4.7 Article

Solid Lipid Nanoparticles Containing Morin: Preparation, Characterization, and Ex Vivo Permeation Studies

Related references

Note: Only part of the references are listed.
Article Chemistry, Analytical

Drug discovery from natural products-Old problems and novel solutions for the treatment of neurodegenerative diseases

Urmila Maitra et al.

Summary: The use of natural products in drug discovery has been fruitful, but many pharmaceutical companies have reduced their natural product discovery programs in the last two decades. Novel approaches are needed in the early stages of drug discovery to identify promising molecules efficiently.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

Review Pharmacology & Pharmacy

Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Nose-to-Brain Delivery

Thi-Thao-Linh Nguyen et al.

Summary: This article reviews the latest research progress in nose-to-brain drug delivery and focuses on the use of SLN and NLC formulations for the treatment of central nervous system diseases. These formulations can overcome the challenges of limited drug absorption and small nasal cavity volume, thereby improving drug bioavailability.

PHARMACEUTICS (2022)

Article Pharmacology & Pharmacy

Chitosan-Hyaluronan Nanoparticles for Vinblastine Sulfate Delivery: Characterization and Internalization Studies on K-562 Cells

Carmela Cannava et al.

Summary: In this study, chitosan/hyaluronan nanoparticles (CS/HY NPs) for tumor targeting were developed and their formation mechanism was investigated. The prepared nanoparticles showed good stability and drug encapsulation efficiency, and exhibited rapid internalization ability in leukemia cells in vitro, with the involvement of CD44 in the internalization process.

PHARMACEUTICS (2022)

Article Biochemistry & Molecular Biology

α-Acylamino-β-lactone N-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors Encapsulated in PLGA Nanoparticles: Improvement of the Physical Stability and Protection of Human Cells from Hydrogen Peroxide-Induced Oxidative Stress

Agnese Gagliardi et al.

Summary: In this study, polymeric nanoparticles were used to encapsulate the NAAA inhibitor URB866, improving its physical stability. The nanoparticles demonstrated time- and temperature-dependent stability and a greater ability to retain the compound. The nanoparticles also enhanced the photostability of URB866 and displayed better antioxidant properties on various cell lines at a certain concentration.

ANTIOXIDANTS (2022)

Review Materials Science, Multidisciplinary

On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles

Maria L. Formica et al.

Summary: Intranasal administration provides a promising route for delivering drugs to the brain due to its unique anatomical features. Nanoparticle-based systems have demonstrated outstanding ability to overcome the challenges of this route and achieve drug accumulation in the brain while avoiding systemic distribution.

APPLIED MATERIALS TODAY (2022)

Article Chemistry, Medicinal

Chitosan/Cyclodextrin Nanospheres for Potential Nose-to-Brain Targeting of Idebenone

Federica De Gaetano et al.

Summary: In this study, cyclodextrin-based chitosan nanospheres were developed as potential carriers for nose-to-brain targeting of Idebenone (IDE). The nanospheres showed good encapsulation efficiency and drug loading, and achieved controlled release of IDE. In vitro studies demonstrated that the nanospheres preserved the antioxidant activity of IDE and improved its permeation through the nasal mucosa. These findings suggest that the developed nanospheres have potential for enhancing the delivery of IDE to the brain.

PHARMACEUTICALS (2022)

Article Biotechnology & Applied Microbiology

Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of Flavonoids

Ya. F. Zverev et al.

Summary: This review focuses on the targeted delivery of flavonoids using modern nanocarrier systems, which is crucial for improving their bioavailability and potential clinical applications.

APPLIED BIOCHEMISTRY AND MICROBIOLOGY (2022)

Article Oncology

Overview of Morin and Its Complementary Role as an Adjuvant for Anticancer Agents

Solaipriya Solairaja et al.

Summary: The global cancer data for 2018 revealed around 18.1 million new cases and approximately 9.8 million deaths. Dietary agents are being focused on for their potential in preventing and treating cancer by disrupting cancer hallmarks. Morin, a bioflavonoid, has shown promising pharmacological properties against a variety of cancers and is being studied for its potential in enhancing the effects of other anticancer agents.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2021)

Review Neurosciences

Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol

Rahul et al.

