Related references
Note: Only part of the references are listed.Microenvironment-driven metabolic adaptations guiding CD8+T cell anti-tumor immunity
Jaeoh Park et al.
IMMUNITY (2023)
PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity
Christopher Ronald Funk et al.
BLOOD (2022)
Restricting tumor lactic acid metabolism using dichloroacetate improves T cell functions
Hosein Rostamian et al.
BMC CANCER (2022)
The hallmarks of cancer metabolism: Still emerging
Natalya N. Pavlova et al.
CELL METABOLISM (2022)
Microenvironmental influences on T cell immunity in cancer and inflammation
Darren R. Heintzman et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2022)
Decade-long leukaemia remissions with persistence of CD4(+) CAR T cells
J. Joseph Melenhorst et al.
NATURE (2022)
Pretherapy metabolic tumor volume is associated with response to CD30 CAR T cells in Hodgkin lymphoma
Timothy J. Voorhees et al.
BLOOD ADVANCES (2022)
A novel adoptive synthetic TCR and antigen receptor (STAR) T-Cell therapy for B-Cell acute lymphoblastic leukemia
Jiasheng Wang et al.
AMERICAN JOURNAL OF HEMATOLOGY (2022)
Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia
Paul M. Maciocia et al.
BLOOD (2022)
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
Mathias Wenes et al.
CELL METABOLISM (2022)
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
Lupeng Ye et al.
CELL METABOLISM (2022)
Chimeric antigen receptors containing the OX40 signalling domain enhance the persistence of T cells even under repeated stimulation with multiple myeloma target cells
Jingwen Tan et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)
Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results
Changsong Qi et al.
NATURE MEDICINE (2022)
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
Vivek Narayan et al.
NATURE MEDICINE (2022)
BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity
Taylor L. Hickman et al.
PLOS ONE (2022)
Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis
Jun-Long Zhao et al.
CELL REPORTS (2022)
Metabolic reprogramming by ex vivo glutamine inhibition endows CAR-T cells with less-differentiated phenotype and persistent antitumor activity
Luyan Shen et al.
CANCER LETTERS (2022)
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies
Daniel B. Goodman et al.
Science Translational Medicine (2022)
FOXM1 regulates glycolysis and energy production in multiple myeloma
Yan Cheng et al.
ONCOGENE (2022)
The Past, Present, and Future of Non-Viral CAR T Cells
Alex Moretti et al.
FRONTIERS IN IMMUNOLOGY (2022)
Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains
Khloe S. Gordon et al.
NATURE BIOMEDICAL ENGINEERING (2022)
Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
Dominic Denk et al.
IMMUNITY (2022)
Metabolic communication in the tumour-immune microenvironment
Kung-Chi Kao et al.
NATURE CELL BIOLOGY (2022)
Clinical implications of T cell exhaustion for cancer immunotherapy
Andrew Chow et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2022)
CD28.OX40 co-stimulatory combination is associated with long in vivo persistence and high activity of CAR.CD30 T cells
Marika Guercio et al.
HAEMATOLOGICA (2021)
An NK-like CAR T cell transition in CAR T cell dysfunction
Charly R. Good et al.
CELL (2021)
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor
Yuying Liu et al.
NATURE IMMUNOLOGY (2021)
Regnase-1 suppresses TCF-1+ precursor exhausted T-cell formation to limit CAR-T-cell responses against ALL
Wenting Zheng et al.
BLOOD (2021)
Optimization of metabolism to improve efficacy during CAR-T cell manufacturing
Meng Zhang et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2021)
Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma
Nikhil C. Munshi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2021)
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity
Brooke Prinzing et al.
SCIENCE TRANSLATIONAL MEDICINE (2021)
A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity
Huihui Zhang et al.
SCIENCE TRANSLATIONAL MEDICINE (2021)
Cell-programmed nutrient partitioning in the tumour microenvironment
Bradley Reinfeld et al.
NATURE (2021)
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Nathalie M. Schmidt et al.
NATURE COMMUNICATIONS (2021)
Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia
Hardikkumar Jetani et al.
BLOOD (2021)
Ciltacabtagene autoleucel, a B-cell maturation antigendirected chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study
Jesus G. Berdeja et al.
