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Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems

PHARMACEUTICS (2023)

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Article Materials Science, Biomaterials

Paclitaxel-loaded cubosome lipid nanocarriers stabilised with pH and hydrogen peroxide-responsive steric stabilisers as drug delivery vehicles

Xudong Cai et al.

Summary: Responsive nanoparticle delivery systems have potential for reducing off-target side effects in chemotherapeutic treatment. In this study, lipid-based cubosomes loaded with paclitaxel were formulated and stabilized by novel amphiphilic block copolymers containing pH-responsive and/or hydrogen peroxide-responsive blocks. The cubosomes demonstrated high encapsulation efficiency and controlled release of the drug in response to pH and H2O2 changes. In vitro cytotoxicity and cell uptake studies showed that the cubosomes had higher toxicity and cell internalization efficiency compared to free paclitaxel and cubosomes stabilized by non-responsive block copolymers. The results highlight the potential of responsive block copolymers in stabilizing lipid cubosomes and enhancing drug release and cellular uptake.

JOURNAL OF MATERIALS CHEMISTRY B (2023)

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Article Polymer Science

Fabrication and Assessment of Orodispersible Tablets Loaded with Cubosomes for the Improved Anticancer Activity of Simvastatin against the MDA-MB-231 Breast Cancer Cell Line

Randa Mohammed Zaki et al.

Summary: This study aimed to analyze the efficacy of simvastatin (SIM)-loaded cubosomes against breast cancer. SIM-loaded cubosomes were prepared using different ratios of glyceryl monooleate, Pluronic F127 (PF-127), and polyvinyl alcohol (PVA), and PF-127 positively affected drug loading and release. The in vitro dissolution analysis showed that SIM exhibited an initial dissolution of 10.4% within the first 5 min, and 63.5% of the loaded drug was released after 1 h. Furthermore, cubosome formula F3 significantly decreased the viability of MDA cells at doses of 25 and 50 μg/mL compared to the control.

POLYMERS (2023)

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Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using In Vitro and In Vivo Models

Arindam Pramanik et al.

Summary: Scientists have developed a targeted drug delivery system based on lyotropic liquid crystalline nanoparticles and demonstrated its high specificity and therapeutic efficacy for colorectal cancer through preclinical studies.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Micro- and nanoformulations of paclitaxel based on micelles, liposomes, cubosomes, and lipid nanoparticles: Recent advances and challenges

Mehran Alavi et al.

Summary: In this article, we provide an overview of micro- and nanoformulations of paclitaxel (PTX) based on micelles, liposomes, cubosomes, and lipid nanoparticles (LNPs) to improve the therapeutic effects of this drug both in vitro and in vivo.

DRUG DISCOVERY TODAY (2022)

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Comparison of lipid liquid crystal formulation and Vivitrol® for sustained release of Naltrexone: In vitro evaluation and pharmacokinetics in rats

Hossein Kamali et al.

Summary: This study aimed to develop a method for obtaining a sustained-release formulation of naltrexone using a lipid liquid crystal-based approach. The results showed that the new method using sorbitan monooleate was effective in sustaining the release of naltrexone and had better uniformity compared to existing formulations. The study also confirmed the biocompatibility of the new delivery system.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Controlling the pH dependent transition between monoolein Fd3m micellar cubosomes and hexosomes using fatty acetate and fatty acid additive mixtures

Jiali Zhai et al.

Summary: The study hypothesized that specific fatty acetates could induce the formation of unique structures in nanoparticles for sustained drug release. Experiment results demonstrated that precise control of nanoparticle phase transition pH could be achieved by doping specific fatty acetates, offering potential application in orally administrated formulations.

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Comparison of cubosomes and hexosomes for the delivery of phenytoin to the brain

Younus Mohammad et al.

Summary: The study explored the formulation of cubosomes and hexosomes with different stabilizers, encapsulation of an anti-seizure drug, and compared their in vivo brain delivery in rats. Cubosomes showed superiority in brain concentrations and brain to plasma ratio compared to hexosomes.

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Lipid-Based Nanocarriers via Nose-to-Brain Pathway for Central Nervous System Disorders

Thuy Trang Nguyen et al.

Summary: Neurodegenerative disorders are characterized by the gradual deterioration of the nervous system due to various factors, with different lipid-based nanocarriers showing promising results in alleviating symptoms of NDs. Challenges in translating lipid nanocarriers from bench to bed side are also discussed.

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Human Antimicrobial Peptide Triggered Colloidal Transformations in Bacteria Membrane Lipopolysaccharides

Linda Hong et al.

Summary: This study investigates the interactions between E. coli LPS and human cathelicidin AMP LL-37, as well as their effects in different nanocarriers. The addition of LL-37 induces structural changes in LPS, potentially guiding the design of LPS-responsive antimicrobial nanocarriers.

SMALL (2022)

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Preclinical assessment of nanostructured liquid crystalline particles for the management of bacterial keratitis: in vivo and pharmacokinetics study

Shreya Kaul et al.

