4.7 Review

Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

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Ines Miranda et al.

Summary: This review provides an overview of the properties of PDMS and its applications in the field of micro and nanoengineering. PDMS is widely used in biomedical applications due to its excellent optical, electrical, and mechanical properties, as well as biocompatibility. The introduction of the soft-lithography technique has facilitated the rapid prototyping of micro and nanostructures using PDMS, leading to advances in microfluidics, electronics, and biomedicine.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2022)

Article Engineering, Multidisciplinary

The Development of Biomimetic Aligned Skeletal Muscles in a Fully 3D Printed Microfluidic Device

Rodi Abdalkader et al.

Summary: In this study, a 3D printed micropatterned microfluid device was developed to replicate the aligned microstructure of skeletal muscles for drug development applications. Cells grown on the device were able to differentiate into aligned bundles of myotubes based on the micropattern dimensions. Furthermore, electrical pulses stimulus conditions improved the maturation of the cells.

BIOMIMETICS (2022)

Review Materials Science, Biomaterials

Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems

Scott B. Campbell et al.

Summary: PDMS is commonly used in organ-on-a-chip devices and microphysiological systems due to its ease-of-use, elasticity, and optical transparency, but its limitations in the absorption of small molecules and high-throughput manufacturing have led researchers to explore alternative materials such as elastomers, hydrogels, and thermoplastic polymers. The development of organ-on-a-chip devices based on these alternative materials is trending, with researchers focusing on overcoming obstacles to create versatile devices for personalized medicine and drug discovery.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

Article Chemistry, Multidisciplinary

Surfactant-free production of biomimetic giant unilamellar vesicles using PDMS-based microfluidics

Naresh Yandrapalli et al.

Summary: The microfluidic method presented allows for the production of surfactant-free and additive-free giant lipid vesicles of various sizes, with verified purity and functionality of the membranes. By encapsulating different components, the usability as artificial cells is demonstrated, showing the potential value of this method in synthetic biology and membrane function research.

COMMUNICATIONS CHEMISTRY (2021)

Article Biophysics

Endothelialization of PDMS-based microfluidic devices under high shear stress conditions

Asma Siddique et al.

Summary: Functionalizing PDMS surfaces with APTES and utilizing collagen as a model ECM protein can provide stable protein coatings in microfluidic systems, leading to consistent cell adhesion under high shear stress conditions.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Engineering, Chemical

Plasma treatment of polymethyl methacrylate to improve surface hydrophilicity and antifouling performance

Siyuan Sui et al.

Summary: The surface modification of PMMA by O-2/CF4 plasma improves its hydrophilicity and antifouling performance, with higher CF4 content leading to a more hydrophobic surface. The presence of functional groups C-O and C-F on the plasma-treated PMMA surface can be controlled by the O-2/CF4 volume ratio in the working gas, influencing its antifouling properties.

POLYMER ENGINEERING AND SCIENCE (2021)

Article Engineering, Electrical & Electronic

Monolithic integration of a smart temperature sensor on a modular silicon-based organ-on-a-chip device

Ronaldo Martins da Ponte et al.

Summary: This paper presents the co-fabrication of a CMOS smart sensor for real-time temperature measurement in organ-on-a-chip (OOC) technology, showing its advantages in temperature control.

SENSORS AND ACTUATORS A-PHYSICAL (2021)

Article Chemistry, Analytical

Surface Modification of PDMS-Based Microfluidic Devices with Collagen Using Polydopamine as a Spacer to Enhance Primary Human Bronchial Epithelial Cell Adhesion

Mohammadhossein Dabaghi et al.

Summary: PDMS is a silicone-based synthetic material with various biomedical applications, however, surface modification is necessary to enhance cell attachment. This study investigates static and dynamic coating methods using PDA to covalently bind collagen within PDMS-based microfluidic devices, showing improved cell adhesion without significant difference between static and dynamic methods. These findings suggest the feasibility of coating extracellular matrix proteins onto PDMS-based microfluidic devices.

MICROMACHINES (2021)

Article Engineering, Biomedical

Fabrication of a hydroxyapatite-PDMS microfluidic chip for bone-related cell culture and drug screening

Qiangqiang Tang et al.

