Small bowel adenocarcinoma in neoterminal ileum in setting of stricturing Crohn's disease: A case report and review of literature

Review Gastroenterology & Hepatology

Small bowel adenocarcinoma in Crohn's disease: a systematic review and meta-analysis of the prevalence, manifestation, histopathology, and outcomes

Yip Han Chin et al.

Summary: The research identified a prevalence rate of 1.15 per 1000 CD patients for CD-SBA, with a poor 5-year overall survival rate. Diagnosis of CD-SBA requires a high index of suspicion due to non-specific presenting symptoms.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2022)

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Article Oncology

Inflammatory bowel disease and risk of adenocarcinoma and neuroendocrine tumors in the small bowel

J. Yu et al.

Summary: This population-based cohort study found that patients with inflammatory bowel disease (IBD) have a higher risk of small bowel adenocarcinoma and neuroendocrine tumors. Specifically, patients with Crohn's disease (CD) had an eightfold increased risk of small bowel adenocarcinoma, patients with both UC and CD had about a twofold increased risk of neuroendocrine tumors, and patients with UC had a twofold increased risk of small bowel adenocarcinoma. However, due to the small absolute excess cancer risk, active surveillance to diagnose small intestinal cancer early may not be cost-effective.

ANNALS OF ONCOLOGY (2022)

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Review Oncology

Liquid biopsies to monitor and direct cancer treatment in colorectal cancer

Gianluca Mauri et al.

Summary: Colorectal cancer is a prevalent and deadly cancer, and there is a clinical need for better patient selection for systemic treatments. Genotyping circulating tumour DNA is a potential method to personalize treatment and overcome limitations of traditional biopsy approaches. This review summarizes the evidence of ctDNA applicability in colorectal cancer and discusses ongoing clinical trials.

BRITISH JOURNAL OF CANCER (2022)

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Review Oncology

Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer

Afsheen Raza et al.

Summary: Colorectal cancer (CRC) is a common cancer worldwide. Liquid biopsy has gained significant attention in CRC due to its advantages over tissue biopsy and its approval for comprehensive screening, diagnosis, and prognosis of CRC. Various liquid biopsy biomarkers are being researched, including components of the microbiome, non-coding RNAs, extracellular vesicles, and circulating tumor DNA.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

Hui Zhou et al.

Summary: Colorectal cancer is one of the most common cancers worldwide and a leading cause of carcinogenic death. Surgical resection is considered the gold standard for clinical decisions. However, conventional tissue biopsy has limitations and there is a need for new minimally invasive or noninvasive diagnostic strategies. Liquid biopsy, which allows repeated analysis of blood samples, has gained attention as a new diagnostic concept for monitoring tumor recurrence, metastasis, and therapeutic responses.

MOLECULAR CANCER (2022)

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Article Oncology

Molecular Landscape of Small Bowel Adenocarcinoma

Karan Pandya et al.

Summary: Small bowel adenocarcinoma (SBA) is a rare malignancy with poor prognosis. Over 90% of SBA tumors have targetable genetic alterations. Molecular analysis is critical for identifying these alterations and guiding treatment decisions. SBA is a molecularly unique intestinal cancer, with distinct genomic alterations predictive of response to targeted therapy and immunotherapy.

CANCERS (2022)

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Review Oncology

Liquid biopsies for colorectal cancer: a narrative review of ongoing clinical trials and the current use of this technology at a comprehensive cancer center

Sacha P. Broccard et al.

Summary: The use of liquid biopsies for colorectal cancer is actively being investigated in clinical trials and requires close attention. The Mayo Clinic Enterprise currently uses LB in non-interventional, interventional, and surveillance settings, but not for screening. Results from these trials may help establish the use of LB in the management of colorectal cancer.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2022)

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Article Oncology

Crohn's disease with infliximab treatment complicated by rapidly progressing colorectal cancer: A case report

Lin Xiao et al.

Summary: This case report highlights the importance of considering the possibility of malignancy in CD patients treated with infliximab. A 40-year-old male with a 6-year history of CD developed rapidly progressive colorectal cancer after receiving infliximab therapy, ultimately leading to his death in June 2020. This emphasizes the need for further research on the safety and potential risks associated with infliximab treatment for CD patients.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

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Article Oncology

Role of Phenotypes of Circulating Tumor Cells in the Diagnosis and Treatment of Colorectal Cancer

Yuchen Zhong et al.

Summary: The positive rate of M-CTCs is closely related to tumor size, T stage, TNM stage, pathological characteristics, and CEA level. As the disease progresses, the proportion of M-CTCs gradually increases, and patients with a high positive rate of M-CTCs exhibit worse survival outcomes.

CANCER MANAGEMENT AND RESEARCH (2021)

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Article Surgery

Minimally invasive surgery with adenocarcinoma of jejunum diagnosed pathologically before surgery: A case report

Sung Chul Lee

Summary: The article presents a rare case of jejunal adenocarcinoma diagnosed histologically before surgery. The patient underwent small bowel resection and standard laparoscopic surgery without complications. Further treatment is underway for the patient confirmed in the high-risk stage 2 group.

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS (2021)

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Article Gastroenterology & Hepatology