.

MOLECULES (2018)

Review Cell Biology

Bach1: Function, Regulation, and Involvement in Disease

Xinyue Zhang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

Review Biochemistry & Molecular Biology

Modulation of the Oxidative Stress and Lipid Peroxidation by Endocannabinoids and Their Lipid Analogues

Cristina Anna Gallelli et al.

ANTIOXIDANTS (2018)

Review Biochemistry & Molecular Biology

Nrf2, the Master Regulator of Anti-Oxidative Responses

Sandra Vomund et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Chemistry, Analytical

Development of a new extraction technique and HPLC method for the analysis of non-psychoactive cannabinoids in fibre-type Cannabis sativa L. (hemp)

Virginia Brighenti et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2017)

Review Sport Sciences

Cannabis: Exercise performance and sport. A systematic review

Michael C. Kennedy

JOURNAL OF SCIENCE AND MEDICINE IN SPORT (2017)

Review Neurosciences

Therapeutic potential of autophagy-enhancing agents in Parkinson's disease

Tim E. Moors et al.

MOLECULAR NEURODEGENERATION (2017)

Review Behavioral Sciences

A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia

Ashleigh L. Osborne et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

Article Medicine, General & Internal

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Orrin Devinsky et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Cell Biology

Collaborative Power of Nrf2 and PPARγ Activators against Metabolic and Drug-Induced Oxidative Injury

Choongho Lee

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Review Pharmacology & Pharmacy

The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABAA receptors

T. Bakas et al.

PHARMACOLOGICAL RESEARCH (2017)

Review Pharmacology & Pharmacy

Cannabidiol: State of the art and new challenges for therapeutic applications

Simona Pisanti et al.

PHARMACOLOGY & THERAPEUTICS (2017)

Article Clinical Neurology

Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia

Marco Aurelio Mori et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2017)

Review Sport Sciences

Fatigue and Recovery in Rugby: A Review

Francisco Tavares et al.

SPORTS MEDICINE (2017)

Article Pharmacology & Pharmacy

Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life

Antonio W. Zuardi et al.

Frontiers in Pharmacology (2017)

Article Pharmacology & Pharmacy

In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease

Georgia Watt et al.

FRONTIERS IN PHARMACOLOGY (2017)

Review Biochemistry & Molecular Biology

Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer's disease

Alexandre Vallee et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2017)

Review Pharmacology & Pharmacy

An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies

Kerstin Iffland et al.

CANNABIS AND CANNABINOID RESEARCH (2017)

Article Biochemistry & Molecular Biology

Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells

Rosaliana Libro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Neurosciences

Evidences for the Anti-panic Actions of Cannabidiol

Vanessa P. Soares et al.

CURRENT NEUROPHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Functional and Structural Divergence in Human TRPV1 Channel Subunits by Oxidative Cysteine Modification

Nozomi Ogawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

Wenzhang Wang et al.

NATURE MEDICINE (2016)

Review Pharmacology & Pharmacy

An update on PPAR activation by cannabinoids

Saoirse Elizabeth O'Sullivan

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Article Pharmacology & Pharmacy

Cannabidiol, neuroprotection and neuropsychiatric disorders

Alline C. Campos et al.

PHARMACOLOGICAL RESEARCH (2016)

Review Clinical Neurology

Therapeutic potential of cannabis-related drugs

Stephen P. H. Alexander

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2016)

Review Plant Sciences

Cannabis sativa: The Plant of the Thousand and One Molecules

Christelle M. Andre et al.

FRONTIERS IN PLANT SCIENCE (2016)

Review Neurosciences

CB2 Cannabinoid Receptor As Potential Target against Alzheimer's Disease

Ester Aso et al.

FRONTIERS IN NEUROSCIENCE (2016)

Article Pharmacology & Pharmacy

Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats

Fernanda F. Peres et al.

