☆ 4.7 Review

Nanosystems for oxidative stress regulation in the anti-inflammatory therapy of acute kidney injury

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

Related references

Note: Only part of the references are listed.
Review Transplantation

Overcoming barriers in the design and implementation of clinical trials for acute kidney injury: a report from the 2020 Kidney Disease Clinical Trialists meeting

Daniel Lazzareschi et al.

Summary: Acute kidney injury is a growing epidemic that is associated with increased risk of death, chronic kidney disease, and cardiovascular events. Clinical trials in this field are challenging due to the heterogeneity of the disease. Identifying subphenotypes of acute kidney injury can help elucidate its diverse etiologies and enhance prevention and treatment strategies.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

Add to Collection
Article Chemistry, Multidisciplinary

Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

Rui Liu et al.

Summary: Decades have passed since the approval of the first nanoparticles-based medicine for human cancer treatment, and research and development in nanoparticles for drug delivery have been continuing. Today, there have been significant advancements in nanoparticles, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines, and nano-antibodies. These nanoparticles have shown great potential in the treatment and diagnosis of challenging diseases such as cancer and neurodegenerative diseases, making them promising drug carriers and therapeutic agents in the future.

CHINESE CHEMICAL LETTERS (2023)

Add to Collection
Article Biochemistry & Molecular Biology

Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury

Juan Zhang et al.

Summary: Alisol B attenuates cisplatin-induced acute kidney injury by reducing renal tubular apoptosis, inflammatory response, and oxidative stress through targeted inhibition of soluble epoxide hydrolase (sEH) via multiple signaling pathways.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2023)

Add to Collection
Review Engineering, Biomedical

Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

Qiaohui Chen et al.

Summary: This review article introduces the potential and advantages of nanodrugs in treating acute kidney injury (AKI). Traditional small molecule drugs have limitations in AKI treatment, while nanodrugs with kidney targeting ability can overcome these limitations and achieve significant therapeutic effects.

BIOACTIVE MATERIALS (2023)

Add to Collection
Review Chemistry, Applied

Polysaccharide hydrogels: Functionalization, construction and served as scaffold for tissue engineering

Qian Yang et al.

Summary: This review provides a comprehensive framework about the potential and challenges that polysaccharide hydrogels face in tissue engineering. It introduces the strategies for modifying polysaccharides and the techniques for inducing hydrogel formation. It also highlights the applications of polysaccharide hydrogels in vivo and addresses future research prospects and challenges.

CARBOHYDRATE POLYMERS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Preferential siRNA delivery to injured kidneys for combination treatment of acute kidney injury

Weimin Tang et al.

Summary: This study introduces a siRNA carrier designed for injured kidneys in AKI, showing potential to enhance therapeutic effects and improve kidney function. By inhibiting CXCR4 and p53 simultaneously, the PCX/sip53 polyplexes can selectively deliver therapeutic siRNA in AKI, reducing renal damage.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection
Article Chemistry, Physical

A novel electrochemical kidney injury molecule-1 (KIM-1) immunosensor based covalent organic frameworks-gold nanoparticles composite and porous NiCo2S4@CeO2 microspheres: The monitoring of acute kidney injury

Havva Boyacioglu et al.

Summary: This study describes a new method for rapid diagnosis of kidney injury. A sensitive and selective kidney injury immunosensor was fabricated using porous NiCo2S4@CeO2 microspheres as a signal amplifier and COFs-AuNPs composite as an electrochemical sensor platform. The immunosensor showed high detection sensitivity and accuracy, making it a valuable tool for monitoring acute kidney injury.

APPLIED SURFACE SCIENCE (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Renal Nano-drug delivery for acute kidney Injury: Current status and future perspectives

Hui Nee Geo et al.

Summary: This article reviews the current status and future trajectories of renal nanomedicine research for the management of acute kidney injury (AKI). The use of nanosized drug carriers (NDCs) for the delivery of reno-protective agents is evaluated, with a focus on improving renal tissue targeting selectivity and efficacy. The need to identify accumulation sites of NDCs in renal tissues during in vivo assessments is highlighted.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection
Article Urology & Nephrology

Kidney targeting of formoterol containing polymeric nanoparticles improves recovery from ischemia reperfusion-induced acute kidney injury in mice

Ernest L. Vallorz et al.

