4.7 Article

pH-Dependent Behavior of Novel 5-FU Delivery System in Environmental Conditions Comparable to the Gastro-Intestinal Tract

Related references

Note: Only part of the references are listed.
Article Chemistry, Physical

A calcium phosphate drug carrier loading with 5-fluorouracil achieving a synergistic effect for pancreatic cancer therapy

Junzong Chen et al.

Summary: In this study, amino-capped polyamidoamine dendrimer was used as a macromolecular template to form amino-modified calcium phosphate hollow sphere for drug delivery application. The system loaded with 5-fluorouracil performed synergistic cancer chemotherapy by inducing calcium overload and reactive oxygen species accumulation in cancer cells, leading to apoptosis. The delivery system showed high tumor inhibition via chemotherapy with minimal impact on normal cells and organs, demonstrating good biocompatibility.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

Article Pharmacology & Pharmacy

Smart Injectable Chitosan Hydrogels Loaded with 5-Fluorouracil for the Treatment of Breast Cancer

Ahmed A. H. Abdellatif et al.

Summary: The present study developed an innovative method for treating breast cancer by using chitosan hydrogel for localized drug delivery. The modified hydrogel demonstrated excellent physicochemical properties and sustained release of the drug. Both in vitro and in vivo experiments showed that the hydrogel exhibited superior anticancer activity and reduced side effects.

PHARMACEUTICS (2022)

Review Biochemistry & Molecular Biology

Anti-Oxidant and Anti-Inflammatory Effects of Astaxanthin on Gastrointestinal Diseases

Jaeeun Lee et al.

Summary: A moderate amount of ROS plays an important role in cell signaling and immune response, while excessive production can lead to inflammation and pathological conditions. The gastrointestinal mucosa is continuously exposed to ROS, increasing the risk of GI disorders. AST, a compound with antioxidant and anti-inflammatory properties, has shown protective effects against GI diseases through various mechanisms, including ROS neutralization, enhancement of antioxidant enzyme activity, and suppression of inflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Engineering, Multidisciplinary

Carbonaceous nanomaterials incorporated biomaterials: The present and future of the flourishing field

Narsimha Mamidi et al.

Summary: In the past decade, nanotechnology has rapidly advanced disease diagnosis and therapy, particularly with the use of carbonaceous nanomaterials (CNMs) to enhance biomaterials. CNMs offer outstanding properties such as electrical conductivity, mechanical strength, and a high surface area, making them ideal for applications in orthopedics, bioimaging, and wearable biosensors. This review discusses the recent progress and future trends of CNMs integrated with biomaterials in biomedical applications.

COMPOSITES PART B-ENGINEERING (2022)

Article Engineering, Chemical

Mesoporous silica nanostructure modified with azo gatekeepers for colon targeted delivery of 5-fluorouracil

Fatemeh Farjadian et al.

Summary: This study synthesized amino-functionalized mesoporous silica particles and loaded them with the anticancer drug 5-Fu, creating an enzyme-responsive drug delivery system. The structure and properties of the system were validated through experimental tests. The system demonstrated controlled drug release under specific conditions, suggesting potential clinical applications.

AICHE JOURNAL (2022)

Article Pharmacology & Pharmacy

Eudragit-Coated Sporopollenin Exine Microcapsules (SEMC) of Phoenix dactylifera L. of 5-Fluorouracil for Colon-Specific Drug Delivery

Mohammad Raish et al.

Summary: In this study, 5-FU was successfully loaded into pollens of Phoenix dactylifera and coated with ERS for colon-targeted drug delivery, resulting in a significantly higher relative bioavailability in colon tissues compared to uncoated SEMC.

PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

Rapid and Application-Tailored Assessment Tool for Biogenic Powders from Crustacean Shell Waste: Fourier Transform-Infrared Spectroscopy Complemented with X-ray Diffraction, Scanning Electron Microscopy, and Nuclear Magnetic Resonance Spectroscopy

Lovro Ogresta et al.

Summary: This study investigated the potential applications of crustacean shell waste through developing an IR-based technique to differentiate various biogenic powders. Different treatments led to changes in properties and compositions of the waste shells, with the unexpected discovery of hydrated calcium carbonate in aged shells. Deproteinization caused alterations in mechanical properties and particle size distribution, providing valuable insights for further utilization of waste shells.

ACS OMEGA (2021)

Article Chemistry, Multidisciplinary

Novel Drug Carrier: 5-Fluorouracil Formulation in Nanoporous Biogenic Mg-calcite from Blue Crab Shells-Proof of Concept

Geza Lazar et al.