Summary: The research showed that the developed nanostructured liquid crystalline particles can improve the ocular residence time, permeability, and therapeutic effects of vancomycin. This novel ocular drug carrier may be a promising alternative for treating bacterial keratitis.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Article Pharmacology & Pharmacy

Formation of Self-Assembled Liquid Crystalline Nanoparticles and Absorption Enhancement of O-3s by Phospholipids and Oleic Acids

Sang-Won Jeon et al.

Summary: This study optimized and evaluated self-assembled liquid crystalline nanoparticles (SALCs) to enhance the absorption of omega-3s. The study found that the structure and formulation of SALCs played a crucial role in improving the dissolution, permeation, and oral bioavailability of omega-3. The dissolution rates of omega-3 SALCs were 1.7 to 2.3-fold higher than those of the reference Omacor soft capsules, and the oral bioavailability of omega-3 in SALCs was increased by 2.5-fold for EPA and 3.1-fold for DHA compared to the reference. The study provides a novel formulation that improves the bioavailability of EPA and DHA by spontaneously forming liquid crystal-based nanoparticles.

PHARMACEUTICS (2022)

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Article Chemistry, Physical

Balanced lipase interactions for degradation-controlled paclitaxel release from lipid cubic phase formulations

Michele Dully et al.

Summary: Lipid cubic phase (LCP) formulations play a crucial role in enhancing the intestinal solubility and bioavailability of hydrophobic drugs by reducing precipitation and facilitating drug transport. Lipolytic enzymes accelerate the release of hydrophobic agents from lipid bilayers by acting at the interface of water and insoluble lipids. Lipase effectors play a balancing role in creating a precisely-controlled release system for drugs like paclitaxel.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Physical

Exploring the affluent potential of glyceryl mono oleate - myristol liquid crystal nanoparticles mediated localized topical delivery of Tofacitinib: Study of systematic QbD, skin deposition and dermal pharmacokinetics assessment

Srividya Gorantla et al.

Summary: This study aimed to design and characterize Tofacitinib-loaded lyotropic liquid crystalline nanoparticles gel using quality by design-driven approach to enhance the skin delivery of Tofacitinib. The optimized lyotropic liquid crystals system showed appropriate particle size, good entrapment efficiency, sustained release, and improved penetration ability compared to conventional cream. The tape stripping studies indicated that the developed gel retained more Tofacitinib in the skin layers. In summary, this study demonstrated the potential of lyotropic liquid crystalline nanoparticles gel in enhancing the skin delivery of Tofacitinib.

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Article Pharmacology & Pharmacy

Lipid-liquid crystals for 2 months controlled risperidone release: In-vitro evaluation and pharmacokinetics in rabbits

Elham Khodaverdi et al.

Summary: This study developed a drug delivery system based on lipid liquid crystal (LLC) for long-term delivery of risperidone to improve psychological treatment. The optimized LLC formulation achieved maximum release after 60 days using different ratios of phosphatidylcholine (PC) to sorbitol monooleate (PC: SMO), tween grade 80, and tocopherol acetate (TA). In vitro and ex vivo studies, pharmacokinetics, and histopathological examination in rabbits were conducted to compare the optimized LLC with Risperdal CONSTA (R). The results showed that the optimized LLC formulation had the highest drug release percentage (100%) and better pharmacokinetic potentials compared to Risperdal CONSTA (R).

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

A sustain-release lipid-liquid crystal containing risperidone based on glycerol monooleate, glycerol dioleate, and glycerol trioleate: In-vitro evaluation and pharmacokinetics in rabbits

Seyedeh Nesa Rezaeian Shiadeh et al.

Summary: The present study developed an in-situ forming gel (ISFG) vehicle for sustained release of risperidone to schizophrenic patients. The use of glycerol dioleate (GDO) in the formulation resulted in lower initial burst release and hexagonal structures. The optimal lipid liquid crystal (LLC) formulation containing GDO/PC ratio of 2.2:1 and 30% NMP showed consistent release profiles in vitro and in vivo during 60 days. Histopathological studies in rabbits showed minimal side effects for this formulation.

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Quality by design assisted optimization of temozolomide loaded PEGylated lyotropic liquid crystals: Investigating various formulation and process variables along with in-vitro characterization

Tejashree Waghule et al.

Summary: This study developed and characterized Temozolomide (TMZ) loaded lyotropic liquid crystals (LLCs) for intravenous delivery. Various formulation and process variables were investigated, and the optimized LLCs demonstrated good particle size and entrapment efficiency, with sustained release up to 72 hours. PEGylation of the LLCs allowed for long plasma circulation and achieved low hemolysis. TMZ loaded LLCs showed higher cytotoxicity compared to native TMZ. The prepared LLCs could potentially enhance the efficacy of TMZ as a delivery system.