Summary: The study demonstrates that formoterol can restore kidney function in acute and chronic kidney injury through inducing mitochondrial biogenesis, while minimizing adverse cardiovascular effects by reducing the effective dose. By developing biodegradable polymeric nanoparticles that specifically target the kidney, formoterol-containing nanoparticles can effectively improve kidney recovery and reduce cardiovascular side effects in ischemia-reperfusion-induced acute kidney injury.

KIDNEY INTERNATIONAL (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Liposomes as Multifunctional Nano-Carriers for Medicinal Natural Products

Xiamin Cheng et al.

Summary: This review discusses the targeted delivery of medicinal natural products, focusing on the preparation of functional liposomes and the application of liposomal medicinal natural products. It provides useful guidance to enhance targeted therapy of medicinal natural products.

FRONTIERS IN CHEMISTRY (2022)

Add to Collection
Review Medicine, General & Internal

Meta-analytic Techniques to Assess the Association Between N-acetylcysteine and Acute Kidney Injury After Contrast Administration A Systematic Review and Meta-analysis

Kate Magner et al.

Summary: This article systematically reviewed the literature on N-acetylcysteine (NAC) for the prevention of contrast-induced acute kidney injury (CI-AKI) and found that although there were significant publication biases and heterogeneity, more robust and neutral effect sizes could be obtained when restricting the analysis to large randomized controlled trials (RCTs) or trials with clinical outcomes.

JAMA NETWORK OPEN (2022)

Add to Collection
Editorial Material Critical Care Medicine

New drugs for acute kidney injury

Peter Pickkers et al.

INTENSIVE CARE MEDICINE (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Targeted delivery via albumin corona nanocomplex to renal tubules to alleviate acute kidney injury

Shuo Qin et al.

Summary: In this study, a high loading capacity nanocomplex core was developed with celastrol entrapped in D-alpha-tocopherol polyethylene glycol 1000 succinate. Bovine serum albumin was adsorbed onto the core surface to improve the targeting efficiency and stability. The nanocomplex showed good stability and renal tubule-specific distribution in in vitro and in vivo experiments. Pharmacodynamic studies demonstrated that the nanocomplex effectively alleviated acute kidney injury-induced injuries.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection
Article Plant Sciences

Role of curcumin in the treatment of acute kidney injury: research challenges and opportunities

Yi Cai et al.

Summary: Acute kidney injury (AKI) is a common complication in clinical inpatients, and current chemical drugs often have limited efficacy and toxic side effects in AKI treatment. Therefore, finding natural interventions, such as curcumin, is of great clinical significance. Curcumin, a natural phenolic compound, shows therapeutic effects in AKI by restoring renal function through multiple mechanisms. However, the low bioavailability of curcumin hinders its clinical application.

PHYTOMEDICINE (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Hydrogenated Germanene Nanosheets as an Antioxidative Defense Agent for Acute Kidney Injury Treatment

Zhixin Chen et al.

Summary: This study reports the use of hydrogen-terminated germanene nanosheets as an antioxidative defense nanoplatform against acute kidney injury (AKI). The results show that H-germanene can effectively scavenge reactive oxygen species (ROS) and accumulate in injured kidneys, providing a potential treatment option for renal diseases.

ADVANCED SCIENCE (2022)

Add to Collection
Article Medicine, Research & Experimental

Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1/NLRP3/Caspase-1 pathway

Shaobo Wang et al.

Summary: This study demonstrates an effective therapeutic option by using Se@BSA nanoparticles to treat IRI-induced AKI. By correcting selenium deficiency and inhibiting inflammatory responses, Se@BSA nanoparticles show promising results in mitigating AKI and preventing fibrosis formation.

