Journal
FRONTIERS IN ONCOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2023.1154493
Keywords
cancer treatment; G-CSF; DOCETAXEL; prostate cancer; dose optimization; PK; PD model; neutropenia; personalised dosing
Categories
Ask authors/readers for more resources
Most pharmaceutical products are approved based on their effect in patients who represent the average population in registrational trials, with limited room for dose reduction in case of toxicity. This article explores the evidence supporting personalized dosing in cancer treatment and demonstrates how optimizing the dose, including increasing it, can significantly improve efficacy outcomes. It also discusses the obstacles in implementing personalized dosing in real-world settings, using a personalized dosing platform for docetaxel treatment in prostate cancer as an example.
Almost all pharmaceutical products are approved on the basis of their effect in patients representing the average of the population studied in registrational trials, with most drug labels allowing, at most, for empirical dose reduction in the case of toxicity. In this perspective article we explore some of the evidence that supports the use of personalised dosing in cancer treatment and show how we have been able to build on existing models linking dose, exposure and toxicity to demonstrate how dose optimisation, including increasing the dose, has the potential to significantly improve efficacy outcomes. We also explore, through the lens of our own experience of developing a personalised dosing platform, some of the hurdles that stand in the way of implementing a personalised approach to dosing in real world settings. In particular, our experience is illustrated by the application of a dosing platform for docetaxel treatment in prostate cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available