Antioxidant and anticancer activities of nematocyst venom protein of five scyphozoan Chrysaora jellyfish's species from the coastal waters of Tamil Nadu, India

The present study aimed to investigate the antioxidant and antiproliferative activity of partially purified venom protein extracted from five different species of Chrysaora jellyfish. The extracted venom was subjected to total protein analysis and the molecular weight was determined. The venom protein of Chrysaora fuscescens among tested exhibits free radical scavenging activity of about 77.3 and 56.5% by DPPH and ABTS, respectively. In addition, the venom protein exhibited lipid peroxidase (77.66%) and nitric oxide (72.07%) inhibition properties. Furthermore, venom protein exhibits antiproliferative activity against cancer cell lines, MCF-7 and A549, in a dose-dependent manner after 48 h of treatment, with IC50 values 63.70 and 44.20 mu g/mL, respectively. Overall, this study demonstrates the antioxidant and antiproliferative potential of Chrysaora species venom protein and could be utilized in pharmacological industries.

Automated summary

The present study aimed to investigate the antioxidant and antiproliferative activity of partially purified venom protein extracted from five different species of Chrysaora jellyfish. The venom protein of Chrysaora fuscescens exhibited strong free radical scavenging activity and inhibition properties on lipid peroxidase and nitric oxide. Furthermore, the venom protein showed dose-dependent antiproliferative activity against cancer cell lines MCF-7 and A549. Overall, this study demonstrates the potential of Chrysaora species venom protein in pharmaceutical industries.