THERANOSTICS (2022)

Add to Collection
Article Engineering, Environmental

Tetrahedral framework nucleic acids act as antioxidants in acute kidney injury treatment

Qi Zhang et al.

Summary: This study demonstrates that tetrahedral framework nucleic acids (tFNAs) exhibit protective effects by relieving oxidative stress and inhibiting apoptosis in treating rhabdomyolysis (RM)-AKI, showing promise as a novel class of antioxidative nanomaterials with excellent antioxidant efficiency, superior structure stability, preferential kidney accumulation, and good biocompatibility.

CHEMICAL ENGINEERING JOURNAL (2021)

Add to Collection
Article Engineering, Biomedical

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

X. Huang et al.

Summary: ROS can mediate various physiological functions, but their over-accumulation can lead to premature aging or death, as well as inflammatory conditions. Advances in nanoscience have led to the development of nanomaterials with unique ROS-scavenging abilities, allowing for the emergence of next-generation strategies to ameliorate ROS-related inflammatory conditions. Ongoing studies and clinical applications of nanomedicine based on ROS scavenging stand to benefit from this interdisciplinary field.

MATERIALS TODAY BIO (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation

Junjie Li et al.

Summary: The text emphasizes the evolution of nanomedicine from biologically inert entities to smarter systems aimed at advancing in vivo functionality. It highlights the importance of focusing on nano-bio interactions and desirable functionality in tissue, cellular, and molecular levels, as well as providing definitive evidence for proof-of-mechanism.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Add to Collection
Article Materials Science, Multidisciplinary

Nanozyme-involved biomimetic cascade catalysis for biomedical applications

Xiaoli Cai et al.

Summary: Nanozymes, as substitutes for enzymes, possess enzymelike activities with high stability and tolerance, making them ideal for biomimetic catalysis systems in biomedical applications.

MATERIALS TODAY (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Reactive Oxygen Species-Regulating Strategies Based on Nanomaterials for Disease Treatment

Chenyang Zhang et al.

Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.

ADVANCED SCIENCE (2021)

Add to Collection
Review Chemistry, Multidisciplinary

DNA Nanostructures: Current Challenges and Opportunities for Cellular Delivery

Aurelie Lacroix et al.

Summary: Despite the programmable assembly and precise control of size, shape, and function offered by DNA nanotechnology, challenges such as enzymatic hydrolysis, low cellular uptake, immune cell recognition and degradation, and unclear biodistribution profiles still need to be addressed before utilizing DNA particles in biological applications. Rigorous methodologies are necessary to study, understand, and control the fate of self-assembled DNA structures under physiological conditions. Achieving a detailed understanding of the fate of DNA nanostructures within living organisms through thorough characterization is crucial for driving the translation of DNA constructs toward preclinical design and clinical maturity.

ACS NANO (2021)

Add to Collection
Article Chemistry, Applied

Engineering of stepwise-targeting chitosan oligosaccharide conjugate for the treatment of acute kidney injury

Dong-Wei Wang et al.

Summary: This study developed a novel stepwise-targeting compound for the treatment of sepsis-induced acute kidney injury, demonstrating enhanced therapeutic effects both in vitro and in vivo.

CARBOHYDRATE POLYMERS (2021)

Add to Collection
Article Nanoscience & Nanotechnology

Sustained local inhibition of thrombin preserves renal microarchitecture and function after onset of acute kidney injury

Ian Vargas et al.

Summary: This study demonstrates that inhibition of thrombin-driven clotting and inflammatory signaling using locally-acting thrombin-targeted perfluorocarbon nanoparticles protects renal vasculature and modulates various inflammatory processes that cause renal ischemia reperfusion injury.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

Add to Collection
Article Nanoscience & Nanotechnology

Fucoidan-based micelles as P-selectin targeted carriers for synergistic treatment of acute kidney injury

Gaofeng Shu et al.

