☆ 4.7 Review

Macrophages-bone marrow mesenchymal stem cells crosstalk in bone healing

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Engineering, Biomedical

Extracellular vesicle-loaded hydrogels for tissue repair and regeneration

Yikun Ju et al.

Summary: Extracellular vesicles (EVs) are secreted by cells and have significant potential in regenerative medicine. Mesenchymal stem cells can secrete EVs that promote tissue repair and regeneration. However, EVs are rapidly cleared by the circulatory system, so using hydrogels to carry and slow the release of EVs can be an effective approach.

MATERIALS TODAY BIO (2023)

Add to Collection

Article Engineering, Biomedical

Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization

Yongzheng Li et al.

Summary: This study demonstrates that injectable photo-cross-linkable porous GelMA/SilMA hydrogels encapsulating GMSCs can facilitate epithelial sealing around implants and promote M2-polarized macrophage infiltration. The hydrogels support the proliferation, survival, and spread of GMSCs, and upregulate HDs-related genes and proteins expression. The application of these hydrogels in a rat model of implant placement enhances protein expression at the implant-PIE interface and reduces HRP penetration.

ACTA BIOMATERIALIA (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Characterization of mesenchymal stem cells in human fetal bone marrow by single-cell transcriptomic and functional analysis

Ping Zhang et al.

Summary: In this study, the expression landscape of human fetal bone marrow nucleated cells (BMNCs) was examined through single-cell transcriptomic analysis. LIFR(+)PDGFRB(+) was identified as a specific marker for MSCs, which were able to form bone tissues and reconstitute HME effectively in vivo. Additionally, a subpopulation of bone unipotent progenitor cells expressing TM4SF1(+)CD44(+)CD73(+) was identified, which had osteogenic potentials but could not reconstitute HME.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

Add to Collection

Review Biochemistry & Molecular Biology

Macrophages and Bone Marrow-Derived Mesenchymal Stem Cells Work in Concert to Promote Fracture Healing: A Brief Review

Qing Zhao et al.

Summary: This review provides a deep insight into the synergistic performance of BMSCs and macrophages in fracture healing, discussing their respective functions, relevant impact factors, and mechanisms. It aims to offer valuable cues and technical support for research on macrophage- and BMSC-related treatments, such as combined cell therapy for bone fractures.

DNA AND CELL BIOLOGY (2022)

Add to Collection

Review Endocrinology & Metabolism

Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis

Stuart B. Goodman et al.

Summary: This article discusses the crucial role of macrophages in the innate immune system and emphasizes the importance of osteoimmunology in joint replacement. The communication between macrophages and cells of the osteoblast lineage plays a significant role in maintaining the stability of the prosthesis-host interface.

CURRENT OSTEOPOROSIS REPORTS (2022)

Add to Collection

Article Oncology

SENP3 loss promotes M2 macrophage polarization and breast cancer progression

Ming Xiao et al.

Summary: Deletion of SUMO-specific protease 3 in macrophages promotes polarization towards the M2 subtype and accelerates breast cancer malignancy. The deficiency of SENP3 leads to increased SUMOylation of Akt1, resulting in hyper-phosphorylation and activation of Akt1, thus facilitating M2 polarization and tumor progression.

MOLECULAR ONCOLOGY (2022)

Add to Collection

Article Nanoscience & Nanotechnology

Immunomodulation of Telmisartan-Loaded PCL/PVP Scaffolds on Macrophages Promotes Endogenous Bone Regeneration

Siyu Wu et al.

Summary: In this study, a nanostructured scaffold loaded with telmisartan was developed to modulate the immune response and promote bone healing. The results showed that telmisartan-loaded scaffolds exhibited anti-inflammatory activity and enhanced bone regeneration by regulating macrophage polarization.

ACS APPLIED MATERIALS & INTERFACES (2022)

Add to Collection

Article Engineering, Biomedical

Biomimetic glycopeptide hydrogel coated PCL/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation

Yaping Wang et al.

Summary: A synthetic fibrous glycopeptide hydrogel was developed and composited with 3D-printed PCL/nHA scaffold for cranial bone regeneration, showing significant promotion of stem cell proliferation and osteogenic differentiation as well as enhanced interaction between macrophages and stem cells. The composite scaffold exhibited superior efficacy in bone regeneration and osseointegration, creating a reparative microenvironment similar to normal cranium with increased anti-inflammatory macrophages and osteoblasts.

BIOMATERIALS (2022)

Add to Collection

Article Biochemical Research Methods

Integrated computational and in vivo models reveal Key Insights into macrophage behavior during bone healing

Etienne Baratchart et al.

Summary: This study investigates the role of myeloid-derived monocytes and macrophages in bone remodeling and injury repair. The authors used a mathematical model to analyze cellular dynamics and polarization states over time. The results suggest that anti-inflammatory macrophages play a key role in inhibiting osteoclasts, while pro-inflammatory macrophages are involved in promoting osteoclast activity. The study also demonstrates the reliability of the mathematical model through comparison with experimental data.

PLOS COMPUTATIONAL BIOLOGY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Increased BMSC exosomal miR-140-3p alleviates bone degradation and promotes bone restoration by targeting Plxnb1 in diabetic rats

Ning Wang et al.