LANCET (2021)
Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis
Nicholas A. Vitanza et al.
NATURE MEDICINE (2021)
A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains
Kathryn M. Cappell et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2021)
Amino Acid Transport and Metabolism in Myeloid Function
Marie Jo Halaby et al.
FRONTIERS IN IMMUNOLOGY (2021)
Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors
Tamara Muliaditan et al.
CELL REPORTS MEDICINE (2021)
Cellular networks controlling T cell persistence in adoptive cell therapy
Jack D. Chan et al.
NATURE REVIEWS IMMUNOLOGY (2021)
The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells
Taisuke Kondo et al.
CANCER RESEARCH (2020)
STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth
Chunyan Zhang et al.
CELL METABOLISM (2020)
Enhanced Lipid Accumulation and Metabolism Are Required for the Differentiation and Activation of Tumor-Associated Macrophages
Pan Su et al.
CANCER RESEARCH (2020)
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors
Haiping Wang et al.
NATURE IMMUNOLOGY (2020)
Chimeric Antigen Receptor-Glypican-3 T-Cell Therapy for Advanced Hepatocellular Carcinoma: Results of Phase I Trials
Donghua Shi et al.
CLINICAL CANCER RESEARCH (2020)
KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma
Michael Wang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Cancer Cells Don't Live Alone: Metabolic Communication within Tumor Microenvironments
Fuming Li et al.
DEVELOPMENTAL CELL (2020)
Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity
Livingstone Fultang et al.
BLOOD (2020)
Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy
Wentao Li et al.
IMMUNITY (2020)
IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors
Lauren Giuffrida et al.
MOLECULAR THERAPY (2020)
CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?
Jessica Wagner et al.
MOLECULAR THERAPY (2020)
Disturbed mitochondrial dynamics in CD8+TILs reinforce T cell exhaustion
Yi-Ru Yu et al.
NATURE IMMUNOLOGY (2020)
Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas
Qing Deng et al.
NATURE MEDICINE (2020)
Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design
Saba Ghassemi et al.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)
Antitumor activity without on-target off-tumor toxicity of GD2-chimeric antigen receptor T cells in patients with neuroblastoma
Karin Straathof et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Lactate Limits T Cell Proliferation via the NAD(H) Redox State
William J. Quinn et al.
CELL REPORTS (2020)
Metabolically Flexible CAR T Cells (mfCAR-T), with Constitutive Expression of PGC-1α Resistant to Post Translational Modifications, Exhibit Superior Survival and Function in Vitro
Reginald M. Atkins et al.
BLOOD (2020)
MyD88/CD40 signaling retains CAR T cells in a less differentiated state
Brooke Prinzing et al.
JCI INSIGHT (2020)
Metabolic and epigenetic regulation of T-cell exhaustion
Fabien Franco et al.
NATURE METABOLISM (2020)
Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies
Matthew R. Collinson-Pautz et al.
LEUKEMIA (2019)
The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity
Sanjivan Gautam et al.
NATURE IMMUNOLOGY (2019)
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
Xiaoyun Li et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2019)
IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype
Darya Alizadeh et al.
CANCER IMMUNOLOGY RESEARCH (2019)
Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy
Jaco A. C. van Bruggen et al.
BLOOD (2019)
CD19 CAR T cell product and disease attributes predict leukemia remission durability
Olivia C. Finney et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers
Andrew R. Haas et al.
MOLECULAR THERAPY (2019)
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
Will Bailis et al.
NATURE (2019)
T Cell Dysfunction in Cancer Immunity and Immunotherapy
Anliang Xia et al.
FRONTIERS IN IMMUNOLOGY (2019)
Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance
Dayana B. Rivadeneira et al.
IMMUNITY (2019)
WNT/β-Catenin Signaling Pathway Regulating T Cell-Inflammation in the Tumor Microenvironment
Xin Li et al.
FRONTIERS IN IMMUNOLOGY (2019)
Toxicity and response after CD19-specific CAR T-cell therapy in pediatric/young adult relapsed/refractory B-ALL
Kevin J. Curran et al.
