4.6 Review

Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

A Cascade Nanozyme with Amplified Sonodynamic Therapeutic Effects through Comodulation of Hypoxia and Immunosuppression against Cancer

Na Tao et al.

Summary: The study presents a multifunctional platform based on Au nanoparticles and carbon dots modified hollow black TiO2 nanosphere for reversing immunosuppression and alleviating hypoxia in the tumor microenvironment. This platform effectively kills tumor cells by eliciting immune infiltration, alleviating hypoxia, and improving sonodynamic therapy efficiency.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Fibronectin-Coated Metal-Phenolic Networks for Cooperative Tumor Chemo-/Chemodynamic/Immune Therapy via Enhanced Ferroptosis-Mediated Immunogenic Cell Death

Yao Xu et al.

Summary: The development of a multifunctional theranostic nanoplatform based on doxorubicin-loaded tannic acid-iron networks is described. The platform shows excellent stability, strong targeting ability, and provides the advantages of cooperative immune therapy through iron-based chemodynamic therapy and doxorubicin chemotherapy.

ACS NANO (2022)

Article Engineering, Biomedical

Perfluorocarbon loaded fluorinated covalent organic polymers with effective sonosensitization and tumor hypoxia relief enable synergistic sonodynamic-immunotherapy

Zhijuan Yang et al.

Summary: This study presents a multifunctional nano-sonosensitizer PFCE@THPPpf-COPs, capable of alleviating tumor hypoxia and immunosuppression, and synergistically suppressing tumor growth by priming host's antitumor immunity, particularly in combination with anti-CD47 immunotherapy.

BIOMATERIALS (2022)

Article Medicine, Research & Experimental

A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy

Qinqin Jiang et al.

Summary: By developing a H2O2 economizer, on-demand O-2 supply and reactive oxygen species production can be achieved during ultrasound activation, alleviating tumor hypoxia limitations and enhancing the efficacy of sonodynamic immunotherapy.

THERANOSTICS (2022)

Review Oncology

Sonodynamic therapy: Rapid progress and new opportunities for non-invasive tumor cell killing with sound

Katherine M. M. Nowak et al.

Summary: The treatment of solid tumors is challenging due to the ease with which tumor cells acquire resistance mechanisms. Sonodynamic therapy (SDT), which combines sonosensitizers with focused ultrasound, offers a promising approach for achieving highly localized tumor cell killing.

CANCER LETTERS (2022)

Article Oncology

Ultrasound combined with nanobubbles promotes systemic anticancer immunity and augments anti-PD1 efficacy

Jianjun Hu et al.

Summary: By using ultrasound-stimulated nanobubbles (USNB) to enhance tumor immunogenicity, the efficacy of anti-programmed cell death protein 1 (anti-PD1) immune checkpoint blockade (ICB) can be improved. USNB promotes the infiltration and antitumor activity of CD8+ T cells, and the combination of USNB and anti-PD1 blockade enhances systemic antitumor immunity and generates long-term immune memory protection after complete tumor remission.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Article Engineering, Biomedical

Cancer cell membrane-coated C-TiO2 hollow nanoshells for combined sonodynamic and hypoxia-activated chemotherapy

Shipeng Ning et al.

Summary: In this study, a biomimetic drug delivery system was synthesized for combined sonodynamic therapy and hypoxia-activated chemotherapy. The system showed good tumor targeting and biocompatibility, and improved the therapeutic effect by exploiting tumor hypoxia.

ACTA BIOMATERIALIA (2022)

Review Medicine, General & Internal

Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives

Qing-Long Guo et al.

Summary: Glioblastoma multiforme (GBM) is a common and difficult-to-treat brain tumor. Sonodynamic therapy (SDT) is a new treatment method that uses activated sonosensitizers and low-intensity ultrasound to treat tumors. However, traditional sonosensitizers have difficulty reaching brain tumor regions. Therefore, there is a need to develop a method to help therapeutic agents pass through the blood-brain barrier. With the development of novel nanosensitizers and combination strategies, the efficacy of SDT has improved.

MILITARY MEDICAL RESEARCH (2022)

Review Engineering, Biomedical

Free radicals for cancer theranostics

Xiao-Qiang Wang et al.

Summary: Free radicals, traditionally seen as harmful, can also have beneficial applications in health due to their unique electronic structure. Their properties like high reactivity and conversion ability make them attractive for biomedical applications.

BIOMATERIALS (2021)

Article Chemistry, Multidisciplinary

Metal-Phenolic Network-Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy

Zhan Zhang et al.

Summary: The constructed nanocomplex can remodel the immunosuppressive tumor microenvironment and achieve effective inhibition of tumors through sonodynamic therapy, while alleviating tumor hypoxia and acidic environment.

