Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 10, Issue 4, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofad117
Keywords
Fournier's gangrene; necrotizing fasciitis; necrotizing soft tissue infection
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This study retrospectively analyzed the effect of early surgery combined with empiric antimicrobials on mortality in necrotizing soft tissue infections (NSTIs). The results showed that early surgery independently reduced 30-day mortality, and the choice of empiric antimicrobials did not further enhance this effect.
Necrotizing soft tissue infections (NSTIs) are associated with high morbidity and mortality. We retrospectively examined the impact of empiric antimicrobials coupled with early surgery on mortality in NSTI. Early surgery independently reduced 30-day mortality (odds ratio, .16; 95% confidence interval, .05-.51; P < .001) that was not further augmented by empiric antimicrobial choice.
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