Prevascularization techniques for dental pulp regeneration: potential cell sources, intercellular communication and construction strategies

Article Dentistry, Oral Surgery & Medicine

Cav1.2 regulated odontogenic differentiation of NG2+ pericytes during pulp injury

Yunyu Fu et al.

Summary: NG2(+) pericytes have the ability to differentiate into odontoblasts, and Ca(v)1.2 plays a vital role in this differentiation process.

ODONTOLOGY (2023)

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Article Dentistry, Oral Surgery & Medicine

Role of Heparan Sulfate in Vasculogenesis of Dental Pulp Stem Cells

A. Li et al.

Summary: This study reveals the crucial role of heparan sulfate (HS) in endothelial differentiation and vasculogenesis of dental pulp stem cells (DPSCs). The results show that inhibiting HS activity decreases the proliferation and sprouting ability of DPSCs and reduces the expression of proangiogenic markers. Silencing the HS biosynthesis key enzyme EXT1 alters the gene expression profile and vascular formation capacity of DPSCs. The findings provide new perspectives for the application of HS in tissue engineering and dental pulp regeneration.

JOURNAL OF DENTAL RESEARCH (2023)

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Review Cell & Tissue Engineering

ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming

Tae Min Kim et al.

Summary: The transcription factor ETV2/ER71 plays a crucial role in vascular regeneration and tissue repair by regulating endothelial cell generation and function. It has the ability to reprogram non-ECs into functional ECs, making it a potential therapeutic target for vascular diseases.

STEM CELL RESEARCH & THERAPY (2023)

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Article Engineering, Biomedical

Injectable decellularized dental pulp matrix-functionalized hydrogel microspheres for endodontic regeneration

Liwen Zheng et al.

Summary: This study proposes a new strategy for pulp regeneration by using hydrogel microspheres incorporated with decellularized dental pulp matrix-derived bioactive factors to simulate a pulp-specific three-dimensional microenvironment. The constructed microspheres exhibit favorable plasticity, biocompatibility, and biological performances, and hDPSCs cultured on the microspheres demonstrate enhanced pulp-formation ability. In vivo experiments show that the microspheres facilitate the regeneration of pulp-like tissue and new dentin. The decellularized pulp matrix-derived bioactive factors mediate the multi-directional differentiation of hDPSCs to regenerate the pulp tissue.

ACTA BIOMATERIALIA (2023)

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Article Biochemistry & Molecular Biology

Development of an Animal Model for Traumatic Brain Injury Augmentation of Heterotopic Ossification in Response to Local Injury

Chandrasekhar Kesavan et al.

Biomedicines (2023)

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Article Biochemistry & Molecular Biology

Exosome-Based Cell Homing and Angiogenic Differentiation for Dental Pulp Regeneration

Venkateswaran Ganesh et al.

Summary: This study aimed to determine the effect of exosomes on cell homing and angiogenic differentiation for pulp regeneration. The eoxsomes significantly promoted cell proliferation and migration, enhanced the expression of angiogenic markers, and identified key exosomal microRNAs for cell homing and angiogenesis. Overall, the exosome-based strategy has significant therapeutic potential for pulp regeneration.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Cell & Tissue Engineering

Implementation of Pericytes in Vascular Regeneration Strategies

Elana M. Meijer et al.

Summary: Graft (pre)vascularization is crucial for the survival and integration of complex large-sized tissue-engineered organ constructs, ensuring medium or blood supply by mimicking the morphology and functionality of the microcapillary bed. Pericytes play a crucial role in microvascular function, blood vessel stability, and maintenance of specific functions in different organs, making them the preferred cell type for application in TE grafts. Utilizing tissue-specific pericytes that match the TE organ may benefit organ function.

TISSUE ENGINEERING PART B-REVIEWS (2022)

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Article Engineering, Biomedical

Gelatin methacryloyl-alginate core-shell microcapsules as efficient delivery platforms for prevascularized microtissues in endodontic regeneration

Xi Liang et al.

Summary: This study successfully fabricated GelMA-alginate core-shell microcapsules using a novel preparation technique, and co-cultured human dental pulp stem cells (hDPSCs) and human umbilical vein endothelial cells (HUVECs) in them. In the microcapsules, the co-culture group showed higher cell proliferation rates and the formation of 3D capillary-like networks. Furthermore, the co-culture group exhibited enhanced osteo/odontogenic differentiation. In vivo experiments confirmed better microvessel formation and pulp-like tissue regeneration in the co-culture group.