ACS NANO (2021)

Article Nanoscience & Nanotechnology

Organic Near-Infrared-II Nanophotosensitizer for Safe Cancer Phototheranostics and Improving Immune Microenvironment against Metastatic Tumor

Chuanhui Song et al.

Summary: In this study, novel organic photosensitizer Y8 synthesized nanoparticles (Y8 NPs) were found to effectively induce antitumor immunity through photodynamic and photothermal therapy in metastatic tumor-bearing murine models. The Y8 NPs showed practical photodynamic and photothermal effects with 808 nm laser irradiation, and excellent imaging effects in the near-infrared-II region. This research offers a promising therapeutic strategy for synergetic phototherapy and immunotherapy in tumor treatment.

ACS APPLIED MATERIALS & INTERFACES (2021)

Review Chemistry, Multidisciplinary

Sono/Photodynamic Nanomedicine-Elicited Cancer Immunotherapy

Yuce Li et al.

Summary: Immunotherapy is a potent cancer therapy but its clinical applications are limited by low response rates and immune-related adverse effects. Sono/photodynamic nanomedicines (SPNs) have gained attention for enhancing immunotherapy by generating reactive oxygen species and promoting immunogenic cancer cell death.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Oncology

Sonodynamic therapy-derived multimodal synergistic cancer therapy

Mimi Xu et al.

Summary: Sonodynamic therapy (SDT) offers a promising approach for non-invasively eliminating solid tumors, and combining it with other therapeutic methods can enhance tumor treatment effects. The potential of SDT-based synergistic therapeutics is highlighted for precision tumor treatment medicine.

CANCER LETTERS (2021)

Article Oncology

Sonodynamic therapy complements PD-L1 immune checkpoint inhibition in a murine model of pancreatic cancer

Heather Nesbitt et al.

Summary: The study demonstrates that sonodynamic therapy (SDT) combined with anti-PD-L1 immune checkpoint inhibitor (ICI) treatment significantly reduces tumor volume and promotes increased infiltration of CD4+ and CD8+ T lymphocytes in off-target tumors in a pancreatic cancer model.

CANCER LETTERS (2021)

Article Engineering, Environmental

Protonated 2D carbon nitride sensitized with Ce6 as a smart metal-free nanoplatform for boosted acute multimodal photo-sono tumor inactivation and long-term cancer immunotherapy

Mengya Chen et al.

Summary: A smart metal-free two-dimensional nanoplatform was developed for cancer therapy, demonstrating excellent stability, compatibility, and efficacy, enhancing the long-term effects of immunotherapy.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Engineering, Biomedical

Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy

Jinsheng Huang et al.

Summary: A novel nanocarrier was developed for tumor-targeted delivery in melanoma to activate anti-tumor immunity and reduce adverse effects. Additionally, combining sonodynamic therapy with immunotherapy effectively promotes anti-cancer immunity and suppresses melanoma growth.

BIOMATERIALS (2021)

Article Engineering, Biomedical

Noninvasively immunogenic sonodynamic therapy with manganese protoporphyrin liposomes against triple-negative breast cancer

Huaqing Chen et al.

Summary: Sonodynamic therapy (SDT) shows promise for tumor treatment by activating immune responses and suppressing tumor growth. A multifunctional nanosonosensitizer system (FA-MnPs) has been developed, demonstrating deep-responsive SDT and immune activation, leading to tumor growth inhibition.

BIOMATERIALS (2021)

Article Nanoscience & Nanotechnology

Phase-Transformation Nanoparticle-Mediated Sonodynamic Therapy: An Effective Modality to Enhance Anti-Tumor Immune Response by Inducing Immunogenic Cell Death in Breast Cancer

Yiran Si et al.

Summary: Nanoparticle-mediated sonodynamic therapy can promote anti-tumor immune response of breast cancer cells by inhibiting cell proliferation, promoting apoptosis, increasing CD4 and CD8 T cell subsets, and reducing PD-1 positive T cells, leading to suppressed tumor growth.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Article Nanoscience & Nanotechnology

Nanosonosensitizer-Augmented Sonodynamic Therapy Combined with Checkpoint Blockade for Cancer Immunotherapy

Xiaoning Lin et al.

Summary: Sonodynamic therapy (SDT) and checkpoint blockade immunotherapy are promising treatments for solid cancers, but their efficacy can be limited. By combining SDT with immunotherapy and nanoparticles, such as TiO2, Chlorin e6, and CpG ODN, a multifunctional nanosonosensitizer was developed to enhance antitumor efficacy of anti-PD-L1 antibody. The nanosonosensitizers not only effectively inhibited tumor growth but also stimulated immune responses, leading to efficient primary tumor growth inhibition and inhibition of distant tumors by inducing a strong tumor-specific immune response. This innovative approach offers a promising strategy for treating malignant tumors.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Article Chemistry, Multidisciplinary

Oxygen and oxaliplatin-loaded nanoparticles combined with photo-sonodynamic inducing enhanced immunogenic cell death in syngeneic mouse models of ovarian cancer

Jiao Zheng et al.