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Review Chemistry, Medicinal

Lyotropic Liquid Crystalline Nanostructures as Drug Delivery Systems and Vaccine Platforms

Maria Chountoulesi et al.

Summary: This review provides an overview of the engineering and characterization of non-lamellar lyotropic liquid crystalline nanosystems (LLCN), highlighting their advantages as drug delivery nanocarriers and innovative vaccine platforms. Non-lamellar LLCN demonstrate stimuli-responsive and controlled release properties, as well as unique adjuvant properties for immune system activation.

PHARMACEUTICALS (2022)

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Article Chemistry, Physical

Structural investigation and steric stabilisation of Guerbet glycolipid-based cubosomes and hexosomes using triblock polyethylene oxide-polypropylene oxide-polyethylene oxide copolymers

N. Idayu Zahid et al.

Summary: Aqueous dispersions of inverse nonlamellar liquid crystalline nanostructures such as cubosomes and hexosomes have potential applications in drug delivery. In this study, Guerbet glycolipids were investigated as potential cubosome and hexosome-forming agents using Pluronic copolymers as stabilizers. The performance of different Pluronics in stabilizing the dispersions was evaluated, and the internal structures were analyzed using synchrotron small-angle X-ray scattering. The results showed that the stability and internal structure of the dispersions were influenced by the choice of Pluronic stabilizer and temperature. The S-Xyl-OC10C6 counterpart formed a stable inverse hexagonal phase structure, suggesting its potential for drug delivery applications.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2022)

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Review Chemistry, Multidisciplinary

Lyotropic liquid crystals for parenteral drug delivery

Vivek P. Chavda et al.

Summary: The development of novel long-acting parenteral formulations based on lipid-based liquid crystals has been encouraged by the need for long-term treatments of chronic diseases. These liquid crystal systems, formed by amphiphilic molecules, spontaneously form liquid crystal nanoparticles in aqueous tissue environments, creating an in-situ long-acting sustained-release depot for extended treatment efficacy. This manuscript summarizes the different types of liquid crystals, recent formulation advancements, analytical evaluation, and therapeutic application of lyotropic liquid crystals in the field of parenteral sustained release drug delivery.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Medicinal

Bioavailability and Antidiabetic Activity of Gliclazide-Loaded Cubosomal Nanoparticles

Mohamed Nasr et al.

Summary: The study prepared gliclazide-loaded cubosomal nanoparticles that showed promising results in improving the oral absorption and antidiabetic activity of gliclazide in both in vitro and in vivo evaluations.

PHARMACEUTICALS (2021)

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Article Pharmacology & Pharmacy

Central composite optimization of ocular mucoadhesive cubosomes for enhanced bioavailability and controlled delivery of voriconazole

Mayada Said et al.

Summary: This study aimed to optimize cubosomal formulations loaded with voriconazole to enhance ocular bioavailability. The chitosan-coated cubosomal formulation showed high mucoadhesive properties and increased drug concentration in vitreous humor compared to voriconazole suspension. The optimized cubosomal formulation can be considered as an efficient ocular nanocarrier for voriconazole.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Design of Swollen Lipidic Cubic Phase to Increase Transcutaneous Penetration of Biomacromolecules

Shuto Kozaka et al.

Summary: Lipidic cubic phase (LCP) is a self-assembled system composed of lipids with interpenetrated aqueous channels, and its potential in drug delivery systems has been investigated. This study demonstrates that swollen LCP (SLCP) with larger aqueous channels can enhance the diffusion and skin penetration of peptides and proteins compared to regular LCP, providing an effective strategy for designing LCP systems for transcutaneous delivery of biomacromolecules.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Medicine, Research & Experimental

Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression

Sameh Saber et al.

Summary: The study found that albendazole can inhibit hepatocellular carcinoma through various mechanisms, including antioxidative stress, liver function improvement, antiangiogenic, antimetastatic, apoptosis induction, and antiproliferative activities. These effects contribute to increased survival rates for patients with HCC.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Luliconazole loaded lyotropic liquid crystalline nanoparticles for topical delivery: QbD driven optimization, in-vitro characterization and dermatokinetic assessment

Arisha Mahmood et al.

Summary: The study focuses on the formulation and characterization of luliconazole loaded lyotropic liquid crystalline nanoparticles (LCNP), which demonstrated promising drug release and skin permeation properties, suggesting LCNP as an effective carrier system for antifungal drugs.

CHEMISTRY AND PHYSICS OF LIPIDS (2021)

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Article Chemistry, Physical

In situ monitoring of the formation of lipidic non-lamellar liquid crystalline depot formulations in synovial fluid

Anan Yaghmur et al.

Summary: Parenteral administration of liquid crystalline phases with tunable nanostructural features and sustained release properties is a promising approach for infection treatment and local drug delivery, as well as postoperative pain management. Understanding the dynamic structural transitions of low-viscous stimulus-responsive lipid precursors in biological environments is crucial for optimizing drug delivery using this principle.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Medicine, Research & Experimental

Development of a Liquid Crystal Formulation that Can Penetrate the Stratum Corneum for Intradermal Delivery of Small Interfering RNA

Misako Kawai et al.