Summary: This study found that exosomes derived from diabetes mellitus BMSCs had lower osteogenic potential in bone defect repair compared to exosomes derived from normal BMSCs. The study also found that the level of miR-140-3p was significantly altered in exosomes derived from BMSCs, ADSCs, and serum from DM rats. Upregulating miR-140-3p promoted the differentiation of DM BMSCs into osteoblasts.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Add to Collection

Review Genetics & Heredity

Macrophage Polarization in Atherosclerosis

Sahar Eshghjoo et al.

Summary: This article discusses the different roles and metabolic pathways of pro-inflammatory and anti-inflammatory macrophages in atherosclerosis, emphasizing the importance of the polarization state of Macs for the progression and stability of atherosclerotic plaques.

GENES (2022)

Add to Collection

Article Multidisciplinary Sciences

Lipopolysaccharide-activated macrophages regulate the osteogenic differentiation of bone marrow mesenchymal stem cells through exosomes

Xiao Song et al.

Summary: This study demonstrates that in periodontitis, macrophages mediate inflammatory stimulation and inhibit the osteogenic differentiation of bone cells through the release of exosomes, providing new insights for the treatment of bone tissue regeneration in inflammatory states.

PEERJ (2022)

Add to Collection

Article Cell Biology

Equilibrium among Inflammatory Factors Determines Human MSC-Mediated Immunosuppressive Effect

Yulia Suzdaltseva et al.

Summary: Mesenchymal stem cells (MSCs) have multiple paracrine and immunomodulatory properties, providing protection from chronic inflammation and promoting tissue repair. The interaction between MSCs and immune cells can result in immunosuppression, inhibiting the proliferation of peripheral blood mononuclear cells (PBMCs). Direct cell-cell contact between MSCs and PBMCs plays a role in the regulation of IDO, IL-1, IL-6, and G-CSF.

CELLS (2022)

Add to Collection

Review Pharmacology & Pharmacy

Effects of BMSC-Derived EVs on Bone Metabolism

Xuchang Zhou et al.

Summary: Extracellular vesicles (EVs) are small membrane vesicles that can be secreted by most cells. EVs, especially BMSC-EVs, have therapeutic effects such as tissue repair, inhibition of macrophage polarization, and promotion of angiogenesis. BMSC-EVs also serve as efficient nanocarriers for drug delivery with advantages such as low immunogenicity, no ethical controversy, good stability, and easy storage.

PHARMACEUTICS (2022)

Add to Collection

Article Cell Biology

Promotion of osteogenesis in BMSC under hypoxia by ATF4 via the PERK-eIF2α signaling pathway

Yuan Feng et al.

Summary: This study revealed a novel mechanism of ATF4-mediated regulation of BMSC under hypoxia. Hypoxia promoted migration, osteoblast differentiation, and ATF4 expression in BMSC, while knockdown of ATF4 inhibited these effects. This research is of great significance for understanding the role of BMSC in MDO.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2022)

Add to Collection

Review Cell & Tissue Engineering

The crosstalk between macrophages and bone marrow mesenchymal stem cells in bone healing

Yu-Hao Wang et al.

Summary: Bone injury is a global problem that affects millions of patients and puts a heavy burden on the public medical insurance system. Autologous bone transplantation is considered to be the gold standard for treating large-scale bone defects, but it has limitations. Therefore, there is an urgent need for basic research on new therapeutic methods. In-depth research on the crosstalk between macrophages and bone marrow mesenchymal stem cells reveals a close relationship between inflammation and regeneration. The interaction between macrophages, bone marrow mesenchymal stem cells, and biomaterials is expected to be the mainstream for exploring new methods for bone injury in the future.

STEM CELL RESEARCH & THERAPY (2022)

Add to Collection

Article Orthopedics

Serology and Comorbidities in Patients With Fracture Nonunion: A Multicenter Evaluation of 640 Patients

Joshua A. Shapiro et al.

Summary: This multicenter cohort study found that serologic abnormalities and comorbid conditions are common in patients with nonunion, especially septic nonunion. However, the frequency of serologic abnormalities may be lower than previously thought. Septic nonunion is associated with inflammation, younger age, and malnourishment.

JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS (2022)

Add to Collection

Article Cell & Tissue Engineering

Three-Dimensional Culture of Equine Bone Marrow-Derived Mesenchymal Stem Cells Enhances Anti-Inflammatory Properties in a Donor-Dependent Manner

Sophie H. H. Bogers et al.

Summary: This study evaluated the characteristics of equine bone marrow-derived mesenchymal stem cells (eBMSCs) in three-dimensional (3D) culture and the impact of this culture method on their anti-inflammatory properties. The results showed that 3D culture enhanced the production of key regulators of inflammation in eBMSCs, and this enhancement was influenced by both the cell donor and cytokine exposure.

STEM CELLS AND DEVELOPMENT (2022)

Add to Collection

Article Multidisciplinary Sciences

Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression

Yukari Watanabe et al.

Summary: Priming gingival tissue-derived MSCs (GMSCs) with a combination of pro-inflammatory cytokines TNF-alpha and IFN-alpha can synergistically promote anti-inflammatory M2 macrophage polarization and increase the expression of CD73 and CD5L. This pre-licensing approach is significant in enhancing the anti-inflammatory function of EVs.