Summary: The study developed kidney-targeted OSA-Fucoidan/Cur micelles with sustained drug release behavior and excellent physicochemical stability. Cellular uptake studies demonstrated the specific binding between fucoidan and P-selectin, leading to higher internalization of the micelles, which exhibited ideal kidney-targeted characteristics. In vivo studies showed that the micelles possessed anti-inflammatory and antioxidant abilities, enhancing the therapeutic efficacy of AKI.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

Add to Collection
Article Physics, Applied

Biodegradable Nanodots: Biodegradable Self‐Assembled Ultrasmall Nanodots as Reactive Oxygen/Nitrogen Species Scavengers for Theranostic Application in Acute Kidney Injury (Small 8/2021)

Dong‐Yang Zhang et al.

Small (2021)

Add to Collection
Article Multidisciplinary Sciences

Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics

Qinjie Weng et al.

Summary: Catalytic activity tunable ceria nanoparticles have been reported as potential agents for preventing chemotherapy-induced acute kidney injury without compromising the efficacy of chemotherapeutic agents. This context-dependent reactive oxygen species scavenger shows promise for clinical application in cancer patients.

NATURE COMMUNICATIONS (2021)

Add to Collection
Review Cell Biology

Evolving concepts in NAD+ metabolism

Claudia C. S. Chini et al.

Summary: NAD and NADP have diverse roles beyond co-factors in oxidation-reduction reactions, including signaling pathways, post-translational modifications, epigenetic changes, and RNA regulation. Recent studies have shown that NAD metabolism is highly dynamic with a short halflife in some tissues, and new concepts are emerging in the roles of NAD pathway metabolites in various disease states. Resolving open questions in NAD biology will lead to significant advancements in the field.

CELL METABOLISM (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Nanozymes for regulation of reactive oxygen species and disease therapy

Yujie Dai et al.

Summary: Nanozymes possess high catalytic activity and stability, making them advantageous in generating or eliminating reactive oxygen species (ROS) for potential applications in disease therapy. Researchers are exploring catalytic mechanisms and strategies to design nanozyme-based platforms for cancer therapy, pathogen infection, neurodegenerative diseases, and more. Challenges and future opportunities for the development and application of nanozymes are also being discussed.

CHINESE CHEMICAL LETTERS (2021)

Add to Collection
Review Pharmacology & Pharmacy

Approaches to surface engineering of extracellular vesicles

Maximilian Richter et al.

Summary: Extracellular vesicles (EVs) are cell-derived nanoparticles mediating intercellular communication, showing promise for therapeutic and drug-delivery applications. Researchers aim to enhance their performance by equipping EVs with new moieties on their surface while preserving vesicle integrity. Techniques for introducing these moieties can be classified as pre or post-isolation approaches, involving genetic manipulation, metabolic engineering, physical, or chemical means.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Hyaluronic acid coated bilirubin nanoparticles attenuate ischemia reperfusion-induced acute kidney injury

Zhi-Wei Huang et al.

Summary: Acute kidney injury (AKI) is a common pathological process associated with high morbidity and mortality worldwide. Bilirubin, with its antioxidant, anti-inflammatory, and anti-apoptotic properties, shows promise as a therapeutic candidate for AKI. Nanotechnology-mediated therapy, particularly using hyaluronic acid-coated epsilon-polylysine-bilirubin conjugate nanoparticles (nHA/PLBR), has shown potential for targeted delivery and enhanced efficacy in protecting against renal injury induced by oxidative stress and inflammation in AKI.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions

Yi Huang et al.

Summary: Kidney-targeted nanoparticles offer a promising approach for drug delivery to diseased tissues with reduced side effects, and understanding the impact of nanoparticle properties such as size, charge, shape, and material density on kidney interaction is crucial for designing effective drug delivery systems for chronic kidney disease. Active targeting strategies can enhance nanoparticle retention in the kidney, showing potential for improving treatment outcomes in kidney diseases.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection
Article Urology & Nephrology

Exosome-based delivery of super-repressor IκBα ameliorates kidney ischemia-reperfusion injury

Seonghun Kim et al.

Summary: Ischemia-reperfusion injury is a major cause of acute kidney injury, and immune responses play a significant role in this process. Treatment with Exo-srI kappa B can reduce post-ischemic damage in mice by decreasing NF-kappa B activity and modulating immune cell populations.

