4.7 Article

Chitosan-Based Nanoparticles for Targeted Nasal Galantamine Delivery as a Promising Tool in Alzheimer's Disease Therapy

Related references

Note: Only part of the references are listed.
Review Multidisciplinary Sciences

Drug release study of the chitosan-based nanoparticles

Yedi Herdiana et al.

Summary: This article summarizes the relationship between modification in chitosan-based drug nanoparticles (CSNPs) as multifunctional delivery systems and drug release properties and kinetics. The study found that almost all CSNPs show biphasic release, with an initial burst release followed by controlled release as expected.

HELIYON (2022)

Review Biochemistry & Molecular Biology

Chitosan Nanoparticles-Insight into Properties, Functionalization and Applications in Drug Delivery and Theranostics

Jhanvi Jhaveri et al.

Summary: The development of nanotechnology-based drug delivery systems has significant implications for drug formulation research, allowing for improved administration of new and complex drugs. Chitosan, a polysaccharide widely used in nano drug delivery systems, plays a crucial role in enhancing drug delivery and reducing side effects across various disease categories. Recent advancements in functionalized chitosan have shown promise in areas such as anticancer therapeutics, cancer immunotherapy, and multistage delivery systems.

MOLECULES (2021)

Article Pharmacology & Pharmacy

Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury

Hua Jin et al.

Summary: The study developed chitosan nanoparticles loaded with hesperidin (HPD/NPs) for nasal delivery of the anti-inflammatory HPD compound to inflammatory lungs. In vitro and in vivo, HPD/NPs showed enhanced cellular uptake in the inflammatory microenvironment compared to free HPD. In a mouse model of inflammatory lung disease, HPD/NPs significantly inhibited lung injury by reducing inflammatory cytokine levels and suppressing vascular permeability.

FRONTIERS IN PHARMACOLOGY (2021)

Review Polymer Science

Chitosan: An Overview of Its Properties and Applications

Inmaculada Aranaz et al.

Summary: Chitosan, a polymer with diverse properties and potential applications, is facing challenges such as poor solubility, complex molecular structure, and varied biological properties. Researchers are exploring the chemistry of chitosan to improve its solubility and enhance its properties, focusing on its biological and technological performance. Additionally, applications of chitosan in green processes, such as the synthesis of metallic nanoparticles and support for biocatalysts, are being investigated for their potential in drug delivery systems.

POLYMERS (2021)

Article Biochemical Research Methods

LC-MS bioanalysis of targeted nasal galantamine bound chitosan nanoparticles in rats' brain homogenate and plasma

Mahmoud Agami et al.

Summary: A validated LC-MS method was developed for the direct quantitative analysis of galantamine in rat cerebrospinal fluid, brain homogenate, and plasma samples. The method showed good linearity, trueness, precision, and recoveries, meeting FDA guidelines.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Intranasal galantamine/chitosan complex nanoparticles elicit neuroprotection potentials in rat brains via antioxidant effect

Lamia Said Kandil et al.

Summary: This study aimed to investigate whether the long-term administration of CX-NP2 leads to biochemical toxicity in rat brains compared to GH nasal solution. The results showed that after 30 days of treatment, CX-NP2 did not induce a statistically significant oxidative stress or neuroinflammation in rat brains, but rather elicited neuroprotective potentials.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2021)

Review Biotechnology & Applied Microbiology

Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System

Doddy Denise Ojeda-Hernandez et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Review Biochemistry & Molecular Biology

Use of Biodegradable, Chitosan-Based Nanoparticles in the Treatment of Alzheimer's Disease

Eniko Manek et al.

MOLECULES (2020)

Review Pharmacology & Pharmacy

Potential of Chitosan and its derivatives for controlled drug release applications - A review

Rizwan Safdar et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

Article Pharmacology & Pharmacy

Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain

Shanshan Liu et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Review Pharmacology & Pharmacy

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

Munawar A. Mohammed et al.

PHARMACEUTICS (2017)

Proceedings Paper Materials Science, Textiles

Biopolymers in Medical Implants: A Brief Review

Rita Rebelo et al.

3RD INTERNATIONAL CONFERENCE ON NATURAL FIBERS: ADVANCED MATERIALS FOR A GREENER WORLD, ICNF 2017 (2017)

Article Pharmacology & Pharmacy

Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity

D. Bento et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

Review Biochemistry & Molecular Biology

Chitosan as a suitable nanocarrier material for anti-Alzheimer drug delivery

Jayrajsinh Sarvaiya et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

Review Chemistry, Medicinal

Stability of Chitosan-A Challenge for Pharmaceutical and Biomedical Applications

Emilia Szymanska et al.

MARINE DRUGS (2015)

Article Chemistry, Medicinal

Effect of moisture content, temperature and exposure time on the physical stability of chitosan powder and tablets

Joe M. Viljoen et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2014)

Article Materials Science, Biomaterials

Development of Chitosan Nanoparticles as a Stable Drug Delivery System for Protein/siRNA

Haliza Katas et al.

INTERNATIONAL JOURNAL OF BIOMATERIALS (2013)

Review Pharmacology & Pharmacy

Intranasal delivery of biologics to the central nervous system

Jeffrey J. Lochhead et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Article Medicine, Research & Experimental

Insight on the Formation of Chitosan Nanoparticles through Ionotropic Gelation with Tripolyphosphate

Emmanuel N. Koukaras et al.

MOLECULAR PHARMACEUTICS (2012)

Review Pharmacology & Pharmacy

Current perspectives on pharmacotherapy of Alzheimer's disease

Kanwaljit Chopra et al.

EXPERT OPINION ON PHARMACOTHERAPY (2011)

Review Materials Science, Multidisciplinary

Chitosan composites for biomedical applications: status, challenges and perspectives

S. Hein et al.

MATERIALS SCIENCE AND TECHNOLOGY (2008)

Review Pharmacology & Pharmacy

The basics and underlying mechanisms of mucoadhesion

JD Smart

ADVANCED DRUG DELIVERY REVIEWS (2005)

Review Chemistry, Multidisciplinary

Chitosan chemistry and pharmaceutical perspectives

MNVR Kumar et al.

CHEMICAL REVIEWS (2004)

Review Pharmacology & Pharmacy

Galantamine - A review of its use in Alzheimer's disease

LJ Scott et al.

DRUGS (2000)