4.7 Article

Long-term event-free and overall survival after risk-adapted melphalan and SCT for systemic light chain amyloidosis

Journal

LEUKEMIA
Volume 31, Issue 1, Pages 136-142

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2016.229

Keywords

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Funding

  1. NIH [CA05826]
  2. FDA [R01-002174]
  3. Celgene
  4. Millennium Pharmaceuticals
  5. Amyloidosis Research Fund
  6. Werner and Elaine Dannheiser Fund for Research on the Biology of Aging of the Lymphoma Foundation
  7. Memorial Sloan Kettering P30 NCI Cancer Center Support Grant (CCSG) [P30 CA008748]
  8. Thomas Israel Foundation

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Stem cell transplantation (SCT), an effective therapy for amyloid light chain (AL) amyloidosis patients, is associated with low treatment-related mortality (TRM) with appropriate patient selection and risk-adapted dosing of melphalan (RA-SCT). Consolidation after SCT increases hematologic complete response (CR) rates and may improve overall survival (OS) for patients with

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