Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid

Bullous pemphigoid (BP) is an autoimmune blistering skin disease, of which the incidence has increased in recent years. BP is characterized by circulating IgG and IgE autoantibodies against the hemidesmosomal proteins BP180 and BP230. Although autoantibodies trigger inflammatory cascades that lead to blister formation, effector cells and cell-mediated autoimmunity must also be considered as important factors in the pathogenesis of BP. The aim of this review is to outline the current knowledge on the role of eosinophils, basophils, and neutrophils in BP.

Automated summary

Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by circulating autoantibodies against BP180 and BP230 proteins. In addition to autoantibodies, effector cells and cell-mediated immunity play important roles in BP pathogenesis. This review aims to summarize the current understanding of eosinophils, basophils, and neutrophils in BP.