☆ 4.7 Review

Clinical Translation of Long-Acting Drug Delivery Systems for Posterior Capsule Opacification Prophylaxis

PHARMACEUTICS (2023)

Related references

Note: Only part of the references are listed.

Review Pharmacology & Pharmacy

Ocular Drug Delivery: a Comprehensive Review

Sadek Ahmed et al.

Summary: The human eye has complex anatomy and physiology that pose challenges for drug delivery to targeted ophthalmic sites. Overcoming ocular barriers and finding effective routes of administration and dosage forms are important for successful drug delivery. Nanotechnology-based carriers have gained attention due to their ability to entrap drugs, improve ocular permeability, and enhance bioavailability. Different characterization methods help predict the performance of these nanocarriers. This review provides insights into eye anatomy, ocular diseases, obstacles to drug delivery, advantages and drawbacks of different routes of administration and dosage forms, and advancements in ocular delivery.

AAPS PHARMSCITECH (2023)

Add to Collection

Review Pharmacology & Pharmacy

Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives

Haijie Han et al.

Summary: Ocular diseases have a significant impact on patients' vision and quality of life, with a global prevalence of over 43 million blindness. However, delivering drugs effectively to the eyes, especially for intraocular disorders, remains a major challenge due to various ocular barriers. Recent advancements in nanocarrier technology provide a promising solution by improving drug penetration, retention, solubility, toxicity reduction, release duration, and targeted drug delivery. This review highlights the progress and applications of nanocarriers, specifically polymer- and lipid-based nanocarriers, in treating different eye diseases and their potential for efficient ocular drug delivery. It also discusses ocular barriers, administration routes, and future prospects and challenges in the field of nanocarriers for ocular disease treatment.

ADVANCED DRUG DELIVERY REVIEWS (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Highly Retina-Permeating and Long-Acting Resveratrol/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration

Duc Dung Nguyen et al.

Summary: We developed a nanomedicine strategy to create nanotherapeutics with high retinal permeability and sustained bioactive delivery. The nanotherapeutics were designed through aminolysis of resveratrol-encapsulated polycaprolactone nanoparticles, followed by the formation of amide linkages with a transacting activator of transcription cell penetrating peptide and metformin. In vitro and in vivo studies demonstrated the effectiveness of the nanotherapeutics in improving retinal permeability and targeting retinal diseases.

ACS NANO (2023)

Add to Collection

Article Engineering, Biomedical

Prophylaxis of posterior capsule opacification through autophagy activation with indomethacin-eluting intraocular lens

Xiaobo Zhang et al.

Summary: Posterior capsule opacification (PCO) is a common complication of cataract surgery, but a novel indomethacin-eluting intraocular lens (IOL) with sustained drug release behavior showed excellent anti-inflammatory and anti-PCO effects in a rabbit model. Indomethacin suppressed cell migration and down-regulated COX-2 and EMT markers, as well as promoted autophagy activation in lens epithelial cells (LECs), making it a promising pharmacological intervention for PCO prophylaxis. The developed IOL, with its sustained indomethacin release property, served as a drug delivery platform and prevented PCO in vivo.

BIOACTIVE MATERIALS (2023)

Add to Collection

Article Engineering, Biomedical

Centrifugally concentric ring-patterned drug-loaded polymeric coating as an intraocular lens surface modification for efficient prevention of posterior capsular opacification

Duoduo Lu et al.

Summary: A concentric ring-patterned drug-loaded PLGA coating was designed and fabricated for IOL modification to prevent PCO, showing inhibition of LEC proliferation through autophagy-mediated cell death pathway. The drug-eluting IOLs exhibited reliable in vivo PCO prevention, with great potential for clinical translation due to the simple and economical spin coating technique.

ACTA BIOMATERIALIA (2022)

Add to Collection

Review Biochemistry & Molecular Biology

The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases

Yi-Jen Hsueh et al.

Summary: This article summarizes and provides updates on the research and treatment methods of ocular degenerative diseases related to oxidative stress. The article reviews the oxidative damage that occurs in different areas of the eye and introduces the antioxidant mechanisms present in the eye as well as the ocular diseases that occur as a result of antioxidant imbalances and relevant biomarkers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Engineering, Environmental

Synthesis, bioactive properties, and biomedical applications of intrinsically therapeutic nanoparticles for disease treatment

Duc Dung Nguyen et al.

