4.6 Review

Strategies to overcome myeloid cell induced immune suppression in the tumor microenvironment

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models

Meenal Datta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

Review Immunology

Targeting tumour-reprogrammed myeloid cells: the new battleground in cancer immunotherapy

Francesco De Sanctis et al.

Summary: The tumour microenvironment is a complex ecosystem in which myeloid cells play a crucial role. These cells, including neutrophils, macrophages, dendritic cells, and monocytes, not only have immunosuppressive effects but also assist tumour invasion through non-immunological activities. These tumour-supporting myeloid cell populations significantly impact tumour progression and cancer therapy, making them potential targets for new cancer treatments.

SEMINARS IN IMMUNOPATHOLOGY (2023)

Article Oncology

CXCR1/2 dual-inhibitor ladarixin reduces tumour burden and promotes immunotherapy response in pancreatic cancer

Geny Piro et al.

Summary: This study evaluated the effectiveness of combining a CXCR1/2 inhibitor with anti-PD-1 in treating immunosuppression in PDAC. The results showed that this combination therapy can reverse M2 macrophage polarization, reduce tumor burden, and improve the efficacy of immunotherapy.

BRITISH JOURNAL OF CANCER (2023)

Review Medicine, Research & Experimental

Role of chemokines in the crosstalk between tumor and tumor-associated macrophages

Rui Qin et al.

Summary: Tumor microenvironment (TME) is a complex network consisting of various non-tumoral stromal cells, among which tumor-associated macrophages (TAMs) play a crucial role in tumor development and metastasis. Chemokines serve as important messengers in the interaction between TAMs and tumor cells. Different chemokines are involved in the generation, polarization, and suppressive function of TAMs. Modulating the effects of TAMs with chemokine antagonists shows promise as a therapeutic approach for cancer treatment.

CLINICAL AND EXPERIMENTAL MEDICINE (2023)

Review Biochemistry & Molecular Biology

Roles of the CXCL8-CXCR1/2 Axis in the Tumor Microenvironment and Immunotherapy

Zhi-Jian Han et al.

Summary: Interleukin-8 (IL-8 or CXCL8) plays multiple roles within the tumor microenvironment (TME), affecting various components of TME and influencing tumor progression and therapeutic resistance. CXCL8 could be used as a prognostic biomarker and targeting the CXCL8-CXCR1/2 axis shows promise in improving antitumor efficacy. Understanding the interactions between TME components and the CXCL8-CXCR1/2 axis is important for developing novel immunotherapy strategies.

MOLECULES (2022)

Article Oncology

Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition

Rohit Rao et al.

Summary: This study identified functionally distinct TAM subpopulations in different glioma subtypes, showing varied responses to TAM targeting. Particularly, proneural tumors exhibited significant inhibition with CSF1R inhibition, while mesenchymal tumors showed potential responsiveness to combined anti-angiogenic therapy and CSF1R inhibition.

NEURO-ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment

Klaire Yixin Fjaestad et al.

Summary: The development of immune checkpoint inhibitors (ICI) has been an important breakthrough in cancer therapies, but only a limited number of patients benefit from them. Recently, the nonselective beta blocker propranolol has been shown to be effective in treating angiosarcoma and soft tissue sarcomas. It works by reducing tumor angiogenesis and promoting an anti-tumoral microenvironment with increased T cell infiltration. The combination of propranolol with immune checkpoint inhibitors can significantly enhance their efficacy.

ONCOGENE (2022)

Article Multidisciplinary Sciences

The efficacy of PI3Kγ and EGFR inhibitors on the suppression of the characteristics of cancer stem cells

Yanning Xu et al.

Summary: This study established a model of cancer stem cells (CSCs) derived from mouse induced pluripotent stem cells (miPSCs) and found that the activation of PI3K-Akt and EGFR signaling pathways played significant roles in the process. The inhibitors targeting these pathways showed significant anti-tumor effects in vitro and in vivo, with PI3K-gamma inhibitor Eganelisib demonstrating better therapeutic efficacy and fewer side effects.

