☆ 4.7 Review

Exploring the Contribution of Curcumin to Cancer Therapy: A Systematic Review of Randomized Controlled Trials

PHARMACEUTICS (2023)

Related references

Note: Only part of the references are listed.

Review Biochemistry & Molecular Biology

A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health

Siyu Liu et al.

Summary: Curcumin, as the most important active component in turmeric extracts, exhibits various beneficial pharmacological activities such as anti-inflammation, antioxidation, antitumor, and immune regulation. It shows therapeutic potential in neurodegenerative, cardiovascular, and cerebrovascular diseases. However, the clinical transformation of curcumin is challenging due to its low solubility, poor bioavailability, and controversies regarding its purity and effectiveness.

MOLECULES (2022)

Add to Collection

Review Nutrition & Dietetics

Curcuminoids for Metabolic Syndrome: Meta-Analysis Evidences Toward Personalized Prevention and Treatment Management

Agustina Dwi Retno Nurcahyanti et al.

Summary: Metabolic syndrome (MS) is a multifactorial syndrome associated with economic burden and healthcare costs, requiring multiple drug treatments that may have interactions and side effects. Therefore, developing new safe and effective drugs for MS is necessary.

FRONTIERS IN NUTRITION (2022)

Add to Collection

Review Medicine, Research & Experimental

An examination of the protective effects and molecular mechanisms of curcumin, a polyphenol curcuminoid in diabetic nephropathy

Xiaoyu Zhu et al.

Summary: Diabetic nephropathy is a leading cause of end-stage renal disease, causing significant burden on patients and society. Curcumin, a polyphenol curcuminoid, has been shown to have anti-inflammatory, antioxidative, anti-apoptotic, and anti-fibrosis properties, which are beneficial for diabetic nephropathy. Understanding the pharmacological effects of curcumin on diabetic nephropathy may lead to the development of new therapies.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Review Plant Sciences

The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

Maria Vranceanu et al.

Summary: Current studies suggest that diet plays a significant role in cancer-related deaths, with about one-third of deaths being preventable through balanced nutrition. Nutraceuticals derived from plants, such as curcumin and resveratrol, have been shown to have positive effects on gene expression and can reduce the incidence of cancer. These compounds can modulate epigenetic changes and have antioxidant and anticarcinogenic properties. The review also discusses the issue of low bioavailability of nutraceuticals and suggests ways to overcome it for effective oral administration. Understanding the mechanisms by which nutraceuticals influence gene expression could lead to the development of an epigenetic diet for cancer therapy.

PLANTS-BASEL (2022)

Add to Collection

Review Plant Sciences

The Synergistic Effects of Curcumin and Chemotherapeutic Drugs in Inhibiting Metastatic, Invasive and Proliferative Pathways

Maria Younes et al.

Summary: Curcumin, a phytochemical found in Curcuma longa L., has shown promising effects in the treatment of various cancers. This review focuses on the molecular mechanism of curcumin in combination with therapeutic drugs and light radiation in inhibiting metastasis, invasion, and proliferation. The findings suggest that the combination therapy with different drugs and light radiation can ameliorate metastatic pathways in various types of cancer, but further research is needed to understand the underlying causes.

PLANTS-BASEL (2022)

Add to Collection

Article Oncology

Multicenter randomized phase II study comparing docetaxel plus curcumin versus docetaxel plus placebo in first-line treatment of metastatic castration-resistant prostate cancer

Judith Passildas-Jahanmohan et al.

Summary: Despite good compliance and verified absorption of curcumin, the study showed no significant difference in progression-free survival between the curcumin and placebo groups, as well as in the secondary endpoints such as PSA response rate, overall survival, and quality of life. Consequently, the study was discontinued due to lack of efficacy.

CANCER MEDICINE (2021)

Add to Collection

Review Biochemistry & Molecular Biology

A State of the Art of Antioxidant Properties of Curcuminoids in Neurodegenerative Diseases

Serena Silvestro et al.

Summary: Neurodegenerative diseases are characterized by irreversible loss of neuronal cells, with oxidative phosphorylation and oxidative stress playing key roles in their pathogenesis. While there are currently no definitive treatments, natural products such as curcuminoids show promise for neuroprotection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Nutrition & Dietetics

Pharmacokinetics of a Single Dose of Turmeric Curcuminoids Depends on Formulation: Results of a Human Crossover Study

Pascale Fanca-Berthon et al.

Summary: The study suggests that the novel natural dried colloidal suspension of turmeric provides significantly better absorption of curcuminoids compared to other turmeric formulations, particularly when compared to a high dose of standard extract. Both unconjugated and conjugated curcuminoid absorption levels were higher with the dried colloidal suspension than with other formulations, and no significant adverse events were reported.