Summary: ITNPs are a special class of nanomaterials with intrinsic therapeutic capabilities, which can be utilized to treat diseases associated with oxidative stress, inflammation, angiogenesis, and infection. Recent advancements in the field of nanotherapeutics have been significantly influenced by ITNPs.

CHEMICAL ENGINEERING JOURNAL (2022)

Add to Collection

Article Engineering, Biomedical

Drug-eluting intraocular lens with sustained bromfenac release for conquering posterior capsular opacification

Xiaobo Zhang et al.

Summary: Cataract is a leading cause of visual impairment, with posterior capsular opacification (PCO) being a common complication of cataract surgery. This study found that bromfenac can effectively inhibit cell migration and epithelial-mesenchymal transition (EMT) to prevent PCO development. Additionally, the researchers developed a drug-eluting intraocular lens (IOL) for sustained release of bromfenac, which showed promising results in preventing PCO in animal models.

BIOACTIVE MATERIALS (2022)

Add to Collection

Review Biotechnology & Applied Microbiology

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

Chenqi Luo et al.

Summary: Advancements in cataract surgery have increased the demand for intraocular lens (IOL) materials. The research progress of IOL materials focuses on improving biocompatibility, visual quality, adjustable ability, and dealing with complications. Most of the studies are still in the laboratory stage and require further clinical trials before commercialization.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Two-dimensional ultrathin Ti3C2 MXene nanosheets coated intraocular lens for synergistic photothermal and NIR-controllable rapamycin releasing therapy against posterior capsule opacification

Zi Ye et al.

Summary: This study presents a novel drug-loaded intraocular lens (IOL) called Rapa@Ti3C2-IOL, which is fabricated using ultrathin Ti3C2 MXene nanosheets and rapamycin (Rapa) with the properties of synergistic photothermal and NIR-controllable drug release. This IOL effectively prevents posterior capsule opacification (PCO) and demonstrates excellent biocompatibility.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Add to Collection

Article Engineering, Biomedical

Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement

Siqing Zhu et al.

Bioactive Materials (2022)

Add to Collection

Article Ophthalmology

Quantification of Inflammation Following Nd:YAG Laser Capsulotomy and Assessing the Anti-inflammatory Effects of Nepafenac 0.1% and Betamethasone 0.1%

Jitender Jinagal et al.

Summary: Inflammation in the eye following Nd:YAG capsulotomy is transient and minimal, with similar outcomes observed in different anti-inflammatory regimes. Prophylactic use of anti-inflammatory agents may not be necessary based on the study findings.

OCULAR IMMUNOLOGY AND INFLAMMATION (2021)

Add to Collection

Review Ophthalmology

Posterior capsule opacification: What's in the bag?

I. M. Wormstone et al.

Summary: Cataract, the most common cause of blindness worldwide, is treated with surgical intervention, which may lead to posterior capsule opacification (PCO) in fibrotic or regenerative forms, both of which result in reduced visual quality. This review explores tools for PCO research, current knowledge, and potential management strategies from IOL design to pharmacological interventions.

PROGRESS IN RETINAL AND EYE RESEARCH (2021)

Add to Collection

Article Materials Science, Biomaterials

Drug-Eluting Hydrophilic Coating Modification of Intraocular Lens via Facile Dopamine Self-Polymerization for Posterior Capsular Opacification Prevention

Sihao Liu et al.

Summary: A synergistic coating with drug-eluting and hydrophilic properties was designed and applied to IOLs to prevent posterior capsular opacification effectively. In vitro and in vivo studies demonstrated the coating's ability to induce cell apoptosis, thereby preventing PCO development while ensuring safety and biocompatibility to surrounding tissues.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

Add to Collection

Article Ophthalmology

Utilizing dexamethasone intravitreal implant to control postoperative inflammation in refractory uveitis undergoing cataract surgery

Yong-Tao Li et al.

Summary: The study demonstrates that in refractory uveitis patients, cataract surgery combined with Ozurdex implantation significantly improves BCVA and effectively controls postoperative inflammation, while reducing systemic steroid usage. Some patients may experience inflammation relapse after the anti-inflammatory effects of Ozurdex diminish, but it can be controlled with topical steroids.

