4.7 Article

Potent GST Ketosteroid Isomerase Activity Relevant to Ecdysteroidogenesis in the Malaria Vector Anopheles gambiae

Related references

Note: Only part of the references are listed.
Article Biology

Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti

Kazue Inaba et al.

Summary: This study reveals the mode of action of flavonoids on the Ae. aegypti Nobo protein, showing that they inhibit the activity of the protein and the inhibitory activity correlates with larvicidal activity.

BMC BIOLOGY (2022)

Review Physiology

Transcriptional Regulators of Ecdysteroid Biosynthetic Enzymes and Their Roles in Insect Development

Takumi Kamiyama et al.

Summary: This review summarizes the crucial transcriptional regulators controlling the expression of ecdysteroid biosynthetic enzymes and their roles in insect development, using the fruit fly Drosophila melanogaster as a model organism.

FRONTIERS IN PHYSIOLOGY (2022)

Article Multidisciplinary Sciences

Ensemble-function relationships to dissect mechanisms of enzyme catalysis

Filip Yabukarski et al.

Summary: Decades of structure-function studies have provided extensive understanding of enzymes, but traditional structural models can only capture snapshots of conformational ensembles. By studying ketosteroid isomerase, researchers demonstrate the importance of conformational ensembles in understanding enzyme function. Ensemble-function analyses reveal the effects of changing conformation probabilities and reactivity on enzyme function, which is crucial for advancing our knowledge of enzymes and developing new ones.

SCIENCE ADVANCES (2022)

Review Biochemistry & Molecular Biology

Functional and Structural Diversity of Insect Glutathione S-transferases in Xenobiotic Adaptation

B. K. Sonu Koirala et al.

Summary: This article provides a comprehensive overview of the versatile functions and diverse structures of insect GSTs in detoxifying chemical compounds. Recent advancements in technology have greatly enhanced our understanding of the functional and structural diversity of these enzymes.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

Article Biology

Control of the insect metamorphic transition by ecdysteroid production and secretion

Xueyang Pan et al.

Summary: Ecdysteroids, a type of steroid hormones, regulate molting and metamorphosis in insects, being produced in the prothoracic gland through reduction-oxidation reactions from dietary sterols. The prothoracic gland acts as a central node integrating signals to control ecdysteroid biosynthesis and secretion, ensuring precise pulses of these hormones during metamorphosis. Recent research has focused on characterizing ecdysone biosynthesis, steroid trafficking pathways, and identifying new factors that regulate prothoracic gland function.

CURRENT OPINION IN INSECT SCIENCE (2021)

Review Biochemistry & Molecular Biology

Glutathione Transferases as Efficient Ketosteroid Isomerases

Bengt Mannervik et al.

Summary: The research focuses on the role of glutathione transferases in ketosteroid isomerase activity, which is crucial for steroid hormone biosynthesis. GST A3-3 in humans and horses show high catalytic efficiency, supporting the formation of various steroid hormones, while some mammals lack this specific activity.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Article Infectious Diseases

Pyriproxyfen-treated bed nets reduce reproductive fitness and longevity of pyrethroid-resistant Anopheles gambiae under laboratory and field conditions

Nelson Grisales et al.

Summary: This study found that exposure to a mixture of PPF and pyrethroids on netting shortens the lifespan of mosquitoes and reduces reproductive output. Sterilization of vectors lasted at least one year under operational conditions.

MALARIA JOURNAL (2021)

Review Biology

An update on ecdysone signaling during insect oogenesis

Luc Swevers

CURRENT OPINION IN INSECT SCIENCE (2019)

Article Multidisciplinary Sciences

Functional genetic validation of key genes conferring insecticide resistance in the major African malaria vector, Anopheles gambiae

Adriana Adolfi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Entomology

Regulatory Pathways Controlling Female Insect Reproduction

Sourav Roy et al.

ANNUAL REVIEW OF ENTOMOLOGY, VOL 63 (2018)

Article Biochemistry & Molecular Biology

Characterization of equine GST A3-3 as a steroid isomerase

Helena Lindstrom et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

The silkworm glutathione S-transferase gene noppera-bo is required for ecdysteroid biosynthesis and larval development

Sora Enya et al.

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Article Cell Biology

Pri peptides are mediators of ecdysone for the temporal control of development

Helene Chanut-Delalande et al.

NATURE CELL BIOLOGY (2014)

Review Pharmacology & Pharmacy

Insect glutathione transferases

Albert J. Ketterman et al.

DRUG METABOLISM REVIEWS (2011)

Article Biochemistry & Molecular Biology

Glutathione Transferases Are Structural and Functional Outliers in the Thioredoxin Fold

Holly J. Atkinson et al.

BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Studies on the black box: Incorporation of 3-oxo-7-dehydrocholesterol into ecdysteroids by Drosophila melanogaster and Manduca sexta

James T. Warren et al.

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Targeting human glutathione transferase A3-3 attenuates progesterone production in human steroidogenic cells

Francoise Raffalli-Mathieu et al.

BIOCHEMICAL JOURNAL (2008)

Article Biochemistry & Molecular Biology

Bioinformatic and enzymatic characterization of the MAPEG superfamily

A Bresell et al.

FEBS JOURNAL (2005)

Review Biochemistry & Molecular Biology

Enzymatic mechanisms for catalysis of enolization: ketosteroid isomerase

RM Pollack

BIOORGANIC CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

The role of glutathione in the isomerization of Δ5-androstene-3,17-dione catalyzed by human glutathione transferase A1-1

PL Pettersson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)