4.5 Article

Potential inhibitory effect of fish, maize, and whey protein hydrolysates on advanced glycation end-products (AGEs)

Related references

Note: Only part of the references are listed.
Article Food Science & Technology

Inhibitory effect of Ginkgo biloba seeds peptides on methylglyoxal-induced glycations

Yejun Deng et al.

Summary: The aim of this study was to investigate the antiglycation activity and mechanism of two peptides identified from Ginkgo biloba seeds protein hydrolysates. Both peptides exhibited efficient antiglycation activity, but VVFPGCPE showed higher activity. VVFPGCPE exerted its effects by scavenging free radicals, chelating metal ions, and stabilizing protein structure. This study provides a theoretical basis for the development of VVFPGCPE as an effective antiglycation agent.

FOOD AND CHEMICAL TOXICOLOGY (2023)

Article Materials Science, Paper & Wood

Inhibitory effect of a Chinese quince seed peptide on protein glycation: A mechanism study

Yejun Deng et al.

Summary: A peptide called NYRRE extracted from Chinese quince seed protein hydrolysate was found to have anti-glycation activity and can effectively inhibit protein glycation induced by reducing sugars. It exhibited antioxidant activity, stabilized the structure of BSA, and interacted with glycation sites.

JOURNAL OF BIORESOURCES AND BIOPRODUCTS (2023)

Article Chemistry, Applied

Occurrence of dietary advanced glycation end-products in commercial cow, goat and soy protein based infant formulas

Yajing Xie et al.

Summary: This study aimed to evaluate the glycation degree in infant formula (IF) in relation to the ingredients of the formula. Results indicated that the protein source, protein composition, and amount and type of carbohydrates determine the level of protein glycation in IFs. The investigated soy-based formula had significantly higher concentrations of arginine and arginine-derived glycation end-products than cow-based and goat-based formulas. IF containing hydrolyzed proteins had higher glycation end-products concentrations than those containing intact proteins. Lactose-containing formula was more prone to glycation than those containing sucrose and maltodextrin. Data showed that the glycation degree in IF cannot be estimated by a single compound, but the complete picture of the glycation end-products should be considered.

FOOD CHEMISTRY (2023)

Review Chemistry, Applied

Mechanism of natural antioxidants regulating advanced glycosylation end products of Maillard reaction

Wei Jia et al.

Summary: This review discusses the potentially harmful substances produced by the Maillard reaction and the impact of advanced glycosylation end products (AGEs) on health. The inhibition mechanism of natural antioxidants on AGEs and their potential application in food processing are also explored.

FOOD CHEMISTRY (2023)

Review Chemistry, Applied

Influence mechanism of polysaccharides induced Maillard reaction on plant proteins structure and functional properties: A review

Chuxin Ke et al.

Summary: Plant proteins have high nutritional value, a wide range of sources, and low cost. The Maillard reaction induced by polysaccharides can improve the functionality of plant proteins and enhance their functional properties and biological activity.

CARBOHYDRATE POLYMERS (2023)

Review Biochemistry & Molecular Biology

A review on prevention of glycation of proteins: Potential therapeutic substances to mitigate the severity of diabetes complications

Sharat Sarmah et al.

Summary: Glycation of proteins plays a crucial role in the progression of various metabolic and pathophysiological mechanisms, and can be prevented through synthetic and natural inhibitors. Synthetic inhibitors can suppress protein glycation through multiple pathways, while naturally occurring plant products are non-toxic, cost-effective, and ingestible. This review provides an overview of the Maillard reaction, the formation and characterization of AGEs, potential therapeutic approaches against glycation, and the mechanisms of natural and synthetic inhibitors.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Article Chemistry, Applied

The antioxidant and antiglycation activities of selected spices and other edible plant materials and their decay in sugar-protein systems under thermal stress

Leonardo Cristian Favre et al.

Summary: The antiglycation activities of herbs and spices were analyzed in sugar-protein systems, showing that the extracts of allspice, thyme, green pepper, and black pepper were the most effective inhibitors. These activities were related to polyphenols content, radical scavenging, and iron-reducing power. However, the antioxidant activity decreased over time due to the depletion of polyphenols.

FOOD CHEMISTRY (2022)

Article Food Science & Technology

Comparative study of antioxidant and flavour characteristics of Maillard reaction products from five types of protein hydrolysates

Ildephonse Habinshuti et al.

Summary: This study compared the antioxidant, structural, and flavor characteristics of Maillard reaction products (MRPs) prepared from different hydrolysates of plant proteins. The results showed that MRPs prepared from whey protein isolate exhibited the highest progress of Maillard reaction, highest oxygen radical absorbance capacity, and strongest umami taste. Compared to MRPs prepared from whey protein isolate, MRPs derived from sweet potato protein had fewer harmful compounds.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2022)

Article Food Science & Technology

Inhibitory Mechanism of Advanced Glycation End-Product Formation by Avenanthramides Derived from Oats through Scavenging the Intermediates

Pei Zhu et al.

Summary: As a special polyphenolic compound in oats, oat avenanthramides (AVAs) have diverse biological activities, including inhibiting the formation of advanced glycation end-products (AGEs) and suppressing the generation of reactive oxygen species. Among AVAs, AVA 2f was found to be more efficient than AVA 2p in inhibiting the generation of superoxide anion radical, hydroxyl radical, and singlet oxygen. These findings suggest the potential application of AVAs from oats in inhibiting food-borne AGEs formed during food processing.

FOODS (2022)

Article Food Science & Technology

Antioxidant, antihypertensive and antidiabetic potential of peptidic fractions obtained from tarwi (Lupinus mutabilis) protein hydrolysate and identification of promising multifunctional bioactive peptides

Rosana Chirinos et al.