ACTA BIOMATERIALIA (2022)

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Article Biochemistry & Molecular Biology

CD146+ Pericytes Subset Isolated from Human Micro-Fragmented Fat Tissue Display a Strong Interaction with Endothelial Cells: A Potential Cell Target for Therapeutic Angiogenesis

Ekta Manocha et al.

Summary: Pericytes, as a type of mesenchymal stromal cells, have a crucial role in tissue regeneration and vascular homeostasis. This study found that CD146(+) pericytes from adipose tissue may have a higher efficacy in promoting angiogenesis and vascular stabilization compared to CD146(-) pericytes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell & Tissue Engineering

Pro-angiogenic potential of a functionalized hydrogel scaffold as a secretome delivery platform: An innovative strategy for cell homing-based dental pulp tissue engineering

Giovanna Lopes Carvalho et al.

Summary: Angiogenesis is a crucial process in tissue engineering, but faces challenges in regenerative endodontic procedures. This study explores a functionalized chitosan hydrogel scaffold loaded with secretomes from stem cells as a platform for cell homing-based tissue engineering. The results show that the functionalized scaffold can sustainably release trophic factors, leading to improved cell proliferation, chemotaxis, and angiogenesis. Thus, this functionalized scaffold holds promise in promoting tissue engineering through cell homing approaches.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2022)

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Article Biotechnology & Applied Microbiology

Apoptotic vesicles activate autophagy in recipient cells to induce angiogenesis and dental pulp regeneration

Zihan Li et al.

Summary: In this study, the researchers found that apoptotic cell-derived extracellular vesicles (apoVs) were ingested by endothelial cells (ECs) and elevated the expression of angiogenesis-related genes, leading to pulp revascularization and tissue regeneration.

MOLECULAR THERAPY (2022)

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Article Multidisciplinary Sciences

Chemical reprogramming of human somatic cells to pluripotent stem cells

Jingyang Guan et al.

Summary: This study demonstrates the chemical reprogramming of human somatic cells to human chemically induced pluripotent stem cells, which exhibit key features of embryonic stem cells. The induction of an intermediate plastic state and inhibition of the JNK pathway are crucial for successful chemical reprogramming.

NATURE (2022)

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Article Cell Biology

Exosomes Derived From Hypoxia-Conditioned Stem Cells of Human Deciduous Exfoliated Teeth Enhance Angiogenesis via the Transfer of let-7f-5p and miR-210-3p

Panpan Liu et al.

Summary: This study demonstrates that exosomes derived from hypoxic-preconditioned SHED cells promote angiogenesis by transferring let-7f-5p and miR-210-3p, which may regulate angiogenesis via different signal pathways.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Dentistry, Oral Surgery & Medicine

HIF-1α Stabilization Boosts Pulp Regeneration by Modulating Cell Metabolism

Y. Han et al.

Summary: Stabilization of HIF-1 alpha enhances the survival of stem cells from human exfoliated deciduous teeth (SHED) and promotes dental pulp regeneration. This method reduces cell apoptosis, enhances vascularization and dentin formation, and modulates multiple target genes and signaling pathways.

JOURNAL OF DENTAL RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

Qing-Fang Han et al.

Summary: This review systematically summarizes recent progress in understanding the mechanisms of exosome biogenesis in cancer and highlights pharmacological targeting of exosome biogenesis as a promising therapeutic strategy.

MOLECULAR CANCER (2022)

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Article Cell Biology

PDGF-BB signaling via PDGFR-β regulates the maturation of blood vessels generated upon vasculogenic differentiation of dental pulp stem cells

Zhaocheng Zhang et al.

Summary: Dental pulp stem cells (DPSC) can differentiate into functional blood vessels via vasculogenesis, and the maturation of these vessels is regulated by PDGF-BB signaling through PDGFR-beta.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Dentistry, Oral Surgery & Medicine

Fabrication of Tapered Fluidic Microchannels Conducive to Angiogenic Sprouting within Gelatin Methacryloyl Hydrogels

Yubingqing Qi et al.

