4.7 Article

Intravitreal Neuroglobin Mitigates Primate Experimental Glaucomatous Structural Damage in Association with Reduced Optic Nerve Microglial and Complement 3-Astrocyte Activation

Related references

Note: Only part of the references are listed.
Review Ophthalmology

Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets

Gulgun Tezel

Summary: Neuroinflammation plays a significant role in the neurodegenerative processes of glaucoma, with glial cells and peripheral immune cells causing toxicity to retinal ganglion cells. The interaction between glial cells and immune cells is crucial in amplifying neuroinflammation and determining the neurodegenerative outcome. Inhibition of neurodegenerative inflammation may provide a broad treatment strategy for rescuing retinal ganglion cell integrity and function, while targeting both inflammatory toxicity and mitochondrial dysfunction.

PROGRESS IN RETINAL AND EYE RESEARCH (2022)

Article Immunology

Astrocytic A1/A2 paradigm participates in glycogen mobilization mediated neuroprotection on reperfusion injury after ischemic stroke

Haiyun Guo et al.

Summary: The mobilization of astrocytic glycogen inhibits A1-like astrocytes and enhances A2-like astrocytes during reperfusion, leading to reduced reactive oxygen species levels and increased production of NADPH and glutathione. This neuroprotection is mediated through ROS-mediated NF-kappa B inhibition and STAT3 activation, presenting a promising metabolic target for brain reperfusion injury in ischemic stroke.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Neurosciences

Neuroglobin effectively halts vision loss in Harlequin mice at an advanced stage of optic nerve degeneration

Helene Cwerman-Thibault et al.

Summary: Mitochondrial diseases, a prevalent group of inherited neurological disorders, currently have no cure. Gene therapy in Harlequin mice has shown to protect retinal ganglion cells and preserve visual function, indicating potential breakthrough in treating optic neuropathies.

NEUROBIOLOGY OF DISEASE (2021)

Review Pharmacology & Pharmacy

Potential roles of astrocytes and Muller cells in the pathogenesis of glaucoma

Youichi Shinozaki et al.

Summary: Glaucoma, a progressive optic neuropathy and leading cause of blindness worldwide, is characterized by impairment of retinal ganglion cells (RGCs), with elevated intraocular pressure as a major risk factor. However, a notable proportion of patients, especially in Japan, have normal intraocular pressure. The role of glial cells in glaucoma pathogenesis is being increasingly recognized, with reactive glial cells identified in glaucoma patients and animal models, suggesting their potential involvement in the disease process.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)

Review Neurosciences

Reactive astrocyte nomenclature, definitions, and future directions

Carole Escartin et al.

Summary: The article highlights the challenges and uncertainties surrounding reactive astrocytes, advocating for comprehensive research that includes assessment of multiple molecular and functional parameters, preferably in vivo, along with multivariate statistics and determination of impact on pathological hallmarks in relevant models.

NATURE NEUROSCIENCE (2021)

Article Clinical Neurology

Complement component 3 from astrocytes mediates retinal ganglion cell loss during neuroinflammation

Marjan Gharagozloo et al.

Summary: The study found that C3 expression in the eyes of patients with multiple sclerosis (MS) may be related to neuronal cell damage, while global C3(-/-) EAE mice have less retinal ganglion cell loss. These data reveal the important role of C3 in neurologic pathology, providing important clues for the study of retinal neurodegeneration.

ACTA NEUROPATHOLOGICA (2021)

Review Neurosciences

The Interaction Between Microglia and Macroglia in Glaucoma

Xiaohuan Zhao et al.

Summary: Glaucoma, a neurodegenerative disease that leads to irreversible vision loss, is typically associated with elevated intraocular pressure (IOP) but can also occur in patients with normal IOP, with unclear underlying mechanisms. Recent studies have highlighted the significant roles of retinal glia, particularly microglia and macroglia, in the initiation and progression of glaucoma, suggesting potential therapeutic targets for prevention and treatment. The interaction between microglia and macroglia in the context of glaucoma, including their roles in neuroinflammation and neuroprotection, may offer new insights into developing treatment options.

FRONTIERS IN NEUROSCIENCE (2021)

Review Cell Biology

Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration

Andrew M. Boal et al.

Summary: Astrocytes play a crucial role in responding to neurodegenerative stress and are interconnected through gap junctions, primarily composed of connexin-43 (Cx43), forming a broader network. This network contributes to various important processes and is likely to influence the progression of neurodegenerative diseases. Targeting these networks may be critical in the treatment of glaucomatous neurodegeneration and other optic neuropathies.