Summary: This study successfully fabricated phase-changeable core-shell nanoparticles, which have great potential for enhancing photoacoustic imaging. By combining chemotherapy and photo-sonodynamic therapy, the treatment strategy induced immunogenic cell death and significantly enhanced antitumor immunity, inhibiting the growth of ovarian cancer.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Chemistry, Multidisciplinary

Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma

Yifei Yin et al.

Summary: By utilizing continuous ultrasound-triggered inertial cavitation, a nanoplatform has been developed to accelerate ROS production, enhancing immunogenic cell death and inhibiting tumor growth, while alleviating the intratumoral immunosuppressive microenvironment.

NANO TODAY (2021)

Article Chemistry, Multidisciplinary

Transformable Nanosensitizer with Tumor Microenvironment-Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy

Xuan Tan et al.

Summary: The study introduces a smart nanosonosensitizer TiO2@CaP which enhances the generation of reactive oxygen species (ROS) under ultrasound activation, inducing mitochondrial dysfunction in the tumor microenvironment and promoting immunogenic cell death, resulting in T-cell infiltration and systemic antitumor immunity. This approach holds promise for developing TME-activatable sonosensitizers with temporospatial control over antitumor responses.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Engineering, Biomedical

Engineering oxygen-deficient ZrO2-x nanoplatform as therapy-activated immunogenic cell death (ICD) inducer to synergize photothermal-augmented sonodynamic tumor elimination in NIR-II biological window

Xiaodan Jiao et al.

Summary: An oxygen-deficient zirconia-based nanoplatform, surface PEGylated and cyclic-Arg-Gly-Asp (cRGD) peptide functionalized, was designed for therapy-activated immunogenic cell death induction to enhance photothermal-augmented sonodynamic tumor elimination. This study demonstrates the potential of zirconia in tumor theranostics as a promising translational medicine.

BIOMATERIALS (2021)

Article Materials Science, Multidisciplinary

Titanium-based sonosensitizers for sonodynamic cancer therapy

YuqiD Yang et al.

Summary: Sonodynamic therapy is a new cancer treatment strategy that uses ultrasound to trigger sonosensitizers to produce reactive oxygen species to kill malignant tumors. Titanium-based nanomaterials, particularly TiO2, are high-efficiency sonosensitizers with unique physicochemical properties widely applied in SDT.

APPLIED MATERIALS TODAY (2021)

Article Nanoscience & Nanotechnology

Homology and Immune Checkpoint Dual-Targeted Sonocatalytic Nanoagents for Enhancing Sonodynamic Tumor Therapy

Xin Wei et al.

Summary: A new TiO2-based Sonocatalytic nanoagent functionalized with malignant melanoma cell membrane and programmed cell death-ligand 1 antibody was synthesized for enhanced sonodynamic tumor therapy. In vitro experiments proved that the functionalized nanoagent exhibited precise targeting effects and high tumor cell uptake, resulting in the generation of localized ROS for tumor cell killing.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Nanoscience & Nanotechnology

Tumor Microenvironment-Activated Nanoparticles Loaded with an Iron-Carbonyl Complex for Chemodynamic Immunotherapy of Lung Metastasis of Melanoma In Vivo

Tianli Zhai et al.

Summary: This work describes the construction of a nanoplatform loaded with an iron-carbonyl complex, which showed excellent efficacy against lung metastasis of melanoma through chemodynamic therapy and immunogenic cell death-induced immunotherapy. The nanomaterials released CO and generated ferrous iron to cause tumor cell death via mitochondrial damage and oxidative stress, while also inducing immunotherapy to further enhance therapeutic effects. This self-assembling nanoplatform utilized simple building blocks to target tumors and has the potential for future clinical applications in treating various types of tumors.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Chemistry, Multidisciplinary

Catalytically Active CoFe2O4 Nanoflowers for Augmented Sonodynamic and Chemodynamic Combination Therapy with Elicitation of Robust Immune Response

Shiyan Fu et al.

Summary: The PEGylated CoFe2O4 nanoflowers (CFP) with multiple enzymatic activities are synthesized as bioreactors responsive to TME cues for augmented sonodynamic therapy (SDT) and chemodynamic therapy (CDT), eliciting a strong immune response.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Liquid exfoliation of TiN nanodots as novel sonosensitizers for photothermal-enhanced sonodynamic therapy against cancer

Xianwen Wang et al.