Summary: This study aimed to explore methods to enhance angiogenesis in the root canal by fabricating built-in microchannels with different tapers. Through experiments with varying ratios of HUVECs-GFP and SCAPs implanted in GelMA hydrogel of different concentrations, it was found that coculturing SCAPs and HUVECs-GFP at a 1:1 ratio in 0.04 taper fluidic microchannels fabricated with 5% GelMA hydrogel was the optimal condition to promote angiogenesis.

JOURNAL OF ENDODONTICS (2021)

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Article Engineering, Biomedical

Dual 3D printing for vascularized bone tissue regeneration

Sung Yun Hann et al.

Summary: The development of vascular networks is crucial for tissue fabrication in regenerative medicine. 3D printing vascularized bone has gained attention due to bone disorders, but challenges persist due to the need for nanoscale precision. A novel 3D printing approach was combined with biocompatible materials to enhance vascular growth and tissue bioactivity.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Microvascular maturation by mesenchymal stem cells in vitro improves blood perfusion in implanted tissue constructs

Yoann Atlas et al.

Summary: The study aimed to fabricate mature microvascular networks in vitro to enhance the success of stem cell therapies. Results showed that perivascular recruitment of dental pulp stem cells is driven by PDGF-BB, leading to deposition of vascular basement membrane and vessel maturation. In vitro matured microvascular networks improved blood perfusion and cell survival within the construct.

BIOMATERIALS (2021)

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Article Cell Biology

Conditioned medium derived from 3D tooth germs: A novel cocktail for stem cell priming and early in vivo pulp regeneration

Tengfei Zhou et al.

Summary: The study showed that the conditioned medium from 3D tooth germs can enhance the proliferation and differentiation of DPSCs, promoting pulp regeneration, with a protein profile containing more odontogenic and angiogenic growth factors.

CELL PROLIFERATION (2021)

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Article Dentistry, Oral Surgery & Medicine

Investigating the vascularization capacity of a decellularized dental pulp matrix seeded with human dental pulp stem cells: in vitro and preliminary in vivo evaluations

H. Alghutaimel et al.

Summary: The study focused on investigating the vascularization capacity of a decellularized dental pulp matrix seeded with human dental pulp stem cells both in vitro and in vivo. Findings showed that recellularization with hDPSCs led to enhanced vascularization and expression of angiogenesis markers, with significant improvement in vascularization compared to unseeded groups. This suggests a promising strategy for dental pulp regeneration with the combination of DDP and hDPSCs.

INTERNATIONAL ENDODONTIC JOURNAL (2021)

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Article Polymer Science

Synergies of Human Umbilical Vein Endothelial Cell-Laden Calcium Silicate-Activated Gelatin Methacrylate for Accelerating 3D Human Dental Pulp Stem Cell Differentiation for Endodontic Regeneration

Wei-Yun Lai et al.

Summary: The study successfully fabricated cell blocks containing human dental pulp stem cells and human umbilical vascular endothelial cells, with silicon ion-infused fish gelatin methacrylate (FGelMa) enhancing the expression of dentin regeneration-related markers. This novel combination of materials may serve as a platform for future clinical applications and dentin regeneration.

POLYMERS (2021)

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Article Chemistry, Multidisciplinary

Fluorescent Nanodiamonds for Detecting Free-Radical Generation in Real Time during Shear Stress in Human Umbilical Vein Endothelial Cells

Rokshana Sharmin et al.

Summary: The study investigates the role of free-radical generation and shear stress in cardiovascular diseases, focusing on the impact on vascular endothelial cell function. Using diamond magnetometry and fluorescent reactive oxygen species assays, the researchers examined free-radical formation in HUVECs under different flow conditions, with varying results.

ACS SENSORS (2021)

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Article Dentistry, Oral Surgery & Medicine

Fabrication of Vascularized DPSC Constructs for Efficient Pulp Regeneration

C. Katata et al.

Summary: Vascularized DPSC constructs, formed by inducing endothelial differentiation, showed enhanced blood supply and pulp regeneration when transplanted into human pulpless teeth, compared to DPSC constructs without prevascularization. This study demonstrates the potential of vascularized DPSC constructs as a biomaterial for novel dental pulp regeneration.

JOURNAL OF DENTAL RESEARCH (2021)

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Article Dentistry, Oral Surgery & Medicine

Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Dental Pulp Regeneration

Xun Xu et al.