SCIENTIFIC REPORTS (2022)

Article Immunology

Polymorphonuclear Myeloid-Derived Suppressor Cells Are Abundant in Peripheral Blood of Cancer Patients and Suppress Natural Killer Cell Anti-Tumor Activity

Nicola Tumino et al.

Summary: The presence of polymorphonuclear myeloid-derived suppressor cells (MDSC) in the tumor microenvironment (TME) can inhibit the anti-tumor activity of natural killer (NK) cells. The interaction between MDSC and NK cells leads to the inhibition of major activating NK receptors, NK cytolytic activity, and cytokine production. Exosomes derived from MDSC are responsible for the immunosuppressive effect on NK cell-mediated anti-tumor activity.

FRONTIERS IN IMMUNOLOGY (2022)

Article Medicine, Research & Experimental

Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment

May Wathone Oo et al.

Summary: Research has found that oral cancer stroma recruits CCR2(+) MDSCs from the bone marrow to the tumor microenvironment through the secretion of CCL2.

JCI INSIGHT (2022)

Review Oncology

Effects of the Anti-Tumor Agents Trabectedin and Lurbinectedin on Immune Cells of the Tumor Microenvironment

Paola Allavena et al.

Summary: Immune cells in the tumor micro-environment (TME) have complex interactions with cancer cells and can significantly impact disease progression and response to therapy. Tumor-Associated Macrophages (TAMs) are abundant in the TME and actively promote cancer cell proliferation and spreading, as well as contribute to an immune-suppressive environment. Certain anti-tumor agents, such as trabectedin and lurbinectedin, have the ability to directly affect immune cells and alter the features of the TME. These compounds can induce apoptosis in monocytes and macrophages, inhibit the transcription of inflammatory mediators, and alleviate immune suppression, leading to enhanced anti-tumor response.

FRONTIERS IN ONCOLOGY (2022)

Article Oncology

High Expression of CSF-1R Predicts Poor Prognosis and CSF-1Rhigh Tumor-Associated Macrophages Inhibit Anti-Tumor Immunity in Colon Adenocarcinoma

Xingchao Wang et al.

Summary: CSF-1R is overexpressed in colon adenocarcinoma and associated with prognosis. CSF-1R may be involved in tumor immune response and regulation of tumor microenvironment.

FRONTIERS IN ONCOLOGY (2022)

Review Oncology

The Role of Metabolic Plasticity of Tumor-Associated Macrophages in Shaping the Tumor Microenvironment Immunity

Md Nabiul Hasan et al.

Summary: Tumor-associated macrophages support tumor progression and inhibit immune function by rewiring their metabolism. Understanding the metabolic changes of macrophages in the tumor microenvironment is essential for developing novel immune cell metabolism-targeted therapies.

CANCERS (2022)

Review Oncology

Myeloid-Derived Suppressor Cells as Key Players and Promising Therapy Targets in Prostate Cancer

Izabela Sieminska et al.

Summary: Prostate cancer is the second most commonly diagnosed malignancy in men and a leading cause of cancer death worldwide. Environmental factors and immune cells, particularly MDSCs, play a significant role in the development and progression of prostate cancer. Clinical trials targeting MDSCs or affecting their function may hold promise as a new direction for anti-cancer therapy.

FRONTIERS IN ONCOLOGY (2022)

Review Medicine, General & Internal

A brief glimpse of a tangled web in a small world: Tumor microenvironment

Iman M. Talaat et al.

Summary: A tumor is formed through stepwise accumulation of genetic and epigenetic alterations. The immune system has also been used for tumor treatment. Recent breakthroughs have broadened our understanding of other participants in tumor tissue, and the tumor microenvironment plays a significant role in regulating cell interactions.

FRONTIERS IN MEDICINE (2022)

Review Medicine, Research & Experimental

Myeloid derived suppressor cells and innate immune system interaction in tumor microenvironment

Anik Pramanik et al.