CELLS (2021)

Review Public, Environmental & Occupational Health

Strength of nonhuman primate studies of developmental programming: review of sample sizes, challenges, and steps for future work

Hillary F. Huber et al.

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2020)

Article Biochemistry & Molecular Biology

Negative surface charges in neuroglobin modulate the interaction with cytochrome c

Jesus Tejero

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Neurosciences

Glaucoma as a Neurodegenerative Disease Caused by Intrinsic Vulnerability Factors

Ana Artero-Castro et al.

PROGRESS IN NEUROBIOLOGY (2020)

Article Cell Biology

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

Kevin A. Guttenplan et al.

CELL REPORTS (2020)

Review Ophthalmology

Neuroprotection in glaucoma: recent advances and clinical translation

Chelsea Guymer et al.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2019)

Review Neurosciences

Neuroinflammation and microglia in glaucoma: time for a paradigm shift

Xin Wei et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2019)

Article Multidisciplinary Sciences

Towards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate

Wendi S. Lambert et al.

SCIENTIFIC REPORTS (2019)

Article Biotechnology & Applied Microbiology

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma

Alejandra Bosco et al.

MOLECULAR THERAPY (2018)

Article Biochemistry & Molecular Biology

Neuroglobin protects astroglial cells from hydrogen peroxide-induced oxidative stress and apoptotic cell death

Fatma Amri et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Article Medicine, Research & Experimental

Neuroglobin Can Prevent or Reverse Glaucomatous Progression in DBA/2J Mice

Helene Cwerman-Thibault et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2017)

Article Biochemistry & Molecular Biology

A novel function of neuroglobin for neuroregeneration in mice after optic nerve injury

Kayo Sugitani et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Biochemistry & Molecular Biology

Neuroglobin: From structure to function in health and disease

Paolo Ascenzi et al.

MOLECULAR ASPECTS OF MEDICINE (2016)

Article Clinical Neurology

Protection by Neuroglobin expression in Brain Pathologies

Eliana Baez et al.

FRONTIERS IN NEUROLOGY (2016)

Article Ophthalmology

The non-human primate experimental glaucoma model

Claude F. Burgoyne

EXPERIMENTAL EYE RESEARCH (2015)

Article Ophthalmology

Glaucoma as a Neurodegenerative Disease

Helen V. Danesh-Meyer et al.

JOURNAL OF NEURO-OPHTHALMOLOGY (2015)

Article Ophthalmology

Determinants of Optical Coherence Tomography-Derived Minimum Neuroretinal Rim Width in a Normal Chinese Population

Tin A. Tun et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)

Article Biotechnology & Applied Microbiology

Neuroglobin Gene Therapy Prevents Optic Atrophy and Preserves Durably Visual Function in Harlequin Mice

Christophe Lechauve et al.

MOLECULAR THERAPY (2014)

Article Biochemistry & Molecular Biology

Neuroglobin involvement in visual pathways through the optic nerve

Christophe Lechauve et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2013)

Review Biochemistry & Molecular Biology

Neuroglobin, a Novel Target for Endogenous Neuroprotection against Stroke and Neurodegenerative Disorders

Zhanyang Yu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

Article Ophthalmology

Neuroglobin Protection in Retinal Ischemia

Anita S. Y. Chan et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2012)

Article Clinical Neurology

Neuroglobin Expression in Ischemic Stroke

Kunlin Jin et al.

STROKE (2010)

Review Pharmacology & Pharmacy

Neuroglobin: an endogenous neuroprotectant

David A. Greenberg et al.

CURRENT OPINION IN PHARMACOLOGY (2008)

Article Ophthalmology

Glaucoma as a neurodegenerative disease

Neeru Gupta et al.

CURRENT OPINION IN OPHTHALMOLOGY (2007)

Article Ophthalmology

Primate glaucoma models

CA Rasmussen et al.

JOURNAL OF GLAUCOMA (2005)

Article Neurosciences

Presence of neuroglobin in cultured astrocytes

XQ Chen et al.

Article Multidisciplinary Sciences

Neuroglobin protects the brain from experimental stroke in vivo

YJ Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemical Research Methods

Experimental glaucoma in the primate induced by latex microspheres

AJ Weber et al.

JOURNAL OF NEUROSCIENCE METHODS (2001)