Journal
BIOMOLECULES
Volume 13, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/biom13020308
Keywords
H-type pseudoknot structure; RNA; bulges; internal loops; parser; CFG
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This paper aims to create a pioneering framework for predicting specific RNA structures, particularly focusing on H-type pseudoknots including bulges and internal loops. The proposed framework, Knotify+, leverages the power context-free grammar (CFG) along with maximum base pairing and minimum free energy to effectively address this ambiguous task. Knotify+ outperforms state-of-the-art frameworks in terms of accuracy in core stems prediction, providing higher accuracy in small sequences and comparable accuracy in larger ones, while requiring less execution time compared to well-known platforms.
The accurate base pairing in RNA molecules, which leads to the prediction of RNA secondary structures, is crucial in order to explain unknown biological operations. Recently, COVID-19, a widespread disease, has caused many deaths, affecting humanity in an unprecedented way. SARS-CoV-2, a single-stranded RNA virus, has shown the significance of analyzing these molecules and their structures. This paper aims to create a pioneering framework in the direction of predicting specific RNA structures, leveraging syntactic pattern recognition. The proposed framework, Knotify+, addresses the problem of predicting H-type pseudoknots, including bulges and internal loops, by featuring the power of context-free grammar (CFG). We combine the grammar's advantages with maximum base pairing and minimum free energy to tackle this ambiguous task in a performant way. Specifically, our proposed methodology, Knotify+, outperforms state-of-the-art frameworks with regards to its accuracy in core stems prediction. Additionally, it performs more accurately in small sequences and presents a comparable accuracy rate in larger ones, while it requires a smaller execution time compared to well-known platforms. The Knotify+ source code and implementation details are available as a public repository on GitHub.
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