BLOOD (2019)
VISTA is an acidic pH-selective ligand for PSGL-1
Robert J. Johnston et al.
NATURE (2019)
Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial
Frederick L. Locke et al.
LANCET ONCOLOGY (2019)
Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Stephen J. Schuster et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy
Jun Wei et al.
NATURE (2019)
Memory stem T cells generated by Wnt signaling from blood of human renal clear cell carcinoma patients
Cihui Yan et al.
CANCER BIOLOGY & MEDICINE (2019)
Cholesterol Esterification Enzyme Inhibition Enhances Antitumor Effects of Human Chimeric Antigen Receptors Modified T Cells
Lei Zhao et al.
JOURNAL OF IMMUNOTHERAPY (2018)
A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8(+) T cells
Ruihua Ma et al.
NATURE CELL BIOLOGY (2018)
Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/gamma H2AX pathway
Zhong Wang et al.
ACTA PHARMACOLOGICA SINICA (2018)
CRISPR/Cas9-Mediated Knockout of DGK Improves Antitumor Activities of Human T Cells
In-Young Jung et al.
CANCER RESEARCH (2018)
4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses
Ashley V. Menk et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells
Wenting Zheng et al.
LEUKEMIA (2018)
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
Joseph A. Fraietta et al.
NATURE MEDICINE (2018)
Understanding the tumor immune microenvironment (TIME) for effective therapy
Mikhail Binnewies et al.
NATURE MEDICINE (2018)
Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth
Ilenia Pacella et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
CAR T cell immunotherapy for human cancer
Carl H. June et al.
SCIENCE (2018)
IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner
Romy Loschinski et al.
Oncotarget (2018)
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
Joseph A. Fraietta et al.
NATURE (2018)
Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation
Daniel Ackerman et al.
CELL REPORTS (2018)
Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
Toszka Bohn et al.
NATURE IMMUNOLOGY (2018)
Phase I Study of Chimeric Antigen Receptor-Modified T Cells in Patients with EGFR-Positive Advanced Biliary Tract Cancers
Yelei Guo et al.
CLINICAL CANCER RESEARCH (2018)
4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8+ T cell proliferation
Beom K. Choi et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2017)
Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels
James N. Kochenderfer et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA+ Metastatic Colorectal Cancers
Chengcheng Zhang et al.
MOLECULAR THERAPY (2017)
CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma
Andras Heczey et al.
MOLECULAR THERAPY (2017)
FOXM1 regulates glycolysis in hepatocellular carcinoma by transactivating glucose transporter 1 expression
Runze Shang et al.
ONCOLOGY REPORTS (2017)
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
Donald M. O'Rourke et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Inducible Activation of MyD88 and CD40 in CAR T Cells Results in Controllable and Potent Antitumor Activity in Preclinical Solid Tumor Models
Melinda Mata et al.
CANCER DISCOVERY (2017)
Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy
Christopher A. Klebanoff et al.
JCI INSIGHT (2017)
Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition
Rasha Abu Eid et al.
CANCER RESEARCH (2017)
De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation
Hazem E. Ghoneim et al.
CELL (2017)
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
Alessia Angelin et al.
CELL METABOLISM (2017)
CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells
Alan L. Chang et al.
CANCER RESEARCH (2016)
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Michael D. Buck et al.
CELL (2016)
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Roger Geiger et al.
CELL (2016)
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
Almut Brand et al.
Cell Metabolism (2016)
The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
Nicole E. Scharping et al.
IMMUNITY (2016)
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8+ T Cell Exhaustion
Bertram Bengsch et al.
IMMUNITY (2016)
Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
Wei Yang et al.
NATURE (2016)
Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
Min Peng et al.
SCIENCE (2016)
Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner
Lianjun Zhang et al.
CELL REPORTS (2016)
Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host
Anna Schurich et al.
Cell Reports (2016)
Metabolic communication in tumors: a new layer of immunoregulation for immune evasion
Ping-Chih Ho et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2016)
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells
Zeguo Zhao et al.
CANCER CELL (2015)
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
Ping-Chih Ho et al.
CELL (2015)
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang et al.
CELL (2015)
Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation
Alex J. Bott et al.
