Functional role of MicroRNA/PI3K/AKT axis in osteosarcoma

Osteosarcoma (OS) is a primary malignant bone tumor that occurs in children and adolescents, and the PI3K/AKT pathway is overactivated in most OS patients. MicroRNAs (miRNAs) are highly conserved endogenous non-protein-coding RNAs that can regulate gene expression by repressing mRNA translation or degrading mRNA. MiRNAs are enriched in the PI3K/AKT pathway, and aberrant PI3K/AKT pathway activation is involved in the development of osteosarcoma. There is increasing evidence that miRNAs can regulate the biological functions of cells by regulating the PI3K/AKT pathway. MiRNA/PI3K/AKT axis can regulate the expression of osteosarcoma-related genes and then regulate cancer progression. MiRNA expression associated with PI3K/AKT pathway is also clearly associated with many clinical features. In addition, PI3K/AKT pathway-associated miRNAs are potential biomarkers for osteosarcoma diagnosis, treatment and prognostic assessment. This article reviews recent research advances on the role and clinical application of PI3K/AKT pathway and miRNA/PI3K/AKT axis in the development of osteosarcoma.

Automated summary

Osteosarcoma is a primary malignant bone tumor that mainly affects children and adolescents, and it is often associated with overactivation of the PI3K/AKT pathway. MicroRNAs (miRNAs) are small RNA molecules that play a role in gene regulation, and they are involved in the PI3K/AKT pathway and the development of osteosarcoma. MiRNAs can influence various cellular functions by targeting the PI3K/AKT pathway and regulating the expression of osteosarcoma-related genes. Additionally, miRNAs associated with the PI3K/AKT pathway have potential as biomarkers for osteosarcoma diagnosis, treatment, and prognosis assessment.