SCIENTIFIC REPORTS (2022)

Add to Collection

Review Biotechnology & Applied Microbiology

Dynamic Culture of Mesenchymal Stromal/Stem Cell Spheroids and Secretion of Paracrine Factors

Paloma Fuentes et al.

Summary: Conditioned medium (CM) obtained from the culture of mesenchymal stromal/stem cells (MSCs) has been shown to effectively promote tissue repair and modulate the immune response, offering advantages over direct MSC implantation. Research has focused on characterizing CM components and optimizing preconditioning strategies to enhance therapeutic potential. Dynamic cultivation conditions, like 3D culture, have been shown to impact MSC behavior and increase growth factor production for potential CM applications.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Add to Collection

Editorial Material Biochemistry & Molecular Biology

Monocyte and Macrophage Function Diversity

Malgorzata Kloc et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Role of Mesenchymal Stem Cells and Their Paracrine Mediators in Macrophage Polarization: An Approach to Reduce Inflammation in Osteoarthritis

Sree Samanvitha Kuppa et al.

Summary: Osteoarthritis is a low-grade inflammatory disorder of the joints, but there are limited treatment options currently available. This article explores the use of mesenchymal stem cells and their secreted factors for intervention in osteoarthritis, with a focus on the polarization of macrophages to reduce inflammation and symptoms.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Remotely Temporal Scheduled Macrophage Phenotypic Transition Enables Optimized Immunomodulatory Bone Regeneration

Donghua Huang et al.

Summary: Precise timing of macrophage polarization plays a vital role in immunomodulation of tissue regeneration. In this study, a superparamagnetic hydrogel was developed to control the polarization of macrophages, enabling precise manipulation of inflammation progression and promoting tissue healing.

SMALL (2022)

Add to Collection

Article Multidisciplinary Sciences

BMSC-derived exosomal miR-27a-3p and miR-196b-5p regulate bone remodeling in ovariectomized rats

Guohua Lai et al.

Summary: In the bone marrow microenvironment of postmenopausal osteoporosis, BMSC-derived exosomal miRNAs, specifically miR-27a-3p and miR-196b-5p, have been found to play an important regulatory role in bone formation and bone resorption. The study suggests that these miRNAs may have therapeutic potential for the treatment of osteoporosis.

PEERJ (2022)

Add to Collection

Review Immunology

Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells

Madina Sarsenova et al.

Summary: The review summarizes various approaches to enhance the clinical outcomes of mesenchymal stem cell (MSC) therapy and revises current and future perspectives for the creation of improved cellular products with potential for diverse clinical applications.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Medicine, General & Internal

Fracture-related infection

T. Fintan Moriarty et al.

Summary: Fracture-related infection (FRI) is a common complication of bone fractures, where pathogenic bacteria enter the wound and hinder the healing process. This Primer provides an overview of the epidemiology, pathobiology, diagnosis, and management of these infections, as well as their impact on patient quality of life.

NATURE REVIEWS DISEASE PRIMERS (2022)

Add to Collection

Article Biology

Cross talk between glucose metabolism and immunosuppression in IFN-γ-primed mesenchymal stem cells

Mengwei Yao et al.

Summary: Glucose metabolism regulates the immunosuppressive function of MSCs through the JAK-STAT pathway, and ATP enhances the interaction between glucose metabolism and the JAK-STAT system, improving the therapeutic efficacy of hUC-MSCs against acute pneumonia.

LIFE SCIENCE ALLIANCE (2022)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Delayed Fracture Healing

Paul Mick et al.

SEMINARS IN MUSCULOSKELETAL RADIOLOGY (2022)

Add to Collection

Review Cell & Tissue Engineering

Insights into skeletal stem cells

Qiwen Li et al.

Summary: Tissue-resident skeletal stem cells (SSCs) provide cells for the development and homeostasis of the skeletal system. Recent studies using advanced techniques have identified different types of SSCs and revealed their properties. This review summarizes the identification and functional studies of SSCs, highlights the pioneering findings in lineage atlas plotting, and discusses the roles of SSCs in different tissues.

BONE RESEARCH (2022)

Add to Collection

Review Medicine, General & Internal

Non-steroidal anti-inflammatory drugs and bone healing in animal models-a systematic review and meta-analysis

Haider Al-Waeli et al.

Summary: This study conducted a systematic review and meta-analysis on the effects of NSAID administration after bone fracture in animal models. The results indicate that NSAIDs can decrease the biomechanical properties of healing bones, with variations observed in different sites, sex, and assessment times.

SYSTEMATIC REVIEWS (2021)

Add to Collection

Article Biophysics

Substrate Stiffness Modulates the Crosstalk Between Mesenchymal Stem Cells and Macrophages

Rukmani Sridharan et al.

Summary: This study aimed to investigate the role of substrate stiffness in modulating the immunomodulatory properties of MSCs and their interactions with macrophages. The results showed that a bidirectional crosstalk between MSCs and macrophages is necessary for promoting anti-inflammatory responses, dependent on the stiffness of the underlying substrate. Additionally, the study demonstrated that biophysical cues like stiffness presented by biomaterials can be tuned to promote positive interactions between MSCs and macrophages for directing regenerative responses.