Summary: Kaempferol, a flavonoid compound found in various plants, has neuroprotective effects against several neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's diseases. It delays the initiation and progression of these disorders by acting as a scavenger of free radicals and preserving the activity of antioxidant enzymes. Its ability to cross the Blood-Brain Barrier enhances its protective effects, making it a potential dietary supplement in preventing and treating neurodegenerative diseases.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2021)

Article Biochemistry & Molecular Biology

Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation

Federica De Gaetano et al.

Summary: This study successfully prepared and characterized solid lipid nanoparticles loading rutin, showing potential therapeutic effects in treating oxidative stress-induced diseases. Through various analyses, it was found that solid lipid nanoparticles efficiently encapsulated rutin, with excellent release properties and potential antioxidant activity.

MOLECULES (2021)

Review Pharmacology & Pharmacy

Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier

David Lee et al.

Summary: The blood-brain barrier poses a challenge to delivering therapeutic molecules to the brain, but nose-to-brain drug delivery bypasses this barrier and increases drug concentration in the brain, improving treatment efficacy. Recent advances in nanotechnology have played a significant role in this area.

PHARMACEUTICS (2021)

Article Pharmacology & Pharmacy

Topical Unsaturated Fatty Acid Vesicles Improve Antioxidant Activity of Ammonium Glycyrrhizinate

Maria Chiara Cristiano et al.

Summary: Linoleic and oleic acids are used as natural components to design unsaturated fatty acids vesicles containing ammonium glycyrrhizinate, which have shown to improve the in vitro percutaneous permeation and antioxidant activity. In vivo studies on human volunteers demonstrated the biocompatibility of these vesicles for potential clinical application in treating topical diseases.

PHARMACEUTICS (2021)

Review Biochemistry & Molecular Biology

Mitophagy and Oxidative Stress: The Role of Aging

Anna De Gaetano et al.

Summary: Mitochondrial dysfunction is a key characteristic of aging, with mitophagy playing a crucial role in eliminating damaged mitochondria. Oxidative stress is a major factor in aging, triggering mitophagy to remove dysfunctional mitochondria. However, chronic oxidative stress can lead to mitochondrial damage that overwhelms the autophagic pathways, disrupting the delicate balance between mitophagy, ROS production, and mitochondrial damage, which can accelerate the aging process.

ANTIOXIDANTS (2021)

Article Pharmacology & Pharmacy

Comparison of Modern In Vitro Permeability Methods with the Aim of Investigation Nasal Dosage Forms

Csilla Bartos et al.

Summary: This study aimed to compare two in vitro permeability investigation methods for nasal formulations, finding that the Side-Bi-Side cell was suitable for spray and powder forms, while the Franz cell was desirable for nasal gels.

PHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

Giovanna Rassu et al.

Summary: Cyclodextrins (CDs) have various biological activities and are used in nasal formulations for versatile drug delivery systems intended for local and systemic effects, as well as for nose-to-brain transport of drugs. The research on new nasal applications of CDs is evolving and Italian research will continue to contribute to this field in the coming years.

PHARMACEUTICS (2021)

Article Pharmacology & Pharmacy

Endocytic Uptake of Solid Lipid Nanoparticles by the Nasal Mucosa

Ammar S. Al Khafaji et al.

Summary: Nanoparticles administered via the nasal cavity demonstrated uptake through various endocytic pathways, with continued uptake observed even after exposure to pharmacological inhibitors. The study revealed that a combination of endocytic pathways are involved in the transfer of nanoparticles into the nasal mucosa. Additionally, non-energy-dependent pathways for nanoparticle uptake were observed following exposure to general metabolic inhibitors, highlighting the potential for lipid nanoparticles in local and systemic drug delivery following nasal administration.

PHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

Polymeric Nanoparticles for Nasal Drug Delivery to the Brain: Relevance to Alzheimer's Disease

Navid Rabiee et al.

Summary: Alzheimer's disease is the leading cause of dementia cases, but the exact cause of the disease remains unknown. Drug delivery through the nasal pathway is seen as a promising method for treating AD. This review discusses the use of natural and polymeric nanoparticles for nasal drug delivery to the brain for AD treatment.

ADVANCED THERAPEUTICS (2021)

Article Biochemistry & Molecular Biology

The Interaction of Flavonols with Membrane Components: Potential Effect on Antioxidant Activity

Sarmistha Saha et al.

