LncRNAs and regulated cell death in tumor cells

Regulated Cell Death (RCD) is a mode of cell death that occurs through drug or genetic intervention. The regulation of RCDs is one of the significant reasons for the long survival time of tumor cells and poor prognosis of patients. Long non-coding RNAs (lncRNAs) which are involved in the regulation of tumor biological processes, including RCDs occurring on tumor cells, are closely related to tumor progression. In this review, we describe the mechanisms of eight different RCDs which contain apoptosis, necroptosis, pyroptosis, NETosis, entosis, ferroptosis, autosis and cuproptosis. Meanwhile, their respective roles in the tumor are aggregated. In addition, we outline the literature that is related to the regulatory relationships between lncRNAs and RCDs in tumor cells, which is expected to provide new ideas for tumor diagnosis and treatment.

Automated summary

Regulated Cell Death (RCD) is a mode of cell death that occurs through drug or genetic intervention, and the regulation of RCDs is a significant factor in tumor cell survival and patient prognosis. Long non-coding RNAs (lncRNAs) play a role in regulating tumor biological processes, including RCDs on tumor cells, and are closely related to tumor progression. This review describes the mechanisms of eight different RCDs and their roles in tumors, while also outlining the regulatory relationships between lncRNAs and RCDs in tumor cells, aiming to provide new insights for tumor diagnosis and treatment.