Summary: In this study, a microfluidic chip using HA as a component was developed to create a highly bionic bone environment, which was found to be more conducive to cell proliferation and osteogenic differentiation compared to PDMS. The chip successfully generated a concentration gradient of model drug and determined the drug's IC50, showing great potential in high-throughput bone-related drug screening and research.

BIOACTIVE MATERIALS (2021)

Article Chemistry, Analytical

Electrochemical paper-based analytical device for multiplexed, point-of-care detection of cardiovascular disease biomarkers

Suchanat Boonkaew et al.

Summary: The study demonstrated an electrochemical paper-based analytical device (ePAD) combined with a label-free immunoassay for the simultaneous determination of three important cardiovascular disease biomarkers. The ePAD showed good linearity, low detection limits, and good reproducibility, enabling the simultaneous detection of the three biomarkers in serum samples. The proposed immunosensor can be a great alternative for the early detection of cardiovascular diseases at the point-of-care.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

Article Chemistry, Analytical

Development of a Mobile Analytical Chemistry Workstation Using a Silicon Electrochromatography Microchip and Capacitively Coupled Contactless Conductivity Detector

Yineng Wang et al.

Summary: Capillary electrochromatography (CEC) combines liquid chromatography (LC) and capillary electrophoresis (CE), providing rapid separations, high efficiency, and high selectivity. The use of capacitively coupled contactless conductivity detection (CD-D-4) allows for contactless electrode configuration, preventing contamination.

MICROMACHINES (2021)

Article Chemistry, Analytical

Fundamental Studies of Rapidly Fabricated On-Chip Passive Micromixer for Modular Microfluidics

Wenpeng Guo et al.

Summary: This paper presents the first report on the simple and rapid fabrication of an on-chip compact micromixer using laser-ablated irregular microspheric surfaces on a polymethyl methacrylate (PMMA) microfluidic chip for continuous mixing in modular microfluidics. The micromixer is designed for sequential mixing of nanoliter fluids in about 1 second, and can achieve up to 90% fluid mixing in a short channel under optimized conditions. Computational flow dynamics simulations and experimental results demonstrate good agreement.

MICROMACHINES (2021)

Article Multidisciplinary Sciences

Aspiration-mediated hydrogel micropatterning using rail-based open microfluidic devices for high-throughput 3D cell culture

Dohyun Park et al.

Summary: Microfluidics offer promising methods for aligning cells in physiologically relevant configurations in order to recapitulate human organ functionality. A swift and robust hydrogel patterning technique is presented for 3D cell culture, demonstrating the potential for high-throughput cellular co-culture using a microfluidic device. This technique allows for the controlled formation of multiple, discontinuous hollow channels within the device.

SCIENTIFIC REPORTS (2021)

Article Chemistry, Analytical

Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene

Markus Mader et al.

Summary: Polystyrene (PS) is widely used in biomedical and life science research, and this study presents a novel approach of 3D printing transparent PS microfluidic chips. The successful development of this prototyping method using fused deposition modeling (FDM) will significantly accelerate the production of future biomedical microfluidic chips.

MICROMACHINES (2021)

Article Biotechnology & Applied Microbiology

3D Printed Integrated Multi-Layer Microfluidic Chips for Ultra-High Volumetric Throughput Nanoliposome Preparation

Han Shan et al.

Summary: This study presents a method for ultra-high volumetric throughput nanoliposome preparation using 3D printed microfluidic chips. By adopting a three-layer layout for microchannels, the microfluidic chip achieved a total flow rate up to 474 ml min(-1) and controlled the liposome size to be as small as 80 nm. The experimental results demonstrate the great potential of the 3D printed integrated microfluidic chip in targeting drug delivery systems.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Article Chemistry, Analytical

A 3D-Printed Microfluidic Device for qPCR Detection of Macrolide-Resistant Mutations of Mycoplasma pneumoniae

Anyan Wang et al.

Summary: The 3D-printed microfluidic device described in this paper enables rapid and accurate identification of Mycoplasma pneumonia and its mutant types, providing a potential solution for precise medication.