Summary: The study aimed to develop a lyotropic liquid crystalline (LC) system containing Tat and AT1002 for effective siRNA penetration through the SC. The results showed that the peptides in the LC formulation increased SC penetration and intradermal delivery, which had a significant effect on healthy skin.

MOLECULAR PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Optimized Icariin Cubosomes Exhibit Augmented Cytotoxicity against SKOV-3 Ovarian Cancer Cells

Usama A. Fahmy et al.

Summary: The optimized ICA-loaded cubosomes showed enhanced cytotoxicity and apoptotic potential against ovarian cancer cell lines, with improved solubility and cellular permeability compared to free ICA, indicating a prospective approach for better control of ovarian cancer growth.

PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

Liquid Crystalline Phases for Enhancement of Oral Bioavailability

Xingwang Zhang et al.

Summary: Liquid crystalline phases (LCPs) are generated in the gastrointestinal tract upon lipolysis of ingested lipids, leading to advanced vesicular and micellar structures that facilitate the oral absorption of lipids and co-loaded drugs. With sustained or controlled drug release, bioadhesiveness, and capability of loading drugs with different properties, LCPs show promise as vehicles for enhancing oral bioavailability.

AAPS PHARMSCITECH (2021)

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Article Pharmacology & Pharmacy

Cubosomes enhance drug permeability across the blood-brain barrier in zebrafish

H. Azhari et al.

Summary: The study explored the potential of custom cubosomes to deliver drugs to the brain, with findings showing significantly improved drug uptake in zebrafish when using cubosomes coated with Tween 80. This offers new opportunities to overcome challenges in drug delivery across the blood-brain barrier.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Physical

Temperature-sensitive lyotropic liquid crystals as systems for transdermal drug delivery

Jinpeng Liu et al.

Summary: The study successfully developed temperature-sensitive lyotropic liquid crystals (LLC) that can adjust their structure to match human body temperature, showing potential for application as transdermal drug delivery systems by influencing their composition and temperature.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Article Chemistry, Medicinal

Cubosomes as a Potential Oral Drug Delivery System for Enhancing the Hepatoprotective Effect of Coenzyme Q10

Amira Mohamed Mohsen et al.

Summary: This study aimed to develop CoQ10-loaded cubosomes to enhance its oral delivery and hepatoprotective activity. The developed cubosomes showed good drug entrapment efficiency, nanometric dimensions, sustained release of CoQ10, and potential in enhancing the hepatoprotective activity of CoQ10.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Chemistry, Medicinal

Development, Optimization, and Antifungal Assessment of Ocular Gel Loaded With Ketoconazole Cubic Liquid Crystalline Nanoparticles

Mahmoud A. Elfaky et al.

Summary: This research aims to address the limitations of current marketed ketoconazole products by developing a new ophthalmic drug delivery system using cubosomes. The inclusion of ketoconazole in cubosomes within a biodegradable gel resulted in enhanced drug permeability, ocular availability, and antifungal activity, showing promising potential for managing eye infections.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Review Neurosciences

Nanocarriers for Inner Ear Disease Therapy

Xiaoxiang Xu et al.

Summary: The development of nanoparticle-based delivery systems for inner ear disease therapy shows promising potential in controlled drug release, improved targeting to specific cells, and reduced systemic side effects, contributing to efficient treatment and potential clinical applications.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Review Pharmacology & Pharmacy

Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles

Anan Yaghmur et al.

Summary: The article focuses on the recent advances and advantages of ISAsomes (including cubosomes and hexosomes) and SLNs as nanocarriers for drug delivery, with a discussion on their applications in oral and pulmonary drug delivery. It highlights the need for further research on the interactions of these nanoparticles with biological fluids and tissues for efficient designing of drug nanocarriers and exploring potential clinical applications.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Engineering, Biomedical

Targeted delivery of LM22A-4 by cubosomes protects retinal ganglion cells in an experimental glaucoma model

Yue Ding et al.

Summary: Glaucoma is a major cause of irreversible blindness worldwide, associated with elevated intraocular pressure and progressive loss of RGCs. Targeting neurotrophic support to injured neurons may be a better neuroprotective strategy. Using nano-carriers for targeted drug delivery shows promising results in glaucoma treatment.

ACTA BIOMATERIALIA (2021)

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Article Pharmacology & Pharmacy

Latanoprost-loaded phytantriol cubosomes for the treatment of glaucoma

Carolina Del Valle Bessone et al.

Summary: Glaucoma is a degenerative optic neuropathy with increased intraocular pressure, leading to blindness if untreated. The study introduced nanosized cubic liquid crystals (cubosomes) as a drug carrier for latanoprost, showing slow drug release and promising hypotensive effects in vivo.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Pharmacology & Pharmacy

Tenoxicam loaded hyalcubosomes for osteoarthritis

Yara E. Elakkad et al.

