Journal
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
Volume 15, Issue 4, Pages 632-643Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4251/wjgo.v15.i4.632
Keywords
Circulating tumor cell; Pancreatic cancer; Portal vein; Outcomes; Prognosis; Survival
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Despite advancements in PC diagnosis and treatment, clinical outcomes remain poor and there is a lack of effective prognostic biomarkers. CTCs, a promising biomarker, are rare in peripheral blood, but portal blood may offer better detection rates. Portal CTC counts are associated with hepatic metastasis, recurrence, and survival, providing information on tumor heterogeneity and prognosis. However, more prospective studies are needed to validate portal CTCs as a biomarker in PC.
Despite recent improvements in the diagnosis and treatment of pancreatic cancer (PC), clinical outcomes remain dismal. Moreover, there are no effective prognostic or predictive biomarkers or options beyond carbohydrate antigen 19-9 for personalized and precise treatment. Circulating tumor cells (CTCs), as a member of the liquid biopsy family, could be a promising biomarker; however, the rarity of CTCs in peripheral venous blood limits their clinical use. Because the first venous drainage of PC is portal circulation, the portal vein can be a more suitable location for the detection of CTCs. Endoscopic ultrasound-guided portal venous sampling of CTCs is both feasible and safe. Several studies have suggested that the detection rate and number of CTCs may be higher in the portal blood than in the peripheral blood. CTC counts in the portal blood are highly associated with hepatic metastasis, recurrence after surgery, and survival. The phenotypic and genotypic properties measured in the captured portal CTCs can help us to understand tumor heterogeneity and predict the prognosis of PC. Small sample sizes and heterogeneous CTC detection methods limit the studies to date. Therefore, a large number of prospective studies are needed to corroborate portal CTCs as a valid biomarker in PC.
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