BIOSENSORS-BASEL (2021)

Article Multidisciplinary Sciences

A microfluidic approach to rapid sperm recovery from heterogeneous cell suspensions

Steven A. Vasilescu et al.

Summary: Separation of sperm cells from a mixed suspension of background cells and debris using inertial microfluidics technology significantly improves sperm recovery rate and does not impact sperm parameters. This technology has great potential for non-motile sperm recovery and simplifying fertility outcomes for severe male infertility cases requiring surgery.

SCIENTIFIC REPORTS (2021)

Article Chemistry, Analytical

Facile Patterning of Thermoplastic Elastomers and Robust Bonding to Glass and Thermoplastics for Microfluidic Cell Culture and Organ-on-Chip

Stefan Schneider et al.

Summary: The success of microfluidic research has been largely dependent on PDMS, but its limitations have led to the exploration of PDMS-free systems, with TPE emerging as a promising alternative. A rapid and scalable fabrication method for microfluidic systems based on PC and TPE hybrid material has been developed. The resulting PC/TPE-hybrid material shows improved device handling and biocompatibility, making it suitable for various microfluidic applications.

MICROMACHINES (2021)

Article Nanoscience & Nanotechnology

3D Printed Microfluidic Device for Magnetic Trapping and SERS Quantitative Evaluation of Environmental and Biomedical Analytes

Lucio Litti et al.

Summary: Surface-enhanced Raman scattering (SERS) is an ideal technique for environmental and biomedical sensor devices due to its highly informative vibrational features and ultrasensitive nature. The use of Janus magnetic/plasmonic Fe3O4/Au nanostars (JMNSs) as SERS colloidal substrates allows for quantitative determination of analytes with the additional amplification of SERS signals using an external magnetic field, showing promising applications in various fields.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Dentistry, Oral Surgery & Medicine

Precision and trueness of maxillary crowded models produced by 2 vat photopolymerization 3-dimensional printing techniques

Carlota Rey-Joly Maura et al.

Summary: This study found that dental models produced using SLA printer showed significantly higher precision and trueness compared to those produced using DLP printer.

AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS (2021)

Article Chemistry, Analytical

Portable Pathogen Diagnostics Using Microfluidic Cartridges Made from Continuous Liquid Interface Production Additive Manufacturing

Jacob Berger et al.

Summary: This paper demonstrates the development and characterization of AM cartridges using CLIP for pathogen detection, and investigates the process characteristics and capabilities of AM microfluidic device manufacturing. The portable diagnostic platform presented could be crucial in scaling up diagnostics for current and future infectious diseases and pandemics.

ANALYTICAL CHEMISTRY (2021)

Article Engineering, Biomedical

CO2 laser fabrication of hydrogel-based open-channel microfluidic devices

Yin Yao et al.

Summary: This study introduces a rapid and low-cost method for fabricating open-channel hydrogel-based microfluidic devices using CO2 laser ablation, with detailed investigation on the profiles of laser-ablated microchannels. Additionally, an easy-to-access storage method for hydrogel-based microfluidic devices is proposed.

BIOMEDICAL MICRODEVICES (2021)

Article Biochemistry & Molecular Biology

Manufacturing of 3D-Printed Microfluidic Devices for the Synthesis of Drug-Loaded Liposomal Formulations

Giulia Ballacchino et al.

Summary: Microfluidic technique is a promising tool for producing stable and monodispersed nanoparticles, with a focus on liposome production in this study. The use of 3D printing for microfluidic device production has provided a revolutionary, low-cost option. The study evaluated the impact of microfluidic parameters, chip manufacturing, material, and channel design on liposomal characteristics, and demonstrated enhanced encapsulation efficiency of curcumin-loaded liposomes produced by microfluidics.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Chemistry, Analytical

A reproducible, low cost microfluidic microcavity array SERS platform prepared by soft lithography from a 2 photon 3D printed template

Rokas Sakalys et al.

Summary: A new and robust, low-cost technique for cavity array SERS substrate fabrication and integration into a microfluidic device has been developed, achieving significant Raman signal enhancement through incorporation of nanostructures plasmonic hot-spots. Utilizing 2-photon 3D printing for nano-sub-structuring cavities results in reproducible enhancements of SERS intensity, with detection capability for analytes demonstrated in a simple test case.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

Article Multidisciplinary Sciences

3D printed microfluidic lab-on-a-chip device for fiber-based dual beam optical manipulation

Haoran Wang et al.

