Employing pigs to decipher the host genetic effect on gut microbiome: advantages, challenges, and perspectives

The gut microbiota is a complex and diverse ecosystem comprised of trillions of microbes and plays an essential role in host's immunity, metabolism, and even behaviors. Environmental and host factors drive the huge variations in the gut microbiome among individuals. Here, we summarize accumulated evidences about host genetic effect on the gut microbial compositions with emphases on the correlation between host genetic kinship and the similarity of microbial compositions, heritability estimates of microbial taxa, and identification of genomic variants associated with the gut microbiome in pigs as well as in humans. A proportion of bacterial taxa have been reported to be heritable, and numerous variants associated with the diversity of the gut microbiota or specific taxa have been identified in both humans and pigs. LCT and ABO gene have been replicated in multiple studies, and its mechanism have been elucidated clearly. We also discuss the main advantages and challenges using pigs as experimental animals in exploring host genetic effect on the gut microbial composition and provided our insights on the perspectives in this area.

Automated summary

The gut microbiota, composed of trillions of microbes, plays a crucial role in the host's immunity, metabolism, and behavior. Both environmental and host factors contribute to the variation in gut microbial compositions among individuals. Research has shown that certain bacterial taxa are heritable, and genomic variants associated with the gut microbiome have been identified in humans and pigs. Pig models offer advantages and challenges in studying the host genetic effect on gut microbial composition.