Direct a-C(sp3)-H thioetheration/selenylation of nafimidone derivatives enabled by electrocatalysis

An effective strategy for direct alpha-C(sp3)-H thioetheration/selenylation of nafimidone derivatives enabled by electrocatalysis has been reported. A wide range of nafimidone, disulfide and diselenide derivatives were well compatible, giving the corresponding products in moderate to good yields. Control experiments suggested that a radical mechanism is responsible for the reaction. Such methodology not only provides a new method for the activation of C(sp3)-H bonds but also enriches the nafimidone derivatives with potential biological activity.

Automated summary

An effective strategy for the direct α- C (sp3)-H thioetheration/selenylation of nafimidone derivatives has been introduced using electrocatalysis. A wide range of nafimidone, disulfide, and diselenide derivatives showed good compatibility and yielded corresponding products in moderate to good yields. Control experiments indicated that the reaction proceeds through a radical mechanism. This methodology not only offers a new approach for C(sp3)-H bond activation but also expands the scope of potential biological activity in nafimidone derivatives.