Recombinant Antimicrobial Peptide OaBac5mini Alleviates Inflammation in Pullorum Disease Chicks by Modulating TLR4/MyD88/NF-?B Pathway

Article Fisheries

TLR4 involved in immune response against Vibrio Parahaemolyticus by MyD88-dependent pathway in Crassostrea hongkongensis

Feifei Yu et al.

Summary: In this study, a new TLR4 gene was identified from the Crassostrea hongkongensis (C. hongkongensis). The ChTLR4 played a crucial role in the innate immune response against V. parahaemolyticus.

FISH & SHELLFISH IMMUNOLOGY (2023)

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Article Cell Biology

Simultaneous control of infection and inflammation with keratin-derived antibacterial peptides targeting TLRs and co-receptors

Yan Sun et al.

Summary: A study showed that keratin 6a-derived antimicrobial peptides (KAMPs) can effectively suppress bacterial infection and inflammation simultaneously, indicating their potential as a multifunctional drug for managing infectious inflammatory diseases.

SCIENCE TRANSLATIONAL MEDICINE (2023)

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Article Veterinary Sciences

Characteristics of antimicrobial peptide OaBac5mini and its bactericidal mechanism against Escherichia coli

Shanshan Shen et al.

Summary: This study demonstrated that OaBac5mini is a stable and potent PrAMP that kills E. coli by inhibiting intracellular targets and damaging the cell membrane.

FRONTIERS IN VETERINARY SCIENCE (2023)

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Article Biology

Salmonella Phage CKT1 Effectively Controls the Vertical Transmission of Salmonella Pullorum in Adult Broiler Breeders

Ketong Cui et al.

Summary: This study evaluated the effect of phage CKT1 on controlling the vertical transmission of Salmonella Pullorum and found that CKT1 could effectively reduce the colonization level of Salmonella in adult chickens, as well as decrease the bacterial load in eggshells and liquid whole eggs, thus decreasing the probability of vertical transmission.

BIOLOGY-BASEL (2023)

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Review Immunology

Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity

Tianhao Duan et al.

Summary: This article provides a detailed overview of the innate immune system's defense mechanisms against pathogens, with a focus on the role of Toll-like receptors (TLRs) in immune responses. TLRs not only link innate immunity to adaptive immunity, but also directly regulate the function of T cells. In addition, the article discusses the critical role of TLR signaling in host defense against infectious diseases, autoimmune diseases, and cancer.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Designing a Novel Functional Peptide With Dual Antimicrobial and Anti-inflammatory Activities via in Silico Methods

Min Kyoung Shin et al.

Summary: This study presents a new approach to develop therapeutic agents with antimicrobial and anti-inflammatory properties by designing functional peptides based on biological resources.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Veterinary Sciences

Seroprevalence of pullorum disease in chicken across mainland China from 1982 to 2020: A systematic review and meta-analysis

Qingbo Lv et al.

Summary: Pullorum disease (PD), caused by Salmonella pullorum, severely threatens chicken health worldwide, especially in China. The overall seroprevalence of PD in chicken flocks in mainland China is 18.2%, with high prevalence in autumn. Chickens older than 120 days have a significantly higher positive rate of PD than younger chickens. Rearing mode is a risk factor, with caged chickens having lower seroprevalence than free-range chickens.

RESEARCH IN VETERINARY SCIENCE (2022)

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Article Immunology

Aeromonas veronii infection remarkably increases expression of lysozymes in grass carp (Ctenopharyngodon idellus) and injection of lysozyme expression cassette along with QCDC adjuvant significantly upregulates immune factors and decreases cumulative mortality

Pei Chen et al.

Summary: This study found that the recombinant proteins rLys-g and rLys-c showed significant antibacterial activity against the pathogenic bacterium AvX005 in grass carp. Injection of pcDNA3.1-lys-g and pcDNA-lys-c increased the survival rate of grass carp infected with AvX005. The activity of lysozyme and alkaline phosphatase in the serum of grass carp was increased, and the expression of immune factors in the kidney was upregulated. These findings suggest that pcDNA3.1-lys-g and pcDNA-lys-c can be used as immunostimulants to protect grass carp from AvX005.

MICROBIAL PATHOGENESIS (2022)

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Article Pharmacology & Pharmacy

Antimicrobial Proteins: Structure, Molecular Action, and Therapeutic Potential

Mohamed Hassan et al.

Pharmaceutics (2022)

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Article Multidisciplinary Sciences

A global dataset for prevalence of Salmonella Gallinarum between 1945 and 2021

Xiao Zhou et al.