Summary: By cotransplanting with adipose tissue-derived microvascular fragments (ad-MVFs), dental pulp stem cells (DPSCs) can be promoted to regenerate dental pulp and improve vascular formation, leading to successful dental pulp regeneration.

JOURNAL OF ENDODONTICS (2021)

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Article Dentistry, Oral Surgery & Medicine

The Role of Small Extracellular Vesicles Derived from Lipopolysaccharide-preconditioned Human Dental Pulp Stem Cells in Dental Pulp Regeneration

Wen-Jin Chen et al.

Summary: The study demonstrated that LPS-preconditioned sEVs can enhance the proliferation, migration, angiogenesis, and differentiation of mesenchymal stem cells, leading to structurally improved regenerated tissue similar to normal dental pulp in vivo. These findings suggest that LPS-preconditioned sEVs play a significant role in dental pulp regeneration.

JOURNAL OF ENDODONTICS (2021)

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Review Biotechnology & Applied Microbiology

Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering

Sepehr Shafiee et al.

Summary: The current focus in research is on optimizing communication and interaction between endothelial cells, supporting cells, biomaterials, and culture conditions to create a stable and functional vascular network for maintaining the viability of engineered tissues. Factors such as the choice of endothelial cell lineage, supporting cell type, culture conditions, and incorporation of pro-angiogenic factors play a crucial role in the development of vascularized bioengineered constructs.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Cell & Tissue Engineering

Conversion of stem cells from apical papilla into endothelial cells by small molecules and growth factors

Baicheng Yi et al.

Summary: This study successfully reprogrammed stem cells from apical papilla (SCAP) into endothelial cells (ECs) using a set of small molecules and growth factors. The SCAP-ECs exhibited characteristics of endothelial cells, including gene expression, protein production, and in vitro and in vivo functionality, suggesting their potential for vascular engineering and treatment of ischemic diseases.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell & Tissue Engineering

DPSCs treated by TGF-β1 regulate angiogenic sprouting of three-dimensionally co-cultured HUVECs and DPSCs through VEGF-Ang-Tie2 signaling

Yuchen Zhang et al.

Summary: This study showed that TGF-beta 1 can induce DPSC differentiation into functional pericyte-like cells. T-DPSCs maintain vessel stability through Ang1/Tie2 and VEGF/VEGFR2 signaling.

STEM CELL RESEARCH & THERAPY (2021)

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Article Engineering, Biomedical

Platelet lysate functionalized gelatin methacrylate microspheres for improving angiogenesis in endodontic regeneration

Qingyuan Zhang et al.

Summary: Incorporating human platelet lysate and nanoclay Laponite into GelMA microsphere system successfully improved the Young's modulus of the hybrid hydrogel, promoted cell migration and tubule formation, and ultimately facilitated vascularized endodontic regeneration.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Schwann cell-derived EVs facilitate dental pulp regeneration through endogenous stem cell recruitment via SDF-1/CXCR4 axis

Dianri Wang et al.

Acta Biomaterialia (2021)

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Article Cell Biology

SHED aggregate exosomes shuttled miR-26a promote angiogenesis in pulp regeneration via TGF-β/SMAD2/3 signalling

Meiling Wu et al.

Summary: The study demonstrated that SHED aggregate-derived exosomes significantly improved pulp tissue regeneration and angiogenesis by regulating miR-26a and the TGF-beta/SMAD2/3 signaling pathway to enhance vascular formation in SHED and HUVECs.

CELL PROLIFERATION (2021)

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Review Biochemistry & Molecular Biology

Functional Dental Pulp Regeneration: Basic Research and Clinical Translation

Zhuo Xie et al.

Summary: Treatment of pulpal and periapical diseases faces challenges, but significant progress has been made in achieving true pulp tissue regeneration through technologies such as stem cells, biomaterials, and growth factors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Inverse and reciprocal regulation of p53/p21 and Bmi-1 modulates vasculogenic differentiation of dental pulp stem cells

Zhaocheng Zhang et al.

Summary: The study shows that p53/p21 functions through Bmi-1 to prevent the vasculogenic differentiation of dental pulp stem cells.

CELL DEATH & DISEASE (2021)

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Article Cell & Tissue Engineering

Stem Cells from Human Exfoliated Deciduous Teeth (SHEDs) and Dental Pulp Stem Cells (DPSCs) Display a Similar Profile with Pericytes

Shao Yue Zhu et al.