KIDNEY INTERNATIONAL (2021)

Add to Collection
Review Medicine, Research & Experimental

Renal Cell-Targeted Drug Delivery Strategy for Acute Kidney Injury and Chronic Kidney Disease: A Mini-Review

Di Liu et al.

Summary: Kidney diseases, including AKI and CKD, are major global public health concerns with limited effective drug therapies. Kidney-targeted drug delivery is a potential strategy to improve therapeutic efficacy and reduce side effects. This review discusses renal cell-targeted formulations for AKI and CKD, providing biodistribution data and proposing future research directions.

MOLECULAR PHARMACEUTICS (2021)

Add to Collection
Article Biotechnology & Applied Microbiology

Prussian blue-based theranostics for ameliorating acute kidney injury

Dong-Yang Zhang et al.

Summary: In this study, ultrasmall Prussian blue nanozymes were synthesized as theranostics for AKI treatment, showing excellent performance in eliminating RONS and treating AKI, suggesting great potential for AKI management.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Redox-Mediated Artificial Non-Enzymatic Antioxidant MXene Nanoplatforms for Acute Kidney Injury Alleviation

Xing Zhao et al.

Summary: Acute kidney injury (AKI) is a common oxidative stress-related renal disease with limited treatment options. Researchers have developed a novel non-enzymatic antioxidant strategy based on ultrathin Ti3C2-PVP nanosheets for AKI treatment, showing excellent biocompatibility and reactivity towards multiple ROS. This approach has great potential in scavenging ROS and suppressing oxidative stress-induced inflammatory responses for AKI treatment.

ADVANCED SCIENCE (2021)

Add to Collection
Article Medicine, General & Internal

Acute kidney injury

John A. Kellum et al.

Summary: Acute kidney injury (AKI) describes a sudden loss of kidney function which can lead to long term damage. AKI and AKD are global issues with different causes and management strategies in various regions. Prevention and early detection of AKI are crucial for better outcomes.

NATURE REVIEWS DISEASE PRIMERS (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Novel Nanoliposomes Alleviate Contrast-Induced Nephropathy by Mediating Apoptosis Response in New Zealand Rabbits

Peng Zhang et al.

Summary: The study demonstrated that nano liposomes can effectively prevent contrast-induced nephropathy by reducing apoptosis and minimizing kidney damage caused by contrast agents. Compared with hydration group, the nano liposome group showed superior protection of renal function, indicating potential clinical application value.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Add to Collection
Review Pharmacology & Pharmacy

Recent advances in nanotherapeutics for the treatment and prevention of acute kidney injury

Hui Yu et al.

Summary: Nanotherapeutics based on nanotechnology have been proven to be an emerging and promising treatment strategy for AKI, improving drug delivery efficiency, reducing side effects, and achieving better treatment outcomes.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Add to Collection
Review Biochemistry & Molecular Biology

The biological applications of DNA nanomaterials: current challenges and future directions

Wenjuan Ma et al.

Summary: DNA nanotechnology has been widely applied in various biological fields, showing great potential in altering cell behaviors and serving as drug carriers. The development of different DNA nanomaterials with diverse shapes and sizes has opened up new possibilities for innovative designs and biological applications. However, further research is needed to overcome current challenges and realize the full potential of DNA materials in real-life applications.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Add to Collection
Article Medicine, Research & Experimental

Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Meng Zhao et al.

Summary: Reducing mtROS levels attenuated renal dysfunction, mitochondrial damage, and inflammation in IRI-AKI mice. The loss of TFAM can impact mtDNA maintenance, mitochondrial energy metabolism, and cytokine release. Insights into the role of mtROS and TFAM in IRI-AKI provide potential therapeutic targets for renal repair.

THERANOSTICS (2021)

Add to Collection
Article Engineering, Biomedical

A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury

Shuyun Liu et al.

ACTA BIOMATERIALIA (2020)

Add to Collection
Article Biochemical Research Methods

Functional role of microRNA-500a-3P-loaded liposomes in the treatment of cisplatin-induced AKI

Suhua Zhang et al.

