4.7 Article

ARAG, an Antioxidant-Rich Gel, Shows Superiority to Mepilex Ag in the Treatment of Deep Partial Thickness Burns without Sacrificing Antimicrobial Efficiency

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

p53 in senescence - it's a marathon not a sprint

Eleanor Sheekey et al.

Summary: The tumour suppressor p53 plays a central role in cellular senescence by regulating both senescence-associated stable proliferative arrest and the secretion of bioactive factors known as the senescence-associated secretory phenotype (SASP). Senescence is associated with various physiological and pathological conditions, including ageing, cancer, and other age-related disorders. Cell functions are determined by the expression of lineage-specific genes, which are also influenced by p53. Additionally, p53 is tightly regulated at the protein level, and its activity is sustained and fine-tuned during senescence and other prolonged pathological conditions.

FEBS JOURNAL (2023)

Review Pharmacology & Pharmacy

Vitamin E TPGS-Based Nanomedicine, Nanotheranostics, and Targeted Drug Delivery: Past, Present, and Future

Abhishesh Kumar Mehata et al.

Summary: TPGS, a water-soluble version of vitamin E, has been widely used in drug delivery systems for 70 years. It has been approved for the formulation of four drugs in the US and Europe, and has shown potential in improving drug solubility, bioavailability, and preventing multidrug resistance. Clinical trials and applications in various diseases have been conducted based on TPGS.

PHARMACEUTICS (2023)

Article Critical Care Medicine

Evaluating effects of burn injury characteristics on quality of life in pediatric burn patients and caregivers

Kelli N. Patterson et al.

Summary: This study aimed to evaluate the quality of life (QoL) of pediatric burn patients and caregivers, and identify clinical characteristics associated with psychological stress. The results showed that a substantial proportion of pediatric burn patients experience impacts on their QoL. Larger burn size and increased burn depth were found to cause more psychological stress in children, and caregivers may require more extensive psychological evaluation.

BURNS (2023)

Article Multidisciplinary Sciences

Severity of thermal burn injury is associated with systemic neutrophil activation

Maria Laggner et al.

Summary: Burn injuries elicit a unique stress response and can lead to burn injury progression. This study found that levels of neutrophil-derived factors were significantly elevated in burn victims, and leukocyte and neutrophil counts were increased while lymphocytes were decreased. These factors did not predict mortality, but were associated with higher burn severity scores in patients with third-degree burns.

SCIENTIFIC REPORTS (2022)

Review Biochemistry & Molecular Biology

Cell cycle regulation: p53-p21-RB signaling

Kurt Engeland

Summary: RB and p53 are central tumor suppressors that play key roles in regulating the cell division cycle. RB downregulates numerous genes by forming complexes with E2F transcription factors, and its repression is released through phosphorylation. p53 activates CDKN1A gene to regulate RB phosphorylation, leading to expression of cell cycle regulators. There is an overlap between RB and DREAM signaling pathways.

CELL DEATH AND DIFFERENTIATION (2022)

Review Chemistry, Medicinal

Antimicrobial activity of quaternary ammonium salts: structure-activity relationship

Mallikarjuna N. Nadagouda et al.

Summary: Quaternary ammonium salts (QASs) are an emerging group of antibacterial agents that have gained much attention in research. They have various applications such as disinfectants, inhibitors of biofilm growth, and antibacterials.

MEDICINAL CHEMISTRY RESEARCH (2022)

Review Urology & Nephrology

Cellular senescence: the good, the bad and the unknown

Weijun Huang et al.

Summary: Cellular senescence plays important roles in tissue remodeling, but excessive senescence may lead to cancer and age-related diseases. It involves cell-cycle arrest and the release of inflammatory cytokines with autocrine, paracrine, and endocrine activities. Therapeutic interventions targeting cellular senescence have shown potential benefits in extending lifespan and reducing tissue injury.

NATURE REVIEWS NEPHROLOGY (2022)

Review Biotechnology & Applied Microbiology

Microbial silver resistance mechanisms: recent developments

Ergi Terzioglu et al.

