The progress in our understanding of CIN in breast cancer research

Chromosomal instability (CIN) is an important marker of cancer, which is closely related to tumorigenesis, disease progression, treatment efficacy, and patient prognosis. However, due to the limitations of the currently available detection methods, its exact clinical significance remains unknown. Previous studies have demonstrated that 89% of invasive breast cancer cases possess CIN, suggesting that it has potential application in breast cancer diagnosis and treatment. In this review, we describe the two main types of CIN and discuss the associated detection methods. Subsequently, we highlight the impact of CIN in breast cancer development and progression and describe how it can influence treatment and prognosis. The goal of this review is to provide a reference on its mechanism for researchers and clinicians.

Automated summary

Chromosomal instability (CIN) is an important marker of cancer, closely related to tumorigenesis, disease progression, treatment efficacy, and patient prognosis. Its clinical significance remains unclear due to limitations in current detection methods. However, studies have shown that CIN is present in 89% of invasive breast cancer cases, indicating its potential for breast cancer diagnosis and treatment. This review provides insights into the types of CIN, detection methods, and its impact on breast cancer development, treatment, and prognosis, aiming to serve as a reference for researchers and clinicians.