IET NANOBIOTECHNOLOGY (2020)

Add to Collection
Article Multidisciplinary Sciences

Exosome-based delivery of super-repressor I kappa B alpha relieves sepsis-associated organ damage and mortality

Hojun Choi et al.

SCIENCE ADVANCES (2020)

Add to Collection
Review Pharmacology & Pharmacy

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Yanlong Yin et al.

PHARMACEUTICS (2020)

Add to Collection
Article Multidisciplinary Sciences

Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI

Tao-Tao Tang et al.

SCIENCE ADVANCES (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Normobaric hyperoxia plays a protective role against renal ischemia-reperfusion injury by activating the Nrf2/HO-1 signaling pathway

Jun Pei et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Add to Collection
Article Cell Biology

Ceftriaxone Calcium Crystals Induce Acute Kidney Injury by NLRP3-Mediated Inflammation and Oxidative Stress Injury

Zhang Yifan et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Add to Collection
Article Multidisciplinary Sciences

Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

Tengfei Liu et al.

NATURE COMMUNICATIONS (2020)

Add to Collection
Review Materials Science, Multidisciplinary

Structure and activity of nanozymes: Inspirations for de novo design of nanozymes

Zhuoran Wang et al.

MATERIALS TODAY (2020)

Add to Collection
Article Multidisciplinary Sciences

ROS-responsive chitosan-SS31 prodrug for AKI therapy via rapid distribution in the kidney and long-term retention in the renal tubule

Di Liu et al.

SCIENCE ADVANCES (2020)

Add to Collection
Article Medicine, Research & Experimental

Renal proximal tubular NEMO plays a critical role in ischemic acute kidney injury

Sang Jun Han et al.

JCI INSIGHT (2020)

Add to Collection
Article Nanoscience & Nanotechnology

Ceria Nanozymes with Preferential Renal Uptake for Acute Kidney Injury Alleviation

Dong-Yang Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Add to Collection
Review Chemistry, Medicinal

Exosomes from different cells: Characteristics, modifications, and therapeutic applications

Mingyuan Li et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Add to Collection
Article Cell Biology

Dexmedetomidine Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting p75NTR-Mediated Oxidative Stress and Apoptosis

Zhe Wang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Add to Collection
Article Medicine, Research & Experimental

ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury

Hui Yu et al.

THERANOSTICS (2020)

Add to Collection
Review Anesthesiology

Acute Kidney Injury After Cardiac Surgery: A Narrative Review of the Literature

Sophia Tsong Huey Chew et al.

JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA (2019)

Add to Collection
Review Chemistry, Medicinal

Targeting strategies for drug delivery to the kidney: From renal glomeruli to tubules

Chun-Ping Liu et al.

MEDICINAL RESEARCH REVIEWS (2019)

Add to Collection
Review Pharmacology & Pharmacy

Acute kidney injury overview: From basic findings to new prevention and therapy strategies

Sabrina Ribeiro Gonsalez et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

A Melanin-Based Natural Antioxidant Defense Nanosystem for Theranostic Application in Acute Kidney Injury

Tuanwei Sun et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Add to Collection
Article Engineering, Biomedical

Enhanced efficiency of mitochondria-targeted peptide SS-31 for acute kidney injury by pH-responsive and AKI-kidney targeted nanopolyplexes

Di Liu et al.

BIOMATERIALS (2019)

Add to Collection
Review Chemistry, Multidisciplinary

Degradability and Clearance of Inorganic Nanoparticles for Biomedical Applications

Guangbao Yang et al.

ADVANCED MATERIALS (2019)

Add to Collection
Review Urology & Nephrology

Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications

Chunyuan Guo et al.

NATURE REVIEWS NEPHROLOGY (2019)

Add to Collection
Review Urology & Nephrology

Mechanisms and therapeutic targets of ischemic acute kidney injury

Sang Jun Han et al.