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2021)

Add to Collection

Article Endocrinology & Metabolism

SDF-1 mediates mesenchymal stem cell recruitment and migration via the SDF-1/CXCR4 axis in bone defect

Heli Zhang et al.

Summary: The study demonstrated that up-regulation of SDF-1 can promote the mobilization and migration of MSCs through the activation of the SDF-1/CXCR4 signaling pathway, contributing to bone repair.

JOURNAL OF BONE AND MINERAL METABOLISM (2021)

Add to Collection

Article Cell Biology

Enhanced viability and function of mesenchymal stromal cell spheroids is mediated via autophagy induction

Shobha Regmi et al.

Summary: The study found that 3D-cultured MSCs (MSC3D) showed highly induced autophagy and suppressed ROS production compared to 2D-cultured MSCs (MSC2D). Autophagy induction significantly influenced the cell viability and apoptotic activity in MSC3D. The HIF1A-HMOX1 axis played a crucial role in modulating ROS production and autophagy induction in MSC3D.

AUTOPHAGY (2021)

Add to Collection

Article Engineering, Biomedical

Resolution of inflammation in bone regeneration: From understandings to therapeutic applications

Hunter Newman et al.

Summary: Impaired bone healing affects 5-10% of cases after injury, with timely resolution of inflammation being crucial for normal healing. Modulating the initial inflammatory phase and promoting its resolution can create a pro-regenerative environment for bone regeneration.

BIOMATERIALS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Macrophage-Derived Inflammation Induces a Transcriptome Makeover in Mesenchymal Stromal Cells Enhancing Their Potential for Tissue Repair

Ines Maldonado-Lasuncion et al.

Summary: Pre-clinical and clinical studies have shown that conditioning mesenchymal stromal cells (MSC) with macrophage-derived inflammation enhances their ability to support tissue repair by increasing the secretion of key growth factors. This conditioning results in significant transcriptional changes in MSC, challenging their viability and mobility, but ultimately leading to increased therapeutic potential of MSC transplants.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Cell Biology

BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes

Honggang Xu et al.

Summary: The study aimed to investigate the effect and mechanism of miR-326 in exosomes secreted by bone marrow mesenchymal stem cells on cartilage pyroptosis and osteoarthritis improvement. Results showed that miR-326 in BMSC-Exos can inhibit chondrocyte and cartilage pyroptosis by targeting HDAC3 and STAT1/NF-kappa B p65 signaling pathway, providing a new mechanism for the treatment of OA with BMSC-Exos.

MEDIATORS OF INFLAMMATION (2021)

Add to Collection

Review Engineering, Biomedical

The multifaceted roles of macrophages in bone regeneration: A story of polarization, activation and time

Claudia Schlundt et al.

Summary: Macrophages are a highly plastic and multifunctional cell population found in all tissues of the human body. In bone, different subpopulations of macrophages play essential roles in the cascade of regeneration and reconstitution, participating in both the inflammatory phase and later phases of healing. The M1/M2 paradigm may not fully capture the dynamic plasticity of macrophages, and understanding the specific mechanisms driving macrophage function in impaired healing scenarios could lead to new therapeutic targets.

ACTA BIOMATERIALIA (2021)

Add to Collection

Article Multidisciplinary Sciences

Lactate supports a metabolic-epigenetic link in macrophage polarization

Jordan T. Noe et al.

Summary: Lactate accumulation plays a key role in the activation of M2 macrophages, promoting histone acetylation, M2 gene transcription, and functional immune suppression. Metabolism of M2 macrophages is dependent on mitochondrial function and the glucose/lactate metabolic pathway.

SCIENCE ADVANCES (2021)

Add to Collection

Review Immunology

Tissue-resident macrophages: guardians of organ homeostasis

Samuel Philip Nobs et al.

Summary: Tissue-resident macrophages are crucial in regulating the balance between organ health and disease, with distinct subsets fulfilling specific functions in different organs. Recent research highlights the importance of metabolism in understanding macrophage activation states and how intrinsic and extrinsic factors influence macrophage metabolic control. More studies are needed to address open questions in the field and develop tissue-specific therapeutic approaches.

TRENDS IN IMMUNOLOGY (2021)

Add to Collection

Review Immunology

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

Yao Yao et al.

Summary: Osteoimmunity plays a crucial role in regulating the balance of bone remodeling and resorption, particularly through the macrophage-osteoclast axis. Understanding the role of this axis in osteoimmunity is significant for treating bone damage caused by inflammation and immune diseases.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Cell & Tissue Engineering

Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis

Suguru Takeuchi et al.

Summary: The study on small extracellular vesicles (sEVs) derived from interferon-gamma pre-conditioned MSCs showed promising potential in ameliorating inflammation and fibrosis in a cirrhosis mouse model. By inducing anti-inflammatory macrophages and regulatory T cells, this therapeutic approach resulted in efficient tissue repair and indicated a new strategy for liver disease treatment.

NPJ REGENERATIVE MEDICINE (2021)

Add to Collection

Article Endocrinology & Metabolism

Osteal macrophages support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model

Lena Batoon et al.

