Journal
ANTIOXIDANTS
Volume 12, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/antiox12030550
Keywords
winter cherry; ashwagandha; phenolic profile; antioxidant capacity; antimicrobial activity; bioactive compounds; Solanaceae; gooseberry
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In this study, the chemical composition and bioactive properties of commercially available Withania somnifera samples were evaluated. The aqueous extracts showed higher polyphenols, ascorbic acid content, and antioxidant activity compared to the hydromethanolic extracts. On the other hand, the hydromethanolic extracts contained higher amounts of phenolic acids and flavonoids. Samples 4, 6, and 10 exhibited the best antibacterial activity against all tested strains, while the aqueous and hydromethanolic extracts showed the highest inhibitory activities against AChE and BChE, respectively.
In the present study, the chemical composition and bioactive properties of commercially available Withania somnifera samples were evaluated. The hydromethanolic and aqueous extracts of the tested samples were analyzed in terms of phenolic compound composition, ascorbic acid content, antioxidant and antibacterial activity, and acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. Polyphenols and ascorbic acid content, as well as the antioxidant activity, were higher in the aqueous extracts than in the hydromethanolic extracts. Generally, aqueous extracts presented higher antioxidant activity than the hydromethanolic ones, especially in the case of 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay. Moreover, higher amounts of phenolic acids and flavonoids were found in the hydromethanolic extracts compared to the aqueous ones. Regarding the antibacterial properties, samples 4, 6, and 10 showed the best overall performance with growth-inhibitory activities against all the examined bacteria strains. Finally, the aqueous and hydromethanolic extracts were the most efficient extracts in terms of AChE and BChE inhibitory activities, respectively. In conclusion, our results indicate that W. somnifera possesses important bioactive properties which could be attributed to the high amounts of phenolic compounds. However, a great variability was recorded in commercially available products, suggesting significant differences in the origin of product and the processing method.
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