JOURNAL OF NUTRITION (2021)

Add to Collection

Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Add to Collection

Review Oncology

Turmeric in the management of oral submucous fibrosis: A systematic review and meta-analysis

Arpita Rai et al.

Summary: Turmeric shows promise in managing OSMF symptoms, with improvements seen in mouth opening, tongue protrusion, burning sensation, and cheek flexibility. However, more robust evidence is needed through larger, longer randomized controlled trials to further validate its effectiveness in OSMF management.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2021)

Add to Collection

Article Plant Sciences

Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: A comparative, randomized, double-blind, placebo-controlled clinical trial

Tatul Saghatelyan et al.

PHYTOMEDICINE (2020)

Add to Collection

Review Oncology

Radiodermatitis in Patients With Cancer: Systematic Review and Meta-Analysis

Pamela K. Ginex et al.

ONCOLOGY NURSING FORUM (2020)

Add to Collection

Review Chemistry, Medicinal

Effects of turmeric and curcumin on oral mucositis: A systematic review

Ana Gabriela Costa Normando et al.

PHYTOTHERAPY RESEARCH (2019)

Add to Collection

Review Chemistry, Medicinal

Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases

Cheng Li et al.

PHYTOTHERAPY RESEARCH (2019)

Add to Collection

Article Endocrinology & Metabolism

A randomized, double-blind, placebo-controlled trial to evaluate the role of curcumin in prostate cancer patients with intermittent androgen deprivation

Young Hyo Choi et al.

PROSTATE (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Curcumin and Heme Oxygenase: Neuroprotection and Beyond

Emanuela Mhillaj et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Nutrition & Dietetics

Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial

Lynne M. Howells et al.

JOURNAL OF NUTRITION (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Therapeutic effects of turmeric in several diseases: An overview

Eleonora Hay et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2019)

Add to Collection

Article Medicine, General & Internal

RoB 2: a revised tool for assessing risk of bias in randomised trials

Jonathan A. C. Sterne et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

Add to Collection

Review Nutrition & Dietetics

Curcumin, Hormesis and the Nervous System

Maria Concetta Scuto et al.

NUTRIENTS (2019)

Add to Collection

Article Pharmacology & Pharmacy

Randomized Pharmacokinetic Crossover Study Comparing 2 Curcumin Preparations in Plasma and Rectal Tissue of Healthy Human Volunteers

Gary N. Asher et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2017)

Add to Collection

Article Chemistry, Medicinal

The Essential Medicinal Chemistry of Curcumin

Kathryn M. Nelson et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Add to Collection

Article Oncology

A Randomized Double-Blind Placebo-Controlled Phase IIB Trial of Curcumin in Oral Leukoplakia

Moni Abraham Kuriakose et al.

CANCER PREVENTION RESEARCH (2016)

Add to Collection

Article Medicine, Research & Experimental

Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial

Glen R. B. Irving et al.

TRIALS (2015)

Add to Collection

Article Nutrition & Dietetics

Comparative absorption of curcumin formulations

Ralf Jaeger et al.

NUTRITION JOURNAL (2014)

Add to Collection

Review Biochemistry & Molecular Biology

Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicine

Cesare Mancuso et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Add to Collection

Article Oncology

Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers

Masashi Kanai et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2012)

Add to Collection

Letter Biochemistry & Molecular Biology

Curcumin and Alzheimer Disease: This Marriage Is Not to Be Performed

Cesare Mancuso et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Add to Collection

Letter Pharmacology & Pharmacy

Curcumin in clinical practice: myth or reality?

Cesare Mancuso et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

Add to Collection

Editorial Material Pharmacology & Pharmacy

Curcumin as Curecumin:: From kitchen to clinic

Ajay Goel et al.

BIOCHEMICAL PHARMACOLOGY (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells

A. Kunwar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2008)

Add to Collection

Article Pharmacology & Pharmacy

A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95® CG (Biocurcumax™), A Novel Bioenhanced Preparation of Curcumin

B. Antony et al.

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation: H-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groups

WF Chen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin

KI Priyadarsini et al.

FREE RADICAL BIOLOGY AND MEDICINE (2003)

Add to Collection

Article Oncology

A phase II randomized double blinded trial evaluating the efficacy of curcumin with pre-operative chemoradiation for rectal cancer

Jillian R. Gunther et al.

Summary: In this study, the addition of curcumin to chemoradiation therapy did not increase the pathologic complete response rates in locally advanced rectal cancer patients. The unpredictable bioavailability of curcumin contributes to the uncertainties regarding its efficacy.

JOURNAL OF GASTROINTESTINAL ONCOLOGY

Add to Collection

© Peeref 2019-2024. All rights reserved.