Summary: The study successfully developed spherical cubosomes with high entrapment efficiency, and the addition of sodium hyaluronate improved viscosity and spreadability, with drug penetration and safety confirmed through permeation and cell studies. The animal model demonstrated high anti-inflammatory activity, and preliminary clinical study showed the potential efficacy and safety of the formulation in treating OA symptoms.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Norfloxacin loaded nano-cubosomes for enhanced management of otitis externa: In vitro and in vivo evaluation

Abdulaziz M. Al-mahallawi et al.

Summary: The research successfully designed and prepared nano-structured cubosomes loaded with norfloxacin for the management of otitis externa. The experimental results demonstrated that these nano-carriers exhibited good dispersibility, permeation capability, and deposition amount, showing promising potential for enhancing the treatment of otitis externa.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Physical

Stability of cubic phase and curvature tuning in the lyotropic system of branched chain galactose-based glycolipid by amphiphilic additives

Wan Farah Nasuha Wan Iskandar et al.

Summary: Inverse bicontinuous cubic phases are versatile nanostructures capable of accommodating various guest molecules thanks to their highly ordered internal nanostructures with large interfacial areas, which can be tuned and controlled, including hydrophobic, hydrophilic, and amphiphilic molecules, as well as active pharmaceutical ingredients.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2021)

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Immunoenhancement effects of chitosan-modified ginseng stem-leaf saponins-encapsulated cubosomes as an ajuvant

Tianxin Qiu et al.

Summary: The study aimed to develop chitosan-modified ginseng stem-leaf saponins encapsulated cubosomes as a vaccine delivery system, showing excellent stability and sustained release properties. In vitro experiments demonstrated that the nanoparticles improved cellular uptake, stimulated cytokine secretion, and generated more inducible nitric oxide synthase for higher levels of nitric oxide production. Additionally, the immunoadjuvant effects of the nanoparticles were observed through increased CD4+/CD8+ T lymphocytes ratio and high levels of OVA-specific IgG, IgG1, and IgG2a in immunized mice.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Lipid-Based Nanosystems as a Tool to Overcome Skin Barrier

Maddalena Sguizzato et al.

Summary: Skin disorders can be treated with topical drug applications utilizing lipid-based nanosystems, including liposomes, ethosomes, transferosomes, solid lipid nanoparticles, and more. These nanosystems offer efficient delivery of drugs, potentially reducing side effects, and have the ability to administer antioxidant molecules topically. More research is needed to understand the interaction between lipid-based nanosystems and the skin, but highlighting their possibilities could benefit the scientific community.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Novel Amphiphilic Block Copolymers for the Formation of Stimuli-Responsive Non-Lamellar Lipid Nanoparticles

Jiali Zhai et al.

Summary: The study synthesized a series of novel amphiphilic block copolymers (ABCs) using the RAFT technique, which could simultaneously stabilize a range of LLC MO nanoparticles and provide internal particle nanostructure responsiveness to changes of hydrogen peroxide (H2O2) concentrations, pH and temperature. The functional ABCs have the potential to replace existing stabilizers and additives in forming the next generation of non-lamellar lipid nanoparticles, allowing for controlled drug release in tumor microenvironments with endogenous H2O2 and acidic pH conditions.

MOLECULES (2021)

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Article Spectroscopy

Spectrophotometric method to quantify tofacitinib in lyotropic liquid crystalline nanoparticles and skin layers: Application in ex vivo dermal distribution studies

Srividya Gorantla et al.

Summary: A simple and sensitive UV spectrophotometric method was established for the quantitative determination of Tofacitinib in methanol and phosphate buffer saline, showing high linearity and correlation coefficient. The method demonstrated excellent repeatability and intermediate precision, with less than 2% relative standard deviation, and was validated through recovery studies.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

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Article Pharmacology & Pharmacy

Investigating nanostructured liquid crystalline particles as prospective ocular delivery vehicle for tobramycin sulfate: Ex vivo and in vivo studies

Shreya Kaul et al.

Summary: The study demonstrated that tobramycin-loaded nanostructured liquid crystalline particles showed better corneal penetration and efficacy compared to traditional eye drops. Animal experiments indicated significant improvement in reducing bacterial keratitis symptoms with tobramycin cubosomes, along with a notable increase in pharmacokinetic parameters in rabbit aqueous humor.

JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH (2021)

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Article Chemistry, Physical

Comparison of cubosomes and liposomes for the encapsulation and delivery of curcumin

Cuihua Chang et al.

Summary: Inverse bicontinuous cubic phase nanoparticles (cubosomes) have been investigated as delivery vehicles for curcumin, a compound with anti-cancer properties. The study found that the encapsulation efficiency of curcumin within cubosomes varied depending on nanoparticle architecture and curcumin concentration, with cubosomes showing potential for improving curcumin bioavailability and cytotoxicity against melanoma cell lines. These findings suggest the potential of cubosomes as delivery vehicles for curcumin and other poorly water-soluble drugs.

