Biocompatible synthesis of magnesium oxide nanoparticles with effective antioxidant, antibacterial, and anti-inflammatory activities using Magnolia champaca extract

The current research happens green mediated obtaining of MgO nanoparticles via Magnolia champaca (L) plant root for analysis of its significant bio-clinical implementations. The green-mediated obtained magnesium oxide nanoparticles are confirmed through using XRD, FTIR, SEM, TEM, and UV-visible spectroscopy analysis. The green-associated M. champaca synthesized MgO nanoparticles revealed an absorption wavelength of 470 nm which is respective to MgO NPs. FTIR spectrum of the plant obtained MgO NPs showed strong spectrum at 2357, 2178, and 2015cm(-1) (methylene groups of proteins), 1611 cm(-1) (amide or carboxylate salt), 1393 cm(-1) (carboxylate salt as and adsorption of CO32- and CO2 in the surface of MgO-NPs.), 1059 cm(-1) (Mg-OH stretching), 647, and 577 cm(-1) (Mg-O). The shape morphology of plant-mediated MgO NPs was determined through SEM revealing irregular shape and a scale range of 100 nm. Total antioxidant activity, scavenging and DPPH activity of plant-mediated obtained MgO NPs, plant extract, and ascorbic acid are evaluated, and the obtained results show better antioxidant activity in MgO NPs. The higher zone of suppression has seemed on the plant-associated obtained MgO NPs (120 g/mL) towards B. subtilis MTCC 1133 (21 +/- 0.22 mm) and P. aeruginosa MTCC 2582 (23 +/- 0.30 mm). The plant-mediated obtained MgO NPs revealed higher antibacterial properties compared to the antibiotic drug which effectively lower the alterations for the formation of antibiotic resistance of bacterial samples. The plant-mediated and obtained MgO NPs was found to highest antioxidant properties when differentiate from ascorbic acid. Plant-mediated obtained MgO NPs give an effective method that might be safe and high-scale industrial formation showing the merits of eco-friendly and low economic and also useful for various biomedical implementations.

Automated summary

This research investigates the green-mediated synthesis of MgO nanoparticles using the root of Magnolia champaca (L) plant and analyzes its potential bio-clinical applications. The obtained nanoparticles are characterized using various techniques, including XRD, FTIR, SEM, TEM, and UV-visible spectroscopy analysis. The results reveal that the plant-mediated synthesis of MgO nanoparticles exhibits significant antioxidant and antibacterial properties, making them a promising candidate for biomedical applications.