FRONTIERS IN PHARMACOLOGY (2016)

Review Biochemistry & Molecular Biology

Cannabidiol (CBD) and its analogs: a review of their effects on inflammation

Sumner Burstein

BIOORGANIC & MEDICINAL CHEMISTRY (2015)

Article Pharmacology & Pharmacy

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

R. B. Laprairie et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Article Biochemistry & Molecular Biology

The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway

C. Blazquez et al.

CELL DEATH AND DIFFERENTIATION (2015)

Article Nutrition & Dietetics

Patterns of dietary supplement use among college students

Harris R. Lieberman et al.

CLINICAL NUTRITION (2015)

Review Neurosciences

Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair

Sayinthen Vivekanantham et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2015)

Article Medical Laboratory Technology

Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder

Leda Borovac Stefanovic et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2015)

Review Cell Biology

Historical landmarks of autophagy research

Yoshinori Ohsumi

CELL RESEARCH (2014)

Review Chemistry, Multidisciplinary

Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids

Rebecca A. Kohnz et al.

CHEMICAL SOCIETY REVIEWS (2014)

Article Oncology

Origin and pharmacological modulation of tumor- associated regulatory dendritic cells

Hua Zhong et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

Review Dermatology

UV Signaling Pathways within the Skin

Hongxiang Chen et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Article Biochemistry & Molecular Biology

Trans-Caryophyllene Suppresses Hypoxia-Induced Neuroinflammatory Responses by Inhibiting NF-κB Activation in Microglia

Kexin Guo et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2014)

Article Clinical Neurology

Effects of cannabidiol in the treatment of patients with Parkinson's disease: An exploratory double-blind trial

Marcos Hortes N. Chagas et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2014)

Review Behavioral Sciences

A critical role for prefrontocortical endocannabinoid signaling in the regulation of stress and emotional behavior

Ryan J. McLaughlin et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2014)

Review Psychology

The Endocannabinoid System and the Brain

Raphael Mechoulam et al.

ANNUAL REVIEW OF PSYCHOLOGY, VOL 64 (2013)

Article Pharmacology & Pharmacy

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

Javier Fernandez-Ruiz et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2013)

Article Environmental Sciences

Cardioprotective effect of cannabidiol in rats exposed to doxorubicin toxicity

Amr A. Fouad et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2013)

Review Cell Biology

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

Melba C. Jaramillo et al.

GENES & DEVELOPMENT (2013)

Article Biochemistry & Molecular Biology

Understanding the Molecular Aspects of Tetrahydrocannabinol and Cannabidiol as Antioxidants

Rosivaldo S. Borges et al.

MOLECULES (2013)

Review Pharmacology & Pharmacy

Endocannabinoid system and mood disorders: Priming a target for new therapies

Vincenzo Micale et al.

PHARMACOLOGY & THERAPEUTICS (2013)

Article Multidisciplinary Sciences

Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses

Sergiy Sylantyev et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Psychiatry

Why should Cannabis be Considered Doping in Sports?

Mateus M. Bergamaschi et al.

Frontiers in Psychiatry (2013)

Article Pharmacology & Pharmacy

Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis

Tatiana Barichello et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2012)

Review Neurosciences

Endocannabinoid Signaling and Synaptic Function

Pablo E. Castillo et al.

NEURON (2012)

Review Pharmacology & Pharmacy

Phytocannabinoids as novel therapeutic agents in CNS disorders

Andrew J. Hill et al.

PHARMACOLOGY & THERAPEUTICS (2012)

Review Chemistry, Medicinal

Cannabidiol in Humans-The Quest for Therapeutic Targets

Simon Zhornitsky et al.

PHARMACEUTICALS (2012)

Review Pharmacology & Pharmacy

Prospects for cannabinoid therapies in basal ganglia disorders

Javier Fernandez-Ruiz et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Pharmacology & Pharmacy

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes

Luciano De Petrocellis et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Review Biochemistry & Molecular Biology

Cannabinoids: Occurrence and Medicinal Chemistry

G. Appendino et al.

CURRENT MEDICINAL CHEMISTRY (2011)

Review Biochemistry & Molecular Biology

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

George W. Booz

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Neurosciences

Neuroprotective Effects of Phytocannabinoid-Based Medicines in Experimental Models of Huntington's Disease

Onintza Sagredo et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2011)

Article Clinical Neurology

Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania

Samira S. Valvassori et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2011)

Article Clinical Neurology

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report

Jose Alexandre S. Crippa et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2011)

Article Pharmacology & Pharmacy

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

Ana Maria Martin-Moreno et al.

