To explore the change of motor cognitive function in pituitary tumor rats after operation

To study the changes of motor and cognitive function of pituitary tumor rats after the operation. Methods: The experiment was divided into three groups: control group, model group and operation group (30 animals for each group). Female Fischer344 rats were selected. Model group rats were subcutaneously embedded with 10 mg estrogen sustained-release pump to induce a pituitary tumor model, and control group rats were subcutaneously embedded with a normal saline sustained-release pump as control. The operation group was successfully treated by microsurgery after the model was established. The quantitative expressions of PTTG, FGF-2 and VEGF were detected by Western blot. Morris test was used to detect the spatial learning and memory ability of rats. Western blot results showed that compared with the model group, the expression of the operation group was decreased, but still higher than that of the control group (p < 0.05). The water maze test results showed that the incubation period of searching the safe island in the model group was significantly longer than that in the control group on the 8th and 9th day after the injury, and the difference was statistically significant (p < 0.05). The incubation period of searching the safe island on the 8th and 9th day after injury in the operation group was significantly shorter than that in the control group. Through the detection of behavioral-related experimental and protein, the motor memory of rats after pituitary tumor surgery can be improved to some extent.

Automated summary

This study investigated the changes in motor and cognitive function of pituitary tumor rats after surgery. The experiment involved three groups: control, model, and operation (with 30 animals in each group). Results showed that the expression of PTTG, FGF-2, and VEGF in the operation group decreased compared to the model group, but was still higher than the control group. The water maze test demonstrated that the incubation period for searching the safe island was significantly shorter in the operation group compared to the control group on the 8th and 9th day after injury. Overall, this study suggests that motor memory in rats after pituitary tumor surgery can be improved to some extent.