Summary: This mini-review provides an overview of the antimicrobial use of silver ions and nanoparticles against bacteria, fungi, and viruses. It discusses the toxicity of silver compounds, the molecular mechanisms of microbial silver resistance, and recent studies on bacteria and fungi. The roles of various proteins and systems in bacterial and fungal silver resistance are explained. The article also emphasizes the importance of exopolysaccharides and cell wall in defending against silver nanoparticles. Additionally, it discusses the evolutionary aspect of silver resistance, cross-resistance between silver and other substances, and the use of silver for inhibiting biofilm formation and combating viruses.

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2022)

Review Cell Biology

The Immune and Regenerative Response to Burn Injury

Matthew Burgess et al.

Summary: Burns are diverse and complex injuries that have local and systemic effects. Improvements in burn care have been made over the past decades. Severity of burns depends on size, depth, location, age, and underlying diseases.

CELLS (2022)

Review Medicine, General & Internal

A Narrative Review of the History of Burn-Related Depression and Stress Reactions

Shivan N. Chokshi et al.

Summary: Burn care has a long history, while the recognition and treatment of psychiatric trauma are relatively recent. Initially, clinicians focused on the physiological causes of burn mortality, but as burn care improved, attention shifted to the long-term health outcomes and mental health consequences of trauma. The association between burn trauma and mental illness emerged, but the understanding of the pathophysiology of depression among burn survivors is still incomplete.

MEDICINA-LITHUANIA (2022)

Article Infectious Diseases

Burn Infection and Burn Sepsis

Josephine A. D'Abbondanza et al.

Summary: Infection is a common complication and cause of death in burn patients, with diagnosis and treatment relying on physical examination, cultures, and pathology. Various factors increase infection risk, including underlying conditions, burn area, delays in treatment, and microbial virulence. Treatment involves local dressings, early excision, and antimicrobial therapy, with continued efforts essential for timely management and infection prevention.

SURGICAL INFECTIONS (2021)

Review Infectious Diseases

Infection in Elderly Burn Patients: What Do We Know?

Alisa Savetamal

Summary: Elderly burn patients with pre-existing conditions are at higher risk for infections. Limited data is available, highlighting the need for further research to better understand this important issue.

SURGICAL INFECTIONS (2021)

Review Infectious Diseases

Topical Antimicrobial Agents for Burn Wound Care: History and Current Status

Leopoldo C. Cancio

Summary: This article highlights the importance and development of burn wound infection treatment methods through a review of historical literature. While topical antimicrobial care plays a key role in burn patient management, there are still many gaps in treatment, such as fungal infections. Research on optimal topical treatment continues due to challenges in wound healing and access to early excision in certain patient populations and locations.

SURGICAL INFECTIONS (2021)

Article Cell Biology

Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination

Tadahito Yasuda et al.

Summary: In the tumor microenvironment, senescent cancer-associated fibroblasts (CAFs) play a role in promoting gastric cancer (GC) peritoneal tumor formation through maintenance of the senescence-associated secretory phenotype (SASP) and JAK/STAT3 signaling. Single-cell mass cytometry analysis revealed a high expression level of senescent fibroblasts and SASP factors in the ascites of GC patients. These findings provide insights into the molecular mechanisms of inflammation-related SASP maintenance and the involvement of senescent CAFs in GC peritoneal dissemination.

CELL REPORTS (2021)

Review Biology

Interdependence of Anti-Inflammatory and Antioxidant Properties of Squalene-Implication for Cardiovascular Health

Nurul Izzah Ibrahim et al.

Summary: Cardiovascular diseases are the leading cause of global mortality, with hyperlipidemia being the main risk factor. Statins, which lower LDL-C, are the preferred treatment, but their side effects like muscle symptoms can lead to patient nonadherence. Squalene, a natural compound with antioxidant properties, could be an alternative for cardiovascular health.

LIFE-BASEL (2021)

Article Microbiology

Antimicrobial and bacteriostatic activity of surfactants against B. subtilis for microbial cleaner formulation

Meyrem Vehapi et al.

Summary: This study found that B. subtilis has higher growth and viability in neutral pH for microbial cleaner formulation, while it enters the death phase at pH 3. Gram-positive S. aureus and K. pneumoniae are the most sensitive bacteria, while B. cereus is the most resistant.