Summary: 3D printing microfluidic lab-on-a-chip devices allows for rapid prototyping of complex structures, with features such as optimized fiber channel design and optical trapping visualization. The device demonstrates efficient manipulation of microscopic particles and cells for various experiments.

SCIENTIFIC REPORTS (2021)

Article Chemistry, Analytical

Rapid Fabrication by Digital Light Processing 3D Printing of a SlipChip with Movable Ports for Local Delivery to Ex Vivo Organ Cultures

Megan A. Catterton et al.

Summary: SlipChips are microfluidic devices that can be reconfigured for various functions, such as tissue stimulation. The fabrication of these devices at the prototype stage usually requires skilled technicians, but digital light processing (DLP) 3D printing has been shown to be a rapid and reproducible solution. Through a case study, a SlipChip capable of local delivery to live tissue slices was successfully fabricated using multi-layer components and demonstrated effective function with chemical probe delivery. This work establishes design principles for 3D printing of SlipChip devices, enhancing the ability to rapidly prototype such devices at mid-scale production levels.

MICROMACHINES (2021)

Article Materials Science, Biomaterials

Facile Route for 3D Printing of Transparent PETg-Based Hybrid Biomicrofluidic Devices Promoting Cell Adhesion

Viraj Mehta et al.

Summary: This study explores improving the optical transparency of FDM-based microfluidic devices for bright-field microscopy of cells by using transparent polymer filament materials and optimized 3D printing process parameters. The research demonstrates the potential of FDM-based 3D printing to fabricate transparent micromixing devices and hybrid biomicrofluidic devices that promote cell adhesion and allow bright-field microscopy. Additionally, the study shows the feasibility of using other transparent polymers for developing 3D printed microfluidic devices.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

Article Nanoscience & Nanotechnology

A 3D-printed magnetic digital microfluidic diagnostic platform for rapid colorimetric sensing of carbapenemase-producing Enterobacteriaceae

Pojchanun Kanitthamniyom et al.

Summary: MDM Carba is a magnetic digital microfluidic platform developed for rapid identification of Carbapenemase-producing Enterobacteriaceae (CPE). It offers simple operation, automation, and the potential for manual operation in resource-limited settings for point-of-care testing. The platform showed comparable sensitivity and specificity to the widely used Carba NP test, indicating promising potential for improving diagnostics for antibiotic resistance in clinical settings.

MICROSYSTEMS & NANOENGINEERING (2021)

Article Biochemical Research Methods

Preprogrammed microfluidic system for parallel anti-reflection coating by layer-by-layer assembly

Zhenglin Li et al.

Summary: This study introduced a microfluidic platform for fast and parallel Layer-by-Layer assembly, demonstrating the significant impact of shear stress on the thickness and transmittance of coated films. The platform allows for efficient determination of optimized coating conditions, with coating duration 15 times faster than conventional methods.

LAB ON A CHIP (2021)

Article Chemistry, Analytical

Microfluidic system evaluation for the semi-automatic detection of MOG-IgG in serum samples

Numfon Khemthongcharoen et al.

Summary: A microfluidic system for semi-automatic MOG-IgG detection using cell-based immunofluorescence assay was developed in this study. The system showed improved accuracy and sensitivity compared to standard microplate methods, with reduced cell clumping and better limit of detection. Integration with a serial dilution microfluidic allowed for determination of the optimal cutoff titer for MOG-IgG positivity in patient samples using ROC analysis.

SENSING AND BIO-SENSING RESEARCH (2021)

Article Biochemical Research Methods

Human neuromuscular junction on micro-structured microfluidic devices implemented with a custom micro electrode array (MEA)

Pauline Duc et al.

Summary: The study combines microfluidics, soft lithography, and custom microelectrodes array technology to create hNMJs on specific pattern of electrodes, stimulating pre-synaptic axons and recording post-synaptic muscle activity. This platform allows for mature and functional in vitro modeling of hNMJs, demonstrating that electrical activation of MNs can trigger recordable extracellular muscle action potentials.