Summary: By validating a mouse OVX model, the study revealed an important role for osteal macrophages in the pathogenesis of osteoporosis, providing new evidence of their involvement in supporting osteoclast function.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Effect of Bone-Marrow-Derived Mesenchymal Stem Cells on the Healing of Bone Fractures

Shuzan Ali Mohammed et al.

Summary: This study confirmed the effectiveness of mesenchymal stem cells in bone healing, showing that local injection of MSCs is more effective. MSCs can improve or accelerate the healing of bone fractures, and have the potential for bone regeneration.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2021)

Add to Collection

Article Cell Biology

Macrophage M1/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation

Beilei Liang et al.

Summary: After dental implantation, M phi s dynamically adapt their phenotypes and play a key role in coordinating interactions with bone cells. While M1 and M2 M phi s have different functions in bone remodelling, it is important to control immune strategies within proper ranges for optimal tissue engineering implants.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

M1 macrophage-derived exosomes transfer miR-222 to induce bone marrow mesenchymal stem cell apoptosis

Yanyan Qi et al.

Summary: In the microenvironment of myocardial infarction, M1 macrophages secrete exosomes that induce BMSC apoptosis by delivering miR-222, inhibiting the expression of the antiapoptotic gene Bcl-2. This leads to inhibition of BMSC proliferation and migration, potentially affecting the efficacy of BMSC in treating acute myocardial infarction.

LABORATORY INVESTIGATION (2021)

Add to Collection

Article Medicine, General & Internal

Non-union bone fractures

Britt Wildemann et al.

Summary: In essence, non-union refers to a complex chronic medical condition where a broken bone fails to heal within the expected time frame or cannot heal without intervention, severely impacting the quality of life of patients.

NATURE REVIEWS DISEASE PRIMERS (2021)

Add to Collection

Article Endocrinology & Metabolism

Exosomes Derived From M2 Macrophages Facilitate Osteogenesis and Reduce Adipogenesis of BMSCs

Ziyi Li et al.

Summary: Bone regeneration is a complex process involving the coordination of osteogenesis and osteoclastogenesis, with the balance between osteogenesis and adipogenesis of BMSCs playing a critical role. Recent studies have shown that exosomes from M2 macrophages facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis, potentially serving as a therapeutic tool for bone loss diseases.

FRONTIERS IN ENDOCRINOLOGY (2021)

Add to Collection

Review Cell Biology

Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis

Di Lu et al.

Summary: Macrophages play crucial roles in biological systems, while mesenchymal stem cells show promise in immune-related disease treatments due to their ability to regulate immune cells. The interaction between MSCs and macrophages through various methods is important in disease development and maintaining stability in inflammatory microenvironments. Strategies for optimal applications in immune-related disease treatments are discussed.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Review Cell Biology

Pro-regenerative Dialogue Between Macrophages and Mesenchymal Stem/Stromal Cells in Osteoarthritis

Candice Bohaud et al.

Summary: Osteoarthritis is a multifaceted degenerative and inflammatory joint disorder, with current therapies often only providing short-term benefits without complete structural and functional reconstitution. Identifying novel therapeutic targets and strategies is crucial to achieve long-term clinical benefits for OA patients.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Engineering, Biomedical

Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration

Lei Fan et al.

Summary: A BMSC-derived Exos-functionalized implant was developed to accelerate bone integration through immunoregulation, which improved the biocompatibilities of SPEEK and promoted macrophage polarization, osteogenic differentiation, and new bone formation.

BIOACTIVE MATERIALS (2021)

Add to Collection

Review Cell & Tissue Engineering

Macrophages at the nexus of mesenchymal stromal cell potency: The emerging role of chemokine cooperativity

Jacques Galipeau

Summary: Experimental evidence shows that host macrophages play a crucial role in mediating the anti-inflammatory properties of MSCs, while non-phagocytosed MSCs induce tissue macrophages to express IL-10, shaping the immune environment. MSC-derived factors such as IL-6, IDO, and TSG-6 directly influence macrophage polarization, highlighting a necessary functional relationship between MSCs and host macrophages in modulating inflammatory response.

STEM CELLS (2021)

Add to Collection

Article Engineering, Biomedical

Periosteal matrix-derived hydrogel promotes bone repair through an early immune regulation coupled with enhanced angio- and osteogenesis

Pengcheng Qiu et al.

BIOMATERIALS (2020)

Add to Collection

Article Cell & Tissue Engineering

Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion

Lu Zhang et al.

STEM CELL RESEARCH & THERAPY (2020)

Add to Collection

Article Cell & Tissue Engineering

Influence of inflammatory conditions provided by macrophages on osteogenic ability of mesenchymal stem cells

Gema Valles et al.

STEM CELL RESEARCH & THERAPY (2020)

Add to Collection

Article Cell Biology

CCL2 and CXCL12 Derived from Mesenchymal Stromal Cells Cooperatively Polarize IL-10+Tissue Macrophages to Mitigate Gut Injury

Jayeeta Giri et al.

CELL REPORTS (2020)

Add to Collection

Article Cell & Tissue Engineering

The primary cilium directs osteopontin-induced migration of mesenchymal stem cells by regulating CD44 signaling and Cdc42 activation

Mi Nam Lee et al.