INTERNATIONAL JOURNAL OF OPHTHALMOLOGY (2021)

Add to Collection

Article Chemistry, Multidisciplinary

NIR-triggered drug delivery system for chemo-photothermal therapy of posterior capsule opacification

Mao Ying-Yan et al.

Summary: Posterior capsule opacification (PCO) is a common complication after cataract surgery, and pharmacological prophylaxis has been proven effective but lacks suitable clinical options. A novel concept of NIR dual-triggered drug release from black phosphorus-based implantable intraocular lens (IOL) for controlled drug release and chemo-photothermal combination therapy of PCO was proposed. The integrated IOL with black phosphorus-loaded doxorubicin showed good transmittance, mechanical properties, NIR dual-triggered drug release behaviors, and excellent photothermal efficacy, demonstrating promising results in inhibiting PCO in in vivo studies.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Facile multifunctional IOL surface modification via poly(PEGMA-co-GMA) grafting for posterior capsular opacification inhibition

Jiayi Xia et al.

Summary: In this study, a multifunctional binary copolymer PPG was synthesized and used for surface modification of IOL to inhibit LECs adhesion and proliferation effectively. The research validated the anti-cell adhesion and antiproliferative effects of the multifunctional surface coating and concluded its inhibition of PCO through in vivo rabbit eye implantation experiments.

RSC ADVANCES (2021)

Add to Collection

Review Ophthalmology

Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis

Hassan Hashemi et al.

EYE (2020)

Add to Collection

Review Ophthalmology

Advances in ocular drug delivery systems

Jennifer J. Kang-Mieler et al.

EYE (2020)

Add to Collection

Article Pharmacology & Pharmacy

Supercritical fluid technology for the development of innovative ophthalmic medical devices: Drug loaded intraocular lenses to mitigate posterior capsule opacification

Kanjana Ongkasin et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Development of High-Drug-Loading Nanoparticles

Yun Liu et al.

CHEMPLUSCHEM (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Dual drug delivery from hydrophobic and hydrophilic intraocular lenses: in-vitro and in-vivo studies

Ana Topete et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection

Review Chemistry, Medicinal

A Critical Appraisal of New Developments in Intraocular Lens Modifications and Drug Delivery Systems for the Prevention of Cataract Surgery Complications

Ioanna Mylona et al.

PHARMACEUTICALS (2020)

Add to Collection

Review Polymer Science

Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

Duc Dung Nguyen et al.

POLYMER CHEMISTRY (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Zero-order drug delivery: State of the art and future prospects

Mei-Li Laracuente et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection

Article Ophthalmology

AIR/FLUID-DROPPING TECHNIQUE FOR INTRACAPSULAR DISTILLED WATER APPLICATION A Vitrectomy Approach for Selective Targeting of Lens Epithelial Cells

Qi Zhang et al.

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES (2019)

Add to Collection

Review Pharmacology & Pharmacy

Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

Astrid Subrizi et al.

DRUG DISCOVERY TODAY (2019)

Add to Collection

Review Pharmacology & Pharmacy

Therapeutic implications of nanomedicine for ocular drug delivery

Tuo Meng et al.

DRUG DISCOVERY TODAY (2019)

Add to Collection

Review Pharmacology & Pharmacy

Ocular Drug Delivery: Present Innovations and Future Challenges

Vrinda Gote et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Add to Collection

Article Medicine, General & Internal

Cataract surgeon viewpoints on the need for novel preventative anti-inflammatory and anti-posterior capsular opacification therapies

Mahbubul H. Shihan et al.

CURRENT MEDICAL RESEARCH AND OPINION (2019)

Add to Collection

Review Pharmacology & Pharmacy

The safety evaluation of long-acting ocular delivery systems

Evan A. Thackaberry et al.

DRUG DISCOVERY TODAY (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Anti-Adhesive And Antiproliferative Synergistic Surface Modification Of Intraocular Lens For Reduced Posterior Capsular Opacification

Yuemei Han et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Add to Collection

Article Ophthalmology

An In Vitro Human Lens Capsular Bag Model Adopting a Graded Culture Regime to Assess Putative Impact of IOLs on PCO Formation

Julie A. Eldred et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2019)

Add to Collection

Article Ophthalmology

Spatiotemporal dynamics of canonical Wnt signaling during embryonic eye development and posterior capsular opacification (PCO)

Yichen Wang et al.