Summary: The study demonstrates that SHEDs and DPSCs exhibit similar characteristics to pericytes, providing important implications for the clinical potential of using dental pulp stem cells as candidates to replace pericytes.

STEM CELLS INTERNATIONAL (2021)

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Review Cell Biology

Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine

Mangesh D. Hade et al.

Summary: Exosomes are extracellular vesicles secreted by almost all cell types to aid in various cellular functions, including intercellular communication and immune signaling. They carry a multitude of signaling moieties, making them potential candidates for tissue engineering and regenerative medicine. The review highlights the emerging roles and potential applications of exosomes in regenerative medicine, particularly in brain injuries, cardiovascular disease, and COVID-19.

CELLS (2021)

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Article Engineering, Biomedical

Hypoxia response element-directed expression of bFGF in dental pulp stem cells improve the hypoxic environment by targeting pericytes in SCI rats

Sipin Zhu et al.

Summary: DPSCs expressing bFGF under the regulation of 5HRE were found to differentiate into CD13(+) pericytes and upregulate N-cadherin expression, promoting their re-attachment to vascular endothelial cells. This led to an increased flow rate of blood in microvessels and improved the local hypoxia microenvironment in SCI.

BIOACTIVE MATERIALS (2021)

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Article Cell & Tissue Engineering

VEGFR1PRIMES A UNIQUE COHORT OF DENTAL PULP STEM CELLS FOR VASCULOGENIC DIFFERENTIATION

M. T. Bergamo et al.

Summary: The study found that DPSCs contain a unique sub-population of cells with high VEGFR1 expression that are primed to differentiate into vascular endothelial cells, offering the possibility of purifying stem cells with high vasculogenic potential for regeneration of vascularized tissues or in the treatment of ischemic conditions.

EUROPEAN CELLS & MATERIALS (2021)

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Article Cell & Tissue Engineering

Upregulation of ETV2 Expression Promotes Endothelial Differentiation of Human Dental Pulp Stem Cells

Jing Li et al.

Summary: By overexpressing ETV2, human dental pulp stem cells (DPSCs) showed significantly enhanced differentiation into endothelial cells, with increased angiogenic potential both in vitro and in vivo. Proteomic analysis revealed upregulation of VEGF receptors, indicating enhanced VEGF signaling. These results suggest that DPSCs could be a promising cell source for tissue engineering applications.

CELL TRANSPLANTATION (2021)

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Review Cell Biology

Potential of mesenchymal stem cells for bioengineered blood vessels in comparison with other eligible cell sources

Simindokht Afra et al.

CELL AND TISSUE RESEARCH (2020)

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Article Dentistry, Oral Surgery & Medicine

VE-Cadherin and Anastomosis of Blood Vessels Formed by Dental Stem Cells

J. I. Sasaki et al.

JOURNAL OF DENTAL RESEARCH (2020)

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Article Multidisciplinary Sciences

Regeneration of pulpo-dentinal-like complex by a group of unique multipotent CD24a+ stem cells

Hong Chen et al.

SCIENCE ADVANCES (2020)

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Article Biochemistry & Molecular Biology

Extracellular Vesicles-Loaded Fibrin Gel Supports Rapid Neovascularization for Dental Pulp Regeneration

Siyuan Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

SHED promote angiogenesis in stem cell-mediated dental pulp regeneration

Hao Guo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Review Cell & Tissue Engineering

Pluripotent Stem Cell-Based Cell Therapy- Promise and Challenges

Shinya Yamanaka

CELL STEM CELL (2020)

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Article Biochemistry & Molecular Biology

Bcl-2 Overexpression and Hypoxia Synergistically Enhance Angiogenic Properties of Dental Pulp Stem Cells

Waruna L. Dissanayaka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Vasculogenesis from Human Dental Pulp Stem Cells Grown in Matrigel with Fully Defined Serum-Free Culture Media

Jon Luzuriaga et al.

BIOMEDICINES (2020)

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Article Biochemical Research Methods

Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation

William Y. Wang et al.

LAB ON A CHIP (2020)

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Article Engineering, Biomedical

Pre-vascularized dermis model for fast and functional anastomosis with host vasculature

Claudia Mazio et al.

