4.7 Article

Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection

Related references

Note: Only part of the references are listed.
Review Microbiology

Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics

Shannon L. Kordus et al.

Summary: Clostridioides difficile produces up to three different toxins, which play a key role in the pathogenesis of colon infection. In this Review, Kordus, Thomas, and Lacy discuss the structure and function of these toxins and how this information guides new therapeutic approaches. Understanding the mechanisms of host-toxin interactions provides a foundation for developing novel strategies for the treatment and prevention of C. difficile infection.

NATURE REVIEWS MICROBIOLOGY (2022)

Article Microbiology

Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection

F. Christopher Peritore-Galve et al.

Summary: Clostridioides difficile infection (CDI) is the leading cause of nosocomial diarrhea and pseudomembranous colitis in the USA. This study investigates the role of two protein toxins, TcdA and TcdB, produced by the pathogen in causing disease. The study finds that both toxins have an additive role in disease pathogenesis and produce both glucosyltransferase-dependent and independent phenotypes. These findings will contribute to the development of toxin-based therapeutics for CDI.

PLOS PATHOGENS (2022)

Article Oncology

Human Colon Cancer-Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice

Julia L. Drewes et al.

Summary: This study reveals the role of toxigenic Clostridioides difficile in promoting colorectal cancer, suggesting that chronic colonization with this pathogenic bacteria may drive tumor development through the induction of Wnt signaling, reactive oxygen species, and protumorigenic mucosal immune responses.

CANCER DISCOVERY (2022)

Review Gastroenterology & Hepatology

Neutrophil-Epithelial Crosstalk During Intestinal Inflammation

Le Kang et al.

Summary: Neutrophils play a multifaceted role in intestinal inflammation, contributing to the elimination of pathogens but also causing tissue damage. This article focuses on the interactions between neutrophils and epithelial cells in the intestine and highlights the molecular factors involved in neutrophil recruitment, migration, and detachment from the epithelium.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity

Anoop Kumar et al.

Summary: The study demonstrated that DRA deficiency results in increased colonic paracellular permeability and decreased levels of tight junction/adherens junction proteins. Dysregulation of DRA may have potential implications for IBD pathogenesis by compromising intestinal epithelial barrier function.

GASTROENTEROLOGY (2021)

Article Multidisciplinary Sciences

Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease

Steven J. Mileto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Medicine, General & Internal

Trends in US Burden of Clostridioides difficile Infection and Outcomes

Alice Y. Guh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Cell Biology

Trafficking Ion Transporters to the Apical Membrane of Polarized Intestinal Enterocytes

Amy Christine Engevik et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

Article Gastroenterology & Hepatology

Clostridium difficile toxins A and B decrease intestinal SLC26A3 protein expression

Hayley Coffing et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

Review Gastroenterology & Hepatology

The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea

Soumita Das et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

Review Microbiology

The role of toxins in Clostridium difficile infection

Ramyavardhanee Chandrasekaran et al.

FEMS MICROBIOLOGY REVIEWS (2017)

Review Gastroenterology & Hepatology

Intestinal SGLT1 in metabolic health and disease

Anders Lehmann et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

Article Gastroenterology & Hepatology

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology

Jennifer Foulke-Abel et al.

GASTROENTEROLOGY (2016)

Article Biochemistry & Molecular Biology

The Sodium Glucose Cotransporter SGLT1 Is an Extremely Efficient Facilitator of Passive Water Transport

Liudmila Erokhova et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Medicine, General & Internal

Clostridium difficile infection

Wiep Klaas Smits et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Article Gastroenterology & Hepatology

Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile

Melinda A. Engevik et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2015)

Article Biochemistry & Molecular Biology

Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea

Andreas R. Janecke et al.

HUMAN MOLECULAR GENETICS (2015)

Article Medicine, General & Internal

Burden of Clostridium difficile Infection in the United States

Fernanda C. Lessa et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Biochemical Research Methods

Separation of intact intestinal epithelium from mesenchyme

Ali Moussavi Nik et al.

BIOTECHNIQUES (2013)

Article Gastroenterology & Hepatology

Altered Expression and Localization of Ion Transporters Contribute to Diarrhea in Mice With Salmonella-Induced Enteritis

Ronald R. Marchelletta et al.

GASTROENTEROLOGY (2013)

Article Medicine, General & Internal

Health Care-Associated Infections A Meta-analysis of Costs and Financial Impact on the US Health Care System

Eyal Zimlichman et al.

JAMA INTERNAL MEDICINE (2013)

Article Biotechnology & Applied Microbiology

ClosTron-mediated engineering of Clostridium

Sarah A. Kuehne et al.

BIOENGINEERED (2012)

Review Biochemistry & Molecular Biology

Transcriptional regulation of the intestinal luminal Na+ and Cl- transporters

Jaleh Malakooti et al.

BIOCHEMICAL JOURNAL (2011)

Article Biochemistry & Molecular Biology

CcpA-mediated repression of Clostridium difficile toxin gene expression

Ana Antunes et al.

MOLECULAR MICROBIOLOGY (2011)

Article Gastroenterology & Hepatology

Segregation of Na/H exchanger-3 and Cl/HCO3 exchanger SLC26A3 (DRA) in rodent cecum and colon

Colleen Talbot et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Review Gastroenterology & Hepatology

Infectious diarrhea Cellular and molecular mechanisms

Kim Hodges et al.

GUT MICROBES (2010)

Article Gastroenterology & Hepatology

Role of Sp1 and HNF1 transcription factors in SGLT1 regulation during chronic intestinal inflammation

Ramesh Kekuda et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

Article Immunology

Clostridium difficile skin contamination in patients with C-difficile-associated disease

Greg S. Bobulsky et al.

CLINICAL INFECTIOUS DISEASES (2008)

Article Medicine, Research & Experimental

Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo

Daniel R. Clayburgh et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Medicine, Research & Experimental

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo

DR Clayburgh et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Article Gastroenterology & Hepatology

Intestinal NaCl transport in NHE2 and NHE3 knockout mice

LR Gawenis et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)