Summary: The MDSC population in the tumor microenvironment plays a crucial role in tumor immune evasion and cancer progression by disrupting antitumor T cell activity and potentially affecting other immune cell functions.

LIFE SCIENCES (2022)

Review Biochemistry & Molecular Biology

Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy

Yuze Wu et al.

Summary: This review focuses on the classification and inhibitory function of myeloid-derived suppressor cells (MDSCs) in immune checkpoint inhibitor (ICI) therapy, as well as the crosstalk between MDSCs and other myeloid cells. Recent findings suggest that targeting MDSCs may be a promising approach to enhance the efficacy of cancer immunotherapy.

MOLECULAR CANCER (2022)

Article Oncology

Reprogramming the Canine Glioma Microenvironment with Tumor Vaccination plus Oral Losartan and Propranolol Induces Objective Responses

Dylan T. Ammons et al.

Summary: This study evaluated a therapeutic protocol combining myeloid cell-targeted immunotherapy with tumor vaccination to overcome the immune barrier in malignant gliomas. The experiment conducted on a spontaneously occurring canine glioma model showed that this immunotherapy protocol induced tumor regression and improved overall survival time.

CANCER RESEARCH COMMUNICATIONS (2022)

Article Urology & Nephrology

Tryptophan-kynurenine ratio as a biomarker of bladder cancer

Sze Han Lee et al.

Summary: The study revealed that plasma tryptophan levels were significantly decreased in bladder cancer patients, while both plasma and urinary KYN-TRP ratios were increased. Furthermore, the expression of IDO1 was found to be elevated in human bladder tumors. In the murine model, a positive correlation was reported between IDO1 expression, KYN-TRP ratio, normalized PSA to creatinine, and bladder tumor burden.

BJU INTERNATIONAL (2021)

Review Pharmacology & Pharmacy

Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression

Kristen Fousek et al.

Summary: IL-8 plays a significant role in the tumor microenvironment by affecting tumor cell proliferation, invasiveness, drug resistance, and immune cell killing capacity, thereby impacting the efficacy of immunotherapy.

PHARMACOLOGY & THERAPEUTICS (2021)

Review Chemistry, Medicinal

Lenvatinib for Hepatocellular Carcinoma: A Literature Review

Takeshi Hatanaka et al.

Summary: Lenvatinib has shown non-inferiority to sorafenib in terms of overall survival and has higher objective response rate and better progression-free survival in hepatocellular carcinoma (HCC) patients. Good liver function and appropriate treatment strategy are crucial for achieving therapeutic efficacy in BCLC intermediate stage patients. The management of adverse events and the lack of established molecular targeted agents post-lenvatinib treatment are important considerations for further research and clinical practice.

PHARMACEUTICALS (2021)

Article Cell Biology

Comparing thermal stress reduction strategies that influence MDSC accumulation in tumor bearing mice

Cameron MacDonald et al.

Summary: Thermal treatments, including whole-body hyperthermia and housing mice at different temperatures, as well as low dose propranolol therapy, can reduce MDSC accumulation and improve tumor growth control.

CELLULAR IMMUNOLOGY (2021)

Article Oncology

Chronic restraint stress promotes the mobilization and recruitment of myeloid-derived suppressor cells through β-adrenergic-activated CXCL5-CXCR2-Erk signaling cascades

Mingyue Cao et al.

Summary: The study reveals that chronic restraint stress significantly promotes HCC growth and mobilizes MDSCs to spleen and tumor sites from bone marrow through enhancing CXCR2 and pErk1/2 expression. In addition, beta-adrenergic signaling cascade plays a crucial role in the mobilization and recruitment of MDSCs under chronic restraint stress.

INTERNATIONAL JOURNAL OF CANCER (2021)

Review Biochemistry & Molecular Biology

Therapeutic Targeting of the Tumour Microenvironment in Metastatic Colorectal Cancer

Rhynelle S. Dmello et al.