JOURNAL OF MEMBRANE BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Morin hydrate loaded solid lipid nanoparticles: Characterization, stability, anticancer activity, and bioavailability

Swathi Karamchedu et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2020)

Article Pharmacology & Pharmacy

Mechanisms of poor oral bioavailability of flavonoid Morin in rats: From physicochemical to biopharmaceutical evaluations

Jianbo Li et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Review Biochemical Research Methods

Brain targeted delivery of anticancer drugs: prospective approach using solid lipid nanoparticles

Anupriya Anand et al.

IET NANOBIOTECHNOLOGY (2019)

Article Chemistry, Physical

Nanoparticles fabricated from bulk solid lipids: Preparation, properties, and potential food applications

Qixin Zhong et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2019)

Review Chemistry, Medicinal

Medicinal prospects of antioxidants: A review

Kumari Neha et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Chemistry, Medicinal

Role of Cyclodextrins in Nanoparticle-Based Drug Delivery Systems

Haley Shelley et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Review Pharmacology & Pharmacy

Solid lipid nanocarriers in drug delivery: characterization and design

Huiling Mu et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

Review Pharmacology & Pharmacy

Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release

Aldemar Gordillo-Galeano et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

Article Biotechnology & Applied Microbiology

Development and characterization of morin hydrate loaded microemulsion for the management of Alzheimer's disease

Dheeraj Sharma et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2017)

Article Pharmacology & Pharmacy

Formulation and Evaluation of Morin-Loaded Solid Lipid Nanoparticles

Yuri Ikeuchi-Takahashi et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2016)

Article Biochemistry & Molecular Biology

Size-Limited Penetration of Nanoparticles into Porcine Respiratory Mucus after Aerosol Deposition

Xabier Murgia et al.

BIOMACROMOLECULES (2016)

Article Biophysics

Topical Amphotericin B solid lipid nanoparticles: Design and development

Dhruv Butani et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

Article Pharmacology & Pharmacy

Nanotherapeutics for anti-inflammatory delivery

Luisa Di Marzio et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2016)

Article Neurosciences

Neuroprotective and anti-inflammatory effects of morin in a murine model of Parkinson's disease

Kyung Moon Lee et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2016)

Article Pharmacology & Pharmacy

Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases

Tomoharu Kuboyama et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2014)

Review Pharmacology & Pharmacy

Compritol 888 ATO: a multifunctional lipid excipient in drug delivery systems and nanopharmaceuticals

Mona H. Aburahma et al.

EXPERT OPINION ON DRUG DELIVERY (2014)

Article Biophysics

Sustained release solid lipid matrices processed by hot-melt extrusion (HME)

K. Vithani et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2013)

Article Chemistry, Analytical

Interpretation of the IR and Raman spectra of morin by density functional theory and comparative analysis

Jasmina M. Dimitric Markovic et al.

VIBRATIONAL SPECTROSCOPY (2013)

Article Pharmacology & Pharmacy

Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic

Anu Puri et al.

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS (2012)

Article Biochemistry & Molecular Biology

Formulation and evaluation of chitosan solid lipid nanoparticles of carbamazepine

Rahul Nair et al.

LIPIDS IN HEALTH AND DISEASE (2012)

Article Instruments & Instrumentation

SLN approach for nose-to-brain delivery of alprazolam

Alok Pratap Singh et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2012)

Article Pharmacology & Pharmacy

Mathematical modeling of drug release from lipid dosage forms

J. Siepmann et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

Review Pharmacology & Pharmacy

Higuchi equation: Derivation, applications, use and misuse

Juergen Siepmann et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

Article Pharmacology & Pharmacy

Modeling Drug-Carrier Interaction in the Drug Release from Nanocarriers

Like Zeng et al.

JOURNAL OF DRUG DELIVERY (2011)

Article Chemistry, Multidisciplinary

Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo

Zhen-tao Zhang et al.

ACTA PHARMACOLOGICA SINICA (2010)

Review Pharmacology & Pharmacy

The biochemistry and medical significance of the flavonoids

BH Havsteen

PHARMACOLOGY & THERAPEUTICS (2002)

Review Pharmacology & Pharmacy

Modeling and comparison of dissolution profiles

P Costa et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2001)

Review Pharmacology & Pharmacy

Solid lipid nanoparticles (SLN) for controlled drug delivery -: a review of the state of the art

RH Müller et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2000)