MOLECULAR PHARMACOLOGY (2011)

Article Critical Care Medicine

Nrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in Mice

Hye-Youn Cho et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

Article Biochemistry & Molecular Biology

Thioredoxin and thioredoxin reductase: Current research with special reference to human disease

Arne Holmgren et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Pharmacology & Pharmacy

Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation

I. Magen et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Review Pharmacology & Pharmacy

CB2: a cannabinoid receptor with an identity crisis

Brady K. Atwood et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Article Psychiatry

Impact of cannabidiol on the acute and psychotomimetic effects of smoked cannabis: naturalistic study

Celia J. A. Morgan et al.

BRITISH JOURNAL OF PSYCHIATRY (2010)

Review Pharmacology & Pharmacy

The endocannabinoid system as a target for the treatment of neuronal damage

Javier Fernandez-Ruiz et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2010)

Review Biochemistry & Molecular Biology

Eicosanoids and the endogenous control of acute inflammatory resolution

Derek W. Gilroy

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages

Ki Hoon Han et al.

CARDIOVASCULAR RESEARCH (2009)

Article Gastroenterology & Hepatology

Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation

Iddo Magen et al.

JOURNAL OF HEPATOLOGY (2009)

Article Pharmacology & Pharmacy

Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death

Hao Pan et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Article Clinical Neurology

Cannabidiol for the treatment of psychosis in Parkinson's disease

A. W. Zuardi et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2009)

Review Physiology

Endocannabinoid-Mediated Control of Synaptic Transmission

Masanobu Kano et al.

PHYSIOLOGICAL REVIEWS (2009)

Review Chemistry, Medicinal

Cannabidiol in Medicine: A Review of its Therapeutic Potential in CNS Disorders

Caterina Scuderi et al.

PHYTOTHERAPY RESEARCH (2009)

Article Biochemistry & Molecular Biology

Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2

Jingbo Pi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Critical Care Medicine

Time-dependent behavioral recovery after sepsis in rats

Lisiane Tuon et al.

INTENSIVE CARE MEDICINE (2008)

Article Ophthalmology

Mediation of Cannabidiol Anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor

Gregory I. Liou et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)

Article Pharmacology & Pharmacy

Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression

G. Esposito et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Article Biochemistry & Molecular Biology

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

Jacqueline L. Blankman et al.

CHEMISTRY & BIOLOGY (2007)

Review Biochemistry & Molecular Biology

Detecting oxidative post-translational modifications in proteins

E. Gianazza et al.

AMINO ACIDS (2007)

Article Biochemistry & Molecular Biology

The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells

P. Massi et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2006)

Article Multidisciplinary Sciences

Peripheral cannabinoid receptor, CB2, regulates bone mass

O Ofek et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Medicine, Research & Experimental

A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol

E Russo et al.

MEDICAL HYPOTHESES (2006)

Review Biochemistry & Molecular Biology

Oxidative stress and neurodegeneration: where are we now?

Barry Halliwell

JOURNAL OF NEUROCHEMISTRY (2006)

Review Cell Biology

TRP channels and Ca2+ signaling

Baruch Minke

CELL CALCIUM (2006)

Article Pharmacology & Pharmacy

Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity

C Hamelink et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Article Multidisciplinary Sciences

Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription

MJ Calkins et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Brain β-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1

BJ Turner et al.

NEUROCHEMICAL RESEARCH (2004)

Review Biochemistry & Molecular Biology

Evidence of oxidative damage in Alzheimer's disease brain:: central role for amyloid β-peptide

DA Butterfield et al.

TRENDS IN MOLECULAR MEDICINE (2001)

Article Multidisciplinary Sciences

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

BF Cravatt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)