KIDNEY RESEARCH AND CLINICAL PRACTICE (2019)

Add to Collection
Article Pharmacology & Pharmacy

Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury

Meng Zhao et al.

DRUG DELIVERY (2018)

Add to Collection
Article Nanoscience & Nanotechnology

Targeting Delivery of Rapamycin with Anti-Collagen IV Peptide Conjugated Fe3O4 @ Nanogels System for Vascular Restenosis Therapy

Qian Yang et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018)

Add to Collection
Article Chemistry, Physical

Design and in vivo characterization of kidney-targeting multimodal micelles for renal drug delivery

Jonathan Wang et al.

NANO RESEARCH (2018)

Add to Collection
Review Biotechnology & Applied Microbiology

Mitochondria as a therapeutic target for common pathologies

Michael P. Murphy et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Add to Collection
Article Engineering, Biomedical

DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury

Dawei Jiang et al.

NATURE BIOMEDICAL ENGINEERING (2018)

Add to Collection
Review Physiology

Immune cells and inflammation in AKI to CKD progression

Yuki Sato et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

Add to Collection
Article Nanoscience & Nanotechnology

Porous Au@Pt Nanoparticles: Therapeutic Platform for Tumor Chemo-Photothermal Co-Therapy and Alleviating Doxorubicin-Induced Oxidative Damage

Qian Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Add to Collection
Review Urology & Nephrology

Linking acute kidney injury to chronic kidney disease: the missing links

Mohammed A. Kaballo et al.

JOURNAL OF NEPHROLOGY (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Augmented O-GlcNAc, signaling via glucosamine attenuates oxidative stress and apoptosis, following contrast-induced acute kidney injury in rats

Jiachang Hu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Add to Collection
Article Multidisciplinary Sciences

Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

Ling Guo et al.

NATURE COMMUNICATIONS (2017)

Add to Collection
Article Medicine, Research & Experimental

E-selectin-targeted Sialic Acid-PEG-dexamethasone Micelles for Enhanced Anti-Inflammatory Efficacy for Acute Kidney Injury

Jing-Bo Hu et al.

THERANOSTICS (2017)

Add to Collection
Article Pharmacology & Pharmacy

被撤回的出版物: Sialic acid-modified solid lipid nanoparticles as vascular endothelium-targeting carriers for ischemia-reperfusion-induced acute renal injury (Retracted article. See vol. 29, pg. 2632, 2022)

Jing-Bo Hu et al.

DRUG DELIVERY (2017)

Add to Collection
Review Urology & Nephrology

Novel Therapies for Acute Kidney Injury

Huaizhen Chen et al.

KIDNEY INTERNATIONAL REPORTS (2017)

Add to Collection
Article Urology & Nephrology

The Tubulointerstitial Pathophysiology of Progressive Kidney Disease

H. William Schnaper

ADVANCES IN CHRONIC KIDNEY DISEASE (2017)

Add to Collection
Review Transplantation

Mitochondria: a therapeutic target in acute kidney injury

Yu Ishimoto et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Short- and Long-Term Tracking of Anionic Ultrasmall Nanoparticles in Kidney

Xiaowen Liang et al.

ACS NANO (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery

Homan Kang et al.

ADVANCED MATERIALS (2016)

Add to Collection
Article Biochemical Research Methods

Renal Targeting: Peptide-Based Drug Delivery to Proximal Tubule Cells

Artjom Wischnjow et al.

BIOCONJUGATE CHEMISTRY (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Protective Effects of Green Tea Polyphenol Against Renal Injury Through ROS-Mediated JNK-MAPK Pathway in Lead Exposed Rats

Haidong Wang et al.

MOLECULES AND CELLS (2016)

Add to Collection
Article Cell Biology

Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury

Simone Alidori et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Add to Collection
Review Medicine, Research & Experimental

Recent Developments of Liposomes as Nanocarriers for Theranostic Applications

Hang Xing et al.

THERANOSTICS (2016)

Add to Collection
Article Physiology

Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy

Yanjuan Hou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Mesoscale Nanoparticles Selectively Target the Renal Proximal Tubule Epithelium

Ryan M. Williams et al.