CELL METABOLISM (2015)
Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma
Nabil Ahmed et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
Daniel W. Lee et al.
LANCET (2015)
Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection
Jonathan H. Chen et al.
NATURE MEDICINE (2015)
T cell exclusion, immune privilege, and the tumor microenvironment
Johanna A. Joyce et al.
SCIENCE (2015)
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
David L. Porter et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
Nikolaos Patsoukis et al.
NATURE COMMUNICATIONS (2015)
Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies
Fokhrul Hossain et al.
CANCER IMMUNOLOGY RESEARCH (2015)
Tryptophan-degrading enzymes in tumoral immune resistance
Nicolas van Baren et al.
FRONTIERS IN IMMUNOLOGY (2015)
Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics
Joseph G. Crompton et al.
CANCER RESEARCH (2015)
Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15
Yang Xu et al.
BLOOD (2014)
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
Oscar R. Colegio et al.
NATURE (2014)
Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
Karim Bensaad et al.
CELL REPORTS (2014)
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chih-Hao Chang et al.
CELL (2013)
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
Andrew L. Doedens et al.
NATURE IMMUNOLOGY (2013)
CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia
Renier J. Brentjens et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
Arianna Calcinotto et al.
CANCER RESEARCH (2012)
Immune Suppression and Resistance Mediated by Constitutive Activation of Wnt/β-Catenin Signaling in Human Melanoma Cells
Tomonori Yaguchi et al.
JOURNAL OF IMMUNOLOGY (2012)
OX40 signaling favors the induction of TH9 cells and airway inflammation
Xiang Xiao et al.
NATURE IMMUNOLOGY (2012)
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
Chrystal U. Louis et al.
BLOOD (2011)
A Critical Role for STAT3 Transcription Factor Signaling in the Development and Maintenance of Human T Cell Memory
Andrea M. Siegel et al.
IMMUNITY (2011)
Costimulation by chimeric antigen receptors revisited: the T cell antitumor response benefits from combined CD28-OX40 signalling
Andreas A. Hombach et al.
INTERNATIONAL JOURNAL OF CANCER (2011)
Activation of Wnt Signaling Arrests Effector Differentiation in Human Peripheral and Cord Blood-Derived T Lymphocytes
Sujatha Muralidharan et al.
JOURNAL OF IMMUNOLOGY (2011)
The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
Rajesh R. Rao et al.
IMMUNITY (2010)
Constitutive Activation of Wnt Signaling Favors Generation of Memory CD8 T Cells
Dong-Mei Zhao et al.
JOURNAL OF IMMUNOLOGY (2010)
An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
Joshua D. Mezrich et al.
JOURNAL OF IMMUNOLOGY (2010)
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Duevel et al.
MOLECULAR CELL (2010)
Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell-mediated Tumor Eradication
Xiao-Song Zhong et al.
MOLECULAR THERAPY (2010)
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Erika L. Pearce et al.
NATURE (2009)
mTOR regulates memory CD8 T-cell differentiation
Koichi Araki et al.
NATURE (2009)
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
Pratima Sinha et al.
CANCER RESEARCH (2007)
Inhibitory effect of tumor cell-derived lactic acid on human T cells
Karin Fischer et al.
BLOOD (2007)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
MA Pulè et al.
MOLECULAR THERAPY (2005)
During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion
J Hendriks et al.
JOURNAL OF IMMUNOLOGY (2005)
Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission
P Matarrese et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
C Uyttenhove et al.
NATURE MEDICINE (2003)
Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells:: Mediation of suppression by tryptophan metabolites
P Terness et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
The CD28 signaling pathway regulates glucose metabolism
KA Frauwirth et al.
IMMUNITY (2002)
Reactive oxygen species differentially affect T cell receptor-signaling pathways
S Cemerski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism
A Mazzoni et al.
JOURNAL OF IMMUNOLOGY (2002)
Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCR zeta/CD28 receptor
J Maher et al.
NATURE BIOTECHNOLOGY (2002)
The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T cell activation in a calcineurin-dependent manner
J Trama et al.
JOURNAL OF IMMUNOLOGY (2000)
The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion
I Gramaglia et al.
JOURNAL OF IMMUNOLOGY (2000)