Related references
Note: Only part of the references are listed.IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells
Julie M. Mazet et al.
NATURE COMMUNICATIONS (2023)
An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes
Alan G. Derr et al.
DIABETES (2023)
Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach
Yoshiya Tanaka et al.
NATURE REVIEWS RHEUMATOLOGY (2022)
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3
Stephanie Grebinoski et al.
NATURE IMMUNOLOGY (2022)
Oral surveillance and JAK inhibitor safety: the theory of relativity
Kevin L. Winthrop et al.
NATURE REVIEWS RHEUMATOLOGY (2022)
Investigating the efficacy of baricitinib in new onset type 1 diabetes mellitus (BANDIT)-study protocol for a phase 2, randomized, placebo controlled trial
M. Waibel et al.
TRIALS (2022)
Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse
Gaurang Jhala et al.
CELL REPORTS (2022)
The JAK-STAT pathway at 30:Much learned, much more to do
Rachael L. Philips et al.
CELL (2022)
Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine
Madeline E. Kavanagh et al.
NATURE CHEMICAL BIOLOGY (2022)
Diabetes induced by checkpoint inhibition in nonobese diabetic mice can be prevented or reversed by a JAK1/JAK2 inhibitor
Tingting Ge et al.
CLINICAL & TRANSLATIONAL IMMUNOLOGY (2022)
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance
Jeremy T. Warshauer et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2021)
Self-Renewing Islet TCF1+ CD8 T Cells Undergo IL-27-Controlled Differentiation to Become TCF1- Terminal Effectors during the Progression of Type 1 Diabetes
Ashley E. Ciecko et al.
JOURNAL OF IMMUNOLOGY (2021)
Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes
Pavel N. Zakharov et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2020)
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
Maikel L. Colli et al.
NATURE COMMUNICATIONS (2020)
Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure
Decio L. Eizirik et al.
NATURE REVIEWS ENDOCRINOLOGY (2020)
PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells
Markus Flosbach et al.
CELL REPORTS (2020)
Chemokines as Drivers of the Autoimmune Destruction in Type 1 Diabetes: Opportunity for Therapeutic Intervention in Consideration of an Optimal Treatment Schedule
Urs Christen et al.
FRONTIERS IN ENDOCRINOLOGY (2020)
Cytocidal macrophages in symbiosis with CD4 and CD8 T cells cause acute diabetes following checkpoint blockade of PD-1 in NOD mice
Hao Hu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-γ and Common γ Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice
Tingting Ge et al.
FRONTIERS IN IMMUNOLOGY (2020)
Safety Profile of Baricitinib in Patients with Active Rheumatoid Arthritis with over 2 Years Median Time in Treatment
Josef S. Smolen et al.
JOURNAL OF RHEUMATOLOGY (2019)
T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities
Florian Wiede et al.
DIABETES (2019)
The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications
Warren J. Leonard et al.
IMMUNITY (2019)
Type I and II Interferon Receptors Differentially Regulate Type 1 Diabetes Susceptibility in Male Versus Female NOD Mice
Javier A. Carrero et al.
DIABETES (2018)
IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells
Alexandra Coomans de Brachene et al.
DIABETOLOGIA (2018)
The molecular basis of JAK/STAT inhibition by SOCS1
Nicholas P. D. Liau et al.
NATURE COMMUNICATIONS (2018)
Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes
Kevin C. Osum et al.
SCIENTIFIC REPORTS (2018)
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-alpha and-gamma via IRF1 induction
Maikel L. Colli et al.
EBIOMEDICINE (2018)
IFN gamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration
Nicholas A. Scott et al.
FRONTIERS IN IMMUNOLOGY (2018)
Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes
John P. Driver et al.
DIABETES (2017)
The emerging safety profile of JAK inhibitors in rheumatic disease
Kevin L. Winthrop
NATURE REVIEWS RHEUMATOLOGY (2017)
Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ
Robyn M. Sutherland et al.
NATURE COMMUNICATIONS (2017)
Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice
Prerak M. Trivedi et al.
DIABETES (2017)
An Activating Mutation in STAT3 Results in Neonatal Diabetes Through Reduced Insulin Synthesis
Teresa Velayos et al.
DIABETES (2017)
A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice
Ronald G. Gill et al.
DIABETES (2016)
Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes
Prerak Trivedi et al.