Summary: Tarwi, an Andean grain, has high protein content and its protein hydrolysate (TPH) obtained through enzymatic hydrolysis showed important multifunctional properties in coping with oxidative stress, hypertension, and diabetes. The active fraction of TPH, containing low-molecular weight peptides, demonstrated antioxidant, antihypertensive, and antidiabetic properties. Four novel peptides in this fraction showed high bioactivity scores and potential for applications.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2022)

Article Biochemistry & Molecular Biology

Antioxidant and Antiglycation Effects of Polyphenol Compounds Extracted from Hazelnut Skin on Advanced Glycation End-Products (AGEs) Formation

Ludovica Spagnuolo et al.

Summary: The study investigated the inhibitory effect of polyphenol compounds extracted from hazelnut skin on AGEs, demonstrating a concentration-dependent inhibition on the BSA-AGEs model. The phenolic compounds in hazelnut skin possess antioxidant properties, potentially hindering the formation of AGEs and suggesting a new strategy for supporting therapeutic approaches in chronic diseases.

ANTIOXIDANTS (2021)

Article Chemistry, Medicinal

Small-Molecule Inhibitors of Reactive Oxygen Species Production

Elisa Sassetti et al.

Summary: Reactive oxygen species (ROS) play vital roles in physiological cellular processes, and maintaining appropriate levels of cellular ROS is important for redox homeostasis. Directly targeting the sources of ROS production has become a key focus in research due to the potential link between high ROS concentrations and severe diseases.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Food Science & Technology

Influence of fish protein hydrolysate-pistachio green hull extract interactions on antioxidant activity and inhibition of α-glucosidase, α-amylase, and DPP-IV enzymes

Roghayeh Amini Sarteshnizi et al.

Summary: This study found that adding pistachio green hull extract can enhance the antioxidant activity of Sind sardine hydrolysates under various protease types and fractionation conditions, with papain leading to the highest degree of hydrolysis and antioxidant activity. However, the addition of pistachio green hull extract had negative effects on enzyme inhibition, especially in terms of alpha-glucosidase and alpha-amylase inhibition.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

Review Medicine, Research & Experimental

Novel advances in inhibiting advanced glycation end product formation using natural compounds

Qinghe Song et al.

Summary: This paper discusses the formation, classification, and effects of AGEs on human health, with a focus on natural compounds as inhibitors of AGE formation. Major classes of natural inhibitors, including polyphenols, polysaccharides, terpenoids, vitamins, and alkaloids, have been described, with mechanisms of action ranging from scavenging free radicals to lowering blood glucose levels. These natural compounds, despite not being widely used clinically due to their low content levels, will be valuable in inspiring drug discovery.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Chemistry, Physical

Synthesis and characterization of novel piroxicam derivatives and their antiglycation activity

Safi Ullah et al.

Summary: A series of sulfonated esters of piroxicam were synthesized by replacing the hydroxyl OH group of piroxicam with different alkyl/aryl sulfonyl chloride. These derivatives were then analyzed for antiglycation activity, with compound 2 showing the most potent effect compared to the reference compound rutin. The presence of electron withdrawing groups was found to have a negative impact on the inhibition potential of different analogues, depending on the number and positions of the substituents.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Food Science & Technology

Non-nutritive sweeteners are in concomitant with the formation of endogenous and exogenous advanced glycation end-products

Permal Deo et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2020)

Article Biochemical Research Methods

Anti-glycation effect and the α-amylase, lipase, and α-glycosidase inhibition properties of a polyphenolic fraction derived from citrus wastes

Annayara C. F. Fernandes et al.

PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY (2020)

Article Chemistry, Applied

Spray-dried olive mill wastewater reduces Maillard reaction in cookies model system

Antonio Dario Troise et al.

FOOD CHEMISTRY (2020)

Article Agriculture, Multidisciplinary

Green Tea Extract Decreases Arg-Derived Advanced Glycation Endproducts but Not Lys-Derived AGEs in UHT Milk during 1-Year Storage

Mahesha M. Poojary et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

Article Endocrinology & Metabolism

Action of metformin therapy against advanced glycation, oxidative stress and inflammation in type 2 diabetes patients: 3 months follow-up study

Krishna A. Adeshara et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

Review Biochemistry & Molecular Biology

In vitro and in vivo inhibition of maillard reaction products using amino acids, modified proteins, vitamins, and genistein: A review

Md. Anisur Rahman Mazumder et al.

JOURNAL OF FOOD BIOCHEMISTRY (2019)

Editorial Material Nutrition & Dietetics

Use of Grape Pomace Phenolics to Counteract Endogenous and Exogenous Formation of Advanced Glycation End-Products

Pedapati S. C. Sri Harsha et al.

NUTRIENTS (2019)

Article Biochemistry & Molecular Biology

Protein hydrolysate from salmon frames: Production, characteristics and antioxidative activity

Anthony Temitope Idowu et al.

JOURNAL OF FOOD BIOCHEMISTRY (2019)

Article Multidisciplinary Sciences

Drug repurposing: In-vitro anti-glycation properties of 18 common drugs

Saima Rasheed et al.

PLOS ONE (2018)

Article Pharmacology & Pharmacy

In vitro Antiglycation, Antioxidant and Antiproliferative Properties of Peptides Derived from Tryptic Hydrolysis of Soya Bean

Abudukadeer Kuerban et al.

BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH (2017)

Article Agriculture, Multidisciplinary

Optimisation of antioxidant peptide preparation from corn gluten meal

Hong Zhuang et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2013)

Article Food Science & Technology

Antioxidant, anti-microbial and antimutagenicity activities of pistachio (Pistachia vera) green hull extract

Ahmad Rajaei et al.

FOOD AND CHEMICAL TOXICOLOGY (2010)