NANO LETTERS (2015)

Add to Collection
Article Nanoscience & Nanotechnology

Complex wireframe DNA origami nanostructures with multi-arm junction vertices

Fei Zhang et al.

NATURE NANOTECHNOLOGY (2015)

Add to Collection
Review Biotechnology & Applied Microbiology

DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices

Veikko Linko et al.

TRENDS IN BIOTECHNOLOGY (2015)

Add to Collection
Article Medicine, Research & Experimental

Chitosan/siRNA Nanoparticles Targeting Cyclooxygenase Type 2 Attenuate Unilateral Ureteral Obstruction-induced Kidney Injury in Mice

Chuanxu Yang et al.

THERANOSTICS (2015)

Add to Collection
Review Biochemistry & Molecular Biology

The balance of powers: Redox regulation of fibrogenic pathways in kidney injury

Daryl M. Okamura et al.

REDOX BIOLOGY (2015)

Add to Collection
Review Urology & Nephrology

Immune cells in experimental acute kidney injury

Hye Ryoun Jang et al.

NATURE REVIEWS NEPHROLOGY (2015)

Add to Collection
Article Multidisciplinary Sciences

Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1)-Harnessed SAINT-Based Lipid Carrier System

Ganesh Ram R. Visweswaran et al.

PLOS ONE (2015)

Add to Collection
Review Urology & Nephrology

Pathophysiological role of different tubular epithelial cell death modes in acute kidney injury

Sandra M. Sancho-Martinez et al.

CLINICAL KIDNEY JOURNAL (2015)

Add to Collection
Article Endocrinology & Metabolism

Resistin increases platelet P-selectin levels via p38 MAPK signal pathway

Wenbing Qiu et al.

DIABETES & VASCULAR DISEASE RESEARCH (2014)

Add to Collection
Article Biochemistry & Molecular Biology

Selenium Inhibits Renal Oxidation and Inflammation But Not Acute Kidney Injury in an Animal Model of Rhabdomyolysis

Anu Shanu et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Add to Collection
Article Immunology

α-Lipoic acid attenuates LPS-induced cardiac dysfunction through a PI3K/Akt-dependent mechanism

Surong Jiang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2013)

Add to Collection
Review Urology & Nephrology

Selenium and kidney disease

Pedro Iglesias et al.

JOURNAL OF NEPHROLOGY (2013)

Add to Collection
Article Urology & Nephrology

The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusioninduced acute kidney injury

Hong Fan et al.

KIDNEY INTERNATIONAL (2013)

Add to Collection
Review Biochemistry & Molecular Biology

Renoprotective effect of the antioxidant curcumin: Recent findings

Joyce Trujillo et al.

REDOX BIOLOGY (2013)

Add to Collection
Article Biochemical Research Methods

Peptide-Drug Conjugate Linked via a Disulfide Bond for Kidney Targeted Drug Delivery

Qian Geng et al.

BIOCONJUGATE CHEMISTRY (2012)

Add to Collection
Review Urology & Nephrology

Pathophysiology of ischemic acute kidney injury

Asif A. Sharfuddin et al.

NATURE REVIEWS NEPHROLOGY (2011)

Add to Collection
Article Biotechnology & Applied Microbiology

Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies

Vishal S. Vaidya et al.

NATURE BIOTECHNOLOGY (2010)

Add to Collection
Article Cardiac & Cardiovascular Systems

Sodium Bicarbonate Plus N-Acetylcysteine Prophylaxis A Meta-Analysis

Jeremiah R. Brown et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2009)

Add to Collection
Article Transplantation

Kim-1/Tim-1: from biomarker to therapeutic target?

Andrew J. Rees et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2008)

Add to Collection
Article Multidisciplinary Sciences

Podocytes use FcRn to clear IgG from the glomerular basement membrane

Shreeram Akilesh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Add to Collection
Article Pharmacology & Pharmacy

Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium

Sigridur A. Asgeirdottir et al.

MOLECULAR PHARMACOLOGY (2007)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.