SOFT MATTER (2021)

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Article Pharmacology & Pharmacy

Cubogel as potential platform for glaucoma management

Sinar Sayed et al.

Summary: This study investigated the potential of cubogel as an ocular dosage form to enhance the corneal permeability of Dorzolamide Hydrochloride. DZ-loaded cubosomal dispersions were prepared and characterized to determine the optimal formulation. The optimized cubogel showed promising results in terms of safety, stability, corneal delivery capability, and higher bioavailability compared to a market product.

DRUG DELIVERY (2021)

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Article Chemistry, Multidisciplinary

Improved skin-permeated diclofenac-loaded lyotropic liquid crystal nanoparticles: QbD-driven industrial feasible process and assessment of skin deposition

Tejashree Waghule et al.

Summary: The present study optimised diclofenac diethylamine-loaded liquid crystal nanoparticles based on the principles of quality by design, resulting in prolonged drug release and increased skin permeation compared to marketed formulations in ex-vivo skin permeation studies.

LIQUID CRYSTALS (2021)

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Article Biochemistry & Molecular Biology

Bilosomes as a novel carrier for the cutaneous delivery for dapsone as a potential treatment of acne: preparation, characterization and in vivo skin deposition assay

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Theranostic combinatorial drug-loaded coated cubosomes for enhanced targeting and efficacy against cancer cells

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Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain

William M. Pardridge

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Article Biochemistry & Molecular Biology

Adjuvant activities of CTAB-modified Polygonatum sibiricum polysaccharide cubosomes on immune responses to ovalbumin in mice

Zhenguang Liu et al.

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In Situ Hexosomal Gel as a Promising Tool to Ameliorate the Transnasal Brain Delivery of Vinpocetine: Central Composite Optimization and In Vivo Biodistribution

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Production of gold/silver doped carbon nanocomposites for effective photothermal therapy of colon cancer

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Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications

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Formulation and evaluation of cubosomes containing colchicine for transdermal delivery

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DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Physicochemical, morphological and thermal evaluation of lyotropic lipidic liquid crystalline nanoparticles: The effect of stimuli-responsive polymeric stabilizer

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Cubosome: A Potential Liquid Crystalline Carrier System

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Preparation and Evaluation of Cubosomes/Cubosomal Gels for Ocular Delivery of Beclomethasone Dipropionate for Management of Uveitis

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Design and Characterization of Glyceryl Monooleate-Nanostructures Containing Doxorubicin Hydrochloride

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Hexosomes as Efficient Platforms for Possible Fluoxetine Hydrochloride Repurposing with Improved Cytotoxicity against HepG2 Cells

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Article Nanoscience & Nanotechnology

Anticancer Activity of Thymoquinone Cubic Phase Nanoparticles Against Human Breast Cancer: Formulation, Cytotoxicity and Subcellular Localization

Mohammed M. Mehanna et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Pharmacology & Pharmacy

Rapidly dissolving microneedles for the delivery of cubosome-like liquid crystalline nanoparticles with sustained release of rapamycin

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Article Nanoscience & Nanotechnology

In Vitro and In Vivo Toxicity and Biodistribution of Paclitaxel-Loaded Cubosomes as a Drug Delivery Nanocarrier: A Case Study Using an A431 Skin Cancer Xenograft Model

Jiali Zhai et al.

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Article Chemistry, Medicinal

Development of Spray Formulations Applied to the Oral Mucosa Using Non-lamellar Liquid Crystal-Forming Lipids

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Hexosome engineering for targeting of regional lymph nodes

Shen Y. Helvig et al.

MATERIALIA (2020)

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Article Nanoscience & Nanotechnology

Surface-Engineered Cubosomes Serve as a Novel Vaccine Adjuvant to Modulate Innate Immunity and Improve Adaptive Immunity in vivo

Zhenguang Liu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Chemistry, Medicinal

Cubosomal based oral tablet for controlled drug delivery of telmisartan: formulation, in-vitro evaluation and in-vivo comparative pharmacokinetic study in rabbits

Mohamed Yasser et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2019)

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Review Pharmacology & Pharmacy

Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

Heather A. E. Benson et al.

CURRENT DRUG DELIVERY (2019)

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Review Pharmacology & Pharmacy

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

Bahman Homayun et al.

PHARMACEUTICS (2019)

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Review Chemistry, Multidisciplinary

Non-Lamellar Lyotropic Liquid Crystalline Lipid Nanoparticles for the Next Generation of Nanomedicine

Jiali Zhai et al.

ACS NANO (2019)

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Review Pharmacology & Pharmacy

Current potential and challenges in the advances of liquid crystalline nanoparticles as drug delivery systems

Thiagarajan Madheswaran et al.

DRUG DISCOVERY TODAY (2019)

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Article Chemistry, Multidisciplinary

pH Responsiveness of Hexosomes and Cubosomes for Combined Delivery of Brucea javanica Oil and Doxorubicin

Yawen Li et al.