ARCHIVES OF MICROBIOLOGY (2021)

Article Dermatology

Clinically isolated bacteria resistance to silver-based wound dressings

Rhy Norton et al.

Summary: The study revealed that clinically significant silver resistance has emerged in the clinical setting, with resistant microbes capable of sustained silver resistance against a wide variety of silver adjuvants. This suggests that the further development and dissemination of these resistance mechanisms could significantly impact current practices in wound healing.

JOURNAL OF WOUND CARE (2021)

Review Cell Biology

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Ruchi Kumari et al.

Summary: Cellular senescence is a stable cell cycle arrest triggered in response to various stimuli, characterized by dynamic changes in senescent cells. It has both positive effects on tissue repair and anti-cancer mechanisms, but can also negatively impact organismal health. Multiple pathways, including p53/p21 and p16/pRB, play central roles in regulating this process.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Food Science & Technology

A comprehensive study of physical, antimicrobial and emulsifying properties of self-assembled chitosan/lecithin complexes produced in aqueous media

Antonio Matias Navarrete de Toledo et al.

Summary: The study proposed the development of surfactant-polyelectrolyte complexes (SPECs) based on lecithin and chitosan, which have antimicrobial properties and enhance emulsifying properties. SPECs exhibited various sizes and Zeta potential values, with the ability to inhibit Escherichia coli growth and reduce emulsion coalescence.

FUTURE FOODS (2021)

Article Pharmacology & Pharmacy

Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration

Kyeong-A Ryu et al.

PHARMACEUTICS (2020)

Review Biochemistry & Molecular Biology

Role of p53 in the Regulation of Cellular Senescence

Mahmut Mijit et al.

BIOMOLECULES (2020)

Article Materials Science, Biomaterials

Bi-layered α-tocopherol acetate loaded membranes for potential wound healing and skin regeneration

Saba Zahid et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Review Surgery

Silver in Wound Care-Friend or Foe?: A Comprehensive Review

Ibrahim Khansa et al.

PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN (2019)

Article Critical Care Medicine

ISBI Practice Guidelines for Burn Care, Part 2

Nikki Allorto et al.

BURNS (2018)

Review Multidisciplinary Sciences

Inflammation and metabolism in tissue repair and regeneration

Sabine A. Eming et al.

SCIENCE (2017)

Review Immunology

Bacterial Infections After Burn Injuries: Impact of Multidrug Resistance

Anne M. Lachiewicz et al.

CLINICAL INFECTIOUS DISEASES (2017)

Article Surgery

History and Advancement of Burn Treatments

Hai-Fei Liu et al.

ANNALS OF PLASTIC SURGERY (2017)

Editorial Material Endocrinology & Metabolism

Keeping gut lining at bay: impact of emulsifiers

Patrice D. Cani et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)

Review Immunology

Senescence-associated inflammatory responses: aging and cancer perspectives

Audrey Lasry et al.

TRENDS IN IMMUNOLOGY (2015)

Article Engineering, Biomedical

Evaluation of various silver-containing dressing on infected excision wound healing study

Yu-Hsin Lin et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2014)

Article Critical Care Medicine

Development of a porcine deep partial thickness burn model

Carmen Gaines et al.

BURNS (2013)

Article Chemistry, Applied

Physicochemical and antibacterial properties of surfactant mixtures with quaternized chitosan microgels

Kristopher E. Richardson et al.

CARBOHYDRATE POLYMERS (2013)

Review Critical Care Medicine

Clinical review: The critical care management of the burn patient

Jane A. Snell et al.

CRITICAL CARE (2013)

Article Critical Care Medicine

Common pathogens in burn wound and changes in their drug sensitivity

Ezzatollah Rezaei et al.

BURNS (2011)

Article Critical Care Medicine

Advances in surgical care: Management of severe burn injury

Christopher E. White et al.

CRITICAL CARE MEDICINE (2008)

Article Surgery

Topical antimicrobials in pediatric burn wound management

Priti P. Patel et al.

JOURNAL OF CRANIOFACIAL SURGERY (2008)

Review Medicine, General & Internal

ABC of burns - First aid and treatment of minor burns

J Hudspith et al.

BRITISH MEDICAL JOURNAL (2004)