IMMUNOLOGY AND CELL BIOLOGY (2016)
Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype
Julie Toubiana et al.
BLOOD (2016)
How to Make Mice Tell the Truth
Helen E. Thomas et al.
DIABETES (2016)
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes
Sarah J. Richardson et al.
DIABETOLOGIA (2016)
Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset
Susanne M. Cabrera et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2016)
BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells
Balasubramanian Krishnamurthy et al.
DIABETES (2015)
Protein tyrosine phosphatases: molecular switches in metabolism and diabetes
Esteban N. Gurzov et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)
Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
Hong Sheng Quah et al.
DIABETES (2014)
Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease
Sarah E. Flanagan et al.
NATURE GENETICS (2014)
Proinflammatory cytokines contribute to development and function of regulatory T cells in type 1 diabetes
Helen E. Thomas et al.
TRANSLATIONAL IMMUNOLOGY IN ASIA-OCEANIA (2013)
PD-1, but Not PD-L1, Expressed by Islet-Reactive CD4+ T Cells Suppresses Infiltration of the Pancreas During Type 1 Diabetes
Kristen E. Pauken et al.
DIABETES (2013)
Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials
Antoinette Moran et al.
LANCET (2013)
Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse
Javier A. Carrero et al.
PLOS ONE (2013)
Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression
Kate L. Graham et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2012)
Biology and significance of the JAK/STAT signalling pathways
Hiu Kiu et al.
GROWTH FACTORS (2012)
Autoreactive Cytotoxic T Lymphocytes Acquire Higher Expression of Cytotoxic Effector Markers in the Islets of NOD Mice after Priming in Pancreatic Lymph Nodes
Kate L. Graham et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
Florian Wiede et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease
Julie Zikherman et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice
Jonathan Chee et al.
JOURNAL OF IMMUNOLOGY (2011)
Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response
Boris Calderon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis
Atsushi Fukushima et al.
DIABETES (2010)
Beta cell apoptosis in diabetes
Helen E. Thomas et al.
APOPTOSIS (2009)
Interferon signalling in pancreatic beta cells
Helen E. Thomas et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2009)
IFN-γ-Dependent Regulatory Circuits in Immune Inflammation Highlighted in Diabetes
Boris Calderon et al.
JOURNAL OF IMMUNOLOGY (2008)
STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo
Michael Quigley et al.
JOURNAL OF IMMUNOLOGY (2008)
Essential role for signal transducer and activator of transcription-1 in pancreatic β-cell death and autoimmune type 1 diabetes of nonobese diabetic mice
Sunshin Kim et al.
DIABETES (2007)
Cytotoxic T-Cells from T-Cell receptor transgenic NOD8.3 mice destroy β-cells via the perforin and fas pathways
Nadine L. Dudek et al.
DIABETES (2006)
Suppressor of cytokine signaling-1 overexpression protects pancreatic β cells from CD8+ T cell-mediated autoimmune destruction
MMW Chong et al.
JOURNAL OF IMMUNOLOGY (2004)
IL-1 receptor deficiency slows progression to diabetes in the NOD mouse
HE Thomas et al.
DIABETES (2004)
Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of β cell autoantigens
J Yamanouchi et al.
JOURNAL OF IMMUNOLOGY (2003)
Among CXCR3 chemokines, IFN-γ-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-γ (CXCL9) imprints a pattern for the subsequent development of autoimmune disease
U Christen et al.
JOURNAL OF IMMUNOLOGY (2003)
Target cell expression of suppressor of cytokine signaling-1 prevents diabetes in the NOD mouse
M Flodström-Tullberg et al.
DIABETES (2003)
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
MJI Ansari et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Beta cell MHC class I is a late requirement for diabetes
EE Hamilton-Williams et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Cytokine requirements for acute and basal homeostatic proliferation of naive and memory CD8+ T cells
AW Goldrath et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells
JT Tan et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
D Metcalf et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
IFN-γ affects homing of diabetogenic T cells
AY Savinov et al.
JOURNAL OF IMMUNOLOGY (2001)
γ-interferon signaling in pancreatic β-cells is persistent but can be terminated by overexpression of suppressor of cytokine signaling-1
MMW Chong et al.
DIABETES (2001)
Interferon-γ receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice
DV Serreze et al.
DIABETES (2000)
Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-γ receptor loci
O Kanagawa et al.
JOURNAL OF IMMUNOLOGY (2000)