Summary: Liver metastasis is a significant factor in the mortality of colorectal cancer patients. Understanding the cellular interactions in the tumor microenvironment can lead to the development of new therapeutic targets for metastatic colorectal cancer, despite current treatment challenges.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Chemistry, Medicinal

BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate

Robert J. Cherney et al.

Summary: Compound 3, identified as a potent and selective CCR2/5 dual antagonist, demonstrated excellent permeability and stability in vitro, as well as promising pharmacokinetic properties in animal studies, ultimately leading to its selection as a clinical candidate.

ACS MEDICINAL CHEMISTRY LETTERS (2021)

Editorial Material Oncology

AMD3100/Plerixafor overcomes immune inhibition by the CXCL12-KRT19 coating on pancreatic and colorectal cancer cells

Douglas T. Fearon et al.

Summary: Inhibiting the chemokine receptor CXCR4 suppresses intratumoral immune reaction, providing insights into the role of CXCR4 in cancer immunoediting.

BRITISH JOURNAL OF CANCER (2021)

Article Pathology

Expression of B7-H4 and IDO1 is associated with drug resistance and poor prognosis in high-grade serous ovarian carcinomas

Na Niu et al.

Summary: The study identified high levels of immune modulatory proteins including B7-H4, IDO1, Tim3, IL-6, and IL-8 in high-grade serous ovarian carcinoma (HGSC), which were associated with therapy resistance and lower survival rates. These findings suggest novel targets for enhancing immunotherapy in HGSC patients, potentially improving treatment outcomes.

HUMAN PATHOLOGY (2021)

Article Biochemistry & Molecular Biology

Kynurenine/Tryptophan Ratio as a Potential Blood-Based Biomarker in Non-Small Cell Lung Cancer

Martina Mandarano et al.

Summary: The study found that the serum Kyn/Trp ratio may serve as a serum biomarker for risk stratification and therapy optimization in non-small-cell lung cancer patients, with high Kyn/Trp ratio associated with clinical and histopathological parameters.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Advances in Pancreatic Ductal Adenocarcinoma Treatment

Eric M. Anderson et al.

Summary: Pancreatic cancer, with its highly immunosuppressive tumor microenvironment and dense stroma, presents challenges for traditional treatment approaches. Emerging treatment strategies have the potential to significantly improve outcomes for pancreatic cancer patients.

CANCERS (2021)

Article Multidisciplinary Sciences

A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment

Jen-Shin Song et al.

Summary: BPRCX807, a safe, selective, and potent CXCR4 antagonist, significantly suppresses primary tumor growth, prevents distant metastasis/cell migration, reduces angiogenesis, and normalizes the immunosuppressive tumor microenvironment in hepatocellular carcinoma mouse models. When used in combination therapy with sorafenib and anti-PD-1, it synergistically prolongs overall survival and further suppresses distant metastasis.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Oncology

Chronic Adrenergic Stress Contributes to Metabolic Dysfunction and an Exhausted Phenotype in T Cells in the Tumor Microenvironment

Guanxi Qiao et al.

Summary: Chronic stress has been shown to regulate the state of T cells in the tumor microenvironment, leading to metabolic dysfunction and exhaustion in tumor-infiltrating T cells, which in turn affects antitumor immunity and the efficacy of immune checkpoint inhibitors. Blocking chronic adrenergic stress signaling can reduce tumor growth rates and improve antitumor effector functions by increasing glycolysis and oxidative phosphorylation in tumor-infiltrating lymphocytes.

CANCER IMMUNOLOGY RESEARCH (2021)

Article Oncology

Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer

Tiffany R. Emmons et al.

Summary: Research has shown that ascites fluid supernatants from ovarian cancer patients in the tumor microenvironment can prolong neutrophil lifespan, decrease neutrophil density, and induce nuclear hypersegmentation. Ascites fluid supernatants induce distinct neutrophil clusters and stimulate complement deposition and signaling in neutrophils, resulting in neutrophil suppressor function.

CANCER IMMUNOLOGY RESEARCH (2021)

Review Oncology

The Role of Macrophages in Cancer Development and Therapy

Ewa Cendrowicz et al.