LAB ON A CHIP (2021)

Article Engineering, Electrical & Electronic

Miniaturized Thermal Monitoring Module With CO2 Laser Ablated Microfluidic Device for Electrochemically Validated DNA Amplification

Madhusudan B. Kulkarni et al.

Summary: The study aimed to develop a microfluidic PCR platform using a custom-made IoT-enabled portable thermal monitoring module, fabricated on PMMA using CO2 laser, successfully amplifying rat GAPDH gene and validating the amplification effect using agarose gel electrophoresis technique.

IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT (2021)

Article Biochemical Research Methods

Simulating drug concentrations in PDMS microfluidic organ chips

Jennifer Grant et al.

Summary: A combined simulation and experimental approach is described to predict the spatial and temporal concentration profile of a drug in a PDMS Organ Chip, allowing for drug testing without prior knowledge of partition coefficient or diffusion rate in PDMS.

LAB ON A CHIP (2021)

Review Biochemical Research Methods

Conventional and emerging strategies for the fabrication and functionalization of PDMS-based microfluidic devices

Amid Shakeri et al.

Summary: Microfluidics, particularly using polymeric materials like PDMS, offers unique advantages for developing commercial applications, but challenges in commercializing PDMS due to cost and surface modification complexities persist.

LAB ON A CHIP (2021)

Review Biochemical Research Methods

Recent innovations in cost-effective polymer and paper hybrid microfluidic devices

Wan Zhou et al.

Summary: This article introduces recent innovations in different types of low-cost hybrid microfluidic devices, focusing on polymer and paper-based hybrid devices, their fabrication, and unique advantages. It also discusses the broad range of biological and biomedical applications of these devices and explores the trends in hybrid microfluidic systems towards improved fabrication techniques and broader applications.

LAB ON A CHIP (2021)

Article Chemistry, Analytical

Rapid molecular diagnostics of COVID-19 by RT-LAMP in a centrifugal polystyrene-toner based microdevice with end-point visual detection

Kezia Gomes de Oliveira et al.

Summary: Infection by the new coronavirus is a serious global public health issue, with mass testing being a key strategy. Loop-mediated isothermal amplification (LAMP) simplifies infectious disease diagnostics, with easy visual result detection, but caution is required to avoid contamination and false positives. LAMP on microfluidic platforms minimizes false positives and offers potential for point-of-care applications.

ANALYST (2021)

Article Engineering, Biomedical

3D Printed Monolithic Device for the Microfluidic Capture, Perfusion, and Analysis of Multicellular Spheroids

Alex Markoski et al.

Summary: This study demonstrates the use of 3D printing for fabricating monolithic devices capable of capturing and imaging tumor spheroids under dynamic perfusion flow, allowing for the retention and viability of tumor spheroids in a perfusion flow stream. The high precision features obtained through the printing process enable rapid design cycles and may lead to the development of highly multiplexed monolithic arrays for efficient evaluation of therapeutic candidates in cancer drug discovery.

FRONTIERS IN MEDICAL TECHNOLOGY (2021)

Review Nanoscience & Nanotechnology

3D-Printed Microfluidics and Potential Biomedical Applications

Priyanka Prabhakar et al.

Summary: 3D printing technology plays an important role in biomedical applications by allowing fast and accurate design and fabrication of microfluidic devices, which are widely used in various fields. Through the use of 3D printers, a variety of materials and densities of microfluidic devices have been manufactured, providing users with a range of strategic options.

FRONTIERS IN NANOTECHNOLOGY (2021)

Review Engineering, Chemical

Microfluidic Devices and 3D Printing for Synthesis and Screening of Drugs and Tissue Engineering

Harrson S. Santana et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2020)

Article Engineering, Electrical & Electronic

Fabrication of polyimide microfluidic devices by laser ablation based additive manufacturing

Xingjian Hu et al.

MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS (2020)

Review Polymer Science

PDMS microfluidics: A mini review

Kiran M. Raj et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2020)

Review Chemistry, Multidisciplinary

A Review of 3D Printing Technologies for Soft Polymer Materials

Lu-Yu Zhou et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Multidisciplinary Sciences

3D printed mold leachates in PDMS microfluidic devices

Marcia de Almeida Monteiro Melo Ferraz et al.

SCIENTIFIC REPORTS (2020)

Article Materials Science, Multidisciplinary

Transcribing In Vivo Blood Vessel Networks into In Vitro Perfusable Microfluidic Devices

Yih Yang Chen et al.

ADVANCED MATERIALS TECHNOLOGIES (2020)

Article Oncology

Multiplexed drug testing of tumor slices using a microfluidic platform

L. F. Horowitz et al.

NPJ PRECISION ONCOLOGY (2020)

Review Chemistry, Analytical

Microfluidics by Additive Manufacturing for Wearable Biosensors: A Review

Mahshid Padash et al.

SENSORS (2020)

Article Multidisciplinary Sciences

A novel microfluidic chip-based sperm-sorting device constructed using design of experiment method

Chalinee Phiphattanaphiphop et al.

SCIENTIFIC REPORTS (2020)

Article Chemistry, Multidisciplinary

A Microfluidic Approach for Biosensing DNA within Forensics

Brigitte Bruijns et al.

APPLIED SCIENCES-BASEL (2020)

Article Chemistry, Physical

A low-cost, composite collagen-PDMS material for extended fluid retention in the skin-interfaced microfluidic devices

Benjamin Heo et al.

COLLOID AND INTERFACE SCIENCE COMMUNICATIONS (2020)

Review Chemistry, Analytical

Surface Modification Techniques for Endothelial Cell Seeding in PDMS Microfluidic Devices

Fahima Akther et al.

BIOSENSORS-BASEL (2020)

Review Chemistry, Multidisciplinary

From materials to devices using fused deposition modeling: A state-of-art review

Pengfei Zhang et al.

NANOTECHNOLOGY REVIEWS (2020)

Article Biochemistry & Molecular Biology

Cross-linked chitosan biofunctionalized paper-based microfluidic device towards long term stabilization of blood typing antibodies

Shahila Parween et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Biochemical Research Methods

Accurate and rapid 3D printing of microfluidic devices using wavelength selection on a DLP printer

Peter J. E. M. van der Linden et al.

LAB ON A CHIP (2020)

Article Chemistry, Analytical

A Disposable Passive Microfluidic Device for Cell Culturing

Francesco Guzzi et al.

BIOSENSORS-BASEL (2020)

Article Chemistry, Analytical

Enzymatic method of urea determination in LTCC microfluidic system based on absorption photometry

E. Remiszewska et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

Article Biochemical Research Methods

An ultra-thin, all PDMS-based microfluidic lung assist device with high oxygenation capacity

Mohammadhossein Dabaghi et al.

BIOMICROFLUIDICS (2019)

Article Chemistry, Analytical

Epoxy resin mold and PDMS microfluidic devices through photopolymer flexographic printing plate

Carol M. Olmos et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

Article Engineering, Biomedical

Ultra-low-cost fabrication of polymer-based microfluidic devices with diode laser ablation

Kexin Gao et al.

BIOMEDICAL MICRODEVICES (2019)

Article Nanoscience & Nanotechnology

Excellent quality microchannels for rapid microdevice prototyping: direct CO2 laser writing with efficient chemical postprocessing

Matheus J. T. Vargas et al.

MICROFLUIDICS AND NANOFLUIDICS (2019)

Article Engineering, Manufacturing

Wettability modification of cyclic olefin copolymer surface and microchannel using micromilling process

Myeong Gu Gang et al.

JOURNAL OF MANUFACTURING PROCESSES (2019)

Article Nanoscience & Nanotechnology

A novel microscale selective laser sintering (μ-SLS) process for the fabrication of microelectronic parts

Nilabh K. Roy et al.

MICROSYSTEMS & NANOENGINEERING (2019)

Article Multidisciplinary Sciences

Maskless, rapid manufacturing of glass microfluidic devices using a picosecond pulsed laser

Krystian L. Wlodarczyk et al.

