Journal
GUT MICROBES
Volume 15, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2023.2206504
Keywords
Microbiota-gut-brain axis; gut microbiota; dysbiosis; oxidative stress; inflammation; Alzheimer's disease
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The microbiota-gut-brain axis is a crucial pathway that contributes to the pathogenesis of Alzheimer's disease (AD) by altering gut microbiota and increasing oxidative stress and inflammation. The relationship between specific bacteria and brain dysfunction in AD pathology is not fully understood. This review explores the connections between oxidative stress, inflammation, and gut dysbiosis in AD and suggests potential preventative and therapeutic strategies.
The microbiota-gut-brain axis is an important pathway of communication and may dynamically contribute to Alzheimer's disease (AD) pathogenesis. Pathological commensal gut microbiota alterations, termed as dysbiosis, can influence intestinal permeability and break the blood-brain barrier which may trigger AD pathogenesis via redox signaling, neuronal, immune, and metabolic pathways. Dysbiosis increases the oxidative stress. Oxidants affect the innate immune system through recognizing microbial-derived pathogens by Toll-like receptors and initiating the inflammatory process. Most of the gut microbiome research work highlights the relationship between the gut microbiota and AD, but the contributory connection between precise bacteria and brain dysfunction in AD pathology cannot be fully demonstrated. Here, we summarize the current information of the fundamental connections between oxidative stress, inflammation, and gut dysbiosis in AD. This review emphasizes on the involvement of gut microbiota in the regulation of oxidative stress, inflammation, immune responses including central and peripheral cross-talk. It provides insights for novel preventative and therapeutic approaches in AD.
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