Summary: Tumor-Associated Macrophages (TAMs) play a crucial role in tumor development and are potential targets for cancer therapy due to their influence on immunity and tumor microenvironment.

CANCERS (2021)

Article Oncology

Neutrophil-to-Lymphocyte Ratio Is a Predictive Biomarker in Patients with Epidermal Growth Factor Receptor (EGFR) Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) Treated with Tyrosine Kinase Inhibitor (TKI) Therapy

Nicole K. Yun et al.

Summary: This study investigated the predictive value of NLR and other markers in patients with EGFR-mutated NSCLC undergoing TKI therapy. The results showed that high NLR values were associated with worse survival outcomes, suggesting its potential as a predictive biomarker for treatment intensification. Prospective validation of NLR is warranted.

CANCERS (2021)

Article Oncology

A randomized, placebo-controlled phase 2 study of paclitaxel in combination with reparixin compared to paclitaxel alone as front-line therapy for metastatic triple-negative breast cancer (fRida)

Lori J. Goldstein et al.

Summary: The addition of reparixin to first-line therapy with paclitaxel did not significantly prolong progression-free survival in metastatic triple-negative breast cancer patients.

BREAST CANCER RESEARCH AND TREATMENT (2021)

Review Cell Biology

Role of the CCL2-CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

Maosen Xu et al.

Summary: The chemokine ligand CCL2 and its receptor CCR2 play crucial roles in the initiation and progression of cancer by promoting tumor cell growth, migration, and recruitment of immunosuppressive cells. Studies have shown that therapeutic strategies targeting the CCL2-CCR2 axis are promising in combating cancer.

CELL PROLIFERATION (2021)

Article Oncology

Surufatinib for the treatment of advanced extrapancreatic neuroendocrine tumors

Xiuhua Lu et al.

Summary: Surufatinib is a novel oral tyrosine kinase inhibitor with dual anti-angiogenic and immune regulation activities. It has been approved as a monotherapy for advanced extrapancreatic neuroendocrine tumors in China, showing encouraging antitumor activity and manageable safety profile. Ongoing clinical trials are exploring combination therapy strategies and new indications for surufatinib in malignancies.

EXPERT REVIEW OF ANTICANCER THERAPY (2021)

Review Biochemistry & Molecular Biology

Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy

Pedro Bule et al.

Summary: Chemokines play a crucial role in cancer development by influencing various processes such as angiogenesis, metastasis, and stemness. The chemokine network has emerged as a potential target for immunotherapy and may have therapeutic effects when used alone or in combination with other treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Neutrophil extracellular traps in cancer: not only catching microbes

Livia Ronchetti et al.

Summary: Neutrophils are essential in immune defense, but their aberrant activation leading to NETosis in cancer has been associated with increased disease progression and complications. NETosis biomarkers could potentially help in selecting cancer patients for immunotherapy treatment.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Review Medicine, Research & Experimental

Macrophages as a weapon in anticancer cellular immunotherapy

Dmitry Aminin et al.

Summary: Anticancer immunotherapy is a treatment that activates the immune system to fight tumors with high specificity and low side effects. Macrophages show promising potential in cancer therapy, with M1 macrophages being a potential effective weapon in anticancer cellular immunotherapy.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2021)

Article Reproductive Biology

L-Tryptophan activates the aryl hydrocarbon receptor and induces cell cycle arrest in porcine trophectoderm cells

Kang Xu et al.

Summary: This study investigated the impact of tryptophan on the proliferation of porcine trophectoderm cells during embryonic implantation. The results showed that high levels of L-Trp can inhibit cell proliferation and induce cell cycle arrest, with the AHR signaling pathway potentially playing a key role in this process.

THERIOGENOLOGY (2021)

Review Immunology

The Recruitment of Neutrophils to the Tumor Microenvironment Is Regulated by Multiple Mediators

Shuvasree SenGupta et al.