STEM CELL RESEARCH (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3

Yuan Xiong et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Exosomes derived from M0, M1 and M2 macrophages exert distinct influences on the proliferation and differentiation of mesenchymal stem cells

Yu Xia et al.

PEERJ (2020)

Add to Collection

Review Materials Science, Biomaterials

Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration

Yajuan Xie et al.

REGENERATIVE BIOMATERIALS (2020)

Add to Collection

Article Medicine, Research & Experimental

Matrine attenuates heterotopic ossification by suppressing TGF-β induced mesenchymal stromal cell migration and osteogenic differentiation

Dong Mao et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Review Immunology

Determinants of Resident Tissue Macrophage Identity and Function

Camille Bleriot et al.

IMMUNITY (2020)

Add to Collection

Review Endocrinology & Metabolism

Modulation of the Inflammatory Response and Bone Healing

Masahiro Maruyama et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Add to Collection

Article Endocrinology & Metabolism

Bone regeneration is mediated by macrophage extracellular vesicles

Miya Kang et al.

BONE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Learning from Monocyte-Macrophage Fusion and Multinucleation: Potential Therapeutic Targets for Osteoporosis and Rheumatoid Arthritis

Laura Gambari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Nutrition & Dietetics

Macrophage Polarization and Osteoporosis: A Review

Joseph Munoz et al.

NUTRIENTS (2020)

Add to Collection

Review Cell & Tissue Engineering

Mesenchymal stromal cells as potential immunomodulatory players in severe acute respiratory distress syndrome induced by SARS-CoV-2 infection

Panagiotis Mallis et al.

WORLD JOURNAL OF STEM CELLS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue

Agnieszka Arthur et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Article Cell Biology

BMSC-Derived Exosomal miR-29a Promotes Angiogenesis and Osteogenesis

Guo-dong Lu et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Add to Collection

Article Engineering, Biomedical

Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing

Hang Lin et al.

BIOMATERIALS (2019)

Add to Collection

Article Engineering, Biomedical

Mesenchymal stem cell-macrophage crosstalk and bone healing

Jukka Pajarinen et al.

BIOMATERIALS (2019)

Add to Collection

Article Engineering, Biomedical

CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair

Lena Batoon et al.

BIOMATERIALS (2019)

Add to Collection

Article Immunology

Cell-cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models

Yanhong Li et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2019)

Add to Collection

Review Cell & Tissue Engineering

Macrophages in Bone Homeostasis

Lingbo Kong et al.

CURRENT STEM CELL RESEARCH & THERAPY (2019)

Add to Collection

Article Orthopedics

Single-Cell Profiles and Clinically Useful Properties of Human Mesenchymal Stem Cells of Adipose and Bone Marrow Origin

Wenyan Zhou et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2019)

Add to Collection

Article Multidisciplinary Sciences

Developmental origin, functional maintenance and genetic rescue of osteoclasts

Christian E. Jacome-Galarza et al.

NATURE (2019)

Add to Collection

Review Cell & Tissue Engineering

Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

N. C. Nadia de Cassia Noronha et al.

STEM CELL RESEARCH & THERAPY (2019)

Add to Collection

Review Cell Biology

Mesenchymal Stem Cell Migration and Tissue Repair

Xiaorong Fu et al.

CELLS (2019)

Add to Collection

Article Medicine, Research & Experimental

Mesenchymal stem cells promote type 2 macrophage polarization to ameliorate the myocardial injury caused by diabetic cardiomyopathy

Liyuan Jin et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

Add to Collection

Review Biotechnology & Applied Microbiology

Inflammation and Bone Repair: From Particle Disease to Tissue Regeneration

Stuart B. Goodman et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

Add to Collection

Article Cell & Tissue Engineering

MSC-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway

Feng Liu et al.

STEM CELL RESEARCH & THERAPY (2019)

Add to Collection

Article Cell & Tissue Engineering

Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration

Jiaying Liu et al.

STEM CELL RESEARCH & THERAPY (2019)

Add to Collection

Article Immunology

Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function

Julia Loeffler et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Review Immunology

Osteoimmunology: evolving concepts in bone-immune interactions in health and disease

Masayuki Tsukasaki et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Add to Collection

Article Cell Biology

The effects of conditioned media generated by polarized macrophages on the cellular behaviours of bone marrow mesenchymal stem cells

Xiao-Tao He et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Add to Collection

Article Biotechnology & Applied Microbiology

Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells: Characterization, Differentiation, and Applications in Cartilage Tissue Engineering

Xu Li et al.

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2018)

Add to Collection

Article Immunology

Murine macrophage chemokine receptor CCR2 plays a crucial role in macrophage recruitment and regulated inflammation in wound healing

Anna E. Boniakowski et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

Add to Collection

Article Engineering, Biomedical

Effect of micro-roughening of poly(ether ether ketone) on bone marrow derived stem cell and macrophage responses, and osseointegration

Sunarso et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2018)

Add to Collection

Article Engineering, Biomedical

Deproteinized bovine bone matrix induces osteoblast differentiation via macrophage polarization

Miusi Shi et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2018)

Add to Collection

Article Multidisciplinary Sciences

Microenvironmental cues enhance mesenchymal stem cell-mediated immunomodulation and regulatory T-cell expansion

Rohini L. Kadle et al.

