Journal
GUT MICROBES
Volume 15, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2023.2206505
Keywords
Maternal microbiota; microbial metabolite; fetus; neonate; immunity; brain development
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The maternal microbiome plays a crucial role in the healthy growth and development of offspring and has long-lasting effects. Recent studies have shown that it starts regulating fetal health and development during pregnancy and continues to influence early microbial colonization through birth and breastfeeding. There is compelling evidence that it is involved in immune and brain development and affects the risk of related diseases. Modulating offspring development through maternal diet and probiotic intervention during pregnancy and breastfeeding could be a promising future therapy.
The maternal microbiome is essential for the healthy growth and development of offspring and has long-term effects later in life. Recent advances indicate that the maternal microbiome begins to regulate fetal health and development during pregnancy. Furthermore, the maternal microbiome continues to affect early microbial colonization via birth and breastfeeding. Compelling evidence indicates that the maternal microbiome is involved in the regulation of immune and brain development and affects the risk of related diseases. Modulating offspring development by maternal diet and probiotic intervention during pregnancy and breastfeeding could be a promising therapy in the future. In this review, we summarize and discuss the current understanding of maternal microbiota development, perinatal microbial metabolite transfer, mother-to-infant microbial transmission during/after birth and its association with immune and brain development as well as corresponding diseases.
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