EXPERIMENTAL EYE RESEARCH (2018)

Add to Collection

Article Ophthalmology

Three-year incidence of Nd:YAG capsulotomy and posterior capsule opacification and its relationship to monofocal acrylic IOL biomaterial: a UK Real World Evidence study

Paul G. Ursell et al.

EYE (2018)

Add to Collection

Article Ophthalmology

Dexamethasone Intracameral Drug-Delivery Suspension for Inflammation Associated with Cataract Surgery A Randomized, Placebo-Controlled, Phase III Trial

Eric Donnenfeld et al.

OPHTHALMOLOGY (2018)

Add to Collection

Article Biochemical Research Methods

Design and fabrication of drug-eluting polymeric thin films for applications in ophthalmology

Lampros Lamprogiannis et al.

IET NANOBIOTECHNOLOGY (2018)

Add to Collection

Article Ophthalmology

Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery

Jian Jiang et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2018)

Add to Collection

Article Ophthalmology

Aldose Reductase Inhibition Prevents Development of Posterior Capsular Opacification in an In Vivo Model of Cataract Surgery

Leonid M. Zukin et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2018)

Add to Collection

Article Pathology

Reduced Glutathione Level Promotes Epithelial-Mesenchymal Transition in Lens Epithelial Cells via a Wnt/Χ-Catenin-Mediated Pathway Relevance for Cataract Therapy

Zongbo Wei et al.

AMERICAN JOURNAL OF PATHOLOGY (2017)

Add to Collection

Article Engineering, Biomedical

A novel capsular tension ring as local sustained-release carrier for preventing posterior capsule opacification

Ming Lei et al.

BIOMATERIALS (2016)

Add to Collection

Review Ophthalmology

Global prevalence of childhood cataract: a systematic review

S. Sheeladevi et al.

EYE (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Nanomedicine of synergistic drug combinations for cancer therapy - Strategies and perspectives

Rui Xue Zhang et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Add to Collection

Article Nanoscience & Nanotechnology

Polymer-lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin-mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor

Rui Xue Zhang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

Add to Collection

Review Ophthalmology

Prevention of posterior capsular opacification

Lisanne M. Nibourg et al.

EXPERIMENTAL EYE RESEARCH (2015)

Add to Collection

Review Ophthalmology

Preserve the (intraocular) environment: the importance of maintaining normal oxygen gradients in the eye

David C. Beebe et al.

JAPANESE JOURNAL OF OPHTHALMOLOGY (2014)

Add to Collection

Article Ophthalmology

Prevention of capsule opacification after accommodating lens refilling: Pilot study of strategies evaluated in a monkey model

Steven A. Koopmans et al.

JOURNAL OF CATARACT AND REFRACTIVE SURGERY (2014)

Add to Collection

Article Medicine, Research & Experimental

Synergistic Nanoparticulate Drug Combination Overcomes Multidrug Resistance, Increases Efficacy, and Reduces Cardiotoxicity in a Nonimmunocompromised Breast Tumor Model

Adam J. Shuhendler et al.

MOLECULAR PHARMACEUTICS (2014)

Add to Collection

Article Biochemistry & Molecular Biology

UVB Irradiation Enhances TiO2 Nanoparticle-induced Disruption of Calcium Homeostasis in Human Lens Epithelial Cells

Qiuxin Wu et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2014)

Add to Collection

Review Ophthalmology

Intraocular lens as a drug delivery reservoir

Yu-Chi Liu et al.

CURRENT OPINION IN OPHTHALMOLOGY (2013)

Add to Collection

Article Chemistry, Multidisciplinary

Development of a novel bioerodible dexamethasone implant for uveitis and postoperative cataract inflammation

Srinivas Rao Chennamaneni et al.