Summary: This study presents a systematic review and meta-analysis of the global prevalence of Salmonella Gallinarum, which causes pullorum disease and fowl typhoid. The study found that pullorum disease is most common in Asia, especially in eastern China, and identified significant differences in the prevalence of S. Gallinarum based on factors such as gender, breed, raising mode, economic use, and growth stage of the chickens. Vertical transmission plays a critical role in the spread of this disease.

SCIENTIFIC DATA (2022)

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Article Biochemistry & Molecular Biology

Lipopolysaccharide from Porphyromonas gingivalis, but Not from Porphyromonas endodontalis, Induces Macrophage M1 Profile

Pablo Veloso et al.

Summary: The study found that Pg LPS can induce a macrophage M1 phenotype (pro-inflammatory) while Pe LPS does not elicit a significant response. Additionally, the expressions of TLR2 and TLR4 were not modified by Pg or Pe LPS.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Immunology

Contribution of prgH gene for Salmonella Pullorum to virulence and the expression of NLRP3, Caspase-1 and IL-1β in chickens

Junlei Yin et al.

Summary: This study reveals that the prgH gene promotes the virulence of Salmonella Pullorum and the expression of NLRP3, Caspase-1, and IL-1β in chickens.

MICROBIAL PATHOGENESIS (2022)

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Article Multidisciplinary Sciences

Expression strategies for the efficient synthesis of antimicrobial peptides in plastids

Matthijs P. Hoelscher et al.

Summary: This study explores the potential of using chloroplasts in plants to synthesize antimicrobial peptides (AMPs). By utilizing inducible expression and fusions to the cleavable carrier protein SUMO, the cytotoxic effects of AMPs are alleviated and plants with wildtype-like phenotypes are obtained. Furthermore, purified AMP fusion proteins display antimicrobial activity independently of proteolytic removal of the carrier protein.

NATURE COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

Chrysosplenol D protects mice against LPS-induced acute lung injury by inhibiting oxidative stress, inflammation, and apoptosis via TLR4-MAPKs/NF-kappa B signaling pathways

Qinqin Zhang et al.

Summary: The study investigated the effects and mechanisms of chrysosplenol D (CD) on LPS-induced acute lung injury in mice. CD was found to improve lung injury, decrease levels of inflammation, oxidative stress, and cell apoptosis, as well as regulate the immune system. CD protected mice against acute lung injury induced by LPS through inhibiting oxidative stress, inflammation, and apoptosis via the TLR4-MAPKs/NF-kappa B signaling pathways.

INNATE IMMUNITY (2021)

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Review Microbiology

Revisiting Persistent Salmonella Infection and the Carrier State: What Do We Know?

Neil Foster et al.

Summary: Persistent infection of Salmonella enterica serovars can occur for months or years post-convalescence, despite high levels of specific IgG. The bacteria may modulate host response and transform macrophages to maintain infection. Remodulation of the response back to a Th1 type may be possible with cytokine therapy.

PATHOGENS (2021)

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Review Nutrition & Dietetics

Antimicrobial Peptides in Gut Health: A Review

Tao Gong et al.

Summary: Animal antimicrobial peptides (AMPs) are important effector molecules in the innate immune system, showing broad-spectrum antibacterial activity and diverse immune-regulatory functions. While research on their application is incomplete, understanding their classification, biological functions, and mechanisms of action provides important insights for their potential use.

FRONTIERS IN NUTRITION (2021)

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Review Infectious Diseases

Pollution by Antibiotics and Antimicrobial Resistance in LiveStock and Poultry Manure in China, and Countermeasures

Ming Tian et al.

Summary: The demand for animal protein has increased worldwide, especially in China where large numbers of livestock and poultry are produced. Overuse of antibiotics in animal feed has caused serious environmental and health risks, particularly antimicrobial resistance. International cooperation and Chinese regulations restricting antibiotic usage are crucial for addressing these issues.

ANTIBIOTICS-BASEL (2021)

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Article Oncology

Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target

Xuan Xu et al.

Summary: The study demonstrates that phosphorylation of NF-kappa Bp65 plays a crucial role in the hepatocellular carcinogenesis mediated by ARRB1, and inhibiting the phosphorylation of NF-kappa Bp65 can restrain the development of hepatocellular carcinoma. The findings suggest that phosphorylation of NF-kappa Bp65 could be a potential therapeutic target for HCC.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Review Chemistry, Multidisciplinary

The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions

Bee Ha Gan et al.

Summary: Bacterial infections caused by 'superbugs' are on the rise globally, with traditional antibiotics becoming less effective, posing a risk of entering a post-antibiotic era. Antimicrobial peptides (AMPs) have garnered attention for their clinical potential as a new class of antibiotics to combat antimicrobial resistance. This review discusses various aspects of AMPs, including their physicochemical properties, mechanisms of action, and chemical synthesis strategies for developing novel AMPs.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Microbiology