Estimation of a Within-Herd Transmission Rate for African Swine Fever in Vietnam

Simple Summary We describe results from a panel study in which pigs from a 17-sow African swine fever (ASF) positive herd in Thai Binh province, Vietnam, were followed over time to record the date of onset of ASF signs and the date of death from ASF. Our objectives were to (1) fit a susceptible-exposed-infectious-removed disease model to the data with transmission coefficients estimated using approximate Bayesian computation; (2) provide commentary on how a model of this type might be used to provide decision support for disease control authorities. Detailed datasets of epidemics afflicting smallholder herds are rare. This study provides insight into how ASF progresses in a small-scale semi-intensive pig herd in Vietnam and generated a dataset that facilitated the use of a modeling approach to describe the transmission dynamics in this frequently underreported sector. We describe results from a panel study in which pigs from a 17-sow African swine fever (ASF) positive herd in Thai Binh province, Vietnam, were followed over time to record the date of onset of ASF signs and the date of death from ASF. Our objectives were to (1) fit a susceptible-exposed-infectious-removed disease model to the data with transmission coefficients estimated using approximate Bayesian computation; (2) provide commentary on how a model of this type might be used to provide decision support for disease control authorities. For the outbreak in this herd, the median of the average latent period was 10 days (95% HPD (highest posterior density interval): 2 to 19 days), and the median of the average duration of infectiousness was 3 days (95% HPD: 2 to 4 days). The estimated median for the transmission coefficient was 3.3 (95% HPD: 0.4 to 8.9) infectious contacts per ASF-infectious pig per day. The estimated median for the basic reproductive number, R-0, was 10 (95% HPD: 1.1 to 30). Our estimates of the basic reproductive number R-0 were greater than estimates of R-0 for ASF reported previously. The results presented in this study may be used to estimate the number of pigs expected to be showing clinical signs at a given number of days following an estimated incursion date. This will allow sample size calculations, with or without adjustment to account for less than perfect sensitivity of clinical examination, to be used to determine the appropriate number of pigs to examine to detect at least one with the disease. A second use of the results of this study would be to inform the equation-based within-herd spread components of stochastic agent-based and hybrid simulation models of ASF.

Automated summary

This study describes the results of a panel study on an ASF-positive pig herd in Thai Binh province, Vietnam, tracking the onset and death dates of ASF in the pigs. The study aimed to fit a disease model and estimate transmission coefficients, and provide commentary on its use in decision support for disease control authorities. The study provides insight into ASF transmission dynamics in small-scale pig herds and generates data for modeling approaches in this underreported sector.