Electrospinning Nanofibers as a Dressing to Treat Diabetic Wounds

Globally, diabetic mellitus (DM) is a common metabolic disease that effectively inhibits insulin production, destroys pancreatic beta cells, and consequently, promotes hyperglycemia. This disease causes complications, including slowed wound healing, risk of infection in wound areas, and development of chronic wounds all of which are significant sources of mortality. With an increasing number of people diagnosed with DM, the current method of wound healing does not meet the needs of patients with diabetes. The lack of antibacterial ability and the inability to sustainably deliver necessary factors to wound areas limit its use. To overcome this, a new method of creating wound dressings for diabetic patients was developed using an electrospinning methodology. The nanofiber membrane mimics the extracellular matrix with its unique structure and functionality, owing to which it can store and deliver active substances that greatly aid in diabetic wound healing. In this review, we discuss several polymers used to create nanofiber membranes and their effectiveness in the treatment of diabetic wounds.

Automated summary

Globally, diabetic mellitus (DM) is a common metabolic disease that inhibits insulin production, destroys pancreatic beta cells, and promotes hyperglycemia. This disease causes complications such as slow wound healing, increased risk of infection, and development of chronic wounds, which can be fatal. The current methods of wound healing are insufficient for diabetic patients due to a lack of antibacterial ability and sustained delivery of necessary factors. To address this, a new method of creating wound dressings using electrospinning has been developed, which mimics the extracellular matrix and effectively stores and delivers active substances for diabetic wound healing. This review discusses different polymers used in creating nanofiber membranes and their effectiveness in treating diabetic wounds.