BIOMATERIALS (2019)

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Review Cell Biology

Extracellular matrix scaffolding in angiogenesis and capillary homeostasis

Marion Marchand et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

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Article Dentistry, Oral Surgery & Medicine

Overexpression of ephrinB2 in stem cells from apical papilla accelerates angiogenesis

Changyong Yuan et al.

ORAL DISEASES (2019)

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Article Multidisciplinary Sciences

Mature vessel networks in engineered tissue promote graft-host anastomosis and prevent graft thrombosis

Shahar Ben-Shaul et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Cell & Tissue Engineering

In Vitro Conditioning Determines the Capacity of Dental Pulp Stem Cells to Function as Pericyte-Like Cells

Simona Delle Monache et al.

STEM CELLS AND DEVELOPMENT (2019)

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Article Dentistry, Oral Surgery & Medicine

EphrinB2/EphB4 Signaling Regulates DPSCs to Induce Sprouting Angiogenesis of Endothelial Cells

T. Gong et al.

JOURNAL OF DENTAL RESEARCH (2019)

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Article Cell & Tissue Engineering

The potential application of concentrated growth factor in pulp regeneration: an in vitro and in vivo study

Fangfang Xu et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Biochemistry & Molecular Biology

Sema4D/PlexinB1 promotes endothelial differentiation of dental pulp stem cells via activation of AKT and ERK1/2 signaling

Ting Zou et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Review Cell & Tissue Engineering

Oxygen and nutrient delivery in tissue engineering: Approaches to graft vascularization

Timo Rademakers et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

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Review Cell & Tissue Engineering

Strategies for derivation of endothelial lineages from human stem cells

Min Xu et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Materials Science, Biomaterials

Co-culture of human umbilical vein endothelial cells and human bone marrow stromal cells into a micro-cavitary gelatin-methacrylate hydrogel system to enhance angiogenesis

Jian Liu et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Engineering, Biomedical

A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues

Barbara J. Klotz et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Dentistry, Oral Surgery & Medicine

Dental pulp stem cells overexpressing stromal-derived factor-1 and vascular endothelial growth factor in dental pulp regeneration

Lifang Zhu et al.

CLINICAL ORAL INVESTIGATIONS (2019)

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Review Engineering, Biomedical

Upgrading prevascularization in tissue engineering: A review of strategies for promoting highly organized microvascular network formation

Dhavan Sharma et al.

ACTA BIOMATERIALIA (2019)

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Article Cell & Tissue Engineering

Relative contributions of adipose-resident CD146+ pericytes and CD34+ adventitial progenitor cells in bone tissue engineering

Yiyun Wang et al.

NPJ REGENERATIVE MEDICINE (2019)

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Article Multidisciplinary Sciences

Angiogenic properties of dental pulp stem cells conditioned medium on endothelial cells in vitro and in rodent orthotopic dental pulp regeneration

Sueli Patricia Harumi Miyagi de Cara et al.

HELIYON (2019)

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Article Dentistry, Oral Surgery & Medicine

Inhibition of TGF-beta Signaling in SHED Enhances Endothelial Differentiation

J. G. Xu et al.

JOURNAL OF DENTAL RESEARCH (2018)

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Review Cell & Tissue Engineering

Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise

H. -H. Greco Song et al.

CELL STEM CELL (2018)

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Review Hematology

Hereditary hemorrhagic telangiectasia: diagnosis and management from the hematologist's perspective

Athena Kritharis et al.

HAEMATOLOGICA (2018)

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Article Medicine, Research & Experimental

Shear stress promotes differentiation of stem cells from human exfoliated deciduous teeth into endothelial cells via the downstream pathway of VEGF-Notch signaling

Penglai Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

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Article Dentistry, Oral Surgery & Medicine

Pulp Regeneration by 3-dimensional Dental Pulp Stem Cell Constructs

Y. Itoh et al.

JOURNAL OF DENTAL RESEARCH (2018)

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Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Article Cell & Tissue Engineering

Human dental pulp stromal cell conditioned medium alters endothelial cell behavior

M. A. Gharaei et al.

STEM CELL RESEARCH & THERAPY (2018)

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Review Hematology

Hereditary hemorrhagic telangiectasia: diagnosis and management from the hematologist's perspective

Athena Kritharis et al.

