Journal
VACCINES
Volume 11, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/vaccines11020445
Keywords
yellow fever; vaccine; serious adverse events; neurotropic disorder
Categories
Ask authors/readers for more resources
The disease burden of yellow fever virus infection is high in areas with low vaccination coverage. Vaccination is the most effective control strategy for yellow fever, with the licensed vaccines being safe and effective. However, rare cases of neurotropic disease have been observed following vaccination. This report emphasizes the importance of healthcare professionals being aware of and managing such events promptly.
The disease burden of yellow fever virus infection (YFV) is quite high in the tropics where vaccination coverage is low. To date, vaccination is the most effective control strategy to mitigate and eliminate the burden of YF disease. The licensed YF vaccines are safe and effective and serious adverse events are rare. Herein, we report three cases of neurological syndrome, compatible with meningoencephalitis following 17DD vaccination. In all cases, YFV-specific IgM antibodies were detected in the cerebrospinal fluid. Our observations confirm the development of YF vaccine-associated neurotropic disease, a rare serious adverse event, from which all three patients have fully recovered without any long-term sequelae. This report reinforces the need for awareness among health professionals to recognize and effectively manage such events in a timely manner.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available