Summary: Neutrophils play a crucial role in tumor progression and metastasis by sensing and migrating towards chemotactic factors released in the tumor microenvironment. The molecular mechanisms of how cancer cells secrete mediators to recruit neutrophils and the signaling network integration among mediators need further exploration for developing effective therapeutic strategies in cancer treatment.

FRONTIERS IN IMMUNOLOGY (2021)

Review Oncology

CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment

Jiakang Jin et al.

Summary: CCL2 plays a crucial role in tumor microenvironment by recruiting macrophages and stromal cells, impacting tumor progression both negatively and positively by influencing the immune response.

FRONTIERS IN ONCOLOGY (2021)

Review Cell Biology

At the bench: Pre-clinical evidence for multiple functions of CXCR4 in cancer

Gary D. Luker et al.

Summary: Signaling through CXCR4 regulates essential physiological processes and plays crucial roles in tumor growth, invasion, and metastasis. Animal models consistently demonstrate the importance of CXCR4 in cancer initiation and progression.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

Review Chemistry, Medicinal

Small-molecule CSF1R kinase inhibitors; review of patents 2015-present

William A. Denny et al.

Summary: In the past 5 years, there has been a significant increase in activity surrounding small molecule inhibitors of CSF1R, driven by the approval of pexidartinib in 2019. The field has seen surprising diversity in chemical classes and potential disease states targeted by these inhibitors, including cancer, arthritis, and cytokine storm syndromes. The range of potential utilities of CSF1R inhibitors has also expanded to include diseases like dementia, ulcerative colitis/Crohn's disease, rheumatoid arthritis inflammation, and fibrosis.

EXPERT OPINION ON THERAPEUTIC PATENTS (2021)

Review Immunology

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Filippo Veglia et al.

Summary: MDSCs are pathologically activated cells with potent immunosuppressive activity, closely associated with poor clinical outcomes in diseases like cancer. Recent studies have identified key distinctions between MDSCs and classical neutrophils and monocytes, providing new insights into therapeutic targeting for cancer and autoimmune diseases through understanding their genomic and metabolic characteristics. Emerging data also suggest potential involvement of MDSCs in pregnancy, neonatal biology, and COVID-19.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Medicine, General & Internal

Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC

S. S. Ramalingam et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Oncology

Myeloid-derived suppressor cells-new and exciting players in lung cancer

Zhenzhen Yang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Veterinary Sciences

Emerging therapeutic approaches for canine sarcomas: Pushing the boundaries beyond the conventional

Antonella Borgatti et al.

VETERINARY AND COMPARATIVE ONCOLOGY (2020)

Review Cell Biology

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer

Andrew M. K. Law et al.

CELLS (2020)

Review Cell Biology

T Cell Dysfunction and Exhaustion in Cancer

Zhen Zhang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Oncology

Immunoregulation and Clinical Implications of ANGPT2/TIE2+ M-MDSC Signature in Non-Small Cell Lung Cancer

Elodie Lauret Marie Joseph et al.

CANCER IMMUNOLOGY RESEARCH (2020)

Review Immunology

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

Alireza Labani-Motlagh et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

Kobe C. Yuen et al.

NATURE MEDICINE (2020)

Article Multidisciplinary Sciences

Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status

Peishan Li et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

Metabolic reprograming of tumor-associated macrophages

Abhishek Puthenveetil et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

Impairment of Hypoxia-Induced CA IX by Beta-Blocker Propranolol-Impact on Progression and Metastatic Potential of Colorectal Cancer Cells

Monika Barathova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response

Daniele Biasci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Oncology

Tyrosine kinase inhibitors for solid tumors in the past 20 years (2001-2020)

Liling Huang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

The updated landscape of tumor microenvironment and drug repurposing

Ming-Zhu Jin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Oncology

TIPE1 suppresses osteosarcoma tumor growth by regulating macrophage infiltration

P. Chen et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2019)

Article Pharmacology & Pharmacy

CS2164 suppresses acute myeloid leukemia cell growth via inhibiting VEGFR2 signaling in preclinical models

Manman Deng et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

RS 504393 inhibits M-MDSCs recruiting in immune microenvironment of bladder cancer after gemcitabine treatment

Xing-Yu Mu et al.