LANGMUIR (2019)

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Article Multidisciplinary Sciences

Fusion dynamics of cubosome nanocarriers with model cell membranes

Brendan P. Dyett et al.

NATURE COMMUNICATIONS (2019)

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Article Pharmacology & Pharmacy

Cubosomes for topical delivery of the antimicrobial peptide LL-37

Lukas Boge et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Review Chemistry, Multidisciplinary

Self-Assembled Nanostructured Lipid Systems: Is There a Link between Structure and Cytotoxicity?

Angel Tan et al.

ADVANCED SCIENCE (2019)

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Review Pharmacology & Pharmacy

Liquid Crystals: An Approach in Drug Delivery

P. Rajak et al.

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Article Pharmacology & Pharmacy

Lyotropic Liquid Crystalline Nanoparticles of Amphotericin B: Implication of Phytantriol and Glyceryl Monooleate on Bioavailability Enhancement

Sanyog Jain et al.

AAPS PHARMSCITECH (2018)

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Review Pharmacology & Pharmacy

Characterization of Lipid-Based Lyotropic Liquid Crystal and Effects of Guest Molecules on Its Microstructure: a Systematic Review

Xingqi Wang et al.

AAPS PHARMSCITECH (2018)

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Article Nanoscience & Nanotechnology

Paclitaxel-Loaded Self-Assembled Lipid Nanoparticles as Targeted Drug Delivery Systems for the Treatment of Aggressive Ovarian Cancer

Jiali Zhai et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Pharmacology & Pharmacy

Self-assembled phospholipid-based phytosomal nanocarriers as promising platforms for improving oral bioavailability of the anticancer celastrol

May S. Freag et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Review Chemistry, Multidisciplinary

Crossing the blood-brain barrier with nanoparticles

Yiqun Zhou et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Chemistry, Multidisciplinary

Cisplatin Encapsulation Generates Morphologically Different Multicompartments in the Internal Nanostructures of Nonlamellar Liquid-Crystalline Self-Assemblies

Intan Diana Mat Azmi et al.

LANGMUIR (2018)

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Article Oncology

Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes

Mona M. Saber et al.

BMC CANCER (2018)

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Article Pharmacology & Pharmacy

Spray dried cubosomes with ovalbumin and Quil-A as a nanoparticulate dry powder vaccine formulation

Christoffer von Halling Laier et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Pharmacology & Pharmacy

Cubosomes of dapsone enhanced permeation across the skin

Radhakrishnan Nithya et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2018)

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Article Cell Biology

The role of traction in membrane curvature generation

H. Alimohamadi et al.

MOLECULAR BIOLOGY OF THE CELL (2018)

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Review Chemistry, Multidisciplinary

Nanomedicine: Principles, Properties, and Regulatory Issues

Sara Soares et al.

FRONTIERS IN CHEMISTRY (2018)

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Article Pharmacology & Pharmacy

Improved Oral Bioavailability, Therapeutic Efficacy, and Reduced Toxicity of Tamoxifen-Loaded Liquid Crystalline Nanoparticles

Sanyog Jain et al.

AAPS PHARMSCITECH (2018)

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Review Pharmacology & Pharmacy

Phytantriol based smart nano-carriers for drug delivery applications

Samina Akbar et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Review Nanoscience & Nanotechnology

Physicochemical characterization of drug nanocarriers

Eloisa Berbel Manaia et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Pharmacology & Pharmacy

The in vivo transformation and pharmacokinetic properties of a liquid crystalline drug delivery system

Andrew Otte et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Chemistry, Medicinal

Hexagonal Liquid Crystalline Nanodispersions Proven Superiority for Enhanced Oral Delivery of Rosuvastatin: In Vitro Characterization and In Vivo Pharmacokinetic Study

Mai Mahmoud Gabr et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Article Chemistry, Multidisciplinary

Influence of Cubosome Surface Architecture on Its Cellular Uptake Mechanism

Sonal Deshpande et al.

LANGMUIR (2017)

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Article Chemistry, Multidisciplinary

Theranostic hexosomes for cancer treatments: an in vitro study

Valeri Meli et al.

NEW JOURNAL OF CHEMISTRY (2017)

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Review Materials Science, Biomaterials

Thermotropic liquid crystal films for biosensors and beyond

Piotr Popov et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

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Article Medicine, Research & Experimental

In Vivo Formation of Cubic Phase in Situ after Oral Administration of Cubic Phase Precursor Formulation Provides Long Duration Gastric Retention and Absorption for Poorly Water-Soluble Drugs

Anna C. Pham et al.