Summary: The study utilized biogenic calcite from discarded blue crab shells to create a new drug carrier for slow release of 5-fluorouracil, showcasing its potential. Structural and morphological properties of the drug carrier were extensively characterized using techniques such as Raman, X-ray diffraction, and scanning electron microscopy.

ACS OMEGA (2021)

Article Pharmacology & Pharmacy

Biocompatible DNA/5-Fluorouracil-Gemini Surfactant-Functionalized Gold Nanoparticles as Promising Vectors in Lung Cancer Therapy

Rosa M. Giraldez-Perez et al.

Summary: The design and preparation of novel nanocarriers for transporting cancer drugs is crucial in chemotherapy research. By utilizing two new biocompatible gold nanosystems, a new 5-Fluorouracil (5-Fu) transporter was developed, enhancing efficacy, biocompatibility, and selectivity against lung cancer cells. Various techniques were used to study the physicochemical properties and uptake of the nanosystems, demonstrating the potential for improved cancer treatment strategies.

PHARMACEUTICS (2021)

Article Biochemistry & Molecular Biology

Synthesis and Characterization of New Biodegradable Injectable Thermosensitive Smart Hydrogels for 5-Fluorouracil Delivery

Adam Kasinski et al.

Summary: The paper developed injectable, thermosensitive smart hydrogel local drug delivery systems releasing the model antitumour drug 5-fluorouracil (5-FU). The biodegradable triblock copolymers synthesized through ring opening polymerization showed a sharp sol-gel transition at physiological temperature, with good mechanical properties at 37°C. In vitro release kinetics characterization indicated good control, with a total drug release time of approximately 12 hours.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Chemistry, Multidisciplinary

An overview of methods for production and detection of silver nanoparticles, with emphasis on their fate and toxicological effects on human, soil, and aquatic environment

Mohamed Mohamady Ghobashy et al.

Summary: This review delves into the extensive use of silver nanoparticles in various industries and the potential implications they have on humans and the environment. It discusses aspects such as production, detection techniques, fate, and dynamics of AgNPs under different environmental factors. Furthermore, the toxicity mechanism and interactions of AgNPs with different matrices are highlighted, including aquatic environments, soils, crops, and humans, with discussions on reduction measures and future research directions.

NANOTECHNOLOGY REVIEWS (2021)

Article Multidisciplinary Sciences

Color-specific porosity in double pigmented natural 3d-nanoarchitectures of blue crab shell

Fran Nekvapil et al.

SCIENTIFIC REPORTS (2020)

Article Nanoscience & Nanotechnology

Recent Advances in Designing 5-Fluorouracil Delivery Systems: A Stepping Stone in the Safe Treatment of Colorectal Cancer

Elaheh Entezar-Almahdi et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Article Chemistry, Multidisciplinary

From Blue Bioeconomy toward Circular Economy through High-Sensitivity Analytical Research on Waste Blue Crab Shells

Fran Nekvapil et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2019)

Review Pharmacology & Pharmacy

Local delivery of macromolecules to treat diseases associated with the colon

A. Bak et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Article Medicine, General & Internal

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

T. Conroy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Pharmacology & Pharmacy

Effects of HPMC substituent pattern on water up-take, polymer and drug release: An experimental and modelling study

Diego Caccavo et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Review Chemistry, Applied

Alginate microparticles as oral colon drug delivery device: A review

Lissette Aguero et al.

CARBOHYDRATE POLYMERS (2017)

Article Pharmacology & Pharmacy

Novel methods of drug administration for the treatment and care of older patients

Helen L. Quinn et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

Review Pharmacology & Pharmacy

Colon-Targeted Oral Drug Delivery Systems: Design Trends and Approaches

Seth Amidon et al.

AAPS PHARMSCITECH (2015)

Article Engineering, Biomedical

Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors

Lingjie Meng et al.

BIOMATERIALS (2012)

Article Biochemistry & Molecular Biology

Surface-enhanced Raman Spectral Measurements of 5-Fluorouracil in Saliva

Stuart Farquharson et al.

MOLECULES (2008)

Article Chemistry, Physical

Surface-enhanced Raman scattering of methylene blue adsorbed on cap-shaped Silver nanoparticles

Gui-Na Xiao et al.

CHEMICAL PHYSICS LETTERS (2007)

Article Spectroscopy

Vibrational spectra of the hydrated carbonate minerals ikaite, monohydrocalcite, lansfordite and nesquehonite

EE Coleyshaw et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2003)

Review Oncology

5-Fluorouracil: Mechanisms of action and clinical strategies

DB Longley et al.

NATURE REVIEWS CANCER (2003)

Article Pharmacology & Pharmacy

In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil

YSR Krishnaiah et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2002)