HAEMATOLOGICA (2018)

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Article Materials Science, Biomaterials

Engineering Microvascular Networks in LED Light-Cured Cell-Laden Hydrogels

Nelson Monteiro et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Materials Science, Biomaterials

Engineering Microvascular Networks in LED Light-Cured Cell-Laden Hydrogels

Nelson Monteiro et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Dentistry, Oral Surgery & Medicine

Erythropoietin (rhEPOa) promotes endothelial transdifferentiation of stem cells of the apical papilla (SCAP)

Anastasios Koutsoumparis et al.

ARCHIVES OF ORAL BIOLOGY (2018)

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Article Cell & Tissue Engineering

Molecular Programming of Perivascular Stem Cell Precursors

Val Yianni et al.

STEM CELLS (2018)

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Article Dentistry, Oral Surgery & Medicine

GelMA-Encapsulated hDPSCs and HUVECs for Dental Pulp Regeneration

A. Khayat et al.

JOURNAL OF DENTAL RESEARCH (2017)

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Article Engineering, Biomedical

Decellularized extracellular matrix of human umbilical vein endothelial cells promotes endothelial differentiation of stem cells from exfoliated deciduous teeth

Ting Gong et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2017)

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Article Dentistry, Oral Surgery & Medicine

Lipoprotein Receptor-related Protein 6 Signaling is Necessary for Vasculogenic Differentiation of Human Dental Pulp Stem Cells

Gleyce O. Silva et al.

JOURNAL OF ENDODONTICS (2017)

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Article Dentistry, Oral Surgery & Medicine

Human and Swine Dental Pulp Stem Cells Form a Vascularlike Network after Angiogenic Differentiation in Comparison with Endothelial Cells: A Quantitative Analysis

Hacer Aksel et al.

JOURNAL OF ENDODONTICS (2017)

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Article Cell & Tissue Engineering

TGF-β1-induced differentiation of SHED into functional smooth muscle cells

Jian Guang Xu et al.

STEM CELL RESEARCH & THERAPY (2017)

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Review Biochemistry & Molecular Biology

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism

Nihed Draoui et al.

OPEN BIOLOGY (2017)

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Article Multidisciplinary Sciences

A Novel Strategy to Engineer Pre-Vascularized Full-Length Dental Pulp-like Tissue Constructs

Avathamsa Athirasala et al.

SCIENTIFIC REPORTS (2017)

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Review Cardiac & Cardiovascular Systems

Etv2 as an essential regulator of mesodermal lineage development

Naoko Koyano-Nakagawa et al.

CARDIOVASCULAR RESEARCH (2017)

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Article Peripheral Vascular Disease

RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells

Ahmad F. Alghanem et al.

ANGIOGENESIS (2017)

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Article Engineering, Biomedical

Pulp regeneration in a full-length human tooth root using a hierarchical nanofibrous microsphere system

Xiangwei Li et al.

ACTA BIOMATERIALIA (2016)

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Article Dentistry, Oral Surgery & Medicine

EphrinB2 Stabilizes Vascularlike Structures Generated by Endothelial Cells and Stem Cells from Apical Papilla

Changyong Yuan et al.

JOURNAL OF ENDODONTICS (2016)

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Article Engineering, Biomedical

Shear stress and circumferential stretch by pulsatile flow direct vascular endothelial lineage commitment of mesenchymal stem cells in engineered blood vessels

Dong Hwa Kim et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2016)

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Article Biochemistry & Molecular Biology

In Vivo Angiogenic Capacity of Stem Cells from Human Exfoliated Deciduous Teeth with Human Umbilical Vein Endothelial Cells

Ji-Hye Kim et al.

MOLECULES AND CELLS (2016)

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Article Cell & Tissue Engineering

Wnt/β-Catenin Signaling Determines the Vasculogenic Fate of Postnatal Mesenchymal Stem Cells

Zhaocheng Zhang et al.

STEM CELLS (2016)

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Review Cell & Tissue Engineering

The Neurovascular Properties of Dental Stem Cells and Their Importance in Dental Tissue Engineering

Jessica Ratajczak et al.

STEM CELLS INTERNATIONAL (2016)

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Article Peripheral Vascular Disease

Large-scale time series microscopy of neovessel growth during angiogenesis

Urs Utzinger et al.

ANGIOGENESIS (2015)

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