MOLECULAR IMMUNOLOGY (2019)

Review Immunology

Targeting Tumor-Associated Macrophages in Cancer

Paulina Pathria et al.

TRENDS IN IMMUNOLOGY (2019)

Review Oncology

Tumour-associated neutrophils in patients with cancer

Merav E. Shaul et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Editorial Material Medicine, Research & Experimental

Destress and do not suppress: targeting adrenergic signaling in tumor immunosuppression

Ignacio Inigo-Marco et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Oncology

Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

Maria Teresa Masucci et al.

FRONTIERS IN ONCOLOGY (2019)

Review Immunology

VISTA: A novel immunotherapy target for normalizing innate and adaptive immunity

Mohamed A. ElTanbouly et al.

SEMINARS IN IMMUNOLOGY (2019)

Article Medicine, Research & Experimental

Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC

Julia Kargl et al.

JCI INSIGHT (2019)

Article Medicine, Research & Experimental

Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy

Lillian Sun et al.

JCI INSIGHT (2019)

Review Biochemistry & Molecular Biology

Targeting tumour microenvironment by tyrosine kinase inhibitor

Hor-Yue Tan et al.

MOLECULAR CANCER (2018)

Review Biochemistry & Molecular Biology

Third generation EGFR TKIs: current data and future directions

Chee-Seng Tan et al.

MOLECULAR CANCER (2018)

Article Oncology

Programmed Cell Death Ligand 1 (PD-L1) Signaling Regulates Macrophage Proliferation and Activation

Genevieve P. Hartley et al.

CANCER IMMUNOLOGY RESEARCH (2018)

Review Oncology

Targeting the IDO1 pathway in cancer: from bench to bedside

Ming Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Review Immunology

Diamonds in the Rough: Harnessing Tumor-Associated Myeloid Cells for Cancer Therapy

Emile J. Clappaert et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Medicine, General & Internal

The prognostic impact of neutrophil to lymphocyte ratio in advanced non-small cell lung cancer patients treated with EGFR TKI

Thang Thanh Phan et al.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2018)

Review Oncology

The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity

Jan P. Boettcher et al.

TRENDS IN CANCER (2018)

Review Hematology

CTLA-4: a moving target in immunotherapy

Behzad Rowshanravan et al.

BLOOD (2018)

Review Immunology

New checkpoints in cancer immunotherapy

Ling Ni et al.

IMMUNOLOGICAL REVIEWS (2017)

Review Immunology

IDO1: An important immunotherapy target in cancer treatment

Fangxuan Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2017)

Article Multidisciplinary Sciences

Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer

Keehoon Jung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Oncology

Sorafenib: A Review in Hepatocellular Carcinoma

Gillian M. Keating

TARGETED ONCOLOGY (2017)

Article Oncology

Multiple anti-tumor effects of Reparixin on thyroid cancer

Federica Liotti et al.

ONCOTARGET (2017)

News Item Oncology

Why isn't the angiotensin type 1 receptor a target in cancer?

Gavin P. Vinson

ONCOTARGET (2017)

Review Medicine, Research & Experimental

Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases

Helen Ha et al.

THERANOSTICS (2017)

Review Pharmacology & Pharmacy

From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib

Amal Kamal Abdel-Aziz et al.

FRONTIERS IN PHARMACOLOGY (2017)

Review Oncology

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

Michael A. Cannarile et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)

Review Oncology

Mouse versus Human Neutrophils in Cancer: A Major Knowledge Gap

Evgeniy B. Eruslanov et al.

TRENDS IN CANCER (2017)

Review Biotechnology & Applied Microbiology

Sunitinib: the antiangiogenic effects and beyond

Zhonglin Hao et al.

ONCOTARGETS AND THERAPY (2016)

Review Multidisciplinary Sciences

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte et al.