MOLECULAR PHARMACEUTICS (2016)

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Article Pharmacology & Pharmacy

Usefulness of liquid-crystal oral formulations to enhance the bioavailability and skin tissue targeting of p-amino benzoic acid as a model compound

Wesam R. Kadhum et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

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Article Nanoscience & Nanotechnology

Cubosome nanoparticles potentiate immune properties of immunostimulants

Zhenguang Liu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

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Article Pharmacology & Pharmacy

Sorbitol based powder precursor of cubosomes as an oral delivery system for improved bioavailability of poorly water soluble drugs

Mohamed Nasr et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2016)

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Article Biotechnology & Applied Microbiology

Layer-by-layer-coated lyotropic liquid crystalline nanoparticles for active tumor targeting of rapamycin

May S. Freag et al.

NANOMEDICINE (2016)

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Article Nanoscience & Nanotechnology

Multilayer-Coated Liquid Crystalline Nanoparticles for Effective Sorafenib Delivery to Hepatocellular Carcinoma

Raj Kumar Thapa et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Current strategies for targeted delivery of bio-active drug molecules in the treatment of brain tumor

Tarun Garg et al.

JOURNAL OF DRUG TARGETING (2015)

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Article Chemistry, Multidisciplinary

Biotinylated Cubosomes: A Versatile Tool for Active Targeting and Code livery of Paclitaxel and a Fluorescein-Based Lipid Dye

Simone Aleandri et al.

LANGMUIR (2015)

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Article Pharmacology & Pharmacy

In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting

Mohamed Nasr et al.

ACTA PHARMACEUTICA SINICA B (2015)

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Article Chemistry, Multidisciplinary

Novel Steric Stabilizers for Lyotropic Liquid Crystalline Nanoparticles: PEGylated-Phytanyl Copolymers

Josephine Y. T. Chong et al.

LANGMUIR (2015)

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Review Biotechnology & Applied Microbiology

Techniques for physicochemical characterization of nanomaterials

Ping-Chang Lin et al.

BIOTECHNOLOGY ADVANCES (2014)

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Review Pharmacology & Pharmacy

Nanostructured liquid-crystalline particles for drug delivery

Alexandre Lancelot et al.

EXPERT OPINION ON DRUG DELIVERY (2014)

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Article Chemistry, Multidisciplinary

PEGylation of Phytantriol-Based Lyotropic Liquid Crystalline Particles-The Effect of Lipid Composition, PEG Chain Length, and Temperature on the Internal Nanostructure

Christa Nilsson et al.

LANGMUIR (2014)

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Article Chemistry, Multidisciplinary

Bicontinuous Cubic Liquid Crystalline Nanoparticles for Oral Delivery of Doxorubicin: Implications on Bioavailability, Therapeutic Efficacy, and Cardiotoxicity

Nitin K. Swarnakar et al.

PHARMACEUTICAL RESEARCH (2014)

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Article Chemistry, Physical

Advances in drug delivery and medical imaging using colloidal lyotropic liquid crystalline dispersions

Xavier Mulet et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2013)

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Article Chemistry, Multidisciplinary

Cubosomes containing the adjuvants imiquimod and monophosphoryl lipid A stimulate robust cellular and humoral immune responses

S. B. Rizwan et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Article Pharmacology & Pharmacy

A novel small Odorranalectin-bearing cubosomes: Preparation, brain delivery and pharmacodynamic study on amyloid-β25-35-treated rats following intranasal administration

Hongbing Wu et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2012)

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Article Chemistry, Multidisciplinary

High-Throughput Discovery of Novel Steric Stabilizers for Cubic Lyotropic Liquid Crystal Nanoparticle Dispersions

Josephine Y. T. Chong et al.

LANGMUIR (2012)

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Article Pharmacology & Pharmacy

Preparation of phytantriol cubosomes by solvent precursor dilution for the delivery of protein vaccines

S. B. Rizwan et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2011)

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Article Pharmacology & Pharmacy

Design and In Vitro Evaluation of Capsaicin Transdermal Controlled Release Cubic Phase Gels

Xinsheng Peng et al.

AAPS PHARMSCITECH (2010)

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Review Pharmacology & Pharmacy

Lyotropic liquid crystal systems in drug delivery

Chenyu Guo et al.

DRUG DISCOVERY TODAY (2010)

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Article Pharmacology & Pharmacy

Glyceryl Monooleate/Poloxamer 407 Cubic Nanoparticles as Oral Drug Delivery Systems: I. In Vitro Evaluation and Enhanced Oral Bioavailability of the Poorly Water-Soluble Drug Simvastatin

Jie Lai et al.

AAPS PHARMSCITECH (2009)

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Article Chemistry, Applied

Crystallinity and structure of starch using wide angle X-ray scattering

Kris Frost et al.

CARBOHYDRATE POLYMERS (2009)

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Review Pharmacology & Pharmacy

Blood-brain barrier delivery

William M. Pardridge

DRUG DISCOVERY TODAY (2007)

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Article Chemistry, Multidisciplinary

Dry powder precursors of cubic liquid crystalline nanoparticles (cubosomes)

PT Spicer et al.

JOURNAL OF NANOPARTICLE RESEARCH (2002)

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