PLOS ONE (2018)

Add to Collection

Article Materials Science, Biomaterials

Calcium phosphate altered the cytokine secretion of macrophages and influenced the homing of mesenchymal stem cells

Menglu Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

Add to Collection

Review Endocrinology & Metabolism

Clinical and Research Approaches to Treat Non-union Fracture

Claudia Schlundt et al.

CURRENT OSTEOPOROSIS REPORTS (2018)

Add to Collection

Article Cell Biology

Bone marrow-derived stem/stromal cells (BMSC) 3D microtissues cultured in BMP-2 supplemented osteogenic induction medium are prone to adipogenesis

K. Futrega et al.

CELL AND TISSUE RESEARCH (2018)

Add to Collection

Article Cell & Tissue Engineering

Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization

Denise Philipp et al.

STEM CELL RESEARCH & THERAPY (2018)

Add to Collection

Article Medicine, Research & Experimental

1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites

Samiksha Wasnik et al.

JCI INSIGHT (2018)

Add to Collection

Article Oncology

Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and-dependent manners under hypoxic culture

Naoki Takizawa et al.

EXPERIMENTAL CELL RESEARCH (2017)

Add to Collection

Review Immunology

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

Eleni Vergadi et al.

JOURNAL OF IMMUNOLOGY (2017)

Add to Collection

Article Orthopedics

Low-dose BMP-2 and MSC dual delivery onto coral scaffold for critical-size bone defect regeneration in sheep

Adeline Decambron et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2017)

Add to Collection

Article Orthopedics

Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway

Laura Y. Lu et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2017)

Add to Collection

Review Cell & Tissue Engineering

Concise Review: MSC Adhesion Cascade-Insights into Homing and Transendothelial Migration

Franziska Nitzsche et al.

STEM CELLS (2017)

Add to Collection

Review Oncology

Crosstalk between mesenchymal stem cells and macrophages in inflammatory bowel disease and associated colorectal cancer

Fei Mao et al.

WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY (2017)

Add to Collection

Article Cell & Tissue Engineering

Preconditioning of murine mesenchymal stem cells synergistically enhanced immunomodulation and osteogenesis

Tzuhua Lin et al.

STEM CELL RESEARCH & THERAPY (2017)

Add to Collection

Review Cell & Tissue Engineering

Bone Tissue Regeneration - Application of Mesenchymal Stem Cells and Cellular and Molecular Mechanisms

Jin Zhang et al.

CURRENT STEM CELL RESEARCH & THERAPY (2017)

Add to Collection

Article Hematology

Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function

Safa F. Mohamad et al.

BLOOD ADVANCES (2017)

Add to Collection

Article Orthopedics

The risk of non-union per fracture: current myths and revised figures from a population of over 4 million adults

Leanora A. Mills et al.

ACTA ORTHOPAEDICA (2017)

Add to Collection

Article Cell Biology

Macrophage type modulates osteogenic differentiation of adipose tissue MSCs

Yang Zhang et al.

CELL AND TISSUE RESEARCH (2017)

Add to Collection

Article Biology

Analysis of Mitochondrial Transfer in Direct Co-cultures of Human Monocyte-derived Macrophages (MDM) and Mesenchymal Stem Cells (MSC)

Megan Jackson et al.

BIO-PROTOCOL (2017)

Add to Collection

Review Endocrinology & Metabolism

The roles of vascular endothelial growth factor in bone repair and regeneration

Kai Hu et al.

BONE (2016)

Add to Collection

Review Endocrinology & Metabolism

Inflammation, fracture and bone repair

Florence Loi et al.

BONE (2016)

Add to Collection

Article Cell & Tissue Engineering

Combined Use of Mesenchymal Stromal Cell Sheet Transplantation and Local Injection of SDF-1 for Bone Repair in a Rat Nonunion Model

Guangnan Chen et al.

CELL TRANSPLANTATION (2016)

Add to Collection

Article Medicine, Research & Experimental

Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair

Kai Hu et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Add to Collection

Article Cell Biology

Bone Morphogenetic Proteins

Takenobu Katagiri et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

Add to Collection

Article Surgery

Epidemiology of Fracture Nonunion in 18 Human Bones

Robert Zura et al.

JAMA SURGERY (2016)

Add to Collection

Article Cell & Tissue Engineering

No Identical Mesenchymal Stem Cells'' at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels

Benedetto Sacchetti et al.

STEM CELL REPORTS (2016)

Add to Collection

Article Multidisciplinary Sciences

Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo

Yunhao Qin et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Article Multidisciplinary Sciences

Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism

Anoop Babu Vasandan et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Article Engineering, Biomedical

Aging Affects Bone Marrow Macrophage Polarization: Relevance to Bone Healing

E. Gibon et al.

REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE (2016)

Add to Collection

Article Engineering, Biomedical

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds

Kara L. Spiller et al.

BIOMATERIALS (2015)

Add to Collection

Article Engineering, Biomedical

Scaffold composition affects cytoskeleton organization, cell matrix interaction and the cellular fate of human mesenchymal stem cells upon chondrogenic differentiation

Yuk Yin Li et al.