Summary: In this study, ultra-small titanium nitride nanodots were synthesized for photothermal-enhanced sonodynamic therapy against cancer. These nanodots exhibit promising multifunctional properties, combining the advantages of photothermal therapy and sonodynamic therapy for significant synergistic treatment effects on tumors. Importantly, these nanodots can be promptly metabolized from the body, reducing concerns about long-term toxicity.

NANO TODAY (2021)

Review Chemistry, Multidisciplinary

Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development

Dong Li et al.

Summary: Sonodynamic therapy (SDT) is a novel noninvasive therapeutic approach that combines low-intensity ultrasound with sonosensitizers. Compared to phototherapy, SDT offers advantages such as deeper tissue penetration, high accuracy, and reduced side effects. The use of organic sonosensitizers is crucial for therapeutic efficacy, and nanotechnology holds potential for overcoming obstacles and fostering innovation in this field.

SMALL (2021)

Article Medicine, Research & Experimental

Mitochondria-targeted and ultrasound-responsive nanoparticles for oxygen and nitric oxide codelivery to reverse immunosuppression and enhance sonodynamic therapy for immune activation

Changwei Ji et al.

Summary: This study developed mitochondria-targeted nanoparticles to co-deliver oxygen and nitric oxide for enhancing sonodynamic therapy and reversing immunosuppression in the tumor microenvironment. The nanoparticles showed promising results in inhibiting tumor growth, promoting immunogenic cell death, and enhancing immune response both in vitro and in vivo. The findings provide a simple strategy to improve cancer immunotherapy by combining sonodynamic therapy with oxygen and nitric oxide delivery.

THERANOSTICS (2021)

Article Medicine, Research & Experimental

Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors

Qingbo Xu et al.

Summary: The manganese porphyrin-based metal-organic framework (Mn-MOF) demonstrates great potential in enhancing cancer therapy through sonodynamic therapy and ferroptosis, showing strong anticancer activity and antitumor immunity in hypoxic tumors.

THERANOSTICS (2021)

Review Chemistry, Multidisciplinary

Ultrasound-Activated Sensitizers and Applications

Xiahui Lin et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Engineering, Biomedical

Biomimetic Decoy Inhibits Tumor Growth and Lung Metastasis by Reversing the Drawbacks of Sonodynamic Therapy

Hongjuan Zhao et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Article Chemistry, Multidisciplinary

Necroptosis-Inducible Polymeric Nanobubbles for Enhanced Cancer Sonoimmunotherapy

Wooram Um et al.

ADVANCED MATERIALS (2020)

Article Chemistry, Multidisciplinary

Ultrafine Titanium Monoxide (TiO1+x) Nanorods for Enhanced Sonodynamic Therapy

Xianwen Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Food Science & Technology

Talkin’ Toxins: From Coley’s to Modern Cancer Immunotherapy

Robert D. Carlson et al.

Toxins (2020)

Review Oncology

Engineering CAR-T Cells for Next-Generation Cancer Therapy

Mihe Hong et al.

CANCER CELL (2020)

Review Cell Biology

Detection of immunogenic cell death and its relevance for cancer therapy

Jitka Fucikova et al.

CELL DEATH & DISEASE (2020)

Review Cell Biology

Immunogenic cell death in cancer therapy: Present and emerging inducers

Jingyi Zhou et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Article Medicine, Research & Experimental

An in situ microenvironmental nano-regulator to inhibit the proliferation and metastasis of 4T1 tumor

Huijuan Zhang et al.

THERANOSTICS (2019)

Article Chemistry, Multidisciplinary

Nanoscale Metal-Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

Guangxu Lan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Review Oncology

Sonodynamic therapy, a treatment developing from photodynamic therapy

Liu Rengeng et al.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2017)

Review Chemistry, Multidisciplinary

Micro/Nanoparticle-Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Xiaoqin Qian et al.

ADVANCED MATERIALS (2016)

Article Biochemistry & Molecular Biology

Comparison between sonodynamic and photodynamic effect on MDA-MB-231 cells

Haiping Wang et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2013)

Review Oncology

The blockade of immune checkpoints in cancer immunotherapy

Drew M. Pardoll

NATURE REVIEWS CANCER (2012)

Article Medicine, Research & Experimental

Peptide-Conjugated PAMAM for Targeted Doxorubicin Delivery to Transferrin Receptor Overexpressed Tumors

Liang Han et al.

MOLECULAR PHARMACEUTICS (2010)

Review Pharmacology & Pharmacy

CpG oligodeoxynucleotide-based therapy of lymphoid malignancies

George J. Weiner

ADVANCED DRUG DELIVERY REVIEWS (2009)