Trehalose Inhibits Inflammatory Responses through Mitochondrial Reprogramming in RAW 264.7 Macrophages

Article Food Science & Technology

Immune-modulation effect of Halocynthia aurantium tunic lipid on RAW264.7 cells

A-yeong Jang et al.

Summary: The lipid extract from Halocynthia aurantium tunic shows immune-regulatory potential by modulating cytokine expression and phosphorylation pathways, suggesting it as a potential source for immune-regulatory molecules.

FOOD SCIENCE AND BIOTECHNOLOGY (2022)

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Article Food Science & Technology

Resveratrol analogue, HS-1793, inhibits inflammatory mediator release from macrophages by interfering with the TLR4 mediated NF-κB activation

Wol Soon Jo et al.

Summary: HS-1793 is a metabolically stable and more effective derivative that exhibits anti-inflammatory properties by effectively inhibiting the expression and production of inflammatory factors.

FOOD SCIENCE AND BIOTECHNOLOGY (2022)

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Review Pharmacology & Pharmacy

Disaccharide trehalose in experimental therapies for neurodegenerative disorders: Molecular targets and translational potential

Alexander B. Pupyshev et al.

Summary: Trehalose is a promising approach for the treatment of neurodegenerative diseases through its induction of autophagy. It has anti-inflammatory, antioxidant, and neuroprotective effects, reducing the accumulation of abnormal proteins. Trehalose activates lysosome and autophagosome biogenesis pathways. However, further research is needed to understand its pharmacodynamics. Trehalose has demonstrated potential in treating diseases such as Alzheimer's, Parkinson's, and Huntington's in animal models.

PHARMACOLOGICAL RESEARCH (2022)

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Article Food Science & Technology

Rice Bran Oil Attenuates Chronic Inflammation by Inducing M2 Macrophage Switching in High-Fat Diet-Fed Obese Mice

Hyejeong Park et al.

Summary: Research suggests that rice bran oil has an anti-inflammatory effect in diet-induced obese mice, potentially ameliorating chronic low-grade inflammation. Rice bran oil exerts its anti-inflammatory effects by modulating macrophage polarization and inflammatory mediator production in white adipose tissue and bone marrow-derived macrophages.

FOODS (2021)

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Article Biochemistry & Molecular Biology

Improving SIRT1 by trehalose supplementation reduces oxidative stress, inflammation, and histopathological scores in the kidney of aged rats

Faegheh Bahri et al.

Summary: Trehalose supplementation increased SIRT1 levels and alleviated oxidative stress and inflammation in aged tissues, showing renoprotective effects in old rats. By modulating SIRT1 activity, trehalose may be an effective intervention to ameliorate age-associated kidney injury.

JOURNAL OF FOOD BIOCHEMISTRY (2021)

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Article Nutrition & Dietetics

Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea

Kouya Hattori et al.

Summary: Specific gut bacteria, such as Escherichia coli from the Enterobacteriaceae family, play a key role in suppressing sorbitol-induced diarrhea by degrading sorbitol in the intestine. The findings suggest that the gut microbiota's ability to respond to and break down sugar alcohols has implications for microbiome science, processed food science, and public health.

NUTRIENTS (2021)

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Article Immunology

Trehalose-Induced Remodelling of the Human Microbiota Affects Clostridioides difficile Infection Outcome in an In Vitro Colonic Model: A Pilot Study

Anthony M. Buckley et al.

Summary: The study demonstrates that trehalose supplementation remodels the human gut microbiota, preventing simulated C. difficile infection. The microbial functions in the trehalose model differ from those in other models, potentially leading to the prevention of CDI.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Biochemistry & Molecular Biology