NATURE COMMUNICATIONS (2016)

Review Cell Biology

Transcriptional regulation of myeloid-derived suppressor cells

Thomas Condamine et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2015)

Review Cell Biology

T-cell exhaustion in the tumor microenvironment

Y. Jiang et al.

CELL DEATH & DISEASE (2015)

Article Cell Biology

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

Rikke B. Holmgaard et al.

CELL REPORTS (2015)

Review Oncology

β-adrenergic receptor signaling in prostate cancer

Peder Rustoen Braadland et al.

FRONTIERS IN ONCOLOGY (2015)

Article Pharmacology & Pharmacy

Pharmacological Characterization of AZD5069, a Slowly Reversible CXC Chemokine Receptor 2 Antagonist

David J. Nicholls et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)

Article Chemistry, Medicinal

The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists

David W. Porter et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Article Cell Biology

Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells

Rebecca K. Martin et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2014)

Article Cell Biology

CSF-1 Receptor Signaling in Myeloid Cells

E. Richard Stanley et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Article Oncology

CXCL12-CXCR4 Promotes Proliferation and Invasion of Pancreatic Cancer Cells

Bo Shen et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2013)

Article Oncology

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

Giovanni Germano et al.

CANCER CELL (2013)

Article Multidisciplinary Sciences

Targeting CXCL12 from FAP-expressing carcinomaassociated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

Christine Feig et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Oncology

Immunosuppressive Mechanisms of Regulatory Dendritic Cells in Cancer

Galina V. Shurin et al.

CANCER MICROENVIRONMENT (2013)

Review Oncology

Tumor-associated neutrophils: friend or foe?

Zvi G. Fridlender et al.

CARCINOGENESIS (2012)

Review Oncology

On the dual roles and polarized phenotypes of neutrophils in tumor development and progression

H. Piccard et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2012)

Article Medicine, Research & Experimental

CXCR1/2 inhibition enhances pancreatic islet survival after transplantation

Antonio Citro et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Immunology

Coordinated regulation of myeloid cells by tumours

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Article Immunology

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses

Li Wang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Article Oncology

Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy

Xinmei Zhu et al.

JOURNAL OF NEURO-ONCOLOGY (2011)

Review Immunology

Myeloid-derived suppressor cell heterogeneity and subset definition

Elisa Peranzoni et al.

CURRENT OPINION IN IMMUNOLOGY (2010)

Review Veterinary Sciences

Tyrosine Kinase Inhibitors in Veterinary Medicine

Cheryl A. London

TOPICS IN COMPANION ANIMAL MEDICINE (2009)

Review Cell Biology

Immune surveillance: a balance between protumor and antitumor immunity

Suzanne Ostrand-Rosenberg

CURRENT OPINION IN GENETICS & DEVELOPMENT (2008)

Article Immunology

Subsets of myeloid-derived suppressor cells in tumor-bearing mice

Je-In Youn et al.

JOURNAL OF IMMUNOLOGY (2008)

Article Medicine, General & Internal

Sorafenib in advanced hepatocellular carcinoma

Josep M. Llovet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Oncology

B7-H3 and B7-H4 expression in non-small-cell lung cancer

Yuping Sun et al.

LUNG CANCER (2006)

Review Immunology

Colony-stimulating factor-1 in immunity and inflammation

V Chitu et al.

CURRENT OPINION IN IMMUNOLOGY (2006)

Article Pharmacology & Pharmacy

Role of tyrosine kinase inhibitors in cancer therapy

A Arora et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Article Chemistry, Medicinal

2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors

M Allegretti et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Article Oncology

Differential response of primary and metastatic melanomas to neutrophils attracted by IL-8

H Schaider et al.

INTERNATIONAL JOURNAL OF CANCER (2003)

Article Multidisciplinary Sciences

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

Y Iwai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Pharmacology & Pharmacy

Selective inhibition of interleukin-8-induced neutrophil chemotaxis by ketoprofen isomers

C Bizzarri et al.

BIOCHEMICAL PHARMACOLOGY (2001)