JOURNAL OF CONTROLLED RELEASE (2013)

Add to Collection

Article Ophthalmology

Sustained Release of 5-Fluorouracil from Chitosan Nanoparticles Surface Modified Intra Ocular Lens to Prevent Posterior Capsule Opacification: An In Vitro and In Vivo Study

Xiao Huang et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2013)

Add to Collection

Article Biotechnology & Applied Microbiology

Doxorubicin-loaded MePEG-PCL nanoparticles for prevention of posterior capsular opacification

Rajdeep Guha et al.

NANOMEDICINE (2013)

Add to Collection

Review Chemistry, Physical

Stimuli-responsive nanocarriers for drug delivery

Simona Mura et al.

NATURE MATERIALS (2013)

Add to Collection

Article Toxicology

Zinc oxide nanoparticles inhibit Ca2+-ATPase expression in human lens epithelial cells under UVB irradiation

Daoguang Wang et al.

TOXICOLOGY IN VITRO (2013)

Add to Collection

Article Multidisciplinary Sciences

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

Alfiya Akhmetshina et al.

NATURE COMMUNICATIONS (2012)

Add to Collection

Article Engineering, Biomedical

Prevention of capsular opacification after accommodative lens refilling surgery in rabbits

Steven A. Koopmans et al.

BIOMATERIALS (2011)

Add to Collection

Article Pharmacology & Pharmacy

DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles

Yong Zhang et al.

AAPS JOURNAL (2010)

Add to Collection

Article Ophthalmology

Intraocular lens as a drug delivery system for dexamethasone

Maria Kugelberg et al.

ACTA OPHTHALMOLOGICA (2010)

Add to Collection

Article Ophthalmology

Drug-Induced Secondary Cataract Prevention: Experimental ex vivo and in vivo Results with Disulfiram, Methotrexate and Actinomycin D

Katrin Sternberg et al.

OPHTHALMIC RESEARCH (2010)

Add to Collection

Article Ophthalmology

Posterior Capsular Opacification A Problem Reduced but Not Yet Eradicated

Niranjan Awasthi et al.

ARCHIVES OF OPHTHALMOLOGY (2009)

Add to Collection

Review Ophthalmology

Posterior capsule opacification

I. Michael Wormstone et al.

EXPERIMENTAL EYE RESEARCH (2009)

Add to Collection

Review Ophthalmology

Pharmacological attempts to reduce posterior capsule opacification after cataract surgery - a review

Thomas D. Walker

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2008)

Add to Collection

Article Ophthalmology

Comparison of posterior capsule opacification in rabbits receiving either mitomycin-C or distilled water for sealed-capsule irrigation during cataract surgery

Su-Young Kim et al.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2007)

Add to Collection

Review Pharmacology & Pharmacy

Challenges and obstacles of ocular pharmacokinetics and drug delivery

Arto Urtti

ADVANCED DRUG DELIVERY REVIEWS (2006)

Add to Collection

Letter Ophthalmology

YAG laser capsulotomy, an unusual complication

M Vella et al.

EYE (2004)

Add to Collection

Article Ophthalmology

Efficacy of various drugs in the prevention of posterior capsule opacification: Experimental study of rabbit eyes

V Fernandez et al.

JOURNAL OF CATARACT AND REFRACTIVE SURGERY (2004)

Add to Collection

Article Ophthalmology

Selective and specific targeting of lens epithelial cells during cataract surgery using sealed-capsule irrigation

A Maloof et al.

JOURNAL OF CATARACT AND REFRACTIVE SURGERY (2003)

Add to Collection

Article Ophthalmology

Randomized clinical trial of surodex steroid drug delivery system for cataract surgery - Anterior versus posterior placement of two surodex in the eye

DTH Tan et al.

OPHTHALMOLOGY (2001)

Add to Collection

Review Ophthalmology

Shifting the paradigm of the blood-aqueous barrier

TF Freddo

EXPERIMENTAL EYE RESEARCH (2001)

Add to Collection

Article Ophthalmology

Prevention of posterior capsule opacification by intraoperative single-dose pharmacologic agents

ÜÜ Inan et al.

JOURNAL OF CATARACT AND REFRACTIVE SURGERY (2001)

Add to Collection

Review Chemistry, Multidisciplinary

On the importance and mechanisms of burst release in matrix-controlled drug delivery systems

X Huang et al.

JOURNAL OF CONTROLLED RELEASE (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.