BIOMATERIALS (2015)

Add to Collection

Article Endocrinology & Metabolism

Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis

Linda Vi et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2015)

Add to Collection

Review Endocrinology & Metabolism

Macrophages: Their Emerging Roles in Bone

Benjamin P. Sinder et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2015)

Add to Collection

Review Cell Biology

Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages

Giuseppina Turturici et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)

Add to Collection

Article Cell Biology

Inflammatory Microenvironment Changes the Secretory Profile of Mesenchymal Stem Cells to Recruit Mesenchymal Stem Cells

Junchao Xing et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)

Add to Collection

Review Biochemistry & Molecular Biology

Macrophage Polarization in Inflammatory Diseases

Yan-Cun Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2014)

Add to Collection

Article Multidisciplinary Sciences

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

Oscar R. Colegio et al.

NATURE (2014)

Add to Collection

Article Cell Biology

Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes

D-S Lee et al.

CELL DEATH & DISEASE (2014)

Add to Collection

Review Immunology

Macrophage cytokines: involvement in immunity and infectious diseases

Guillermo Arango Duque et al.

FRONTIERS IN IMMUNOLOGY (2014)

Add to Collection

Article Cardiac & Cardiovascular Systems

Human Macrophage Regulation Via Interaction With Cardiac Adipose Tissue-Derived Mesenchymal Stromal Cells

Shimrit Adutler-Lieber et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2013)

Add to Collection

Article Biochemistry & Molecular Biology

The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine

Paolo Bianco et al.

NATURE MEDICINE (2013)

Add to Collection

Article Biochemistry & Molecular Biology

TNF-α Increases Bone Marrow Mesenchymal Stem Cell Migration to Ischemic Tissues

Qiong Xiao et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2012)

Add to Collection

Review Biochemistry & Molecular Biology

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation

Guiqian Chen et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2012)

Add to Collection

Review Rheumatology

Fracture healing under healthy and inflammatory conditions

Lutz Claes et al.

NATURE REVIEWS RHEUMATOLOGY (2012)

Add to Collection

Article Cell & Tissue Engineering

IL1β Induces Mesenchymal Stem Cells Migration and Leucocyte Chemotaxis Through NF-κB

Ruben Carrero et al.

STEM CELL REVIEWS AND REPORTS (2012)

Add to Collection

Review Cell & Tissue Engineering

Markers for Characterization of Bone Marrow Multipotential Stromal Cells

Sally A. Boxall et al.

STEM CELLS INTERNATIONAL (2012)

Add to Collection

Article Endocrinology & Metabolism

Osteal Macrophages Promote In Vivo Intramembranous Bone Healing in a Mouse Tibial Injury Model

Kylie A. Alexander et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2011)

Add to Collection

Article Behavioral Sciences

Long-lasting effects of human mesenchymal stem cell systemic administration on pain-like behaviors, cellular and biomolecular modifications in neuropathic mice

Dario Siniscalco et al.

FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2011)

Add to Collection

Article Engineering, Biomedical

The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation

Janos M. Kanczler et al.

BIOMATERIALS (2010)

Add to Collection

Article Hematology

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

Ingrid G. Winkler et al.

BLOOD (2010)

Add to Collection

Article Oncology

Interleukin 6 mediated recruitment of mesenchymal stem cells to the hypoxic tumor milieu

Yanique Rattigan et al.

EXPERIMENTAL CELL RESEARCH (2010)

Add to Collection

Article Immunology

Mesenchymal Stem Cells Inhibit Human Th17 Cell Differentiation and Function and Induce a T Regulatory Cell Phenotype

Soufiane Ghannam et al.

JOURNAL OF IMMUNOLOGY (2010)

Add to Collection

Article Multidisciplinary Sciences

The Induction of APC with a Distinct Tolerogenic Phenotype via Contact-Dependent STAT3 Activation

Devorah Gur-Wahnon et al.

PLOS ONE (2009)

Add to Collection

Editorial Material Cell & Tissue Engineering

Mesenchymal stem cells: Revisiting history, concepts, and assays

Paolo Bianco et al.

CELL STEM CELL (2008)

Add to Collection

Article Immunology

Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation

Karen English et al.

IMMUNOLOGY LETTERS (2008)

Add to Collection

Article Immunology

Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo

Ming K. Chang et al.

JOURNAL OF IMMUNOLOGY (2008)

Add to Collection

Review Immunology

Exploring the full spectrum of macrophage activation

David M. Mosser et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Add to Collection

Article Immunology

IFN-γ and TNF-α differentially regulate immunomodulation by murine mesenchymal stem cells

Karen English et al.

IMMUNOLOGY LETTERS (2007)

Add to Collection

Article Cell & Tissue Engineering

Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis

Shih-Chieh Hung et al.

STEM CELLS (2007)

Add to Collection

Article Cell & Tissue Engineering

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

M. Dominici et al.

CYTOTHERAPY (2006)

Add to Collection

Article Cell & Tissue Engineering

Hepatocyte growth factor effects on mesenchymal stem cells: Proliferation, migration, and differentiation

G Forte et al.

STEM CELLS (2006)

Add to Collection

Article Gastroenterology & Hepatology

Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones

R Dresner-Pollak et al.

GASTROENTEROLOGY (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.