4.7 Article

Melatonin in Newborn Infants Undergoing Surgery: A Pilot Study on Its Effects on Postoperative Oxidative Stress

Journal

ANTIOXIDANTS
Volume 12, Issue 3, Pages -

Publisher

MDPI
DOI: 10.3390/antiox12030563

Keywords

surgical patients; perioperative oxidative stress; isoprostanes; lipid peroxidation; protein peroxidation; free iron; AOPP

Ask authors/readers for more resources

This pilot study found that oral melatonin supplementation effectively reduces perioperative oxidative stress in newborn infants undergoing surgery. The group receiving melatonin had significantly lower levels of non-protein-bound iron, advanced oxidation protein products, and F2-isoprostanes, indicating a potential role of melatonin in protecting babies from oxidative stress.
Surgery is frequently associated with excessive oxidative stress. Melatonin acts as an antioxidant and transient melatonin deficiency has been described in neonatal surgical patients. This randomized, blinded, prospective pilot study tested the hypothesis that oral melatonin supplementation in newborn infants undergoing surgery is effective in reducing perioperative oxidative stress. A total of twenty-three newborn infants requiring surgery were enrolled: 10 received a single dose of oral melatonin 0.5 mg/kg in the morning, before surgery (MEL group), and 13 newborns served as the control group (untreated group). Plasma concentrations of melatonin, Non-Protein-Bound Iron (NPBI), Advanced Oxidation Protein Products (AOPP), and F2-Isoprostanes (F2-IsoPs) were measured. Both in the pre- and postoperative period, melatonin concentrations were significantly higher in the MEL group than in the untreated group (preoperative: 1265.50 +/- 717.03 vs. 23.23 +/- 17.71 pg/mL, p < 0.0001; postoperative: 1465.20 +/- 538.38 vs. 56.47 +/- 37.18 pg/mL, p < 0.0001). Melatonin significantly increased from the pre- to postoperative period in the untreated group (23.23 +/- 17.71 vs. 56.47 +/- 37.18 pg/mL; pg/mL p = 0.006). In the MEL group, the mean blood concentrations of NPBI, F2-IsoPs, and AOPP significantly decreased from the pre- to the postoperative period (4.69 +/- 3.85 vs. 1.65 +/- 1.18 micromol/dL, p = 0.049; 128.40 +/- 92.30 vs. 50.25 +/- 47.47 pg/mL, p = 0.037 and 65.18 +/- 15.50 vs. 43.98 +/- 17.92 micromol/dL, p = 0.022, respectively). Melatonin concentration increases physiologically from the pre- to the postoperative period, suggesting a defensive physiologic response to counteract oxidative stress. The administration of exogenous melatonin in newborn infants undergoing surgery reduces lipid and protein peroxidation in the postoperative period, showing a potential role in protecting babies from the deleterious consequences of oxidative stress.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available