Gut microbiota: a non-target victim of pesticide-induced toxicity

The human gut microbiota can be potentially disrupted due to exposure of various environmental contaminants, including pesticides. These contaminants enter into non-target species in multiple ways and cause potential health risks. The gut microbiota-derived metabolites have a significant role in maintaining the host's health by regulating metabolic homeostasis. An imbalance in this homeostasis can result in the development of various diseases and their pathogenesis. Pesticides have hazardous effects on the host's gut microbiota, which is evident in a few recent studies. Therefore, there is an urgent need to explore the effect of pesticide on gut microbiota-mediated metabolic changes in the host, which may provide a better understanding of pesticide-induced toxicity. The present review summarizes the pesticide-induced effects on gut microbiota, which in turn, induces changes in the release of their secondary metabolites that could lead to various host health effects.

Automated summary

The human gut microbiota can be disrupted by environmental contaminants such as pesticides, posing potential health risks. The metabolites produced by gut microbiota play a significant role in maintaining host health, and an imbalance in this system can lead to various diseases. Recent studies have shown that pesticides have harmful effects on the host's gut microbiota. Therefore, further research is needed to understand the impact of pesticides on gut microbiota-mediated metabolic changes, which may provide insights into pesticide-induced toxicity.