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Role of ferroptosis in pregnancy related diseases and its therapeutic potential

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)

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SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis

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CELL CHEMICAL BIOLOGY (2020)

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Increased serum iron levels in pregnant women with preeclampsia: a meta-analysis of observational studies

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JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2019)

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1,25(OH)2D3 Protects Trophoblasts Against Insulin Resistance and Inflammation Via Suppressing mTOR Signaling

Guanlin Li et al.

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Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

Ishraq Alim et al.

CELL (2019)

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Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

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NATURE CHEMISTRY (2019)

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NADPH oxidase regulates paraquat and maneb-induced dopaminergic neurodegeneration through ferroptosis

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The effects of flavonoids on human first trimester trophoblast spheroidal stein cell self-renewal, invasion and JNK/p38 MAPK activation: Understanding the cytoprotective effects of these phytonutrients against oxidative stress

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The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

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Ameliorative effects of pre-eclampsia by quercetin supplement to aspirin in a rat model induced by L-NAME

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Expression of vitamin D and vitamin D receptor in chorionic villous in missed abortion

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Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial

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LANCET (2019)

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The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

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CELL REPORTS (2019)

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FSP1 is a glutathione-independent ferroptosis suppressor

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NATURE (2019)

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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

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NATURE (2019)

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The chemical basis of ferroptosis

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NATURE CHEMICAL BIOLOGY (2019)

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LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells

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Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury

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Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

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Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation

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CELL DEATH DISCOVERY (2019)

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OBSTETRICS AND GYNECOLOGY (2019)

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An alternative method for measuring oxidative stress in intrahepatic cholestasis of pregnancy: thiol/disulphide homeostasis

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GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

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Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress

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BIOLOGY OF REPRODUCTION (2018)

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FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

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Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimer's disease

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Oxidative stress in placental pathology

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Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

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AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc- Activity

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CURRENT BIOLOGY (2018)

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BAP1 links metabolic regulation of ferroptosis to tumour suppression

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A promising new approach to cancer therapy: Targeting iron metabolism in cancer stem cells

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Mitochondria and Coenzyme Q10 in the Pathogenesis of Preeclampsia

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Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

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Iron and Ferroptosis: A Still Ill-Defined Liaison

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PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis

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NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

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MOLECULAR CELL (2017)

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Ferroptosis Inhibition: Mechanisms and Opportunities

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On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

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Application of One-Step IADPSG Versus Two-Step Diagnostic Criteria for Gestational Diabetes in the Real World: Impact on Health Services, Clinical Care, and Outcomes

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PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

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CELL (2017)

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Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death

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Autophagy promotes ferroptosis by degradation of ferritin

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Increased oxidative stress from early pregnancy in women who develop preeclampsia

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Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation

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Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

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Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

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ACS CHEMICAL BIOLOGY (2015)

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Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of the Alox15 Gene Does Not Rescue Such Knock-In Mice

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Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8+ T cell function by limiting GSH and Cys availability

Lisa K. Sha et al.

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Apoptosis-inducing Factor (AIF) and Its Family Member Protein, AMID, Are Rotenone-sensitive NADH: Ubiquinone Oxidoreductases (NDH-2)

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Ferroptosis as a p53-mediated activity during tumour suppression

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Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

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Manuela. R. Martinefski et al.

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Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Genome-wide hypermethylation coupled with promoter hypomethylation in the chorioamniotic membranes of early onset pre-eclampsia

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MOLECULAR HUMAN REPRODUCTION (2014)

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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Glutathione synthesis

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Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study

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Physiologic implications of metal-ion transport by ZIP14 and ZIP8

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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5-Lipoxygenase-dependent apoptosis of human lymphocytes in the International Space Station: data from the ROALD experiment

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Genetic polymorphisms in placental transporters: implications for fetal drug exposure to oral antidiabetic agents

Erika K. Pollex et al.

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Safety assessment of coenzyme Q(10) (CoQ(10))

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Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

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Cell biology of lipid droplets

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CURRENT OPINION IN CELL BIOLOGY (2008)

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Oxidation products of polyunsaturated fatty acids in infant formulas compared to human milk - A preliminary study

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Discovery essential of a lysophospholipid acyltransferase family for membrane asymmetry and diversity

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Case series of rosiglitazone used during the first trimester of pregnancy

Ghassan F. Haddad et al.

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Structural biology of mammalian lipoxygenasese enzymatic consequences of targeted alterations of the protein structure

H Kuhn et al.

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Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: Identification of a novel variant of isoform 6

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Plasma malondialdehyde, superoxide dismutase, sE-selectin, fibronectin, endothelin-1 and nitric oxide levels in women with preeclampsia

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EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2004)

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Oxidative stress and preeclampsia - Rationale for antioxidant clinical trials

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HYPERTENSION (2004)

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Intermediate metabolism in normal pregnancy and in gestational diabetes

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AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis

M Wu et al.

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In vitro studies on the relationship between polyunsaturated fatty acids and cancer: tumour or tissue specific effects?

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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

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