Prenatal diagnosis of fetomaternal hemorrhage by a novel hydrogel fluoroimmunoassay that accurately quantifies fetal haemoglobin

Article Obstetrics & Gynecology

Fetomaternal hemorrhage assessment in Rh-negative patients undergoing dilation and evacuation between 20 and 24 weeks? gestational age: A retrospective cohort study

Anne N. Flynn et al.

Summary: This retrospective cohort analysis found that there was no risk of requiring additional Rh D immune globulin after D + E for pregnancies greater than 20 weeks' gestation.

CONTRACEPTION (2022)

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Article Hematology

Fetomaternal hemorrhage: Evidence from a multihospital healthcare system that up to 40% of severe cases are missed

Nicholas R. Carr et al.

Summary: The study found that FMH has adverse effects on neonates, with some cases resulting in death despite emergency transfusions on the day of birth. This highlights the significance of FMH and its relatively high incidence rate, emphasizing the need to raise awareness and improve communication among relevant healthcare professionals.

TRANSFUSION (2022)

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Article Obstetrics & Gynecology

Fetomaternal hemorrhage: a clue to intraplacental choriocarcinoma and neonatal malignancy

Mariana Simoes et al.

Summary: Fetomaternal hemorrhage (FMH) can cause neonatal anemia due to fetal blood loss to the maternal circulation, with causes ranging from disruption of the maternal-fetal barrier to rare entities like intraplacental choriocarcinoma (ICC) which can lead to severe complications. Monitoring serum beta-hCG levels in cases of massive FMH is crucial for timely diagnosis and appropriate management.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

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Article Pathology

Maternal vs Fetal Origin of Placental Intervillous Thrombi

Madina Sukhanova et al.

Summary: This study aimed to determine the origin of blood in placental intervillous thrombi (IVTs) and found evidence supporting a maternal origin for IVTs. The use of immunohistochemistry for IgM and AFP was found to be clinically useful in determining maternal vs fetal contribution to IVTs.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2022)

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Article Obstetrics & Gynecology

Diagnostic accuracy of Kleihauer-Betke (Kb) testing to predict fetal outcomes associated with fetomaternal hemorrhage: a retrospective cohort study

Melanie C. Audette et al.

Summary: The study found that the diagnostic and screening utility of KB testing as a triage tool in predicting adverse fetal outcomes associated with FMH is limited. Although the test exhibited high specificity, the sensitivity was poor, with moderate positive and negative predictive values.

JOURNAL OF PERINATOLOGY (2022)

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Article Computer Science, Interdisciplinary Applications

Convolutional neural network-based automatic classification for incomplete antibody reaction intensity in solid phase anti-human globulin test image

KeQing Wu et al.

Summary: A deep ensemble learning model was proposed for accurate classification of incomplete antibody reaction intensity in hydrogel chromatography medium high density medium solid-phase Coombs test. The model achieved high accuracies in five different IARI categories and improved the performance of immunologists in manual classification.

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING (2022)

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Article Obstetrics & Gynecology

Reduced fetal movements: the case of fetomaternal hemorrhage Case series and proposal of a management protocol

Fernando Ficarola et al.

Summary: This article presents the characteristics, diagnostic methods, and management protocol for fetomaternal hemorrhage, and proposes a flow-chart for early diagnosis and treatment of FMH.

MINERVA OBSTETRICS AND GYNECOLOGY (2022)

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Article Obstetrics & Gynecology

Clinical practices and outcomes of RhD immunoglobulin prophylaxis following large-volume fetomaternal haemorrhage in Queensland, Australia

Shao Yang Tneh et al.

Summary: This study examined the adherence to guidelines for follow-up and management of large-volume FMH in RhD negative women in Queensland, Australia. Results showed poor compliance with guidelines, which may contribute to an increased risk of RhD alloimmunisation. Further data analysis is warranted.

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY (2021)

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Article Medical Laboratory Technology

Maternal ABO Discrepancy Caused by Massive Fetomaternal Hemorrhage: a Case Report

Kexin Fan et al.

Summary: Fetomaternal hemorrhage can result in life-threatening fetal anemia. Mixed-field agglutination of maternal ABO forward typing may be a rare presentation of massive FMH, necessitating further investigation.

CLINICAL LABORATORY (2021)

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Article Hematology

Evaluation of machine learning-driven automated Kleihauer-Betke counting: A method comparison study

Zhuoran Zhang et al.

Summary: The study evaluated an automated KB counting system and compared its accuracy, precision, and efficiency in quantifying FMH with manual counting and flow cytometry. The results showed that the automated counting system was more accurate and efficient compared to manual counting, providing precise FMH quantification results.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2021)

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Article Obstetrics & Gynecology