SCIENTIFIC REPORTS (2019)

Article Chemistry, Analytical

Cyclic Olefin Copolymer Microfluidic Devices for Forensic Applications

Brigitte Bruijns et al.

BIOSENSORS-BASEL (2019)

Article Nanoscience & Nanotechnology

A New Approach to Seal Polymer Microfluidic Devices Using Ultrashort Laser Pulses

Gian-Luca Roth et al.

JOURNAL OF LASER MICRO NANOENGINEERING (2019)

Review Chemistry, Analytical

Emerging paper microfluidic devices

Bingbing Gao et al.

ANALYST (2019)

Article Biochemical Research Methods

Simplified immobilisation method for histidine-tagged enzymes in poly(methyl methacrylate) microfluidic devices

Gulsim Kulsharova et al.

NEW BIOTECHNOLOGY (2018)

Review Biochemical Research Methods

Microfluidics Based Point-of-Care Diagnostics

Chandra M. Pandey et al.

BIOTECHNOLOGY JOURNAL (2018)

Article Physics, Condensed Matter

Investigation of optical properties of aluminium oxide doped polystyrene polymer nanocomposite films

Shilpa Bhavsar et al.

PHYSICA B-CONDENSED MATTER (2018)

Article Multidisciplinary Sciences

Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices

Carlos Matellan et al.

SCIENTIFIC REPORTS (2018)

Article Chemistry, Multidisciplinary

Developing Microfluidic Sensing Devices Using 3D Printing

James F. Rusling

ACS SENSORS (2018)

Article Nanoscience & Nanotechnology

Engineering polymer MEMS using combined microfluidic pervaporation and micro-molding

Damien Thuau et al.

MICROSYSTEMS & NANOENGINEERING (2018)

Article Materials Science, Multidisciplinary

Control of femtosecond laser generated microfluidic channels inside poly(methyl methacrylate)

G-L. Roth et al.

JOURNAL OF LASER APPLICATIONS (2018)

Article Engineering, Electrical & Electronic

Novel solvent bonding method for creation of a three-dimensional, non-planar, hybrid PLA/PMMA microfluidic chip

Lynh Huyen Duong et al.

SENSORS AND ACTUATORS A-PHYSICAL (2018)

Article Nanoscience & Nanotechnology

Drop-on-demand printed microfluidics device with sensing electrodes using silver and PDMS reactive inks

Avinash Mamidanna et al.

MICROFLUIDICS AND NANOFLUIDICS (2017)

Article Chemistry, Analytical

Simplified fabrication of integrated microfluidic devices using fused deposition modeling 3D printing

Gabriel Gaal et al.

SENSORS AND ACTUATORS B-CHEMICAL (2017)

Review Biotechnology & Applied Microbiology

Enabling Microfluidics: from Clean Rooms to Makerspaces

David I. Walsh et al.

TRENDS IN BIOTECHNOLOGY (2017)

Review Nanoscience & Nanotechnology

Interplay between materials and microfluidics

Xu Hou et al.

NATURE REVIEWS MATERIALS (2017)

Review Chemistry, Multidisciplinary

3D-Printed Microfluidics

Anthony K. Au et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Engineering, Electrical & Electronic

Rapid fabrication of microfluidic PDMS devices from reusable PDMS molds using laser ablation

Ziya Isiksacan et al.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2016)

Article Biochemical Research Methods

Synthetic microfluidic paper: high surface area and high porosity polymer micropillar arrays

Jonas Hansson et al.

LAB ON A CHIP (2016)

Review Biochemical Research Methods

3D printed microfluidic devices: enablers and barriers

Sidra Waheed et al.

LAB ON A CHIP (2016)

Article Nanoscience & Nanotechnology

Rapid fabrication of circular channel microfluidic flow-focusing devices for hydrogel droplet generation

Benjamin Parker et al.

MICRO & NANO LETTERS (2016)

Review Engineering, Electrical & Electronic

X-ray lithography: Some history, current status and future prospects

Juan R. Maldonado et al.

MICROELECTRONIC ENGINEERING (2016)

Article Chemistry, Multidisciplinary

Patterned paper as a platform for inexpensive, low-volume, portable bioassays

Andres W. Martinez et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)